{"id":"https://openalex.org/W4397040261","doi":"https://doi.org/10.1681/asn.20233411s11132c","title":"Pauci-Immune ANCA(-) Extracapillary Glomerulonephritis in a Patient with Systemic Lupus Erythematosus (SLE)","display_name":"Pauci-Immune ANCA(-) Extracapillary Glomerulonephritis in a Patient with Systemic Lupus Erythematosus (SLE)","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397040261","doi":"https://doi.org/10.1681/asn.20233411s11132c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s11132c","doi":"https://doi.org/10.1681/asn.20233411s11132c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s11132c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032887365","display_name":"Enrique Fleuvier Morales L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enrique F. Morales Lopez","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103012878","display_name":"Juan Daniel Diaz Garcia","orcid":"https://orcid.org/0000-0002-5240-4782","observed_orcids":["https://orcid.org/0000-0002-5240-4782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan D. Diaz Garcia","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094352584","display_name":"Francisco Javier Hernandez Copca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco J. Hernandez Copca","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098690535","display_name":"Ydris Zelim Rosillo-Salgado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ydris Z. Rosillo-Salgado","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106793512","display_name":"Victor Manuel Ulloa Galv\u00e1n","orcid":"https://orcid.org/0009-0003-4084-382X","observed_orcids":["https://orcid.org/0009-0003-4084-382X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor M. Ulloa Galvan","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112808652","display_name":"Jose L. Ortega","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose L. Ortega","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092362546","display_name":"Mart\u00edn Benjam\u00edn Yam\u00e1 Estrella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin B. Yama Estrella","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012311567","display_name":"Mario Alamilla-Sanchez","orcid":"https://orcid.org/0000-0002-0678-5481","observed_orcids":["https://orcid.org/0000-0002-0678-5481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Alamilla-Sanchez","raw_affiliation_strings":["Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"1132","last_page":"1132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.225600004196167,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pauci-immune-glomerulonephritis","display_name":"pauci-immune glomerulonephritis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/extracapillary-glomerulonephritis","display_name":"extracapillary glomerulonephritis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9039999842643738},{"id":"https://openalex.org/keywords/anca-negative-vasculitis","display_name":"ANCA-negative vasculitis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/crescentic-glomerulonephritis","display_name":"crescentic glomerulonephritis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.6349999904632568},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.949999988079071},{"id":"https://openalex.org/keywords/kidney-biopsy","display_name":"renal biopsy","score":0.48399999737739563},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7754186391830444},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.7456849217414856},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6196376085281372},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.5539926290512085},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.4583854079246521},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44928574562072754},{"id":"https://openalex.org/C2778474638","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Immune complex","level":3,"score":0.4257689118385315},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.40317392349243164},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26530569791793823},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.19013914465904236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14958101511001587}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s11132c","doi":"https://doi.org/10.1681/asn.20233411s11132c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s11132c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4397047986","https://openalex.org/W2783731327","https://openalex.org/W7077678355","https://openalex.org/W4387641432","https://openalex.org/W2836248893","https://openalex.org/W3201741188","https://openalex.org/W2410009096","https://openalex.org/W2121672122","https://openalex.org/W4412032285","https://openalex.org/W4396998058"],"abstract_inverted_index":{"Introduction:":[0],"Although":[1],"ANCA":[2,158],"was":[3,167],"first":[4],"associated":[5,214],"with":[6,40,53,69,81,119,123,131,135,139,150,165,169,215],"primary":[7],"vasculitides,":[8],"it":[9,206],"is":[10,161,177,204,207],"now":[11],"clear":[12],"that":[13],"15-20%":[14],"of":[15,71,77,93,108,133,153,181,212,227,238],"lupus":[16],"patients":[17],"have":[18],"ANCA+,":[19],"in":[20,32,43,91,172,224],"some":[21],"cases,":[22],"although":[23],"negative,":[24],"histological":[25,239],"features":[26],"are":[27,217],"the":[28,200,225,232],"cause":[29],"for":[30,56],"suspicion.":[31],"this":[33,236],"entity.":[34],"Case":[35],"Description:":[36],"A":[37],"29-year-old":[38],"female":[39],"SLE":[41,216],"diagnosed":[42],"2019":[44],"presented":[45],"hematological":[46],"and":[47,63,74,98,127,145,189,220],"mucocutaneous":[48],"disease,":[49],"ANAs":[50],"laboratories":[51],"1:160,":[52],"induction":[54],"treatment":[55,80,164],"one":[57],"year":[58,85],"based":[59],"on":[60],"azathioprine,":[61],"prednisone":[62],"hydroxychloroquine.":[64],"In":[65],"2021":[66],"she":[67,87],"presents":[68],"proteinuria":[70,92,104],"672":[72],"mg":[73],"hematuria,":[75],"creatinine":[76],"0.9":[78],"mg/dl,":[79,95],"mycophenolic":[82],"acid.":[83],"One":[84],"later,":[86],"had":[88],"an":[89],"increase":[90],"703":[94],"ANCAs":[96],"PR3":[97],"MPO":[99],"negative.":[100],"She":[101],"integrates":[102],"hematuria":[103],"syndrome,":[105],"without":[106],"deterioration":[107],"renal":[109],"function,":[110],"eucomplementemic.":[111],"Kidney":[112],"biopsy":[113],"active":[114,120,144],"extracapillary":[115,121,147],"hypercellularity,":[116],"cellular":[117],"crescents":[118],"lesion":[122,183],"fibrocellular":[124],"crescents.":[125],"Prominent":[126],"vacuolated":[128],"podocytes,":[129],"interstitium":[130],"patches":[132],"fibrosis":[134],"tubular":[136],"atrophy,":[137],"IFI":[138],"positive":[140,142],"IGG,":[141],"C3C,":[143],"chronic":[146],"proliferative":[148],"glomerulonephritis":[149,176],"scant":[151],"deposits":[152],"immune":[154],"complexes.":[155],"By":[156],"histopathology,":[157],"(-)":[159],"vasculitis":[160],"suspected.":[162],"Therefore,":[163],"cyclophosphamide":[166],"started,":[168],"subsequent":[170],"improvement":[171],"proteinuria.":[173],"Discussion:":[174],"Crescentic":[175],"a":[178],"severe":[179],"form":[180],"glomerular":[182,201],"characterized":[184],"by":[185],"Bowman's":[186],"capsule":[187],"proliferation":[188],"fibrinoid":[190],"necrosis,":[191],"which":[192,203],"implies":[193],"little":[194],"or":[195],"no":[196],"Ig":[197],"deposition":[198],"at":[199],"level,":[202],"why":[205],"called":[208],"pauciimmune.":[209],"This":[210],"type":[211,237],"lesions":[213],"very":[218],"rare":[219],"even":[221],"more":[222],"so":[223],"context":[226],"negative":[228],"ANCA,":[229],"we":[230],"present":[231],"case":[233],"to":[234],"take":[235],"presentation":[240],"into":[241],"account.":[242]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2024-05-19T00:00:00"}