{"id":"https://openalex.org/W4397024488","doi":"https://doi.org/10.1681/asn.20223311s1190b","title":"12M Interim Analysis of an Open-Label, Non-Randomized Extension of a Phase 2 Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Iptacopan in Subjects With C3G","display_name":"12M Interim Analysis of an Open-Label, Non-Randomized Extension of a Phase 2 Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Iptacopan in Subjects With C3G","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4397024488","doi":"https://doi.org/10.1681/asn.20223311s1190b"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20223311s1190b","doi":"https://doi.org/10.1681/asn.20223311s1190b","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1190b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042194566","display_name":"Carla Nester","orcid":"https://orcid.org/0000-0002-0629-7576","observed_orcids":["https://orcid.org/0000-0002-0629-7576"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla M. Nester","raw_affiliation_strings":["University of Iowa Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011483688","display_name":"Ute Eisenberger","orcid":"https://orcid.org/0000-0003-3862-6933","observed_orcids":["https://orcid.org/0000-0003-3862-6933"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ute Eisenberger","raw_affiliation_strings":["Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025424518","display_name":"Alexandre Karras","orcid":"https://orcid.org/0000-0002-3075-7739","observed_orcids":["https://orcid.org/0000-0002-3075-7739"]},"institutions":[{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Karras","raw_affiliation_strings":["Hopital Europeen Georges Pompidou, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Europeen Georges Pompidou, Paris, France","institution_ids":["https://openalex.org/I4210102325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008005293","display_name":"Liz Lightstone","orcid":"https://orcid.org/0000-0002-4603-4076","observed_orcids":["https://orcid.org/0000-0002-4603-4076"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]},{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Liz Lightstone","raw_affiliation_strings":["Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom","Imperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Imperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052017202","display_name":"Manuel Praga","orcid":"https://orcid.org/0000-0001-9270-1071","observed_orcids":["https://orcid.org/0000-0001-9270-1071"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Praga","raw_affiliation_strings":["Department of Medicine, Complutense University. Hospital Universitario 12 de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Complutense University. Hospital Universitario 12 de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556434","display_name":"Giuseppe Remuzzi","orcid":"https://orcid.org/0000-0002-6194-3446","observed_orcids":["https://orcid.org/0000-0002-6194-3446"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Remuzzi","raw_affiliation_strings":["Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071593060","display_name":"Mar\u00eda Jos\u00e9 Soler","orcid":"https://orcid.org/0000-0003-3621-0766","observed_orcids":["https://orcid.org/0000-0003-3621-0766"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Jose Soler","raw_affiliation_strings":["Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725197","display_name":"Junhao Liu","orcid":"https://orcid.org/0000-0002-2545-7176","observed_orcids":["https://orcid.org/0000-0002-2545-7176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junhao Liu","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, NJ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053507788","display_name":"Matthias Meier","orcid":"https://orcid.org/0009-0008-3272-3365","observed_orcids":["https://orcid.org/0009-0008-3272-3365","https://orcid.org/0000-0001-9455-4538"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Meier","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036626720","display_name":"Ronda Tawfik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronda Tawfik","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, NJ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044897328","display_name":"G. Junge","orcid":"https://orcid.org/0000-0002-8938-3612","observed_orcids":["https://orcid.org/0000-0002-8938-3612"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Guido Junge","raw_affiliation_strings":["Novartis Institutes for BioMedical Research Basel Department of Translational Medicine, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research Basel Department of Translational Medicine, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079213735","display_name":"Andrea Biondani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andrea Biondani","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065799721","display_name":"Angelo J. Trapani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelo J. Trapani","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, NJ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015039473","display_name":"Nicholas J.A. Webb","orcid":"https://orcid.org/0000-0001-8572-5446","observed_orcids":["https://orcid.org/0000-0001-8572-5446","https://orcid.org/0009-0009-9849-1808"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicholas Webb","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021341974","display_name":"Edwin Kwan Soon Wong","orcid":"https://orcid.org/0000-0003-4867-6117","observed_orcids":["https://orcid.org/0000-0003-4867-6117"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edwin K. Wong","raw_affiliation_strings":["National Renal Complement Therapeutics Centre, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom","Newcastle University, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Renal Complement Therapeutics Centre, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I2800516725"]},{"raw_affiliation_string":"Newcastle University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"11S","first_page":"190","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iptacopan","display_name":"iptacopan","score":0.9649999737739563},{"id":"https://openalex.org/keywords/c3-glomerulonephritis","display_name":"C3 glomerulonephritis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/factor-b-inhibitor","display_name":"factor B inhibitor","score":0.7139999866485596},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.9879999756813049},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7459999918937683},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7319999933242798},{"id":"https://openalex.org/keywords/serum-c3","display_name":"serum C3","score":0.8349999785423279},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.7480000257492065},{"id":"https://openalex.org/keywords/long-term-efficacy-and-safety","display_name":"long-term efficacy and safety","score":0.7110000252723694},{"id":"https://openalex.org/keywords/renal-function-preservation","display_name":"renal function preservation","score":0.34299999475479126},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.4620000123977661},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.5640000104904175},{"id":"https://openalex.org/keywords/membranoproliferative-glomerulonephritis","display_name":"membranoproliferative glomerulonephritis","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8788840770721436},{"id":"https://openalex.org/C2776957806","wikidata":"https://www.wikidata.org/wiki/Q4895105","display_name":"Interim","level":2,"score":0.7793134450912476},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.6455985903739929},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.6401430368423462},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5745609998703003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4825303256511688},{"id":"https://openalex.org/C2778029271","wikidata":"https://www.wikidata.org/wiki/Q5421931","display_name":"Extension (predicate logic)","level":2,"score":0.4485458731651306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4105123281478882},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4047289192676544},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.29874005913734436},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18332788348197937},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.10191640257835388},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09635302424430847},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20223311s1190b","doi":"https://doi.org/10.1681/asn.20223311s1190b","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1190b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4398235203","https://openalex.org/W4403902079","https://openalex.org/W4396991752","https://openalex.org/W3169851986","https://openalex.org/W7104551624","https://openalex.org/W4415474581","https://openalex.org/W4403834474","https://openalex.org/W7104550858","https://openalex.org/W4415426104","https://openalex.org/W4403834246"],"abstract_inverted_index":{"Background:":[0],"Iptacopan":[1,206],"(LNP023)":[2],"is":[3,272],"an":[4],"oral,":[5],"first-in-class,":[6],"selective":[7],"inhibitor":[8],"of":[9,15,56,94,100,149,214,276],"factor":[10],"B,":[11],"a":[12,27,43,97],"key":[13],"component":[14],"the":[16,54,92,132,140,153,274],"alternative":[17],"complement":[18],"pathway":[19],"(AP).":[20],"We":[21],"have":[22],"previously":[23,240],"reported":[24,241],"data":[25],"from":[26,106,111,119],"Ph2":[28,81,134],"study":[29,271],"in":[30,42,46,48,113,121,190,197,217,231,245,252,258,263,278],"native":[31,49,63,246,279],"and":[32,115,175,184,210,235],"recurrent":[33,66,253],"C3G":[34,67,280],"(NCT03832114)":[35],"showing":[36],"that":[37,239],"12W":[38,77,133,243],"iptacopan":[39,58,73,95,145,229,277],"treatment":[40,143,227,244],"results":[41,230],"45%":[44],"reduction":[45,105,110,193,234],"proteinuria":[47,160,202,233],"C3G.":[50,247],"Here":[51],"we":[52],"present":[53],"effects":[55],"12M":[57,125],"treatment.":[59,126],"Methods:":[60],"Adults":[61],"with":[62,144,228,255],"(CoA)":[64],"or":[65],"post":[68],"kidney":[69],"transplant":[70],"(CoB)":[71],"received":[72],"for":[74,142],"at":[75,158],"least":[76],"before":[78],"entering":[79],"this":[80],"extension":[82,141],"trial":[83],"(NCT03955445).":[84],"The":[85,266],"primary":[86],"efficacy":[87,275],"objective":[88],"was":[89,161,182,194,203,207,250],"to":[90],"assess":[91],"effect":[93],"on":[96],"composite":[98,154],"endpoint":[99,156],"1)":[101],"stable/improved":[102],"eGFR":[103,167,181,236,249],"[\u226410%":[104],"baseline],":[107],"2)":[108],"\u226550%":[109,117],"baseline":[112,120,201],"UPCR,":[114],"3)":[116],"increase":[118],"serum":[122,259],"C3":[123,176,185,260],"after":[124],"Results:":[127],"Of":[128],"27":[129],"patients":[130,151],"completing":[131],"study,":[135],"26":[136],"(16CoA,":[137],"10CoB)":[138],"entered":[139],"200mg":[146],"b.i.d.":[147],"53%":[148],"CoA":[150],"met":[152],"renal":[155],"criteria":[157],"12M;":[159],"reduced":[162],"by":[163,169,178,188],"57%":[164],"(p<0.0001;":[165],"Fig1),":[166],"increased":[168,177,187],"6.83":[170],"mL/min/1.73":[171],"m2":[172],"(p=0.0174;":[173],"Fig2)":[174],"253%":[179],"(p<0.0001).":[180],"stable":[183,256],"levels":[186,261],"96%":[189],"CoB.":[191],"Proteinuria":[192],"not":[195],"assessed":[196],"CoB":[198],"as":[199],"median":[200],"normal":[204],"(18.4g/moL).":[205],"generally":[208],"well-tolerated":[209],"most":[211],"AEs":[212],"were":[213],"mild":[215],"severity":[216],"both":[218,264],"cohorts.":[219,265],"Biomarkers":[220],"demonstrated":[221],"substantial":[222],"AP":[223],"inhibition.":[224],"Conclusions:":[225],"Long-term":[226],"further":[232],"improvement":[237],"beyond":[238],"following":[242],"Stable":[248],"seen":[251],"C3G,":[254],"increases":[257],"found":[262],"ongoing":[267],"Ph3":[268],"APPEAR-C3G":[269],"(NCT04817618)":[270],"evaluating":[273],"patients.":[281],"Funding:":[282],"Commercial":[283],"Support":[284],"-":[285],"Novartis":[286],"Pharma":[287],"AG":[288]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-05-18T00:00:00"}