{"id":"https://openalex.org/W4397017131","doi":"https://doi.org/10.3389/fphar.2024.1324251","title":"Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis","display_name":"Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis","publication_year":2024,"publication_date":"2024-05-17","ids":{"openalex":"https://openalex.org/W4397017131","doi":"https://doi.org/10.3389/fphar.2024.1324251","pmid":"https://pubmed.ncbi.nlm.nih.gov/38828447","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11140021"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2024.1324251","doi":"https://doi.org/10.3389/fphar.2024.1324251","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1324251","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2024.1324251","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101486404","display_name":"Jin Young Hong","orcid":"https://orcid.org/0000-0001-6941-4832","observed_orcids":["https://orcid.org/0000-0001-6941-4832"]},"institutions":[{"id":"https://openalex.org/I4210103244","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210103244"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Young Hong","raw_affiliation_strings":["Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210103244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084500798","display_name":"Changhwan Yeo","orcid":"https://orcid.org/0000-0001-8738-6695","observed_orcids":["https://orcid.org/0000-0001-8738-6695"]},"institutions":[{"id":"https://openalex.org/I4210103244","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210103244"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Changhwan Yeo","raw_affiliation_strings":["Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210103244"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hyun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103244","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210103244"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Kim","raw_affiliation_strings":["Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210103244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087146429","display_name":"Junseon Lee","orcid":"https://orcid.org/0009-0006-1843-7042","observed_orcids":["https://orcid.org/0009-0006-1843-7042"]},"institutions":[{"id":"https://openalex.org/I4210103244","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210103244"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Junseon Lee","raw_affiliation_strings":["Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210103244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058052682","display_name":"Wan\u2010Jin Jeon","orcid":"https://orcid.org/0000-0002-9381-7591","observed_orcids":["https://orcid.org/0000-0002-9381-7591"]},"institutions":[{"id":"https://openalex.org/I4210103244","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210103244"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wan-Jin Jeon","raw_affiliation_strings":["Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210103244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039225766","display_name":"Yoon Jae Lee","orcid":"https://orcid.org/0000-0002-1532-0942","observed_orcids":["https://orcid.org/0000-0002-1532-0942"]},"institutions":[{"id":"https://openalex.org/I4210103244","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210103244"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Jae Lee","raw_affiliation_strings":["Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210103244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045499208","display_name":"In\u2010Hyuk Ha","orcid":"https://orcid.org/0000-0002-5020-6723","observed_orcids":["https://orcid.org/0000-0002-5020-6723"]},"institutions":[{"id":"https://openalex.org/I4210103244","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210103244"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"In-Hyuk Ha","raw_affiliation_strings":["Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210103244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045499208"],"corresponding_institution_ids":["https://openalex.org/I4210103244"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.1575,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84488033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"15","issue":null,"first_page":"1324251","last_page":"1324251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacopuncture","display_name":"pharmacopuncture","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lumbar-spinal-stenosis","display_name":"lumbar spinal stenosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/epidural-injection","display_name":"epidural injection","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.6710000038146973},{"id":"https://openalex.org/keywords/axon-growth","display_name":"axon growth","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.6389999985694885},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8859999775886536},{"id":"https://openalex.org/keywords/locomotor-recovery","display_name":"locomotor recovery","score":0.8939999938011169},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.703000009059906},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8614356517791748},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.5624947547912598},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.5483695268630981},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5472221374511719},{"id":"https://openalex.org/C2779631646","wikidata":"https://www.wikidata.org/wiki/Q17164695","display_name":"Lumbar spinal stenosis","level":3,"score":0.489855021238327},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4631701111793518},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4227627217769623},{"id":"https://openalex.org/C2780175798","wikidata":"https://www.wikidata.org/wiki/Q1478321","display_name":"Spinal stenosis","level":3,"score":0.42127907276153564},{"id":"https://openalex.org/C2909382400","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Lumbar Spinal Cord","level":3,"score":0.4121183753013611},{"id":"https://openalex.org/C178409289","wikidata":"https://www.wikidata.org/wiki/Q674696","display_name":"Nerve root","level":2,"score":0.410753071308136},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.270191490650177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1971231997013092},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2024.1324251","doi":"https://doi.org/10.3389/fphar.2024.1324251","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1324251","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11140021","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11140021","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11140021/pdf/fphar-15-1324251.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:38828447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38828447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:53c15c71e145422faf027c5a1844a387","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/53c15c71e145422faf027c5a1844a387","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2024.1324251","doi":"https://doi.org/10.3389/fphar.2024.1324251","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1324251","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8959426019","display_name":null,"funder_award_id":"HF21C0100","funder_id":"https://openalex.org/F4320319728","funder_display_name":"Jaseng Medical Foundation"}],"funders":[{"id":"https://openalex.org/F4320319728","display_name":"Jaseng Medical Foundation","ror":"https://ror.org/01bc2nz61"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4397017131.pdf","grobid_xml":"https://content.openalex.org/works/W4397017131.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1987913918","https://openalex.org/W1991267603","https://openalex.org/W2025340409","https://openalex.org/W2043564581","https://openalex.org/W2046767237","https://openalex.org/W2054760685","https://openalex.org/W2056526677","https://openalex.org/W2064212861","https://openalex.org/W2066551129","https://openalex.org/W2073733662","https://openalex.org/W2079177710","https://openalex.org/W2080030828","https://openalex.org/W2104709878","https://openalex.org/W2114497575","https://openalex.org/W2117721412","https://openalex.org/W2148991347","https://openalex.org/W2171603490","https://openalex.org/W2215609377","https://openalex.org/W2298981934","https://openalex.org/W2331526244","https://openalex.org/W2406810131","https://openalex.org/W2408110716","https://openalex.org/W2471717589","https://openalex.org/W2567280934","https://openalex.org/W2580787962","https://openalex.org/W2724960832","https://openalex.org/W2751251113","https://openalex.org/W2767631641","https://openalex.org/W2800834778","https://openalex.org/W2897950921","https://openalex.org/W2910089363","https://openalex.org/W2941797716","https://openalex.org/W3009809674","https://openalex.org/W3035779970","https://openalex.org/W3041431163","https://openalex.org/W3044464952","https://openalex.org/W3094261173","https://openalex.org/W3118655192","https://openalex.org/W3122766555","https://openalex.org/W3160955487","https://openalex.org/W3187807708","https://openalex.org/W3202323002","https://openalex.org/W4200262324","https://openalex.org/W4285740131","https://openalex.org/W4295793026","https://openalex.org/W4306148582","https://openalex.org/W4321166206","https://openalex.org/W4323858111","https://openalex.org/W4375862054","https://openalex.org/W4387763616"],"related_works":["https://openalex.org/W4386780370","https://openalex.org/W4411432795","https://openalex.org/W3202323002","https://openalex.org/W2941797716","https://openalex.org/W2050220036","https://openalex.org/W4375862054","https://openalex.org/W7100992234","https://openalex.org/W4405658410","https://openalex.org/W4323858111","https://openalex.org/W7102399075"],"abstract_inverted_index":{"The":[0,79],"choice":[1],"of":[2,81,133,137,167,177],"treatment":[3,24,35,80,182,252],"for":[4,62,123,145,161,254],"lumbar":[5],"spinal":[6],"stenosis":[7],"(LSS)":[8],"depends":[9],"on":[10],"symptom":[11],"severity.":[12],"When":[13,127],"severe":[14],"motor":[15],"issues":[16],"with":[17,64,93],"urinary":[18],"dysfunction":[19],"are":[20],"not":[21,226],"present,":[22],"conservative":[23,34],"is":[25,36,40,67],"often":[26],"considered":[27],"to":[28,72,105,173],"be":[29,106],"the":[30,46,86,157,170,191,198,208],"priority.":[31],"One":[32],"such":[33],"epidural":[37,71,131,165,223,245],"injection,":[38],"which":[39],"effective":[41,251],"in":[42,75,153,169,184,237],"alleviating":[43],"inflammation":[44,229],"and":[45,100,108,140,194,197,214,235],"pain":[47,236],"caused":[48],"by":[49,190],"LSS-affected":[50],"nerves.":[51],"In":[52],"this":[53],"study,":[54],"Shinbaro2":[55],"(Sh2),":[56],"pharmacopuncture":[57],"using":[58,207],"natural":[59],"herbal":[60],"medicines":[61],"patients":[63],"disc":[65],"diseases,":[66],"introduced":[68],"as":[69,188,249],"an":[70,250],"treat":[73],"LSS":[74,128,162,238],"a":[76,148,174],"rat":[77],"model.":[78],"primary":[82],"sensory":[83],"neurons":[84,92],"from":[85],"rats\u2019":[87],"dorsal":[88],"root":[89],"ganglion":[90],"(DRG)":[91],"Sh2":[94,138,168,181,224,242],"at":[95],"various":[96],"concentrations":[97,136],"(0.5,":[98],"1,":[99],"2":[101,141],"mg/mL)":[102],"was":[103,151,212,217],"found":[104],"safe":[107],"non-toxic.":[109],"Furthermore,":[110],"it":[111],"remarkably":[112],"stimulated":[113],"axonal":[114],"outgrowth":[115],"even":[116],"under":[117],"H2O2-treated":[118],"conditions,":[119],"indicating":[120],"its":[121],"potential":[122,248],"stimulating":[124],"nerve":[125],"regeneration.":[126],"rats":[129],"received":[130],"injections":[132],"two":[134],"different":[135],"(1":[139],"mg/kg)":[142],"once":[143],"daily":[144],"4":[146],"weeks,":[147],"significant":[149,175],"reduction":[150],"seen":[152],"ED1+":[154],"macrophages":[155],"surrounding":[156],"silicone":[158],"block":[159],"used":[160],"induction.":[163],"Moreover,":[164],"injection":[166,225,246],"DRG":[171],"led":[172],"suppression":[176],"pain-related":[178],"factors.":[179],"Notably,":[180],"resulted":[183],"improved":[185,232],"locomotor":[186,233],"recovery,":[187],"evaluated":[189],"Basso,":[192],"Beattie,":[193],"Bresnahan":[195],"scale":[196],"horizontal":[199],"ladder":[200],"test.":[201],"Additionally,":[202],"hind":[203],"paw":[204],"hypersensitivity,":[205],"assessed":[206],"Von":[209],"Frey":[210],"test,":[211],"reduced,":[213],"normal":[215],"gait":[216],"restored.":[218],"Our":[219],"findings":[220],"demonstrate":[221],"that":[222],"only":[227],"reduced":[228],"but":[230],"also":[231],"function":[234],"model":[239],"rats.":[240],"Thus,":[241],"delivery":[243],"via":[244],"has":[247],"option":[253],"LSS.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-05-18T00:00:00"}