{"id":"https://openalex.org/W4397014340","doi":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","title":"Cardiac Toxicity of Trastuzumab in Patients Treated for Breast Cancer HER2 3+ An Algerian Study","display_name":"Cardiac Toxicity of Trastuzumab in Patients Treated for Breast Cancer HER2 3+ An Algerian Study","publication_year":2024,"publication_date":"2024-04-25","ids":{"openalex":"https://openalex.org/W4397014340","doi":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004"},"language":"en","primary_location":{"id":"doi:10.36346/sarjmcr.2024.v05i02.004","doi":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","is_oa":true,"landing_page_url":"http://doi.org/10.36346/sarjmcr.2024.v05i02.004","pdf_url":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","source":{"id":"https://openalex.org/S4387280502","display_name":"SAR Journal of Medical Case Reports","issn_l":"2707-7780","issn":["2707-7780","2709-6947"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAR Journal of Medical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093959616","display_name":"Zakia Batoul Benlahreche","orcid":"https://orcid.org/0009-0004-5499-0991","observed_orcids":["https://orcid.org/0009-0004-5499-0991"]},"institutions":[{"id":"https://openalex.org/I50219554","display_name":"Amar Telidji University of Laghouat","ror":"https://ror.org/018bbh535","country_code":"DZ","type":"education","lineage":["https://openalex.org/I50219554"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Zakia Batoul Benlahrech","raw_affiliation_strings":["Hospital of Laghouat, University Amar Telidji of Laghouat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Laghouat, University Amar Telidji of Laghouat","institution_ids":["https://openalex.org/I50219554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093921382","display_name":"Kamel Ha\u00efl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I50219554","display_name":"Amar Telidji University of Laghouat","ror":"https://ror.org/018bbh535","country_code":"DZ","type":"education","lineage":["https://openalex.org/I50219554"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Kamel Hail","raw_affiliation_strings":["Hospital of Laghouat , University Amar Telidji of Laghouat","University Hospital Center of Algiers , Hospital of Algiers Mustapha , University of Algiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Laghouat , University Amar Telidji of Laghouat","institution_ids":["https://openalex.org/I50219554"]},{"raw_affiliation_string":"University Hospital Center of Algiers , Hospital of Algiers Mustapha , University of Algiers","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114162117","display_name":"Mouna Khireddine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mouna Khireddine","raw_affiliation_strings":["Public Establishment for Local Healthcare Kouba, Algiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Establishment for Local Healthcare Kouba, Algiers","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5098680242","display_name":"Houda Khadroune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I50219554","display_name":"Amar Telidji University of Laghouat","ror":"https://ror.org/018bbh535","country_code":"DZ","type":"education","lineage":["https://openalex.org/I50219554"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Houda Khadroune","raw_affiliation_strings":["Hospital of Laghouat, University Amar Telidji of Laghouat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Laghouat, University Amar Telidji of Laghouat","institution_ids":["https://openalex.org/I50219554"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14022396,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"02","first_page":"27","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.972000002861023},{"id":"https://openalex.org/keywords/echocardiographic-monitoring","display_name":"echocardiographic monitoring","score":0.8240000009536743},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9617579579353333},{"id":"https://openalex.org/C2910163948","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiac toxicity","level":3,"score":0.7218098640441895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7166136503219604},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7010939121246338},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6131605505943298},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5475559830665588},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5220208764076233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5135262608528137}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36346/sarjmcr.2024.v05i02.004","doi":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","is_oa":true,"landing_page_url":"http://doi.org/10.36346/sarjmcr.2024.v05i02.004","pdf_url":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","source":{"id":"https://openalex.org/S4387280502","display_name":"SAR Journal of Medical Case Reports","issn_l":"2707-7780","issn":["2707-7780","2709-6947"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAR Journal of Medical Case Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36346/sarjmcr.2024.v05i02.004","doi":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","is_oa":true,"landing_page_url":"http://doi.org/10.36346/sarjmcr.2024.v05i02.004","pdf_url":"https://doi.org/10.36346/sarjmcr.2024.v05i02.004","source":{"id":"https://openalex.org/S4387280502","display_name":"SAR Journal of Medical Case Reports","issn_l":"2707-7780","issn":["2707-7780","2709-6947"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAR Journal of Medical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4397014340.pdf","grobid_xml":"https://content.openalex.org/works/W4397014340.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2097026108","https://openalex.org/W2101253730","https://openalex.org/W2118878272","https://openalex.org/W2166666753","https://openalex.org/W2436341310","https://openalex.org/W2745907565","https://openalex.org/W4254130498"],"related_works":["https://openalex.org/W2589790483","https://openalex.org/W2268024701","https://openalex.org/W2220374552","https://openalex.org/W2911445457","https://openalex.org/W3013129387","https://openalex.org/W2734796164","https://openalex.org/W3020731322","https://openalex.org/W2341806096","https://openalex.org/W3003660073","https://openalex.org/W2331664680"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,6,28,104,199,218],"is":[2,12,163,258],"the":[3,24,50,63,69,95,164,180,185],"most":[4],"common":[5,260],"in":[7,18,99,126,158,194,211,262],"women":[8],"worldwide,":[9],"its":[10,169],"incidence":[11,96],"increasing":[13],"but":[14,265],"mortality":[15],"has":[16],"decreased":[17],"a":[19,32,75,175],"huge":[20],"way":[21],"due":[22],"to":[23,93,206,239],"growth":[25],"of":[26,54,68,83,89,97,110,145,149,182,192],"various":[27],"treatments.":[29],"Patients":[30],"with":[31,43,152,197,216,225,251,256],"contraindication":[33],"for":[34,81,102,140,168],"trastuzumab,":[35,240],"an":[36,123,155,226],"incomplete":[37,241],"cardiographic":[38],"echo":[39],"record,":[40],"and":[41,129,142,160,184,230,249],"patients":[42,100,112,121,196,237,244,250],"already":[44],"heart":[45,135,228],"disease":[46],"were":[47,66],"excluded":[48,236],"from":[49,203],"history.":[51],"The":[52,86,147],"means":[53],"cardiac":[55,58,161],"monitoring":[56,276],"was":[57,79,92],"ultrasound":[59],"or":[60],"isotopic":[61],"ventriculography,":[62],"toxicity":[64,162],"criteria":[65],"those":[67],"New":[70],"York":[71],"Heart":[72],"Association":[73],"(NYHA),":[74],"detailed":[76],"operating":[77],"sheet":[78],"made":[80],"each":[82],"our":[84,90,111,263],"patients.":[85],"main":[87],"objective":[88],"study":[91,213],"assess":[94],"cardiotoxicity":[98,116,191],"treated":[101,222],"breast":[103,198,217,253],"HER":[105],"2":[106],"3+":[107,201,221],"by":[108,223,277],"trastuzumab.06%":[109],"had":[113,114,122,132],"trastuzumab":[115,153,224,248,257],"(i.e.":[117],"3":[118],"cases);":[119],"two":[120],"asymptomatic":[124],"decrease":[125],"reversible":[127],"LVEF":[128,232],"one":[130],"patient":[131,215],"clinically":[133],"significant":[134],"failure":[136],"requiring":[137],"appropriate":[138],"treatment":[139],"ICS":[141],"permanent":[143],"discontinuation":[144],"trastuzumab.":[146],"protocols":[148],"targeted":[150],"therapy":[151],"are":[154],"essential":[156],"progress":[157],"oncology":[159],"major":[165],"limiting":[166],"factor":[167],"use.":[170],"Our":[171],"work":[172],"focuses":[173],"on":[174],"retrospective":[176],"study,":[177],"conducted":[178],"at":[179],"Department":[181],"Oncology":[183],"Hospital":[186],"Ahmida":[187],"Ben":[188],"adjila":[189],"discussing":[190],"tarstuzumab":[193],"50":[195],"HER2":[200,220],"collected":[202],"january":[204],"2014":[205],"december":[207],"2019.we":[208],"have":[209],"included":[210],"this":[212],"all":[214],"overexpressing":[219],"initial":[227],"function":[229],"preserved":[231],"\u22655":[233],"5%.":[234],"We":[235],"contre":[238],"echocardiographic":[242],"folder,":[243],"who":[245],"received":[246],"neoadjuvant":[247],"metastatic":[252],"cancer.":[254],"Cardiotoxicity":[255],"not":[259],"enough":[261],"series":[264],"it":[266],"does":[267],"exist,":[268],"which":[269],"requires":[270],"several":[271],"careful":[272],"preventive":[273],"measures":[274],"including":[275],"echocardiography.":[278]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-05-18T00:00:00"}