{"id":"https://openalex.org/W4396998940","doi":"https://doi.org/10.1681/asn.20203110s1193a","title":"Lower Urine Citrate Excretion Associated with Advanced CKD Stage Is Mediated by Reduced Plasma Citrate and Decreased Kidney Citrate Clearance","display_name":"Lower Urine Citrate Excretion Associated with Advanced CKD Stage Is Mediated by Reduced Plasma Citrate and Decreased Kidney Citrate Clearance","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396998940","doi":"https://doi.org/10.1681/asn.20203110s1193a"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1193a","doi":"https://doi.org/10.1681/asn.20203110s1193a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1193a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112327253","display_name":"Nimrit Goraya","orcid":"https://orcid.org/0000-0003-1429-5711","observed_orcids":["https://orcid.org/0000-0003-1429-5711"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nimrit Goraya","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX;","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070953919","display_name":"Nicolaos E. Madias","orcid":"https://orcid.org/0000-0001-5436-1512","observed_orcids":["https://orcid.org/0000-0001-5436-1512"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolaos E. Madias","raw_affiliation_strings":["Tufts University School of Medicine, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University School of Medicine, Boston, MA;","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abdullah A. Mamun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdullah A. Mamun","raw_affiliation_strings":["Baylor Scott and White Health and Wellness Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Scott and White Health and Wellness Center, Dallas, TX;","institution_ids":["https://openalex.org/I4210160418"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jan Simoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Simoni","raw_affiliation_strings":["Surgery, Texas Tech University HSC, Lubbock, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Texas Tech University HSC, Lubbock, TX","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019935894","display_name":"Donald E. Wesson","orcid":"https://orcid.org/0009-0007-7952-7401","observed_orcids":["https://orcid.org/0009-0007-7952-7401"]},"institutions":[{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald E. Wesson","raw_affiliation_strings":["Baylor Scott and White Health and Wellness Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Scott and White Health and Wellness Center, Dallas, TX;","institution_ids":["https://openalex.org/I4210160418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"193","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8180000185966492},{"id":"https://openalex.org/keywords/plasma-citrate","display_name":"plasma citrate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/acid-retention","display_name":"acid retention","score":0.7379999756813049},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.4480000138282776},{"id":"https://openalex.org/keywords/ckd-stage","display_name":"CKD stage","score":0.367000013589859},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5329999923706055},{"id":"https://openalex.org/keywords/urinary-bicarbonate","display_name":"urinary bicarbonate","score":0.3720000088214874},{"id":"https://openalex.org/keywords/urinary-potassium","display_name":"urinary potassium","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6168122887611389},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5557764172554016},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5098077654838562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4735129177570343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3891599476337433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38680845499038696},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.38431963324546814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1193a","doi":"https://doi.org/10.1681/asn.20203110s1193a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1193a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396998937","https://openalex.org/W4397046433","https://openalex.org/W4397046346","https://openalex.org/W2951431435","https://openalex.org/W4397046413","https://openalex.org/W2920081892","https://openalex.org/W4315926908","https://openalex.org/W7140294880","https://openalex.org/W2936562811","https://openalex.org/W3045422450"],"abstract_inverted_index":{"Background:":[0],"Lower":[1],"urine":[2],"citrate":[3,82,87,89,318,322,327],"excretion":[4],"(UcitV)":[5],"might":[6],"be":[7],"a":[8],"biomarker":[9,39],"of":[10,37,178],"covert":[11],"acid":[12,129],"(H+)":[13],"retention":[14,215,288,314],"in":[15,45,63,91,154],"patients":[16,31,46,93],"with":[17,32,47,50,94,101,109,115,136,226,235,285,308,315],"CKD":[18,33,48,66,95,102,110,187,189,192,228,237,281],"but":[19],"without":[20],"metabolic":[21],"acidosis":[22],"and":[23,68,85,107,132,141,191,197,208,213,220,241,255,262,270,289,298,320],"so":[24],"mechanisms":[25,69],"that":[26,70,304],"mediate":[27,71],"UcitV":[28,52,64,78,231,306],"differences":[29,62],"among":[30,186],"would":[34],"help":[35],"assessment":[36],"its":[38],"utility.":[40],"Because":[41],"longitudinal":[42],"eGFR":[43,310],"decreases":[44],"associated":[49,284,307],"decreasing":[51],"(Goraya,":[53],"et":[54],"al.":[55],"AJP":[56],"317:F502,":[57],"2019),":[58],"we":[59],"examined":[60],"cross-sectional":[61],"across":[65],"stages":[67],"such":[72],"differences.":[73],"Methods:":[74],"We":[75,120],"measured":[76],"8-hour":[77],"(8h":[79],"UcitV),":[80],"plasma":[81,137],"concentration":[83],"(Pcit),":[84],"kidney":[86,326],"clearance":[88],"(UcitV/Pcit)":[90],"52":[92,108],"1":[96],"(eGFR=99.5\u00b17.7":[97],"ml/min/1.73":[98,105,113,274],"m2),":[99,106],"120":[100],"2":[103,162],"(eGFR=73.4\u00b16.1":[104],"3":[111,193],"(eGFR=40.1\u00b17.6":[112],"m2)":[114],"macroalbuminuric,":[116],"non-diabetic,":[117],"hypertension-associated":[118],"nephropathy.":[119],"assessed":[121],"ongoing":[122],"dietary":[123],"H+":[124,142,214,287,313],"intake":[125],"as":[126,246],"potential":[127],"renal":[128],"load":[130],"(PRAL)":[131],"steady-state":[133],"acid-base":[134],"status":[135],"total":[138],"CO2":[139],"(PTCO2)":[140],"retention,":[143],"the":[144,292],"latter":[145,293],"estimated":[146],"by":[147,295],"comparing":[148],"observed":[149],"to":[150,156],"expected":[151],"PTCO2":[152,202],"increase":[153],"response":[155],"retained":[157],"HCO3":[158,175],"(administered":[159],"minus":[160],"UHCO3V)":[161],"hours":[163],"after":[164],"oral":[165],"NaHCO3":[166],"bolus":[167],"(0.5":[168],"mmol/kg":[169],"bw),":[170],"assuming":[171],"50%":[172],"body":[173,317],"weight":[174],"apparent":[176],"space":[177],"distribution.":[179],"Results:":[180],"Although":[181],"PRAL":[182],"was":[183,203,232,247,283],"not":[184],"different":[185],"1,":[188],"2,":[190],"groups":[194],"(62.4\u00b111.9,":[195],"62.9\u00b114.7,":[196],"65.2\u00b17.9":[198],"mmol/day,":[199],"respectively,":[200,211,224,244,260,276],"p=0.47),":[201],"progressively":[204,216,233],"lower":[205,234,290,296,299],"(26.4\u00b10.7,":[206],"25.9\u00b10.6,":[207],"21.6\u00b11.9":[209],"mM,":[210,259],"p<0.01)":[212,225,245,261],"higher":[217],"(3.9\u00b112.9,":[218],"18.2\u00b114.0,":[219],"25.1":[221],"\u00b113.4":[222],"mmol,":[223],"advancing":[227,236],"stage.":[229],"8h":[230],"stage":[238,282],"(1.14\u00b10.03,":[239],"1.00\u00b10.25,":[240],"0.86\u00b10.10":[242],"mmol/1.73m2,":[243],"Pcit":[248,297],"(0.16":[249],"\u00b1":[250,253,257,265,268,272],"0.01,":[251],"0.15":[252],"0.02,":[254],"0.14":[256],"0.01":[258],"UcitV/Pcit":[263],"(0.015":[264],"0.001,":[266],"0.014":[267],"0.003,":[269],"0.013":[271],"0.001":[273],"m2,":[275],"p<0.01).":[277],"Conclusions:":[278],"Cross-sectional":[279],"advanced":[280],"greater":[286],"UcitV,":[291],"mediated":[294],"UcitV/Pcit.":[300],"The":[301],"data":[302],"support":[303],"reduced":[305,316,325],"decreased":[309],"reflects":[311],"underlying":[312],"stores":[319],"increased":[321],"conservation":[323],"through":[324],"clearance.":[328]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-05-18T00:00:00"}
