{"id":"https://openalex.org/W4396998779","doi":"https://doi.org/10.1681/asn.20203110s1555c","title":"Glomerular Proteomics Reveal Shared Pathways Across Several Disease","display_name":"Glomerular Proteomics Reveal Shared Pathways Across Several Disease","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396998779","doi":"https://doi.org/10.1681/asn.20203110s1555c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1555c","doi":"https://doi.org/10.1681/asn.20203110s1555c","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1555c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058422244","display_name":"Salem J. Almaani","orcid":"https://orcid.org/0000-0003-2271-500X","observed_orcids":["https://orcid.org/0000-0003-2271-500X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salem Almaani","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070696987","display_name":"Isabelle M. Ayoub","orcid":"https://orcid.org/0000-0002-7988-3082","observed_orcids":["https://orcid.org/0000-0002-7988-3082"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabelle Ayoub","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069212517","display_name":"John P. Shapiro","orcid":"https://orcid.org/0000-0001-6698-2340","observed_orcids":["https://orcid.org/0000-0001-6698-2340"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Shapiro","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082905479","display_name":"Sethu M. Madhavan","orcid":"https://orcid.org/0000-0002-0528-7333","observed_orcids":["https://orcid.org/0000-0002-0528-7333"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sethu M. Madhavan","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077634371","display_name":"Anjali A. Satoskar","orcid":"https://orcid.org/0000-0002-3332-0161","observed_orcids":["https://orcid.org/0000-0002-3332-0161"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjali A. Satoskar","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085061817","display_name":"Michael L. Merchant","orcid":"https://orcid.org/0000-0003-4128-4057","observed_orcids":["https://orcid.org/0000-0003-4128-4057"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Merchant","raw_affiliation_strings":["University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111515139","display_name":"Jon B. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon B. Klein","raw_affiliation_strings":["University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042356850","display_name":"Brad H. Rovin","orcid":"https://orcid.org/0000-0001-5639-0210","observed_orcids":["https://orcid.org/0000-0001-5639-0210"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad H. Rovin","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043634316","display_name":"Samir V. Parikh","orcid":"https://orcid.org/0000-0001-7023-525X","observed_orcids":["https://orcid.org/0000-0001-7023-525X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir V. Parikh","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"555","last_page":"555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.8889999985694885},{"id":"https://openalex.org/keywords/complement-regulation","display_name":"complement regulation","score":0.875},{"id":"https://openalex.org/keywords/fibrin-clot-formation","display_name":"fibrin clot formation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":1.0},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5249999761581421},{"id":"https://openalex.org/keywords/kidney-biopsy","display_name":"renal biopsy","score":0.6029999852180481},{"id":"https://openalex.org/keywords/laser-capture-microdissection","display_name":"laser capture microdissection","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6605541706085205},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5458846092224121},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49220433831214905},{"id":"https://openalex.org/C2910856063","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Kidney Glomerulus","level":4,"score":0.4314470887184143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37803518772125244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3444712162017822},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2579837441444397},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.23045551776885986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21673303842544556},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.15168067812919617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11485743522644043},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1555c","doi":"https://doi.org/10.1681/asn.20203110s1555c","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1555c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095468914","https://openalex.org/W2045434917","https://openalex.org/W4403833317","https://openalex.org/W4388182130","https://openalex.org/W4415665594","https://openalex.org/W7130406422","https://openalex.org/W2766236479","https://openalex.org/W4360615547","https://openalex.org/W4403831011","https://openalex.org/W7104556486"],"abstract_inverted_index":{"Background:":[0],"Glomerular":[1],"diseases":[2,101,238,275],"are":[3,23,28,183],"caused":[4],"by":[5],"a":[6,72,87,148,233,271,277],"variety":[7,88,272],"of":[8,21,36,59,89,130,152,213,232,236,273],"immunologic":[9,258],"and":[10,25,38,62,69,102,117,182,194,199,219,259],"metabolic":[11,260],"disturbances.":[12],"While":[13],"there":[14],"is":[15,44],"considerable":[16],"disease":[17,47,132,206,227],"heterogeneity,":[18],"morphologic":[19],"patterns":[20],"injury":[22,43,61],"limited":[24],"clinical":[26],"phenotypes":[27],"similar":[29,45,279],"across":[30,46,86,98,270],"diseases.":[31],"This":[32],"suggests":[33],"that":[34,138,244,262],"mechanisms":[35,51],"inflammation":[37],"the":[39,56,142,209,264],"glomerular":[40,60,90,100,237,252,274],"response":[41],"to":[42,64,81,135,266,280],"states.":[48],"Characterizing":[49],"these":[50],"may":[52,245],"provide":[53],"insights":[54,66],"into":[55,180],"common":[57,83,247],"pathways":[58,85,177,212,222,243,249,255],"lead":[63],"new":[65],"in":[67,141,157,185,191,204,225,276],"pathogenesis":[68],"treatment.":[70],"As":[71],"first":[73],"step,":[74],"we":[75],"used":[76,168],"an":[77],"agnostic":[78],"proteomics":[79],"approach":[80],"identify":[82],"regulated":[84],"disorders.":[91],"Methods:":[92],"Kidney":[93],"biopsies":[94],"from":[95],"36":[96],"patients":[97],"several":[99,240],"21":[103],"controls":[104],"(transplant":[105],"donor":[106],"biopsies)":[107],"were":[108,111,122,133,139,155,167,178,202,223],"used.":[109],"Glomeruli":[110],"isolated":[112],"using":[113,172],"laser-capture":[114],"microdissection,":[115],"processed,":[116],"submitted":[118],"for":[119,124,169],"LC-MS/MS.":[120],"Peptides":[121],"analyzed":[123,140],"spectral":[125,149],"count":[126,150],"quantitation.":[127],"Spectral":[128],"counts":[129],"each":[131],"compared":[134],"control":[136],"samples":[137],"same":[143],"batch.":[144],"Only":[145],"peptides":[146],"with":[147,251],"coefficient":[151],"variation":[153],"<1":[154],"included":[156],"expression":[158,162],"ratio":[159],"calculations.":[160],"Diseaseto-control":[161],"ratios":[163],">2":[164],"or":[165],"<0.5":[166],"pathway":[170],"analysis":[171,231],"Reactome.":[173],"The":[174],"top":[175],"10":[176],"grouped":[179],"domains":[181],"depicted":[184],"figure":[186],"1.":[187],"Results:":[188],"Pathways":[189],"involved":[190],"complement":[192],"regulation":[193],"activation,":[195],"fibrin":[196],"clot":[197],"formation,":[198],"platelet":[200],"aggregation":[201],"upregulated":[203],"most":[205,226],"categories.":[207,228],"On":[208],"other":[210],"hand,":[211],"carbohydrate,":[214],"protein,":[215],"amino":[216],"acid":[217],"metabolism,":[218],"cell":[220],"cycle":[221],"downregulated":[224],"Conclusions:":[229],"Proteomic":[230],"heterogeneous":[234],"population":[235],"identified":[239],"shared":[241],"dysregulated":[242],"reflect":[246,256],"final":[248],"associated":[250],"injury.":[253],"These":[254],"important":[257],"changes":[261],"have":[263],"potential":[265],"be":[267],"leveraged":[268],"therapeutically":[269],"manner":[278],"RAAS":[281],"blockade.":[282]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-18T00:00:00"}