{"id":"https://openalex.org/W4396998653","doi":"https://doi.org/10.1681/asn.20203110s1565b","title":"Nephritic Factor Function Over Time","display_name":"Nephritic Factor Function Over Time","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396998653","doi":"https://doi.org/10.1681/asn.20203110s1565b"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1565b","doi":"https://doi.org/10.1681/asn.20203110s1565b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1565b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044007775","display_name":"Christopher T. Culek","orcid":"https://orcid.org/0009-0001-0305-0359","observed_orcids":["https://orcid.org/0009-0001-0305-0359"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Culek","raw_affiliation_strings":["Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114161828","display_name":"Monica D. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica D. Hall","raw_affiliation_strings":["Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063870739","display_name":"Yuzhou Zhang","orcid":"https://orcid.org/0000-0002-9626-5956","observed_orcids":["https://orcid.org/0000-0002-9626-5956"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuzhou Zhang","raw_affiliation_strings":["Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014833790","display_name":"Richard J. Smith","orcid":"https://orcid.org/0000-0003-1201-6731","observed_orcids":["https://orcid.org/0000-0003-1201-6731"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Smith","raw_affiliation_strings":["Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042194566","display_name":"Carla Nester","orcid":"https://orcid.org/0000-0002-0629-7576","observed_orcids":["https://orcid.org/0000-0002-0629-7576"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla M. Nester","raw_affiliation_strings":["Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Otolaryngology and Renal Research Laboratories, Iowa City, IA;","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"565","last_page":"565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephritic-factor","display_name":"nephritic factor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/c3-glomerulopathy","display_name":"C3 glomerulopathy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/complement-dysregulation","display_name":"complement dysregulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7540000081062317},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.515999972820282},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.8600000143051147},{"id":"https://openalex.org/keywords/serological-markers","display_name":"serological markers","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cd55","display_name":"CD55","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4917915165424347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4867546558380127},{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.47504544258117676},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4586808979511261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.389120489358902},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32710760831832886},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16958388686180115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1578817367553711},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1298985779285431},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1565b","doi":"https://doi.org/10.1681/asn.20203110s1565b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1565b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977196247","https://openalex.org/W4413236633","https://openalex.org/W2186977587","https://openalex.org/W2011344342","https://openalex.org/W1971659350","https://openalex.org/W4403832759","https://openalex.org/W4396995669","https://openalex.org/W2346482252","https://openalex.org/W2411317905","https://openalex.org/W2941771253"],"abstract_inverted_index":{"Background:":[0],"Nephritic":[1],"factors":[2],"(Nef)":[3],"are":[4,53,283],"autoantibodies":[5],"that":[6,69,92,252],"stabilize":[7],"and":[8,134,292],"dysregulate":[9],"the":[10,13,16,28,192,213,268,312],"function":[11,235,316],"of":[12,18,60,72,87,155,194,271,295,314],"C3":[14,29,124,274],"convertase,":[15],"cornerstone":[17],"complement":[19],"amplification.":[20],"Their":[21],"association":[22],"with":[23,47,84,102,115,237,278,291],"renal":[24,121],"inflammation":[25],"central":[26],"to":[27,64,80,160,168,191,216,287,301],"Glomerulopathies":[30],"(C3G)":[31],"is":[32,37,100],"well":[33],"reported,":[34],"however":[35],"it":[36],"unknown":[38],"whether":[39],"Nefs":[40,253,272,307],"1)":[41],"change":[42],"over":[43,75,145,262,308],"time,":[44,309],"2)":[45],"correlate":[46,81],"serologic":[48,88,104,238,279],"biomarker":[49,105,200,239,280,320],"assessments,":[50],"and/or":[51],"3)":[52],"useful":[54],"for":[55,58,170,184,305,321],"predicting":[56],"risk":[57],"relapse":[59],"C3G.":[61],"We":[62,77,90,282],"aimed":[63],"create":[65],"a":[66,112,143,146,247,256,263,303],"novel":[67,248],"assay":[68],"allows":[70],"comparison":[71],"Nef":[73,94,211,234],"properties":[74],"time.":[76],"further":[78],"sought":[79],"these":[82],"results":[83],"an":[85,318],"array":[86],"biomarkers.":[89],"hypothesized":[91],"when":[93],"activity":[95],"remains":[96],"high,":[97],"this":[98,285],"abnormality":[99],"associated":[101],"ongoing":[103],"abnormalities.":[106,281],"Methods:":[107],"The":[108],"test":[109,209,257],"subject":[110,210,258],"was":[111,126,230],"C3G":[113,289,322],"patient":[114],"disease":[116,296],"recurrence":[117,294,323],"7":[118],"months":[119],"after":[120],"transplant.":[122,325],"Reagent":[123],"convertase":[125,196,214,275],"formed":[127],"by":[128,153],"injecting":[129],"factor":[130,132],"B,":[131],"D,":[133],"patient-derived":[135],"IgG":[136,141],"(versus":[137],"normal":[138],"pooled":[139],"human":[140],"as":[142,204,317],"control)":[144],"C3bimmobilized":[147],"CM5":[148],"chip":[149],"(Biacore":[150],"X100)":[151],"followed":[152],"injection":[154],"Decay":[156],"Accelerating":[157],"Factor":[158],"(DAF)":[159],"remove":[161],"unstabilized":[162,221],"convertase.":[163,222],"Nef-stabilized":[164],"convertases":[165],"were":[166,175,189,202],"allowed":[167],"dissociate":[169],"3600":[171],"minutes.":[172],"Kinetic":[173],"data":[174],"collected":[176],"at":[177,197,228,241],"five":[178],"time":[179,187,225],"points":[180],"during":[181],"dissociation.":[182],"Data":[183],"each":[185],"clinical":[186],"point":[188,226],"normalized":[190],"amount":[193],"stabilized":[195,212],"t=0.":[198],"Serologic":[199],"assays":[201],"performed":[203],"previously":[205],"described.":[206],"Results:":[207],"Qualitatively,":[208],"1.32":[215],"1.44":[217],"fold":[218],"longer":[219],"than":[220,232],"Between":[223],"sample":[224],"variability":[227],"800s":[229],"less":[231],"13%.":[233],"correlated":[236,277],"abnormalities":[240],"all":[242],"4":[243],"samples.":[244],"Conclusions:":[245],"Using":[246],"assay,":[249],"we":[250],"show":[251],"isolated":[254],"from":[255],"remained":[259],"remarkably":[260],"stable":[261],"28-month":[264],"period.":[265],"In":[266],"addition,":[267],"stabilizing":[269],"effect":[270],"on":[273],"consistently":[276],"extending":[284],"approach":[286],"additional":[288],"patients":[290],"without":[293],"in":[297,299,324],"transplant":[298],"order":[300],"provide":[302],"method":[304],"comparing":[306],"thereby":[310],"defining":[311],"role":[313],"Nef-stabilizing":[315],"at-risk":[319],"Funding:":[326],"NIDDK":[327],"Support":[328]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-18T00:00:00"}
