{"id":"https://openalex.org/W4396998618","doi":"https://doi.org/10.1681/asn.20203110s1150b","title":"Increased Urinary Leukocyte Esterase Distinguishes Brushite Stone Formers from Patients with Other Stone Types","display_name":"Increased Urinary Leukocyte Esterase Distinguishes Brushite Stone Formers from Patients with Other Stone Types","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396998618","doi":"https://doi.org/10.1681/asn.20203110s1150b"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1150b","doi":"https://doi.org/10.1681/asn.20203110s1150b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1150b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018506694","display_name":"Kristin J. Bergsland","orcid":"https://orcid.org/0000-0002-9212-1963","observed_orcids":["https://orcid.org/0000-0002-9212-1963"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin J. Bergsland","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015891160","display_name":"Fredric L. Coe","orcid":"https://orcid.org/0000-0001-6729-0389","observed_orcids":["https://orcid.org/0000-0001-6729-0389"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredric L. Coe","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017219518","display_name":"Elaine M. Worcester","orcid":"https://orcid.org/0000-0001-7989-2061","observed_orcids":["https://orcid.org/0000-0001-7989-2061"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine M. Worcester","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"150","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-oxalate-stones","display_name":"calcium oxalate stones","score":0.7519999742507935},{"id":"https://openalex.org/keywords/uric-acid-stones","display_name":"uric acid stones","score":0.9049999713897705},{"id":"https://openalex.org/keywords/urine-dipstick","display_name":"urine dipstick","score":0.8289999961853027},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8930000066757202},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.6809999942779541},{"id":"https://openalex.org/keywords/urine-nitrite","display_name":"urine nitrite","score":0.6499999761581421},{"id":"https://openalex.org/keywords/stone-formers","display_name":"stone formers","score":0.5820000171661377},{"id":"https://openalex.org/keywords/kidney-stones","display_name":"kidney stones","score":0.3880000114440918},{"id":"https://openalex.org/keywords/uric-acid-nephrolithiasis","display_name":"uric acid nephrolithiasis","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C22502612","wikidata":"https://www.wikidata.org/wiki/Q2251961","display_name":"Brushite","level":3,"score":0.8267236948013306},{"id":"https://openalex.org/C2910111155","wikidata":"https://www.wikidata.org/wiki/Q245639","display_name":"Urinary sediment","level":3,"score":0.678716778755188},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6495588421821594},{"id":"https://openalex.org/C2992298831","wikidata":"https://www.wikidata.org/wiki/Q3825881","display_name":"Urinary stone","level":3,"score":0.47734788060188293},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3928089439868927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37448573112487793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3428686559200287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2678074240684509},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25115591287612915},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.0617486834526062}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1150b","doi":"https://doi.org/10.1681/asn.20203110s1150b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1150b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3148422592","https://openalex.org/W3006771367","https://openalex.org/W2050587931","https://openalex.org/W7156321272","https://openalex.org/W2421567682","https://openalex.org/W2940593102","https://openalex.org/W2011103582","https://openalex.org/W3043473269","https://openalex.org/W2895866693","https://openalex.org/W4200118064"],"abstract_inverted_index":{"Background:":[0],"Compared":[1],"with":[2,10,26,56,172],"calcium":[3],"oxalate":[4],"(CaOx)":[5],"stone":[6,119,126,168,208,219,235,280,300],"formers":[7],"(SF),":[8],"patients":[9,122],"brushite":[11,189],"(Br)":[12],"stones":[13],"have":[14,325],"elevated":[15],"neutrophil":[16,42,321],"infiltration":[17,322],"in":[18,31,44,50,239,245,254,265,269,327],"their":[19],"renal":[20],"papillae":[21],"which":[22],"may":[23,310,334],"be":[24,48],"associated":[25,55],"the":[27,45,51,92,175,207,225,232,297,317,328,336],"observed":[28,326],"marked":[29],"increase":[30],"papillary":[32,337],"scarring":[33],"and":[34,73,83,141,170,178,184,292,320,333,347],"inflammation.":[35],"We":[36,59,103,111],"investigated":[37],"whether":[38],"a":[39,99,108,146,162,313],"signal":[40],"of":[41,76,121,224,234,286,299,316,330],"elevation":[43],"kidney":[46],"could":[47],"detected":[49],"urine":[52,61,87,105,314],"when":[53],"not":[54,204,216,277,304],"infection.":[57,259],"Methods:":[58],"performed":[60],"dipstick":[62,96],"analyses":[63],"for":[64,231,283],"leukocyte":[65],"esterase":[66],"(LEU),":[67],"an":[68,222],"enzyme":[69],"produced":[70],"by":[71,125,167,228,345],"neutrophils,":[72],"various":[74],"markers":[75],"infection":[77],"including":[78],"nitrite":[79],"(NIT),":[80],"blood":[81],"(BLO)":[82],"protein":[84],"(PRO).":[85],"24-hr":[86],"specimens":[88],"were":[89,144],"tested":[90],"using":[91],"Siemens":[93],"Multistix":[94],"10SG":[95],"read":[97],"on":[98,107,145],"Clinitek":[100],"Status":[101],"analyzer.":[102],"measured":[104],"ammonia":[106,182],"Beckman":[109],"DxC600.":[110],"retrospectively":[112],"analyzed":[113],"812":[114],"urines":[115],"from":[116,257],"215":[117],"patients;":[118],"type":[120,169],"was":[123,156,203,215,242,262,276],"determined":[124],"analysis":[127],"containing":[128],">50%":[129],"apatite":[130],"(Ap),":[131],"Br,":[132],"CaOx":[133,196,246,270,352,363],"or":[134,158,197,353],"uric":[135],"acid":[136],"(UA),":[137],"respectively.":[138],"BLO,":[139,179,291],"PRO":[140,293],"LEU":[142,173,194,227,238,251,261,309,344],"measurements":[143],"5":[147],"point":[148],"scale":[149],"(negative=0,":[150],"trace=0.5,":[151],"small=1,":[152],"moderate=2,":[153],"large=3);":[154],"NIT":[155,202],"yes":[157],"no.":[159],"Results:":[160],"In":[161,221],"fully":[163],"adjusted":[164,230],"ANOVA":[165,223],"model":[166],"sex":[171],"as":[174,187,289,294,296,312],"dependent":[176],"variable":[177],"PRO,":[180],"NIT,":[181,273],"excretion":[183,214],"patient":[185,229],"age":[186],"covariates,":[188],"SF":[190,241,247,255,267,271,332],"had":[191],"significantly":[192,263],"higher":[193,243,264],"than":[195,244,268],"UA":[198],"(Table).":[199],"By":[200],"Chi-square,":[201],"different":[205,217,278],"between":[206,218,279],"types":[209],"(p":[210],"=":[211],"0.25).":[212],"Ammonia":[213],"types.":[220,281],"mean":[226],"number":[233,298],"removal":[236,301],"procedures,":[237],"Br":[240,266,331],"(p<0.01).":[248],"Conclusions:":[249],"Dipstick":[250,260,308,343],"is":[252],"informative":[253],"aside":[256],"predicting":[258],"but":[272],"indicating":[274],"infection,":[275,287],"Adjusting":[282],"other":[284],"indicators":[285],"such":[288],"ammonia,":[290],"well":[295],"procedures":[302],"did":[303],"abolish":[305],"this":[306],"difference.":[307],"serve":[311],"biomarker":[315],"inflammatory":[318],"activity":[319],"that":[323],"we":[324],"kidneys":[329],"reflect":[335],"histopathology.":[338],"Funding:":[339],"NIDDK":[340],"Support":[341],"Table.":[342],"Sex":[346],"Stone":[348],"TypeMean\u00b1SE.":[349],"*p<0.0001":[350],"vs":[351,356,359,362],"UA;":[354,360],"$p<0.001":[355],"Ap;":[357],"#p<0.0001":[358],"+p<0.001":[361]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-05-18T00:00:00"}
