{"id":"https://openalex.org/W4396998461","doi":"https://doi.org/10.1681/asn.20203110s1208d","title":"Rates of Clinical Events in Patients with CKD: A UK Population-Based Cohort Study","display_name":"Rates of Clinical Events in Patients with CKD: A UK Population-Based Cohort Study","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396998461","doi":"https://doi.org/10.1681/asn.20203110s1208d"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1208d","doi":"https://doi.org/10.1681/asn.20203110s1208d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1208d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109548415","display_name":"Alyshah Abdul Sultan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alyshah Abdul Sultan","raw_affiliation_strings":["AstraZeneca, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101499160","display_name":"Ping Sun","orcid":"https://orcid.org/0000-0001-5595-3659","observed_orcids":["https://orcid.org/0000-0001-5595-3659"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ping Sun","raw_affiliation_strings":["AstraZeneca, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042333042","display_name":"Katarina Hedman","orcid":"https://orcid.org/0000-0003-0163-418X","observed_orcids":["https://orcid.org/0000-0003-0163-418X"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Katarina Hedman","raw_affiliation_strings":["AstraZeneca, Gothenburg, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Gothenburg, Sweden;","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397908","display_name":"Xia Wang","orcid":"https://orcid.org/0000-0002-3372-6401","observed_orcids":["https://orcid.org/0000-0002-3372-6401"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xia Wang","raw_affiliation_strings":["AstraZeneca, Gaithersburg, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Gaithersburg, MD","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080026860","display_name":"Mark T. Houser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark T. Houser","raw_affiliation_strings":["AstraZeneca, Gaithersburg, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Gaithersburg, MD","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025264844","display_name":"Dustin J. Little","orcid":"https://orcid.org/0000-0002-4201-0237","observed_orcids":["https://orcid.org/0000-0002-4201-0237"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin J. Little","raw_affiliation_strings":["AstraZeneca, Gaithersburg, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Gaithersburg, MD","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002915181","display_name":"Glen James","orcid":"https://orcid.org/0000-0003-0080-3156","observed_orcids":["https://orcid.org/0000-0003-0080-3156"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Glen James","raw_affiliation_strings":["AstraZeneca, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I105036370"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"208","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adverse-clinical-events","display_name":"adverse clinical events","score":0.7820000052452087},{"id":"https://openalex.org/keywords/dialysis-dependence","display_name":"dialysis dependence","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pre-dialysis-patients","display_name":"predialysis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chronic-kidney-disease-staging","display_name":"CKD staging","score":0.7580000162124634},{"id":"https://openalex.org/keywords/incidence-rates","display_name":"incidence rates","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hyperkalemia","display_name":"hyperkalemia","score":0.75},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.843999981880188},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.546999990940094},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.4560000002384186},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6949999928474426},{"id":"https://openalex.org/keywords/quality-of-care","display_name":"quality of care","score":0.5699999928474426},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.45500001311302185},{"id":"https://openalex.org/keywords/mortality-risk-stratification","display_name":"mortality risk stratification","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6195798516273499},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5636371374130249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4322892427444458},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4294929504394531},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4111785292625427},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36937329173088074},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.17597267031669617}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1208d","doi":"https://doi.org/10.1681/asn.20203110s1208d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1208d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362606648","https://openalex.org/W3164661245","https://openalex.org/W4239773994","https://openalex.org/W6958263153","https://openalex.org/W4232386856","https://openalex.org/W4255556300","https://openalex.org/W4397040037","https://openalex.org/W4397043082","https://openalex.org/W2580286267","https://openalex.org/W4396998524"],"abstract_inverted_index":{"Background:":[0],"Epidemiology":[1],"of":[2,20,35,58,118,170,181,192,234,306,314],"clinical":[3,93,236,308],"event":[4,146,203],"rates":[5,136,204,233,305],"in":[6,76,86,208],"patients":[7,31,81,105,113,162,187,226,325],"with":[8,82,163,326],"chronic":[9],"kidney":[10,332],"disease":[11],"(CKD)":[12],"is":[13,44,62],"limited":[14],"and":[15,27,32,90,99,120,123,132,151,159,174,190,199,217,310,322],"can":[16],"impede":[17],"the":[18,59],"ability":[19],"dialysis":[21,149],"organizations,":[22],"government":[23],"agencies,":[24],"other":[25],"institutions,":[26],"payers":[28],"to":[29,64,213,223],"counsel":[30],"assess":[33],"quality":[34],"care.":[36],"Methods:":[37],"The":[38],"Clinical":[39,126],"Practice":[40],"Research":[41],"Datalink":[42],"(CPRD)":[43],"a":[45,164,175],"large,":[46],"longitudinal":[47],"UK-based":[48],"primary":[49],"care":[50],"database":[51],"that":[52],"covers":[53],"6%":[54],"(\u02dc4":[55],"million":[56],"people)":[57],"population.":[60],"CPRD":[61,87],"linked":[63],"Hospital":[65],"Episode":[66],"Statistics":[67],"(HES),":[68],"which":[69],"contains":[70],"information":[71],"on":[72],"all":[73],"hospital":[74],"admissions":[75],"England.":[77],"We":[78,155],"identified":[79,96,115,129,156],"CKD":[80,152,196,210,215,220,224,244,248],"eGFR":[83],"<60":[84],"ml/min/1.73m2":[85],"between":[88],"2004":[89],"2017.":[91],"Adverse":[92,241],"events":[94,127,237,242,309],"were":[95,106,114,128,141,205],"using":[97,116],"ICD-10":[98],"READ":[100,124,133],"codes.":[101,125,134],"Non-dialysis":[102],"dependent":[103,111],"(NDD)":[104],"staged":[107],"by":[108,130,148],"eGFR.":[109],"Dialysis":[110],"(DD)":[112],"Classification":[117],"Interventions":[119],"Procedures":[121],"(OPCS)":[122],"ICD10":[131],"Incidence":[135,232],"per":[137,238],"100":[138,239],"person-years":[139],"(PY)":[140],"calculated":[142],"for":[143,317,323],"selected":[144],"adverse":[145,235],"stratified":[147],"status":[150],"stage.":[153],"Results:":[154],"310362":[157],"NDD":[158,186,214,243,247,320,324],"5248":[160],"DD":[161,209,251,318],"mean":[165],"(standard":[166],"deviation":[167],"[SD])":[168],"age":[169],"75.5":[171],"(10.2)":[172],"years":[173],"median":[176],"(interquartile":[177],"range":[178],"[IQR])":[179],"follow-up":[180],"87.5":[182],"(46.5-130.9)":[183],"months.":[184],"Among":[185],"96%,":[188],"3%,":[189],"1%":[191],"patient-years":[193],"came":[194],"from":[195],"3,":[197],"4,":[198],"5,":[200],"respectively.":[201],"Most":[202],"consistently":[206],"higher":[207,218],"patients,":[211,321],"compared":[212,222],"patients;":[216],"among":[219],"4/5":[221,249],"3":[225,245],"(Table":[227],"1).":[228],"Table":[229],"1:":[230],"-":[231,337],"PY":[240],"Rate":[246,250,252],"Acidosis":[253],"0.5":[254,293],"1.2":[255],"2.3":[256],"Allergic":[257],"anaphylaxis":[258],"0.1":[259,260,261,276,284,288,289],"Gastrointestinal":[262],"hemorrhage":[263],"2.5":[264],"3.2":[265],"5.8":[266],"Hyperkalemia":[267],"0.7":[268,286],"2.2":[269,273],"4.9":[270],"Sepsis":[271],"1.3":[272],"7.4":[274],"Pancreatitis":[275],"0.2":[277,285],"0.4":[278,292],"Pneumonia":[279],"7.8":[280],"12.2":[281],"15.2":[282],"Pyelonephritis":[283],"Rhabdomyolysis":[287],"0.3":[290],"Seizure":[291],"1.0":[294],"UTI":[295],"7.1":[296],"12.6":[297],"9.8":[298],"Conclusions:":[299],"Our":[300],"results":[301],"help":[302],"establish":[303],"baseline":[304],"specific":[307],"provide":[311],"additional":[312],"evidence":[313],"increased":[315],"morbidity":[316],"vs.":[319,329],"more":[327],"severe":[328,331],"less":[330],"disease.":[333],"Funding:":[334],"Commercial":[335],"Support":[336],"AstraZeneca":[338]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2024-05-18T00:00:00"}