{"id":"https://openalex.org/W4396998016","doi":"https://doi.org/10.1681/asn.20203110s1230b","title":"Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD","display_name":"Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396998016","doi":"https://doi.org/10.1681/asn.20203110s1230b"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1230b","doi":"https://doi.org/10.1681/asn.20203110s1230b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1230b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103919093","display_name":"Xiaojia Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojia Guo","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021277525","display_name":"Leyuan Xu","orcid":"https://orcid.org/0000-0002-3071-9206","observed_orcids":["https://orcid.org/0000-0002-3071-9206"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leyuan Xu","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113735760","display_name":"Heino Vel\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heino Velazquez","raw_affiliation_strings":["VAMC, West Haven, CT;","Yale University School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VAMC, West Haven, CT;","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030329189","display_name":"Chen Tian-min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian-Min Chen","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001800797","display_name":"Ryan M. Williams","orcid":"https://orcid.org/0000-0002-2381-8732","observed_orcids":["https://orcid.org/0000-0002-2381-8732"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Williams","raw_affiliation_strings":["Sloan-Kettering Institute, New York, NY;","The City College of New York Division of Science, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sloan-Kettering Institute, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"The City College of New York Division of Science, New York, NY","institution_ids":["https://openalex.org/I125687163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037355958","display_name":"Daniel A. Heller","orcid":"https://orcid.org/0000-0002-6866-0000","observed_orcids":["https://orcid.org/0000-0002-6866-0000"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Heller","raw_affiliation_strings":["Sloan-Kettering Institute, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sloan-Kettering Institute, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079979942","display_name":"Robert L. Safirstein","orcid":"https://orcid.org/0009-0009-3472-6137","observed_orcids":["https://orcid.org/0009-0009-3472-6137"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Safirstein","raw_affiliation_strings":["VAMC, West Haven, CT;","Yale University School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VAMC, West Haven, CT;","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009238890","display_name":"Gary V. D\u00e9sir","orcid":"https://orcid.org/0000-0001-9289-8978","observed_orcids":["https://orcid.org/0000-0001-9289-8978"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary V. Desir","raw_affiliation_strings":["VAMC, West Haven, CT;","Yale University School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VAMC, West Haven, CT;","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"230","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renalase","display_name":"renalase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.972000002861023},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/kidney-targeted-drug-delivery","display_name":"kidney-targeted drug delivery","score":0.9340000152587891},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.5759999752044678},{"id":"https://openalex.org/keywords/renal-transcriptome","display_name":"renal transcriptome","score":0.5699999928474426},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.6209999918937683},{"id":"https://openalex.org/keywords/chemotherapy-induced-nephrotoxicity","display_name":"chemotherapy-induced nephrotoxicity","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7696202993392944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.642776370048523},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5680273771286011},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.503741443157196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4576526880264282},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.43209755420684814},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.42928147315979004},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.42840060591697693},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23474723100662231},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2307983934879303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19219902157783508},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05319586396217346}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1230b","doi":"https://doi.org/10.1681/asn.20203110s1230b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1230b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200009923","https://openalex.org/W3170910824","https://openalex.org/W4302276684","https://openalex.org/W4206005685","https://openalex.org/W4403812055","https://openalex.org/W3002123044","https://openalex.org/W2620553732","https://openalex.org/W2135491965","https://openalex.org/W2085624687","https://openalex.org/W4397045246"],"abstract_inverted_index":{"Background:":[0],"Cisplatin":[1],"(CP)":[2],"causes":[3],"Chronic":[4],"Kidney":[5],"Disease":[6],"(CKD)":[7],"upon":[8],"repeated":[9,354],"doses":[10,66,355],"and":[11,27,31,59,81,103,122,128,158,225,260,279,294,296,306,310,331],"limits":[12],"its":[13],"chemotherapeutic":[14],"use.":[15],"Renalase":[16],"(RNLS)":[17],"is":[18],"a":[19],"protein":[20],"that":[21,87,302,321,339],"activates":[22],"kinases":[23],"linked":[24],"to":[25,38,44,46,161,181,196,347],"survival":[26],"attenuates":[28,323],"acute":[29],"ischemic":[30],"CP-induced":[32,48,171,324],"kidney":[33,45,148,263],"injury.":[34],"We":[35,319],"now":[36],"seek":[37],"target":[39,88],"delivery":[40],"of":[41,67,134,136,146,356],"RNLS":[42,55,75,107],"specifically":[43],"prevent":[47,348],"CKD.":[49],"Methods:":[50],"CKD":[51,228,261,325,349],"was":[52,79,94,114,124,138,175],"induced":[53],"in":[54,83,96,104,164,199,212,256,350],"knockout":[56],"(KO)":[57],"(severe)":[58],"wild":[60],"type":[61],"(WT)":[62],"mice":[63],"by":[64,126,155,316,326,334],"2":[65,71],"CP":[68,198],"15":[69],"mg/kg":[70],"weeks":[72,222],"apart.":[73],"The":[74,132],"agonist":[76],"peptide":[77],"RP81":[78,185],"synthesized":[80],"encapsulated":[82],"mesoscale":[84],"nanoparticles":[85],"(MNP)":[86],"the":[89],"kidney.":[90],"Its":[91],"cytoprotective":[92],"activity":[93],"tested":[95],"vitro":[97],"using":[98,106,140],"TKPTS":[99,156,168],"proximal":[100,162],"tubule":[101,305],"cells":[102,157,169,314],"vivo":[105],"KO":[108,200,241],"mice.":[109],"RP81MNP":[110,137,166,244,303,322,340],"or":[111],"empty":[112,182],"MNP":[113,151],"administered":[115],"weekly":[116],"for":[117],"4":[118,221],"weeks.":[119],"Renal":[120],"injury":[121],"function":[123],"evaluated":[125],"immunohistochemistry":[127],"plasma":[129,272,288],"creatinine":[130],"(Cr).":[131],"mechanism":[133],"action":[135],"investigated":[139],"single":[141],"cell":[142,173,187,308,328],"RNA":[143],"sequencing":[144],"(scRNAseq)":[145],"whole":[147],"cells.":[149],"Results:":[150],"were":[152,159],"retained":[153],"intracellularly":[154],"localized":[160],"tubules":[163],"vivo.":[165],"protected":[167],"from":[170],"cytotoxicity:":[172],"viability":[174,188],"enhanced":[176],"3.5-fold,":[177],"n=6,":[178,190],"p<.05,":[179],"compared":[180],"MNP.":[183],"Naked":[184],"increased":[186],"1.72-fold,":[189],"p<.05":[191],"over":[192],"BSA":[193],"control.":[194],"Compared":[195],"WT,":[197,213],"caused":[201,315],"more":[202,226],"severe":[203,227],"AKI":[204,246],"(Cr:":[205],"0.61":[206],"mg/dL":[207,251],"\u00b1":[208,231,236,249,254,266],"0.05":[209,250],"vs.":[210],"0.13\u00b10.03":[211],"n=3,":[214],"p<0.05),":[215],"higher":[216],"mortality":[217],"(45%":[218],"death":[219,329],"at":[220],"n=20,":[223],"p<0.005),":[224],"(Cr":[229,247],"0.16":[230],"0.02":[232],"mg/dl,":[233],"vs":[234,252,268,276,283],"0.12":[235],"0.01,":[237],"n=5,":[238,258],"p<0.05;).":[239],"In":[240],"given":[242],"CP,":[243],"ameliorated":[245],"0.30":[248],"0.64":[253],"0.14":[255],"control,":[257],"p<0.05;)":[259],"(increased":[262],"weight:":[264],"176mg":[265],"7.0,":[267],"145.4\u00b1":[269],"4.5,":[270],"decreased":[271,311],"Cr:":[273],"0.10\u00b1":[274],"0.01":[275],"0.16\u00b1":[277],"0.02,":[278],"KIM-1:":[280],"124.3\u00b115.1":[281],"pg/ml":[282],"227\u00b128.4).":[284],"RP81MMP":[285],"significantly":[286],"reduced":[287],"cytokines":[289],"IL-1\u03b2,":[290],"IL-2,":[291],"IL-6,":[292],"KC,":[293],"TNF\u03b1":[295],"inhibited":[297],"regulated":[298],"necrosis.":[299],"ScRNAseq":[300],"revealed":[301],"preserved":[304],"vasculature":[307],"mass":[309],"infiltrated":[312],"immune":[313],"CP.":[317,335],"Conclusions:":[318],"conclude":[320],"diminishing":[327],"pathways":[330],"inflammation":[332],"activated":[333],"These":[336],"data":[337],"suggest":[338],"may":[341],"be":[342],"an":[343],"effective":[344],"therapeutic":[345],"agent":[346],"patients":[351],"treated":[352],"with":[353],"cisplatin.":[357],"Funding:":[358],"NIDDK":[359],"Support":[360]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-05-18T00:00:00"}