{"id":"https://openalex.org/W4396997923","doi":"https://doi.org/10.1681/asn.20203110s1230d","title":"Proximal Tubule-Specific DPP4 Deletion Slows Kidney Disease Progression in Obese Mice","display_name":"Proximal Tubule-Specific DPP4 Deletion Slows Kidney Disease Progression in Obese Mice","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396997923","doi":"https://doi.org/10.1681/asn.20203110s1230d"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1230d","doi":"https://doi.org/10.1681/asn.20203110s1230d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1230d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026369769","display_name":"Ravi Nistala","orcid":"https://orcid.org/0000-0001-9577-8074","observed_orcids":["https://orcid.org/0000-0001-9577-8074"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Nistala","raw_affiliation_strings":["University of Missouri, Columbia, MO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO;","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110849315","display_name":"Jing Li Ren","orcid":"https://orcid.org/0000-0001-5778-4676","observed_orcids":["https://orcid.org/0000-0001-5778-4676"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Ren","raw_affiliation_strings":["University of Missouri, Columbia, MO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO;","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003191442","display_name":"Jianzhong An","orcid":"https://orcid.org/0000-0001-8182-0577","observed_orcids":["https://orcid.org/0000-0001-8182-0577"]},"institutions":[{"id":"https://openalex.org/I4210116071","display_name":"Suzhou Municipal Hospital","ror":"https://ror.org/02cdyrc89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhong An","raw_affiliation_strings":["Suzhou Municipal Hospital, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou Municipal Hospital, Suzhou, China","institution_ids":["https://openalex.org/I4210116071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031419528","display_name":"Tammy L Strawn","orcid":"https://orcid.org/0000-0001-8405-4177","observed_orcids":["https://orcid.org/0000-0001-8405-4177"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy L. Strawn","raw_affiliation_strings":["University of Missouri, Columbia, MO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO;","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012116918","display_name":"Suryanshi Rawat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suryanshi Rawat","raw_affiliation_strings":["University of Missouri, Columbia, MO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO;","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110138196","display_name":"Priyanka Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Patel","raw_affiliation_strings":["University of Missouri, Columbia, MO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO;","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006212343","display_name":"Adam T. Whaley\u2010Connell","orcid":"https://orcid.org/0000-0001-8955-5560","observed_orcids":["https://orcid.org/0000-0001-8955-5560"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Whaley-Connell","raw_affiliation_strings":["University of Missouri, Columbia, MO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO;","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39170484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"230","last_page":"231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-4","display_name":"dipeptidyl peptidase IV","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dpp-4-inhibition","display_name":"DPP-4 inhibition","score":0.8489999771118164},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.7770000100135803},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.9039999842643738},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.7839999794960022},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8410000205039978},{"id":"https://openalex.org/keywords/glomerular-fibrosis","display_name":"glomerular fibrosis","score":0.890999972820282},{"id":"https://openalex.org/keywords/renal-tubular-injury","display_name":"renal tubular injury","score":0.7689999938011169},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6230000257492065},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.906000018119812},{"id":"https://openalex.org/keywords/cell-adhesion-proteins","display_name":"cell adhesion proteins","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.7921496033668518},{"id":"https://openalex.org/C3018884230","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Renal tubule","level":3,"score":0.6658227443695068},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.600700855255127},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5531472563743591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5270659923553467},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49504175782203674},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4761471748352051},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4594796895980835},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.4522157907485962},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.337632954120636}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1230d","doi":"https://doi.org/10.1681/asn.20203110s1230d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1230d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3083962957","https://openalex.org/W4397046649","https://openalex.org/W4225303385","https://openalex.org/W4389023340","https://openalex.org/W2142068814","https://openalex.org/W4225422664","https://openalex.org/W2128562466","https://openalex.org/W3041089775","https://openalex.org/W2195252126","https://openalex.org/W4398232732"],"abstract_inverted_index":{"Background:":[0],"Obesity":[1,291],"is":[2],"a":[3,65,95,149,168,276],"major":[4],"risk":[5],"factor":[6],"for":[7,104,180],"Chronic":[8],"Kidney":[9],"Disease":[10,16],"progression":[11,84],"to":[12,31,81,123,131,174,256,296],"End":[13],"Stage":[14],"Renal":[15],"and/or":[17,23,321],"Dialysis.":[18],"Increased":[19],"absorption":[20],"of":[21,85,100,143,237,318],"fats":[22],"sugars":[24],"from":[25],"Western":[26],"Diet":[27],"(WD)":[28],"likely":[29],"leads":[30,80],"kidney":[32,57,86,125],"tubular":[33,209,213],"injury":[34,58,82],"in":[35,51,55,60,67,152,191,193,200,215,222,233,244,259,280,287,299,301,315],"obesity.":[36],"We":[37],"observed":[38],"that":[39,74,197,219,241,253,266],"whole":[40],"body":[41],"dipeptidyl":[42],"peptidase":[43],"4":[44],"(DPP4)":[45],"deletion":[46],"as":[47,49],"well":[48],"inhibition":[50,308],"WD-fed":[52,137,194,238],"mice":[53,139,146,166,196,218,240],"results":[54],"decreased":[56],"which,":[59],"turn":[61],"was":[62,115,121,178,188,198,220,242,267,275],"associated":[63],"with":[64],"decrease":[66],"proximal":[68,75],"tubule":[69,76],"DPP4.":[70],"Therefore,":[71],"we":[72],"hypothesized":[73],"(PT)":[77],"DPP4":[78,307],"activation":[79],"and":[83,90,102,108,127,147,183,211,235,263,282,304],"disease.":[87],"Methods:":[88],"PT-KO":[89,165,201,223],"WT":[91,138,175,195,217,239],"littermates":[92],"were":[93,110],"fed":[94],"WD":[96],"starting":[97],"4-6":[98],"wks":[99],"age":[101],"continued":[103],"2":[105,158],"years.":[106],"GFR":[107,153,300],"albuminuria":[109,192],"monitored":[111],"periodically.":[112],"Tissue":[113],"histology":[114],"performed":[116],"at":[117],"select":[118],"intervals.":[119],"GeLC-MS":[120],"used":[122,130],"separate":[124],"peptides":[126],"Scaffold":[128],"4/iPathwayguide":[129],"analyze":[132],"the":[133,316],"Proteomics":[134,247],"data.":[135],"Results:":[136],"gained":[140],"150-200%":[141],"weight":[142],"chow-fed":[144],"[CD]":[145],"had":[148,167],"greater":[150],"decline":[151,170,298,311],"than":[154],"CD-fed":[155],"animals":[156],"over":[157],"years":[159],"(50%":[160],"vs.":[161],"20%,":[162],"p<0.05).":[163],"WDfed":[164,216],"lesser":[169],"(\u02dc35%)":[171],"when":[172],"compared":[173],"mice.":[176,185,202,224,246,289,306],"This":[177],"true":[179],"both":[181,302],"male":[182,303],"female":[184,305],"Concomitantly,":[186],"there":[187,274],"an":[189,257],"increase":[190,258],"mitigated":[199,221,243],"PAS/PSR":[203],"stained":[204],"sections":[205],"showed":[206,229,252],"worsening":[207],"fibrosis,":[208],"dilatation":[210],"glomerulomegaly,":[212],"vacuolization":[214],"Oil":[225],"Red":[226],"O":[227],"staining":[228],"increased":[230],"fat":[231],"accumulation":[232],"glomeruli":[234],"tubules":[236],"KO":[245,288],"analysis":[248],"followed":[249],"by":[250,270],"immunoblots":[251],"WD-feeding":[254],"led":[255],"cell":[260],"adhesion":[261],"proteins":[262],"ribosomal":[264],"machinery":[265],"significantly":[268],"suppressed":[269],"KO.":[271],"In":[272],"addition,":[273],"shift":[277],"towards":[278],"reduction":[279],"gluconeogenesis":[281],"improved":[283],"fatty":[284],"acid":[285],"oxidation":[286],"Conclusions:":[290],"without":[292],"diabetes":[293],"can":[294],"lead":[295],"rapid":[297],"may":[309],"slow":[310],"if":[312],"started":[313],"early":[314],"course":[317],"developing":[319],"obesity":[320],"insulin":[322],"resistance.":[323],"Funding:":[324],"NIDDK":[325],"Support,":[326],"Commercial":[327],"Support":[328],"-":[329],"Dialysis":[330],"Clinics":[331],"Inc.":[332]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-18T00:00:00"}