{"id":"https://openalex.org/W4396997229","doi":"https://doi.org/10.1681/asn.20203110s1713a","title":"Decreased CD28 Expression in Memory CD4+ T Cells in Children Awaiting Kidney Transplant Is Associated with Increased Expression of Senescence Markers","display_name":"Decreased CD28 Expression in Memory CD4+ T Cells in Children Awaiting Kidney Transplant Is Associated with Increased Expression of Senescence Markers","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396997229","doi":"https://doi.org/10.1681/asn.20203110s1713a"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1713a","doi":"https://doi.org/10.1681/asn.20203110s1713a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1713a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015910916","display_name":"Charlotte Duneton","orcid":"https://orcid.org/0000-0002-0603-1970","observed_orcids":["https://orcid.org/0000-0002-0603-1970"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte Duneton","raw_affiliation_strings":["Emory University, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063797083","display_name":"Roshan Punnoose George","orcid":"https://orcid.org/0000-0003-3853-967X","observed_orcids":["https://orcid.org/0000-0003-3853-967X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800903681","display_name":"Henrietta Egleston Hospital for Children","ror":"https://ror.org/002q1t780","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800903681","https://openalex.org/I4210146983"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roshan P. George","raw_affiliation_strings":["Children\u2019s Healthcare of Atlanta Egleston Hospital, Atlanta, GA","Emory University, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Healthcare of Atlanta Egleston Hospital, Atlanta, GA","institution_ids":["https://openalex.org/I2800903681","https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Emory University, Atlanta, GA;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087476769","display_name":"Mandy L. Ford","orcid":"https://orcid.org/0000-0001-6736-4421","observed_orcids":["https://orcid.org/0000-0001-6736-4421"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mandy L. Ford","raw_affiliation_strings":["Emory University, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042275952","display_name":"Pamela D. Winterberg","orcid":"https://orcid.org/0000-0002-8555-2837","observed_orcids":["https://orcid.org/0000-0002-8555-2837"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800903681","display_name":"Henrietta Egleston Hospital for Children","ror":"https://ror.org/002q1t780","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800903681","https://openalex.org/I4210146983"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela D. Winterberg","raw_affiliation_strings":["Children\u2019s Healthcare of Atlanta Egleston Hospital, Atlanta, GA","Emory University, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Healthcare of Atlanta Egleston Hospital, Atlanta, GA","institution_ids":["https://openalex.org/I2800903681","https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Emory University, Atlanta, GA;","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"713","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.8220000267028809},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/t-cell-senescence","display_name":"T cell senescence","score":0.8320000171661377},{"id":"https://openalex.org/keywords/belatacept","display_name":"belatacept","score":0.871999979019165},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/pediatric-dialysis","display_name":"pediatric dialysis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/abatacept","display_name":"abatacept","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cd57","display_name":"CD57","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.8289999961853027},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.8610000014305115},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/t-cell-costimulation","display_name":"T cell costimulation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7427431344985962},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.6025326251983643},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.49206775426864624},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.46829739212989807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45090121030807495},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3971220850944519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39223021268844604},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3891102969646454},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.3831615447998047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.380914568901062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3590767979621887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35491394996643066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22454625368118286},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.14067965745925903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1225050687789917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06983080506324768},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1713a","doi":"https://doi.org/10.1681/asn.20203110s1713a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1713a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2774972881","https://openalex.org/W2613714577","https://openalex.org/W2012787931","https://openalex.org/W2761257502","https://openalex.org/W2314483418","https://openalex.org/W2029142216","https://openalex.org/W1559425537","https://openalex.org/W2282232947","https://openalex.org/W326670943","https://openalex.org/W1986634182"],"abstract_inverted_index":{"Background:":[0],"Despite":[1,196],"improved":[2],"patient":[3],"and":[4,96,109,180,200,219],"graft":[5],"outcomes":[6],"with":[7,43,162,231],"CD28-CD80/86":[8],"costimulation":[9,102],"blockade,":[10],"increased":[11],"early":[12,54,235],"acute":[13],"rejection":[14,55,236],"has":[15,28],"hindered":[16],"the":[17,122,153],"widespread":[18],"use":[19],"of":[20,34,82,99,101,121,171,206,223,229,242],"CTLA-4Ig":[21],"(belatacept)":[22],"for":[23,234],"kidney":[24,73],"transplant.":[25,74],"Our":[26],"group":[27],"previously":[29,134],"reported":[30],"lower":[31],"pre-transplant":[32],"frequencies":[33,127,151],"CD28+":[35],"effector":[36],"memory":[37,115],"helper":[38],"T":[39,65,117,165],"cells":[40,85,173,213],"(CD4+TEM":[41],"CCR7-CD45RA-)":[42],"decreased":[44,189,232],"functional":[45,240],"capacity":[46,241],"in":[47,70,136,157,246],"adults":[48,137,230],"that":[49,138,214],"were":[50,139],"subsequently":[51],"free":[52],"from":[53,87],"on":[56,89,114,141,146,208,237],"belatacept.":[57,142,238],"We":[58,76],"aimed":[59],"to":[60],"determine":[61],"if":[62],"a":[63,204,226],"similar":[64],"cell":[66,166,244],"phenotype":[67,167,227],"is":[68],"detectable":[69],"children":[71,88,94,123,145,159,207,247],"awaiting":[72],"Methods:":[75],"analyzed":[77],"existing":[78],"flow":[79],"cytometry":[80],"data":[81],"unstimulated":[83],"blood":[84],"collected":[86],"dialysis":[90,147,209],"(n=30)":[91],"or":[92],"healthy":[93,158],"(n=18)":[95],"examined":[97],"expression":[98,218],"markers":[100,176,191,221],"(CD28),":[103],"senescence":[104,175],"(CD57,":[105],"PD1),":[106],"activation":[107,190],"(CD38)":[108],"cytotoxicity":[110],"(Perforin,":[111],"Granzyme":[112],"B)":[113],"CD4+":[116,211],"cells.":[118],"Results:":[119],"None":[120],"had":[124,149,168],"CD28+CD4+":[125],"TEM":[126,212],"as":[128,130],"low":[129],"those":[131],"we":[132],"have":[133,215],"observed":[135,156],"rejection-free":[140],"However,":[143],"8":[144],"(27%)":[148],"CD28+CD4+TEM":[150],"below":[152],"minimum":[154],"value":[155],"(Fig1A-B).":[160],"Patients":[161],"this":[163],"\u201cstable-like\u201d":[164],"higher":[169],"frequency":[170],"CD4+TEM":[172],"bearing":[174],"(CD57+PD1+":[177],"Fig":[178,186,193],"1C)":[179],"cytolytic":[181],"effectors":[182],"(Granzyme":[183],"B,":[184],"Perforin,":[185],"1D)":[187],"but":[188],"(CD38+":[192],"1E).":[194],"Conclusions:":[195],"their":[197],"young":[198],"age":[199],"limited":[201],"antigen":[202],"experience,":[203],"subset":[205],"accumulate":[210],"lost":[216],"CD28":[217],"bear":[220],"suggestive":[222],"impaired":[224],"function,":[225],"reminiscent":[228],"risk":[233],"The":[239],"these":[243],"populations":[245],"needs":[248],"further":[249],"study.":[250],"Funding:":[251],"NIDDK":[252],"Support,":[253],"Clinical":[254],"Revenue":[255],"Support":[256]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-18T00:00:00"}
