{"id":"https://openalex.org/W4396996841","doi":"https://doi.org/10.1681/asn.20203110s1772a","title":"Post-Kidney Transplant Serum Magnesium Exhibits a U-Shaped Association with Subsequent Mortality","display_name":"Post-Kidney Transplant Serum Magnesium Exhibits a U-Shaped Association with Subsequent Mortality","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W4396996841","doi":"https://doi.org/10.1681/asn.20203110s1772a"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20203110s1772a","doi":"https://doi.org/10.1681/asn.20203110s1772a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1772a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087761313","display_name":"Annalise M. Panthofer","orcid":"https://orcid.org/0000-0001-9973-5960","observed_orcids":["https://orcid.org/0000-0001-9973-5960"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annalise M. Panthofer","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055825704","display_name":"Beini Lyu","orcid":"https://orcid.org/0000-0001-9219-468X","observed_orcids":["https://orcid.org/0000-0001-9219-468X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beini Lyu","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002731748","display_name":"Brad C. Astor","orcid":"https://orcid.org/0000-0002-0876-0069","observed_orcids":["https://orcid.org/0000-0002-0876-0069"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad C. Astor","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784807","display_name":"Tripti Singh","orcid":"https://orcid.org/0000-0002-8855-3421","observed_orcids":["https://orcid.org/0000-0002-8855-3421"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tripti Singh","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008041720","display_name":"Fahad Aziz","orcid":"https://orcid.org/0000-0002-4855-5481","observed_orcids":["https://orcid.org/0000-0002-4855-5481","https://orcid.org/0000-0001-8230-3889"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fahad Aziz","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025694734","display_name":"Didier A. Mandelbrot","orcid":"https://orcid.org/0000-0003-3326-8583","observed_orcids":["https://orcid.org/0000-0003-3326-8583"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Didier A. Mandelbrot","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072339369","display_name":"Sandesh Parajuli","orcid":"https://orcid.org/0000-0003-1667-7465","observed_orcids":["https://orcid.org/0000-0003-1667-7465"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandesh Parajuli","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064893146","display_name":"Maha Mohamed","orcid":"https://orcid.org/0000-0002-7517-8407","observed_orcids":["https://orcid.org/0000-0002-7517-8407"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maha A. Mohamed","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023599044","display_name":"Arjang Djamali","orcid":"https://orcid.org/0000-0001-7675-6128","observed_orcids":["https://orcid.org/0000-0001-7675-6128"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arjang Djamali","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018901490","display_name":"Neetika Garg","orcid":"https://orcid.org/0000-0002-7001-2168","observed_orcids":["https://orcid.org/0000-0002-7001-2168"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neetika Garg","raw_affiliation_strings":["University of Wisconsin School of Medicine and Public Health, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10S","first_page":"772","last_page":"772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10530","display_name":"Magnesium Alloys: Properties and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-magnesium","display_name":"serum magnesium","score":0.7879999876022339},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hypomagnesemia","display_name":"hypomagnesemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/u-shaped-relationship","display_name":"U-shaped relationship","score":0.824999988079071},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8519999980926514},{"id":"https://openalex.org/keywords/calcineurin-inhibitor-nephrotoxicity","display_name":"calcineurin inhibitor nephrotoxicity","score":0.847000002861023},{"id":"https://openalex.org/keywords/renal-magnesium-wasting","display_name":"renal magnesium wasting","score":0.8230000138282776},{"id":"https://openalex.org/keywords/magnesium-supplementation","display_name":"magnesium supplementation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.8370000123977661},{"id":"https://openalex.org/keywords/infection-related-mortality","display_name":"infection-related mortality","score":0.8339999914169312},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6493480205535889},{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.6117924451828003},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.506712019443512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4996044635772705},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.45827221870422363},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.44048547744750977},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.432834655046463},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3447660803794861},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3298734724521637},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1376292109489441},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20203110s1772a","doi":"https://doi.org/10.1681/asn.20203110s1772a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20203110s1772a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3165459051","https://openalex.org/W4414584834","https://openalex.org/W3182046603","https://openalex.org/W4213448002","https://openalex.org/W1536072536","https://openalex.org/W2619673829","https://openalex.org/W2806577568","https://openalex.org/W4364379146","https://openalex.org/W2774158041","https://openalex.org/W2185225019"],"abstract_inverted_index":{"Background:":[0],"Hypomagnesemia":[1],"is":[2,223,228],"common":[3],"in":[4,13,43,77,126,146,221],"kidney":[5],"transplant":[6,56],"recipients":[7],"(KTR),":[8],"likely":[9],"due,":[10],"at":[11,52,65],"least":[12],"part,":[14],"to":[15,21,83,94,200,270],"renal":[16,262],"magnesium":[17],"(Mg)":[18],"wasting":[19,263],"related":[20],"calcineurininhibitor":[22],"(CNI)":[23],"use.":[24],"The":[25,213],"association":[26,97,134],"of":[27,72,107,121,164,175,181,197,242],"serum":[28,40,75,216],"Mg":[29,41,76,99,122,139,163,180,186,217,231,248,273],"levels":[30,42,218,232,251],"and":[31,50,100,105,141,150,158,202,219,264],"KTR":[32],"outcomes":[33],"may":[34,255,259],"provide":[35],"insight":[36],"into":[37],"the":[38,73,78,96,127,136,172,226,239,280],"optimal":[39],"this":[44],"population.":[45],"Methods:":[46],"KTRs":[47,114,222],"between":[48,98,135,215],"01/2000":[49],"12/2016":[51],"a":[53,62],"large":[54],"US":[55],"center":[57],"who":[58],"were":[59,69],"alive":[60],"with":[61,171,179,194,230,285],"functioning":[63],"graft":[64],"6":[66,82],"months":[67,85],"post-transplant":[68],"included.":[70],"Mean":[71,119],"outpatient":[74],"baseline":[79,128,138,154],"period,":[80],"i.e.":[81],"18":[84],"post-transplant,":[86],"was":[87,92,130,144,169,191,283],"used.":[88],"Cox":[89],"proportional-hazards":[90],"regression":[91],"used":[93],"analyze":[95],"all-cause":[101,142],"mortality,":[102,104],"cause-specific":[103],"risk":[106,227,287],"new-onset":[108],"cardiovascular":[109],"events":[110],"post-transplant.":[111],"Results:":[112],"2,131":[113],"met":[115],"our":[116],"inclusion":[117],"criteria.":[118],"number":[120],"measurements":[123],"per":[124],"patient":[125],"period":[129],"2.76.":[131],"A":[132,161],"U-shaped":[133],"mean":[137,162],"level":[140,187],"mortality":[143,198,220],"observed":[145],"both":[147],"unadjusted":[148],"analysis":[149],"after":[151],"adjusting":[152],"for":[153,250,290],"characteristics,":[155],"including":[156],"eGFR":[157],"CNI":[159],"levels.":[160],"1.5":[165,182,189,233,253],"-":[166,183,234,245],"1.8":[167,184,235,275],"mg/dL":[168,190,254,276],"associated":[170,193,284],"lowest":[173,229],"incidence":[174,196],"death":[176],"(Figure).":[177],"Compared":[178],"mg/dL,":[185],"\u2264":[188,252],"also":[192],"higher":[195,286],"due":[199],"infection":[201],"arrhythmia":[203],"but":[204,258,277],"not":[205],"ischemic":[206],"heart":[207,210],"disease":[208],"or":[209],"failure.":[211],"Conclusions:":[212],"relationship":[214],"U-shaped.":[224],"Interestingly,":[225],"mg/dL;":[236],"which":[237],"represents":[238],"lower":[240],"end":[241],"normal":[243,281],"(1.6":[244],"2.6":[246],"mg/dL).":[247],"supplements":[249],"be":[256],"beneficial,":[257],"cause":[260],"increased":[261],"diarrhea.":[265],"Further":[266],"studies":[267],"are":[268],"needed":[269],"understand":[271],"why":[272],">":[274],"well":[278],"within":[279],"range":[282],"despite":[288],"adjustment":[289],"eGFR.":[291],"Funding:":[292],"Private":[293],"Foundation":[294],"Support":[295]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2024-05-18T00:00:00"}