{"id":"https://openalex.org/W4396994744","doi":"https://doi.org/10.1681/asn.20213210s197b","title":"Real-World Effectiveness and Immunogenicity of mRNA-1273 in Dialysis Patients","display_name":"Real-World Effectiveness and Immunogenicity of mRNA-1273 in Dialysis Patients","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4396994744","doi":"https://doi.org/10.1681/asn.20213210s197b"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20213210s197b","doi":"https://doi.org/10.1681/asn.20213210s197b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s197b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009254949","display_name":"Katherine L. Mckeon","orcid":"https://orcid.org/0000-0001-5861-2112","observed_orcids":["https://orcid.org/0000-0001-5861-2112"]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine L. Mckeon","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006636992","display_name":"Scott P. Sibbel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Sibbel","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088603886","display_name":"Jiacong Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiacong Luo","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karl Wendt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Wendt","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000101753","display_name":"Adam G. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam G. Walker","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001993343","display_name":"Rachael Lazar","orcid":"https://orcid.org/0000-0003-0345-0827","observed_orcids":["https://orcid.org/0000-0003-0345-0827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachael Lazar","raw_affiliation_strings":["DaVita Inc, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DaVita Inc, Denver, CO","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051104418","display_name":"Meredith L. Zywno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meredith L. Zywno","raw_affiliation_strings":["DaVita Inc, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DaVita Inc, Denver, CO","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058086747","display_name":"Jeffrey J. Connaire","orcid":"https://orcid.org/0000-0002-2175-1482","observed_orcids":["https://orcid.org/0000-0002-2175-1482"]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey J. Connaire","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064063347","display_name":"Francesca Tentori","orcid":"https://orcid.org/0000-0002-3318-1915","observed_orcids":["https://orcid.org/0000-0002-3318-1915"]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Tentori","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amy Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Young","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025097124","display_name":"Steven M. Brunelli","orcid":"https://orcid.org/0000-0001-8017-1069","observed_orcids":["https://orcid.org/0000-0001-8017-1069"]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Brunelli","raw_affiliation_strings":["Davita Clinical Research, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davita Clinical Research, Minneapolis, MN;","institution_ids":["https://openalex.org/I4210148841"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10S","first_page":"97","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-1273","display_name":"mRNA-1273","score":0.8600000143051147},{"id":"https://openalex.org/keywords/covid-19-vaccines","display_name":"COVID-19 vaccines","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dialysis-patients","display_name":"dialysis patients","score":0.9330000281333923},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7889999747276306},{"id":"https://openalex.org/keywords/vaccine-effectiveness","display_name":"vaccine effectiveness","score":0.9470000267028809},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/anti-sars-cov-2-igg-antibodies","display_name":"anti-SARS-CoV-2 IgG","score":0.8920000195503235},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.7260000109672546},{"id":"https://openalex.org/keywords/covid-19-prevention","display_name":"COVID-19 prevention","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.9160711765289307},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5792679190635681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5774748921394348},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4374930262565613},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42545953392982483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3716881275177002},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3281794786453247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1862008273601532},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16528698801994324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20213210s197b","doi":"https://doi.org/10.1681/asn.20213210s197b","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s197b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3212047549","https://openalex.org/W4309100826","https://openalex.org/W3210592187","https://openalex.org/W4210414557","https://openalex.org/W3184465429","https://openalex.org/W3177491663","https://openalex.org/W3164119498","https://openalex.org/W4213334163","https://openalex.org/W3216557306","https://openalex.org/W4397046227"],"abstract_inverted_index":{"Background:":[0],"mRNA-1273":[1,28,84,174,223,281,303],"(Moderna)":[2],"is":[3,282],"a":[4,72,164,206],"SARS-CoV-2":[5,50,286,294],"vaccine":[6],"that":[7,27,280],"received":[8,222],"an":[9,83],"emergency":[10],"use":[11],"authorization":[12],"from":[13],"the":[14,23,47,77,129,171,185,258],"US":[15,114],"Food":[16],"and":[17,49,118,143,153,190,224,233,245,252],"Drug":[18],"Administration.":[19],"Clinical":[20],"trials":[21],"in":[22,41,65,163,284,288,297,304],"general":[24],"population":[25],"demonstrated":[26],"reduced":[29],"risk":[30],"of":[31,111,116,158,166,188,208,274],"COVID-19":[32,121],"by":[33,127],"94.5%,":[34],"however,":[35],"dialysis":[36,55,74,289],"patients":[37,56,80,145,168,220,260,300],"were":[38,58,68,89,179,194,213,225,238,269,295,307],"not":[39],"represented":[40],"these":[42],"trials.":[43],"Here,":[44],"we":[45],"estimated":[46,126],"effectiveness":[48,78,124],"antibody":[51,263],"response":[52],"among":[53],"real-world":[54],"who":[57,81,169,221],"vaccinated":[59,142,301],"with":[60,205,261,302],"mRNA-1273.":[61],"Methods:":[62],"Patients":[63],"included":[64],"this":[66],"analysis":[67],"adults":[69],"dialyzing":[70],"at":[71],"large":[73],"organization.":[75],"For":[76],"analysis,":[79],"began":[82],"vaccination":[85,175],"series":[86],"(January-March":[87],"2021)":[88],"matched":[90,226],"(with":[91],"replacement)":[92],"to":[93,95,135,196,227,293],"up":[94],"3":[96,147],"previously":[97],"unvaccinated":[98,144,229],"controls":[99],"based":[100],"on":[101],"age,":[102],"diabetes":[103],"status,":[104],"sex,":[105],"race,":[106],"body":[107],"mass":[108],"index,":[109],"date":[110],"first":[112,156],"vaccine,":[113],"state":[115],"residence,":[117],"prior":[119],"known":[120],"diagnosis.":[122],"Vaccine":[123],"was":[125,161],"calculating":[128],"hazard":[130],"ratio":[131],"(HR)":[132],"for":[133],"time":[134],"polymerase":[136],"chain":[137],"reaction":[138],"confirmed":[139],"infection":[140,287],"between":[141],"over":[146],"follow-up":[148],"intervals:":[149],"days":[150,183,254],"1-21,":[151,250],"22-42,":[152,251],"\u226543":[154,253],"after":[155,184],"dose":[157,187],"vaccine.":[159],"Immunogenicity":[160],"measured":[162],"subset":[165],"consented":[167],"completed":[170],"full,":[172],"2-dose":[173],"schedule.":[176],"Blood":[177],"samples":[178],"collected":[180],"approximately":[181],"28":[182],"second":[186],"mRNA-1273,":[189],"indirect":[191],"chemiluminescence":[192],"immunoassays":[193],"used":[195],"measure":[197],"immunoglobulin":[198],"G":[199],"(IgG)":[200],"antibodies":[201,292,306],"against":[202],"SARS-CoV-2.":[203],"Samples":[204],"reading":[207],">1":[209],"arbitrary":[210],"unit":[211],"(AU)":[212],"considered":[214],"IgG+.":[215],"Results:":[216],"We":[217],"identified":[218],"23,037":[219],"64,243":[228],"controls.":[230],"The":[231],"HRs":[232],"95%":[234],"confidence":[235],"intervals":[236],"(CI)":[237],"0.96":[239],"(0.79,":[240],"1.16),":[241],"0.51":[242],"(0.34,":[243],"0.75),":[244],"0.27":[246],"(0.17,":[247],"0.42)":[248],"during":[249],"postvaccination,":[255],"respectively.":[256],"Among":[257],"329":[259],"postvaccination":[262],"measurements,":[264],"96.0%":[265],"(95%":[266],"CI:":[267],"93.3%-97.9%)":[268],"IgG+":[270],"(median:":[271],"100.5":[272],"AU":[273],"IgG).":[275],"Conclusions:":[276],"Our":[277],"results":[278],"indicate":[279],"effective":[283],"preventing":[285],"patients.":[290],"Moreover,":[291],"detected":[296],"nearly":[298],"all":[299],"whom":[305],"measured.":[308]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-05-18T00:00:00"}