{"id":"https://openalex.org/W4396994167","doi":"https://doi.org/10.1681/asn.20213210s1172c","title":"The Kidney Produces a Non-Polymerizing Form of Uromodulin That Associates with Reduced Risk of AKI","display_name":"The Kidney Produces a Non-Polymerizing Form of Uromodulin That Associates with Reduced Risk of AKI","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4396994167","doi":"https://doi.org/10.1681/asn.20213210s1172c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20213210s1172c","doi":"https://doi.org/10.1681/asn.20213210s1172c","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1172c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://dx.doi.org/10.1681/asn.20213210s1172c","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029794052","display_name":"Radmila Micanovic","orcid":"https://orcid.org/0000-0002-8151-0234","observed_orcids":["https://orcid.org/0000-0002-8151-0234"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radmila Micanovic","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086216223","display_name":"Kaice A. LaFavers","orcid":"https://orcid.org/0000-0003-2052-6248","observed_orcids":["https://orcid.org/0000-0003-2052-6248"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaice A. LaFavers","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065588757","display_name":"Kavish Rohit Patidar","orcid":"https://orcid.org/0000-0003-3633-382X","observed_orcids":["https://orcid.org/0000-0003-3633-382X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kavish R. Patidar","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004270795","display_name":"Shehnaz Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shehnaz Khan","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088183139","display_name":"Tarek M. El\u2010Achkar","orcid":"https://orcid.org/0000-0003-4645-3614","observed_orcids":["https://orcid.org/0000-0003-4645-3614"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarek M. El-Achkar","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34965958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10S","first_page":"172","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uromodulin","display_name":"uromodulin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-processing","display_name":"protein processing","score":0.5699999928474426},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.7730000019073486},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/thick-ascending-limb","display_name":"thick ascending limb","score":0.6679999828338623},{"id":"https://openalex.org/keywords/kidney-injury-biomarkers","display_name":"kidney injury biomarkers","score":0.6570000052452087},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C74460091","wikidata":"https://www.wikidata.org/wiki/Q420024","display_name":"Tamm\u2013Horsfall protein","level":3,"score":0.9137108325958252},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.49350249767303467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44541317224502563},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.34402579069137573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3281567692756653}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20213210s1172c","doi":"https://doi.org/10.1681/asn.20213210s1172c","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1172c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1681/asn.20213210s1172c","doi":"https://doi.org/10.1681/asn.20213210s1172c","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1172c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4210535930","https://openalex.org/W2102548810","https://openalex.org/W1980785035","https://openalex.org/W2788779566","https://openalex.org/W6943641915","https://openalex.org/W2769466539","https://openalex.org/W4300797474","https://openalex.org/W2094922355","https://openalex.org/W2892238967","https://openalex.org/W2060551353"],"abstract_inverted_index":{"Background:":[0],"Uromodulin":[1],"(Tamm-Horsfall":[2],"protein,":[3],"THP)":[4],"is":[5,14,64,213],"a":[6,96,152,167,193,248,322],"glycoprotein":[7],"uniquely":[8],"produced":[9],"in":[10,25,30,61,78,144,189,192,232,243,265,279,310],"the":[11,19,26,31,56,62,79,90,145,185,190,200,218,223,280,298,317],"kidney.":[12,147],"It":[13],"released":[15],"by":[16,296],"cells":[17],"of":[18,38,49,74,99,129,132,170,187,202,250,300,319,325],"thick":[20],"ascending":[21],"limbs":[22],"(TAL)":[23],"apically":[24],"urine,":[27],"and":[28,34,67,119,158,163,179,204,328],"basolaterally":[29],"renal":[32],"interstitium":[33],"systemic":[35],"circulation.":[36],"Processing":[37],"mature":[39],"urinary":[40,230,256],"THP,":[41,261],"which":[42,88,212],"polymerizes":[43],"into":[44,293],"supra-molecular":[45],"filaments,":[46],"requires":[47],"cleavage":[48,131,208],"an":[50,84,105,301],"external":[51],"hydrophobic":[52],"patch":[53],"(EHP)":[54],"at":[55,210,240,283],"C":[57,120],"terminus.":[58],"However,":[59],"THP":[60,75,110,231],"circulation":[63],"not":[65,259],"polymerized,":[66],"it":[68,160,236],"remains":[69],"unclear":[70],"if":[71],"non-aggregated":[72],"forms":[73],"exist":[76],"natively":[77],"urine.":[80],"We":[81,102],"propose":[82],"that":[83,107,206],"alternative":[85,302],"processing":[86],"path,":[87],"retains":[89],"EHP":[91,113],"domain,":[92],"can":[93],"lead":[94],"to":[95,125,140,155,315,330],"non-polymerizing":[97],"form":[98],"THP.":[100],"Methods:":[101],"have":[103],"generated":[104],"antibody":[106],"specifically":[108],"recognizes":[109],"with":[111,173,229,252],"retained":[112],"(THP+EHP).":[114],"Liquid":[115],"chromatography,":[116],"mass":[117],"spectrometry":[118],"terminal":[121],"sequencing":[122],"were":[123],"performed":[124],"delineate":[126],"potential":[127],"sites":[128],"enzymatic":[130,207],"immunoprecipitated":[133],"THP+EHP.":[134],"Immunofluorescence":[135],"confocal":[136],"microscopy":[137],"was":[138,237,262,276],"used":[139,159],"localize":[141],"this":[142],"isopform":[143],"human":[146,224],"Finally,":[148],"we":[149,183],"finally":[150],"developed":[151,269],"customized":[153],"ELISA":[154],"measure":[156],"THP+EHP":[157,188,203,226,275,320],"on":[161],"urine":[162,191],"plasma":[164],"samples":[165],"from":[166],"small":[168],"cohort":[169,249],"patients":[171,251,266,311],"hospitalized":[172],"liver":[174,253],"cirrhosis.":[175],"Results:":[176],"Using":[177],"native":[178,195],"denaturing":[180],"Western":[181],"blots,":[182],"established":[184],"presence":[186,299],"non-polymerized":[194],"state.":[196],"Proteomic":[197],"studies":[198],"confirmed":[199],"identity":[201],"suggested":[205],"occurred":[209],"Arg615,":[211],"one":[214],"amino":[215],"acid":[216],"beyond":[217],"GPI":[219],"anchoring":[220],"site.":[221],"In":[222,247],"kidney,":[225],"predominantly":[227],"co-localized":[228],"TAL":[233],"cells,":[234],"but":[235,258],"also":[238,277],"detected,":[239],"lower":[241,264],"levels,":[242],"other":[244],"tubular":[245],"segments.":[246],"disease,":[254],"admission":[255],"THP+EHP,":[257],"total":[260],"significantly":[263],"who":[267],"subsequently":[268],"acute":[270],"kidney":[271,326],"injury":[272],"during":[273],"hospitalization.":[274],"detected":[278],"plasma,":[281],"albeit":[282],"very":[284],"low":[285],"concentrations.":[286],"Conclusions:":[287],"Our":[288,307],"findings":[289,309],"uncover":[290],"novel":[291],"insights":[292],"uromodulin":[294],"biology":[295],"establishing":[297],"path":[303],"for":[304],"cellular":[305],"processing.":[306],"proof-of-principle":[308],"warrant":[312],"further":[313],"investigations":[314],"establish":[316],"utility":[318],"as":[321],"sensitive":[323],"biomarker":[324],"health":[327],"susceptibility":[329],"injury.":[331],"Funding:":[332],"NIDDK":[333],"Support,":[334],"Veterans":[335],"Affairs":[336],"Support":[337]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-05-18T00:00:00"}