{"id":"https://openalex.org/W4396993415","doi":"https://doi.org/10.1681/asn.20213210s1130a","title":"Optimal Cefepime Dosing Regimens in Obese Critically Ill Patients with AKI Receiving Continuous Renal Replacement Therapy","display_name":"Optimal Cefepime Dosing Regimens in Obese Critically Ill Patients with AKI Receiving Continuous Renal Replacement Therapy","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4396993415","doi":"https://doi.org/10.1681/asn.20213210s1130a"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20213210s1130a","doi":"https://doi.org/10.1681/asn.20213210s1130a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1130a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077647778","display_name":"Dhakrit \u201cJesse\u201d Rungkitwattanakul","orcid":"https://orcid.org/0000-0003-2674-342X","observed_orcids":["https://orcid.org/0000-0003-2674-342X"]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhakrit \u201cJesse\u201d Rungkitwattanakul","raw_affiliation_strings":["Howard University College of Pharmacy, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University College of Pharmacy, Washington, DC;","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040181370","display_name":"Andrew A. Yabusaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew A. Yabusaki","raw_affiliation_strings":["Howard University College of Pharmacy, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University College of Pharmacy, Washington, DC;","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108930215","display_name":"Kuang-Heng Hsiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuang-Heng Hsiao","raw_affiliation_strings":["Howard University College of Pharmacy, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University College of Pharmacy, Washington, DC;","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098673836","display_name":"Kendra Getaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendra Getaw","raw_affiliation_strings":["Howard University College of Pharmacy, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University College of Pharmacy, Washington, DC;","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014178126","display_name":"Taniya Charoensareerat","orcid":"https://orcid.org/0000-0002-1100-2162","observed_orcids":["https://orcid.org/0000-0002-1100-2162"]},"institutions":[{"id":"https://openalex.org/I114432228","display_name":"Siam University","ror":"https://ror.org/04j3saz95","country_code":"TH","type":"education","lineage":["https://openalex.org/I114432228"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Taniya Charoensareerat","raw_affiliation_strings":["Siam University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siam University, Bangkok, Thailand","institution_ids":["https://openalex.org/I114432228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013396055","display_name":"Weerachai Chaijamorn","orcid":"https://orcid.org/0000-0003-3781-5062","observed_orcids":["https://orcid.org/0000-0003-3781-5062"]},"institutions":[{"id":"https://openalex.org/I114432228","display_name":"Siam University","ror":"https://ror.org/04j3saz95","country_code":"TH","type":"education","lineage":["https://openalex.org/I114432228"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Weerachai Chaijamorn","raw_affiliation_strings":["Siam University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siam University, Bangkok, Thailand","institution_ids":["https://openalex.org/I114432228"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10S","first_page":"130","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefepime","display_name":"cefepime","score":0.9919999837875366},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.8299999833106995},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9380000233650208},{"id":"https://openalex.org/keywords/continuous-renal-replacement-therapy","display_name":"continuous renal replacement therapy","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-dosing","display_name":"antibiotic dosing","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/probability-of-target-attainment","display_name":"probability of target attainment","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.796999990940094},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9940000176429749},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.777999997138977},{"id":"https://openalex.org/keywords/virtual-patients","display_name":"virtual patients","score":0.4399999976158142},{"id":"https://openalex.org/keywords/loading-dose","display_name":"loading dose","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2777050379","wikidata":"https://www.wikidata.org/wiki/Q2552927","display_name":"Cefepime","level":5,"score":0.9374241828918457},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8458220958709717},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.845479428768158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.838334858417511},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.801100492477417},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5390737652778625},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.44545769691467285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3732873201370239},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.15464186668395996},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.0},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20213210s1130a","doi":"https://doi.org/10.1681/asn.20213210s1130a","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1130a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2891539841","https://openalex.org/W3135986974","https://openalex.org/W4389031114","https://openalex.org/W7123608429","https://openalex.org/W4384660897","https://openalex.org/W4388301505","https://openalex.org/W2048311488","https://openalex.org/W7122363518","https://openalex.org/W2120872706","https://openalex.org/W7154468302"],"abstract_inverted_index":{"Background:":[0],"Cefepime":[1,108],"can":[2],"be":[3,300],"removed":[4],"by":[5,266],"continuous":[6,64],"renal":[7,65],"replacement":[8,66,314],"therapy":[9,67,305],"(CRRT)":[10],"due":[11,224,306],"to":[12,51,83,105,113,225,307],"its":[13],"pharmacokinetics.":[14],"Physiologic":[15],"alterations":[16],"in":[17,31,39,58,157,179,282],"obesity":[18],"and":[19,28,73,133,148,244,313],"critical":[20],"illness":[21],"commonly":[22],"impact":[23,318],"the":[24,53,115,119,158,165,171,184,191,251,275,319],"pharmacokinetics":[25],"of":[26,47,56,121,125,129,142,183,195,211,219,231,241,293],"antibiotics":[27],"may":[29],"result":[30],"suboptimal":[32,308],"dosing.":[33],"The":[34,45,160,255,310],"information":[35],"regarding":[36],"drug":[37],"dosing":[38,55,162,194,292],"this":[40],"population":[41],"is":[42,50,92],"relatively":[43],"limited.":[44],"objective":[46],"our":[48],"study":[49],"determine":[52,114],"appropriate":[54],"cefepime":[57,196,281],"obese":[59,77,283],"critically":[60,78,284],"ill":[61,79,285],"patients":[62,80,145,204,287],"receiving":[63,205,288],"(CRRT).":[68],"Methods:":[69],"All":[70],"necessary":[71],"pharmacokinetic":[72],"pharmacodynamic":[74,247,320],"parameters":[75],"from":[76],"were":[81,111,168,249],"obtained":[82],"develop":[84],"one-compartment":[85],"mathematical":[86],"models":[87],"with":[88,207,228,290],"first-order":[89],"elimination.":[90],"Obesity":[91],"defined":[93,169],"as":[94,170,302],"a":[95,237],"body":[96],"mass":[97],"index":[98],"(BMI)":[99],"greater":[100],"than":[101],"30":[102],"kg/m2":[103],"according":[104],"WHO":[106],"classification.":[107],"concentration-time":[109],"profiles":[110],"calculated":[112],"efficacy":[116],"based":[117],"on":[118,262],"probability":[120],"target":[122,177,312],"attainment":[123],"(PTA)":[124],"both":[126],"pharmacodynamics":[127],"targets":[128,248],"70%":[130,134],"T>":[131,135],"MIC":[132,230,311],"4MIC":[136],"for":[137,154,203,221],"Gram-negative":[138,222],"infections.":[139],"A":[140],"group":[141],"10,000":[143],"virtual":[144,185],"was":[146,272],"simulated":[147],"tested":[149],"using":[150],"Monte":[151],"Carlo":[152],"simulations":[153],"each":[155],"dose":[156,174,257,261],"models.":[159],"optimal":[161],"regimens":[163],"or":[164],"\u201csuccessful":[166],"dose\u201d":[167],"lowest":[172],"daily":[173],"that":[175],"achieved":[176],"PTA":[178,220,253],"at":[180,197,216],"least":[181,217],"90%":[182,218],"patients.":[186],"Results:":[187],"Our":[188],"results":[189],"showed":[190],"highest":[192],"FDA-recommended":[193],"2000":[198,294],"mg":[199,259,268,295],"every":[200,269,296],"8":[201,232,270,297],"hours":[202,298],"CRRT":[206,289],"an":[208,229,245,303],"effluent":[209,239],"rate":[210,240,316],"25":[212],"mL/kg/h":[213,243],"cannot":[214,299],"achieve":[215],"infection":[223],"pseudomonas":[226],"aeruginosa":[227],"mg/L.":[233],"In":[234],"addition,":[235],"when":[236],"higher":[238],"35":[242],"aggressive":[246],"applied,":[250],"%":[252],"decreased.":[254],"successful":[256],"(3000":[258],"loading":[260],"day":[263],"1":[264],"followed":[265],"2500":[267],"hours)":[271],"far":[273],"exceeded":[274],"maximal":[276],"FDA-approved":[277],"doses.":[278],"Conclusions:":[279],"Using":[280],"AKI":[286],"traditional":[291],"recommended":[301],"empiric":[304],"efficacy.":[309],"fluid":[315],"directly":[317],"outcome.":[321]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-18T00:00:00"}