{"id":"https://openalex.org/W4396993149","doi":"https://doi.org/10.1681/asn.20213210s1230c","title":"Evidence for Convergence of NF-\u03baB and Growth Hormone (GH) Signaling on Stem Cell Activation in the Adult Zebrafish Kidney","display_name":"Evidence for Convergence of NF-\u03baB and Growth Hormone (GH) Signaling on Stem Cell Activation in the Adult Zebrafish Kidney","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4396993149","doi":"https://doi.org/10.1681/asn.20213210s1230c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20213210s1230c","doi":"https://doi.org/10.1681/asn.20213210s1230c","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1230c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003474110","display_name":"Heiko Joachim Schenk","orcid":"https://orcid.org/0000-0003-2693-5712","observed_orcids":["https://orcid.org/0000-0003-2693-5712"]},"institutions":[{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Heiko J. Schenk","raw_affiliation_strings":["Medizinische Hochschule Hannover, Hannover, Germany","Mount Desert Island Biological Laboratory, Salsbury Cove, ME;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Mount Desert Island Biological Laboratory, Salsbury Cove, ME;","institution_ids":["https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061129983","display_name":"Caramai N. Kamei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caramai N. Kamei","raw_affiliation_strings":["Mount Desert Island Biological Laboratory, Salsbury Cove, ME;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Desert Island Biological Laboratory, Salsbury Cove, ME;","institution_ids":["https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088446030","display_name":"Amber M. Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber M. Wolf","raw_affiliation_strings":["Mount Desert Island Biological Laboratory, Salsbury Cove, ME;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Desert Island Biological Laboratory, Salsbury Cove, ME;","institution_ids":["https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113210633","display_name":"Samuel M. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel M. Hughes","raw_affiliation_strings":["Mount Desert Island Biological Laboratory, Salsbury Cove, ME;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Desert Island Biological Laboratory, Salsbury Cove, ME;","institution_ids":["https://openalex.org/I2800736356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083204035","display_name":"Iain A. S. Drummond","orcid":"https://orcid.org/0000-0003-3734-1231","observed_orcids":["https://orcid.org/0000-0003-3734-1231","https://orcid.org/0000-0003-0252-2323"]},"institutions":[{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iain A. Drummond","raw_affiliation_strings":["Mount Desert Island Biological Laboratory, Salsbury Cove, ME;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Desert Island Biological Laboratory, Salsbury Cove, ME;","institution_ids":["https://openalex.org/I2800736356"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10S","first_page":"230","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.13809999823570251,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.11209999769926071,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/growth-hormone-signaling","display_name":"growth hormone signaling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/kidney-stem-cells","display_name":"kidney stem cells","score":0.6000000238418579},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tubular-regeneration","display_name":"tubular regeneration","score":0.5789999961853027},{"id":"https://openalex.org/keywords/osr1","display_name":"OSR1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/eya4","display_name":"EYA4","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.6909999847412109},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6890000104904175},{"id":"https://openalex.org/keywords/osmoregulation","display_name":"osmoregulation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/body-mass-growth","display_name":"body mass growth","score":0.531000018119812},{"id":"https://openalex.org/keywords/mesonephros","display_name":"mesonephros","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.888606071472168},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6606193780899048},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5364354848861694},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4959965646266937},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4885343313217163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47917380928993225},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4634304940700531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4410788118839264},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.4357033967971802},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4145921468734741},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3997308611869812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34623581171035767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29141175746917725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11536088585853577},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09663805365562439}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20213210s1230c","doi":"https://doi.org/10.1681/asn.20213210s1230c","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1230c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4397046358","https://openalex.org/W4397048453","https://openalex.org/W7153493239","https://openalex.org/W2951525092","https://openalex.org/W4415549319","https://openalex.org/W1586271419","https://openalex.org/W7100905022","https://openalex.org/W2942671315","https://openalex.org/W2162355576","https://openalex.org/W2076973648"],"abstract_inverted_index":{"Background:":[0],"Adult":[1,67],"progenitor":[2,27,125,221],"cells":[3,28,161,252],"in":[4,61,128,184,239,267,288,297],"the":[5,89,219,229,292],"mesonephric":[6],"kidneys":[7,69,167],"are":[8],"required":[9],"both":[10,53],"during":[11,18,104],"neo-nephrogenesis":[12],"replacing":[13],"injured":[14,71,289],"tubules":[15],"but":[16],"also":[17,208],"overall":[19],"growth.":[20],"Single-cell":[21],"RNA":[22],"transcriptomes":[23],"of":[24,88,101,124,138,198,231,286,294],"adult":[25,249],"kidney":[26,150,178,220,250],"point":[29],"to":[30,144,181,253,269,299],"at":[31,189,214],"least":[32],"two":[33],"receptor":[34],"systems":[35],"that":[36],"may":[37,246,262],"initiate":[38],"stem":[39,63,131,251],"cell-based":[40,64],"nephrogenesis:":[41],"growth":[42,260],"hormone":[43,261],"(GH)":[44,60],"and":[45,57,94,130,158,192,224,259,273,279],"interleukin":[46],"receptors.":[47],"Here":[48],"we":[49],"present":[50],"evidence":[51],"for":[52,275],"injury":[54,83,179,278],"(NF-\u03baB":[55],"activation)":[56],"growth-related":[58],"pathways":[59,245],"stimulating":[62],"nephrogenesis.":[65],"Methods:":[66],"zebrafish":[68],"were":[70,142],"by":[72,85,108,122,135,162,170,205,236],"gentamicin":[73,120,171],"i.p.":[74],"injection.":[75],"NF-\u03baB":[76,90,102,110,186,199,287],"signaling":[77,103,113,141,147],"was":[78,106,114,164],"determined":[79],"four":[80],"days":[81],"post":[82],"(dpi)":[84],"NF-\u03baB:GFP":[86],"detection":[87],"reporter":[91],"line":[92],"Tg(NF-\u03baB:EGFP)":[93],"NF-\u03baB-associated":[95],"gene":[96,202],"expression":[97,134,203,238],"using":[98,173],"qRTPCR.":[99,136,206],"Requirement":[100],"regeneration":[105],"evaluated":[107,115],"pharmacological":[109],"inhibition.":[111],"GH":[112,118,139,146,210,226],"after":[116,149],"either":[117],"or":[119],"injection":[121,172,227],"quantification":[123],"marker":[126,133],"lhx1a:GFP":[127],"Tg(lhx1a:GFP)":[129,237],"cell":[132],"Inhibitors":[137],"downstream":[140,200],"used":[143],"determine":[145],"impact":[148],"injury.":[151,300],"Bulk":[152],"RNAseq":[153],"from":[154,166],"positive":[155],"selected":[156],"GFP+":[157],"mcherry+":[159],"single":[160],"FACS":[163],"performed":[165],"7":[168,215],"dpi":[169,191,216],"Tg(lhx1a:EGFP;cdh17:mCherry)":[174],"fish.":[175],"Results:":[176],"Gentamicin-induced":[177],"leads":[180],"an":[182,196],"increase":[183],"tubular":[185],"nuclear":[187,284],"translocation":[188,285],"4":[190],"is":[193],"associated":[194],"with":[195,218,283],"upregulation":[197,213],"target":[201],"detected":[204],"Gentamicin":[207],"causes":[209],"receptors":[211],"mRNA":[212],"along":[217],"markers":[222],"osr1":[223],"eya4.":[225],"induced":[228],"formation":[230,266],"new":[232,240,255,264],"nephrons":[233],"as":[234],"marked":[235],"nephron":[241,256,265,280],"aggregates.":[242],"Conclusions:":[243],"Multiple":[244],"converge":[247],"on":[248],"activate":[254],"formation.":[257],"Growth":[258],"induce":[263],"response":[268,298],"increased":[270],"body":[271],"mass":[272],"need":[274],"osmoregulation.":[276],"Kidney":[277],"replacement":[281],"correlate":[282],"tubules,":[290],"suggesting":[291],"possibility":[293],"cytokine-mediated":[295],"nephrogenesis":[296],"Funding:":[301],"NIDDK":[302],"Support,":[303],"Other":[304],"NIH":[305],"Support":[306,313],"-":[307,314],"Maine":[308],"INBRE":[309],"grant":[310],"(GM103423),":[311],"Government":[312],"Non-U.S.":[315]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2024-05-18T00:00:00"}