{"id":"https://openalex.org/W4396993103","doi":"https://doi.org/10.1681/asn.20213210s1237d","title":"Interferon-\u03b3 Signaling and the Progression of Early Diabetic Kidney Disease","display_name":"Interferon-\u03b3 Signaling and the Progression of Early Diabetic Kidney Disease","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4396993103","doi":"https://doi.org/10.1681/asn.20213210s1237d"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20213210s1237d","doi":"https://doi.org/10.1681/asn.20213210s1237d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1237d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018962385","display_name":"Viji Nair","orcid":"https://orcid.org/0000-0003-1657-954X","observed_orcids":["https://orcid.org/0000-0003-1657-954X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viji Nair","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082658305","display_name":"Jennifer L. Harder","orcid":"https://orcid.org/0000-0002-7927-608X","observed_orcids":["https://orcid.org/0000-0002-7927-608X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Harder","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085379485","display_name":"Helen C. Looker","orcid":"https://orcid.org/0000-0002-0802-781X","observed_orcids":["https://orcid.org/0000-0002-0802-781X"]},"institutions":[{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen C. Looker","raw_affiliation_strings":["National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003676386","display_name":"Frank Chip Brosius","orcid":"https://orcid.org/0000-0002-4244-8335","observed_orcids":["https://orcid.org/0000-0002-4244-8335"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank C. Brosius","raw_affiliation_strings":["University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048199090","display_name":"Markus Bitzer","orcid":"https://orcid.org/0000-0002-3711-2984","observed_orcids":["https://orcid.org/0000-0002-3711-2984"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Bitzer","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088560891","display_name":"Robert G. Nelson","orcid":"https://orcid.org/0000-0001-7307-3786","observed_orcids":["https://orcid.org/0000-0001-7307-3786"]},"institutions":[{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Nelson","raw_affiliation_strings":["National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073141203","display_name":"Matthias Kretzler","orcid":"https://orcid.org/0000-0003-4064-0582","observed_orcids":["https://orcid.org/0000-0003-4064-0582","https://orcid.org/0009-0003-0511-7208"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias Kretzler","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079319293","display_name":"Wenjun Ju","orcid":"https://orcid.org/0000-0002-9136-8454","observed_orcids":["https://orcid.org/0000-0002-9136-8454"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjun Ju","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10S","first_page":"237","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/interferon-gamma-signaling","display_name":"interferon-gamma signaling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6890000104904175},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pima-indians","display_name":"Pima Indians","score":0.8569999933242798},{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":0.6520000100135803},{"id":"https://openalex.org/keywords/baricitinib","display_name":"baricitinib","score":0.9559999704360962},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mesangial-expansion","display_name":"mesangial expansion","score":0.8899999856948853},{"id":"https://openalex.org/keywords/kidney-organoids","display_name":"kidney organoids","score":0.6940000057220459},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.6819999814033508},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.46299999952316284},{"id":"https://openalex.org/keywords/tubulointerstitial-injury","display_name":"tubulointerstitial injury","score":0.8569999933242798},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate-decline","display_name":"estimated glomerular filtration rate decline","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6394177079200745},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5387768149375916},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.46475258469581604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4050285816192627},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2825956642627716}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20213210s1237d","doi":"https://doi.org/10.1681/asn.20213210s1237d","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1237d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.550000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"Background:":[0],"Inflammation":[1],"plays":[2],"an":[3,260],"important":[4],"role":[5],"in":[6,43,107,141,148,160,171,194,210,243,252,281,284,302],"pathogenesis":[7],"of":[8,48,61,168,219,229,262],"diabetic":[9],"kidney":[10,49,59,88,162,196,207,234,282],"disease":[11,89],"(DKD).":[12],"However,":[13],"the":[14,112,124,129,185,230,293],"pathways":[15,51],"by":[16,199,258],"which":[17,155,255,266],"circulating":[18,41,99,274],"pro-inflammatory":[19],"factors":[20,42],"activate":[21],"intrarenal":[22],"signaling":[23,50,126,270],"and":[24,46,52,68,80,132,138,159,175,212,221,237,240,264,277],"mediate":[25],"DKD":[26,45,53,70,142,158,286,290],"progression":[27,54],"remain":[28],"poorly":[29],"defined.":[30],"Using":[31],"multiscalar":[32],"data":[33,57],"integration":[34],"we":[35],"aimed":[36],"to":[37,74,96,289],"identify":[38,75,97],"links":[39],"between":[40],"early":[44,69,285,303],"activation":[47,208,250,280],"Methods:":[55],"Transcriptomic":[56],"from":[58],"biopsies":[60],"Pima":[62],"Indians":[63],"with":[64,86,111,135,180,216],"type":[65],"2":[66],"diabetes":[67],"(n=74)":[71],"were":[72,102,120,146,178,214],"used":[73,95],"differentially":[76],"expressed":[77],"genes":[78],"(DEGs)":[79],"their":[81,105],"upstream":[82],"regulators":[83],"(URs)":[84],"associated":[85,134,215],"end-stage":[87],"(ESKD).":[90],"Plasma":[91],"proteomics":[92],"(n=162)":[93],"was":[94,109,192,256],"ESKD-associated":[98,169],"proteins.":[100],"URs":[101,167],"selected":[103],"if":[104],"regulation":[106],"plasma":[108],"consistent":[110],"prediction":[113],"based":[114,122],"on":[115,123],"transcriptomic":[116,130],"analysis.":[117,203],"Activation":[118],"scores":[119,209],"computed":[121],"downstream":[125],"cascade":[127],"at":[128],"level":[131],"then":[133],"structural":[136],"lesions":[137],"health":[139],"outcomes":[140],"patients.":[143],"The":[144],"findings":[145],"validated":[147],"podocyte-specific":[149],"JAK2":[150],"transgenic":[151],"Ins2Akita/+":[152],"mice":[153],"(Pod-Jak2TG-Akita)":[154],"develop":[156],"progressive":[157],"human":[161,253],"organoid":[163],"cultures.":[164],"Results:":[165],"Five":[166],"DEGs":[170],"both":[172],"glomeruli":[173],"(Glom)":[174],"tubulointerstitium":[176],"(TI)":[177],"identified,":[179],"interferon":[181],"gamma":[182],"(IFNG)":[183],"exhibiting":[184],"most":[186],"significant":[187],"association.":[188],"IFNG":[189,205,231,235,246,249,269,275,278,294],"receptor":[190],"expression":[191],"detected":[193],"multiple":[195],"cell":[197,201],"types":[198],"single":[200],"RNAseq":[202],"Higher":[204],"pathway":[206,232,279,295],"Glom":[211],"TI":[213],"increased":[217,248],"risk":[218],"ESKD":[220],"faster":[222],"GFR":[223],"decline":[224],"over":[225],"10.5":[226],"years.":[227],"Inhibition":[228],"reduced":[233,257],"score":[236,251],"ameliorated":[238],"albuminuria":[239],"mesangial":[241],"expansion":[242],"Pod-Jak2TG-Akita":[244],"mice.":[245],"significantly":[247],"organoids,":[254],"baricitinib,":[259],"inhibitor":[261],"JAK1":[263],"JAK2,":[265],"are":[267],"major":[268],"mediators.":[271],"Conclusions:":[272],"Increased":[273],"levels":[276],"tissue":[283],"may":[287,296],"lead":[288],"progression.":[291],"Therefore,":[292],"be":[297],"a":[298],"target":[299],"for":[300],"intervention":[301],"DKD.":[304],"Funding:":[305],"NIDDK":[306],"Support":[307]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}