{"id":"https://openalex.org/W4396992453","doi":"https://doi.org/10.1681/asn.20213210s1755c","title":"Critical Role of Histone Demethylase JMJD3 in the Regulation of Macrophage Polarization and Renal Fibrosis","display_name":"Critical Role of Histone Demethylase JMJD3 in the Regulation of Macrophage Polarization and Renal Fibrosis","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4396992453","doi":"https://doi.org/10.1681/asn.20213210s1755c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20213210s1755c","doi":"https://doi.org/10.1681/asn.20213210s1755c","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1755c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016978691","display_name":"Changlong An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changlong An","raw_affiliation_strings":["University of Connecticut School of Medicine, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012954499","display_name":"Baihai Jiao","orcid":"https://orcid.org/0000-0002-2217-981X","observed_orcids":["https://orcid.org/0000-0002-2217-981X"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baihai Jiao","raw_affiliation_strings":["University of Connecticut School of Medicine, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100350717","display_name":"Yanlin Wang","orcid":"https://orcid.org/0000-0002-6908-1529","observed_orcids":["https://orcid.org/0000-0002-6908-1529"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanlin Wang","raw_affiliation_strings":["University of Connecticut School of Medicine, Farmington, CT;","VA Connecticut Healthcare System - West Haven Campus, West Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut School of Medicine, Farmington, CT;","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"VA Connecticut Healthcare System - West Haven Campus, West Haven, CT","institution_ids":["https://openalex.org/I4210086971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10S","first_page":"755","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jmjd3","display_name":"JMJD3","score":1.0},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9559999704360962},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9700000286102295},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.921999990940094},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.7889999747276306},{"id":"https://openalex.org/keywords/h3k27-demethylation","display_name":"H3K27 demethylation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/unilateral-ureteral-obstruction","display_name":"unilateral ureteral obstruction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gsk-j4","display_name":"GSK-J4","score":0.7910000085830688},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.7806476354598999},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.56181800365448},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.49507275223731995},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4755558371543884},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.46716153621673584},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42591696977615356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39378654956817627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3668668270111084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29327166080474854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.182489275932312},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20213210s1755c","doi":"https://doi.org/10.1681/asn.20213210s1755c","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1681/asn.20213210s1755c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4366365208","https://openalex.org/W4396998028","https://openalex.org/W4297257570","https://openalex.org/W7118031831","https://openalex.org/W3118516730","https://openalex.org/W2949372983","https://openalex.org/W4220707883","https://openalex.org/W7138169418","https://openalex.org/W4403833593","https://openalex.org/W3030871963"],"abstract_inverted_index":{"Background:":[0],"Chronic":[1],"kidney":[2,260,290],"disease":[3],"is":[4],"characterized":[5],"by":[6],"macrophage":[7,29,55,220,273],"infiltration":[8,12],"and":[9,13,31,57,80,140,172,174,197,224,248,250,275],"fibrosis.":[10,24,59,103,117,279],"Macrophage":[11],"polarization":[14,30,56,274],"play":[15],"an":[16],"important":[17],"role":[18,46,64],"in":[19,51,67,109,146,179,201,258],"the":[20,26,45,52,63,110,113,147,180,202,259],"development":[21,32,114,276],"of":[22,33,47,54,65,78,115,122,132,163,190,216,232,254,272,277],"renal":[23,34,58,102,116,278],"However,":[25],"mechanisms":[27],"underlying":[28],"fibrosis":[35],"are":[36],"not":[37],"fully":[38],"understood.":[39],"In":[40],"this":[41],"study,":[42],"we":[43,69,81],"examined":[44],"histone":[48,235],"demethylase":[49],"JMJD3":[50,66,91,105,123,133,154,164,191,217,233,267,281],"regulation":[53],"Methods:":[60],"To":[61],"examine":[62],"vivo,":[68],"generated":[70],"mice":[71,84,156,240],"with":[72,85,119,150,157,242],"global":[73,158,185,211],"or":[74,87,127,159,186,212],"myeloid":[75,128,160,187,213],"cell-specific":[76,161,188,214],"deletion":[77,121,131,162,189,215,231],"JMJD3,":[79],"treated":[82,241],"wild-type":[83],"vehicle":[86],"GSK-J4,":[88],"a":[89,269,284],"selective":[90],"inhibitor.":[92],"Unilateral":[93],"ureteral":[94],"obstruction":[95],"(UUO)":[96],"model":[97],"were":[98,137],"used":[99],"to":[100],"induce":[101],"Results:":[104],"expression":[106],"was":[107],"increased":[108,234],"kidneys":[111,181,203],"during":[112],"Mice":[118],"tamoxifen-inducible":[120],"(CAG-Cre,":[124],"floxed":[125,135,153],"JMJD3)":[126,136],"cell":[129],"specific":[130],"(LysM-Cre,":[134],"born":[138],"normal":[139],"had":[141],"no":[142],"obvious":[143],"morphological":[144],"abnormality":[145],"kidney.":[148],"Compared":[149],"Cre":[151],"negative,":[152],"mice,":[155],"displayed":[165],"fewer":[166,245],"F4/80-positive":[167],"macrophages,":[168,171],"CD206-positive":[169],"M2":[170,219,246],"myofibroblasts,":[173],"expressed":[175],"less":[176,252],"\u03b1-SMA":[177],"protein":[178,199,227],"following":[182,261],"UUO.":[183,262],"Furthermore,":[184],"significantly":[192],"reduced":[193],"total":[194],"collagen":[195],"deposition":[196],"ECM":[198],"production":[200],"after":[204],"UUO":[205],"injury.":[206],"Real-time":[207],"RT-PCR":[208],"showed":[209],"that":[210],"attenuated":[218],"polarization,":[221],"fibroblast":[222],"activation,":[223],"extracellular":[225,255],"matrix":[226,256],"production.":[228],"Moreover,":[229],"genetic":[230],"Lys":[236],"27":[237],"dimethylation.":[238],"Wild-type":[239],"GSK-J4":[243],"exhibited":[244],"macrophages":[247],"myofibroblasts":[249],"produced":[251],"amounts":[253],"proteins":[257],"Conclusions:":[263],"Our":[264],"study":[265],"identifies":[266],"as":[268],"critical":[270],"regulator":[271],"Therefore,":[280],"may":[282],"represent":[283],"novel":[285],"therapeutic":[286],"target":[287],"for":[288],"chronic":[289],"disease.":[291],"Funding:":[292],"NIDDK":[293],"Support,":[294],"Veterans":[295],"Affairs":[296],"Support":[297]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-05-18T00:00:00"}