{"id":"https://openalex.org/W4396989979","doi":"https://doi.org/10.1681/asn.20223311s1180c","title":"GSTM1 Deletion Associates With Progression of Glomerular CKD","display_name":"GSTM1 Deletion Associates With Progression of Glomerular CKD","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4396989979","doi":"https://doi.org/10.1681/asn.20223311s1180c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20223311s1180c","doi":"https://doi.org/10.1681/asn.20223311s1180c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1180c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009662927","display_name":"Rebecca V. Levy","orcid":"https://orcid.org/0000-0002-6352-996X","observed_orcids":["https://orcid.org/0000-0002-6352-996X"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Levy","raw_affiliation_strings":["University of Rochester Medical Center, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005791697","display_name":"Kimberly J. Reidy","orcid":"https://orcid.org/0000-0002-7680-457X","observed_orcids":["https://orcid.org/0000-0002-7680-457X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly J. Reidy","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113212431","display_name":"Rick Kaskel","orcid":"https://orcid.org/0000-0002-4002-9559","observed_orcids":["https://orcid.org/0000-0002-4002-9559"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick Kaskel","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107425311","display_name":"Thu H. Le","orcid":"https://orcid.org/0000-0002-6410-1623","observed_orcids":["https://orcid.org/0000-0002-6410-1623"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thu H. Le","raw_affiliation_strings":["University of Rochester Medical Center, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072021080","display_name":"Michal L. Melamed","orcid":"https://orcid.org/0000-0002-2092-1136","observed_orcids":["https://orcid.org/0000-0002-2092-1136"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michal L. Melamed","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047023517","display_name":"NEPTUNE Investigators","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NEPTUNE Investigators","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"11S","first_page":"180","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.4462999999523163,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.4462999999523163,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.08659999817609787,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gstm1-null-genotype","display_name":"GSTM1 null genotype","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.8790000081062317},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7009999752044678},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate-decline","display_name":"estimated glomerular filtration rate decline","score":0.7350000143051147},{"id":"https://openalex.org/keywords/focal-segmental-glomerulosclerosis","display_name":"focal segmental glomerulosclerosis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8550000190734863},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5028626322746277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.379921019077301}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20223311s1180c","doi":"https://doi.org/10.1681/asn.20223311s1180c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1180c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200439537","https://openalex.org/W4387767217","https://openalex.org/W2964133424","https://openalex.org/W3016453564","https://openalex.org/W2294152586","https://openalex.org/W2621173858","https://openalex.org/W2905240908","https://openalex.org/W2132638001","https://openalex.org/W7207766219","https://openalex.org/W2621439420"],"abstract_inverted_index":{"Background:":[0],"Risk":[1],"factors":[2],"for":[3,79,138,167],"progression":[4,19,177,196],"in":[5,14,20,32,60,91,152,160,188,199,207],"glomerular":[6,33,200],"disease":[7,201],"are":[8,89],"not":[9,28,185],"wellunderstood.":[10],"A":[11],"common":[12],"deletion":[13,117,163,173,192],"GSTM1":[15,116,154,162,172,191],"is":[16,48,57,174,193],"associated":[17,175,194],"with":[18,77,115,120,176,186,195],"a":[21,38,107,139],"variety":[22],"of":[23,41,51,85,110,141,178,197],"CKD":[24,179,198],"etiologies":[25],"but":[26,184,202],"has":[27],"been":[29],"previously":[30],"reported":[31],"disease.":[34],"Methods:":[35],"We":[36],"performed":[37],"secondary":[39],"analysis":[40],"the":[42,86,95,147,153,161],"prospective":[43],"NEPTUNE":[44],"cohort.":[45,209],"The":[46,54],"exposure":[47],"\u22651":[49],"copy":[50],"nonfunctional":[52],"GSTM1.":[53],"primary":[55,148],"outcome":[56],"40%":[58],"reduction":[59],"eGFR":[61],"or":[62],"ESKD.":[63],"Secondary":[64],"outcomes":[65],"include":[66],"proteinuria":[67],"remission":[68],"and":[69,104,131,157,169],"relapse.":[70],"Analysis":[71],"was":[72],"by":[73],"multivariable":[74],"logistic":[75],"regression":[76],"adjustment":[78,166],"potential":[80],"confounders.":[81],"Results:":[82],"Baseline":[83],"characteristics":[84],"study":[87],"cohort":[88],"shown":[90],"Table":[92],"1.":[93],"Of":[94],"513":[96],"subjects,":[97],"60%":[98],"were":[99,102,118,125,136],"male,":[100],"57%":[101],"White,":[103],"they":[105,124],"had":[106],"mean":[108,140],"age":[109],"30.4.":[111],"At":[112],"baseline,":[113],"subjects":[114],"younger":[119],"worse":[121],"kidney":[122],"function;":[123],"more":[126],"likely":[127],"to":[128],"have":[129],"FSGS":[130],"self-identify":[132],"as":[133],"Black.":[134],"Participants":[135],"followed":[137],"2.4\u00b11.6":[142],"years;":[143],"118":[144],"participants":[145],"developed":[146],"outcome,":[149],"88":[150],"(23%)":[151],"1/1":[155],"group":[156],"30":[158],"(32%)":[159],"group.":[164],"After":[165],"demographics":[168],"baseline":[170],"severity,":[171],"(OR":[180],"1.91,":[181],"CI":[182],"1.12-3.27)":[183],"changes":[187],"proteinuria.":[189],"Conclusions:":[190],"unlikely":[203],"involves":[204],"proteinuric":[205],"pathways":[206],"this":[208]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2024-05-18T00:00:00"}
