{"id":"https://openalex.org/W4396989401","doi":"https://doi.org/10.1681/asn.20223311s1223c","title":"Association of Isolated Diastolic Hypertension With Risk of Renal and Cardiovascular Outcomes in CKD: A Report From the Chronic Renal Insufficiency Cohort (CRIC) Study","display_name":"Association of Isolated Diastolic Hypertension With Risk of Renal and Cardiovascular Outcomes in CKD: A Report From the Chronic Renal Insufficiency Cohort (CRIC) Study","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4396989401","doi":"https://doi.org/10.1681/asn.20223311s1223c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20223311s1223c","doi":"https://doi.org/10.1681/asn.20223311s1223c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1223c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101355279","display_name":"Saud Abdulelah Alsaleh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saud A. Alsaleh","raw_affiliation_strings":["University Hospitals, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062917056","display_name":"Mirela A. Dobre","orcid":"https://orcid.org/0000-0002-9059-9998","observed_orcids":["https://orcid.org/0000-0002-9059-9998"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mirela A. Dobre","raw_affiliation_strings":["University Hospitals, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035782776","display_name":"Sarah Delozier","orcid":"https://orcid.org/0000-0002-0804-8864","observed_orcids":["https://orcid.org/0000-0002-0804-8864"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Delozier","raw_affiliation_strings":["University Hospitals, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015656712","display_name":"Mahboob Rahman","orcid":"https://orcid.org/0000-0001-9025-7413","observed_orcids":["https://orcid.org/0000-0001-9025-7413"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahboob Rahman","raw_affiliation_strings":["University Hospitals, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030678570","display_name":"Nishigandha Pradhan","orcid":"https://orcid.org/0009-0004-3651-6671","observed_orcids":["https://orcid.org/0009-0004-3651-6671"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nishigandha Pradhan","raw_affiliation_strings":["University Hospitals, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799343972"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"11S","first_page":"223","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isolated-diastolic-hypertension","display_name":"isolated diastolic hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiovascular-outcomes","display_name":"cardiovascular outcomes","score":0.6069999933242798},{"id":"https://openalex.org/keywords/renal-outcomes","display_name":"renal outcomes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7940000295639038},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8619999885559082},{"id":"https://openalex.org/keywords/prevalence-of-hypertension","display_name":"hypertension prevalence","score":0.6119999885559082},{"id":"https://openalex.org/keywords/age-subgroups","display_name":"age subgroups","score":0.5249999761581421},{"id":"https://openalex.org/keywords/chronic-renal-insufficiency-cohort-study","display_name":"Chronic Renal Insufficiency Cohort Study","score":0.8700000047683716},{"id":"https://openalex.org/keywords/2017-acc-aha-hypertension-guidelines","display_name":"2017 ACC/AHA hypertension guidelines","score":0.8610000014305115},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate-decline","display_name":"estimated glomerular filtration rate decline","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.5090000033378601},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5009999871253967},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9319999814033508},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8232868909835815},{"id":"https://openalex.org/C2994292351","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal insufficiency","level":3,"score":0.6013278961181641},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5870160460472107},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5781609416007996},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5130552053451538},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.48781922459602356},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4560511112213135},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4530295431613922},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4167584180831909},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.25795871019363403}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20223311s1223c","doi":"https://doi.org/10.1681/asn.20223311s1223c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1223c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386954387","https://openalex.org/W3209514267","https://openalex.org/W3003272210","https://openalex.org/W4398233714","https://openalex.org/W4403832671","https://openalex.org/W3148040214","https://openalex.org/W3127374446","https://openalex.org/W2350125680","https://openalex.org/W3044357051","https://openalex.org/W3090621303"],"abstract_inverted_index":{"Background:":[0],"Isolated":[1],"Diastolic":[2],"Hypertension":[3],"(IDH)":[4],"has":[5],"drawn":[6],"increased":[7],"interest":[8],"after":[9],"the":[10,17,24,29,46],"new":[11],"definition":[12],"of":[13,26,31,53,83,115,140,196,200,223,228,247,254],"hypertension":[14],"proposed":[15],"by":[16,169],"2017":[18],"ACC/AHA":[19],"guidelines.":[20],"Our":[21],"analysis":[22],"examined":[23],"prevalence":[25],"IDH,":[27],"and":[28,36,69,92,102,121,151,198,250,259,268],"association":[30,148,191],"IDH":[32,62,127,150,197,224,241,258],"with":[33,41,57,111,230,245,265],"adverse":[34,248],"renal":[35],"CV":[37,86,202,251],"outcomes":[38],"in":[39,45,79,130,167,225,238],"patients":[40,56,232],"CKD":[42,58,231],"Methods:":[43],"Participants":[44],"CRIC":[47],"Study;":[48],"a":[49,112],"multicenter":[50],"observational":[51],"cohort":[52,107,227],"ethnically":[54],"diverse":[55],"aged":[59],"21-74":[60],"years.":[61],"was":[63,128,144,192],"defined":[64],"as":[65],"Systolic":[66],"BP\u2264":[67],"130":[68],"DBP":[70],">80.":[71],"Outcomes":[72],"were":[73,119,165],"composite":[74,85,152,201],"kidney":[75,153,249],"events":[76,87,203,252],"(50%":[77],"decline":[78],"eGFR":[80],"or":[81,173,210],"onset":[82],"ESKD),":[84],"(MI,":[88],"CHF,":[89],"stroke,":[90],"PAD)":[91],"all-cause":[93,211],"mortality.":[94],"Cox":[95],"proportional":[96],"hazards":[97],"models":[98],"adjusted":[99],"for":[100],"demographic":[101],"clinical":[103,260],"covariates":[104],"Results:":[105],"The":[106,221],"included":[108],"5621":[109],"participants":[110,133,229,264],"mean":[113],"age":[114,170,255],"59":[116],"years;":[117],"44%":[118],"females":[120],"43%were":[122],"Black.":[123],"51%":[124],"had":[125],"diabetes.":[126],"present":[129],"6.1%":[131],"fof":[132],"at":[134],"baseline.":[135],"After":[136],"median":[137],"follow":[138],"up":[139],"17":[141],"years,":[142],"there":[143],"no":[145],"statistically":[146],"significant":[147],"between":[149,194,257],"outcome":[154],"(Hazrd":[155],"ration":[156],"(HR)":[157],"1.17":[158],"95%":[159,178,184,215],"CI":[160,179,185,207,216],"0.93-1.47,":[161],"p":[162,187,218],"0.18)The":[163],"findings":[164],"consistent":[166],"subgroups":[168],"\u226460":[171],"years":[172,175],">60":[174],"(HR":[176,204,213],"1.14":[177],"0.88-1.48,":[180],"p=0.31and":[181],"HR":[182],"1.55":[183],"0.84-2.83,":[186],"0.16":[188],"respectively)":[189],"No":[190],"found":[193],"presence":[195],"risk":[199,246],"0.91":[205],"(95%":[206],"0.65-1.27,":[208],"p=0.58)":[209],"mortality":[212],"0.82,":[214],"0.57-1.19,":[217],"0.30)":[219],"Conclusions:":[220],"Prevalence":[222],"this":[226],"is":[233,242],"6.1%,":[234],"similar":[235],"to":[236,263],"that":[237],"non-CKD":[239],"populations.":[240],"not":[243],"associated":[244],"irrespective":[253],"Association":[256],"outcomes,":[261],"compared":[262],"normal":[266],"systolic":[267],"diastolic":[269],"BP":[270]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-18T00:00:00"}