{"id":"https://openalex.org/W4396988946","doi":"https://doi.org/10.1681/asn.20223311s1579a","title":"Estimating Underdetection of CKD in Real-World Health Systems","display_name":"Estimating Underdetection of CKD in Real-World Health Systems","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4396988946","doi":"https://doi.org/10.1681/asn.20223311s1579a"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20223311s1579a","doi":"https://doi.org/10.1681/asn.20223311s1579a","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1579a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091041938","display_name":"Chi D. Chu","orcid":"https://orcid.org/0000-0002-6069-1507","observed_orcids":["https://orcid.org/0000-0002-6069-1507"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi D. Chu","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781183","display_name":"Fang Xia","orcid":"https://orcid.org/0000-0002-0676-8606","observed_orcids":["https://orcid.org/0000-0002-0676-8606"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang Xia","raw_affiliation_strings":["Bayer Corporation, Whippany, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Corporation, Whippany, NJ","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090781834","display_name":"Yuxian Du","orcid":"https://orcid.org/0000-0003-2369-0553","observed_orcids":["https://orcid.org/0000-0003-2369-0553"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuxian Du","raw_affiliation_strings":["Bayer Corporation, Whippany, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Corporation, Whippany, NJ","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076142063","display_name":"Delphine S. Tuot","orcid":"https://orcid.org/0000-0003-1484-8945","observed_orcids":["https://orcid.org/0000-0003-1484-8945"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Delphine S. Tuot","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071585977","display_name":"Michael G. Shlipak","orcid":"https://orcid.org/0000-0002-9559-204X","observed_orcids":["https://orcid.org/0000-0002-9559-204X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Shlipak","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005767940","display_name":"Julio Alejandro Lamprea-Montealegre","orcid":"https://orcid.org/0000-0002-5999-4287","observed_orcids":["https://orcid.org/0000-0002-5999-4287"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio Lamprea","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049687972","display_name":"Rakesh Singh","orcid":"https://orcid.org/0000-0003-1479-086X","observed_orcids":["https://orcid.org/0000-0003-1479-086X"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh Singh","raw_affiliation_strings":["Bayer Corporation, Whippany, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Corporation, Whippany, NJ","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104148528","display_name":"Ralph Gualtieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Gualtieri","raw_affiliation_strings":["Bayer Corporation, Whippany, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Corporation, Whippany, NJ","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013645547","display_name":"Sheldon Xiaodong Kong","orcid":"https://orcid.org/0000-0002-8320-6930","observed_orcids":["https://orcid.org/0000-0002-8320-6930"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheldon X. Kong","raw_affiliation_strings":["Bayer Corporation, Whippany, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Corporation, Whippany, NJ","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090209969","display_name":"Todd E Williamson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd E. Williamson","raw_affiliation_strings":["Bayer Corporation, Whippany, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Corporation, Whippany, NJ","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041398963","display_name":"Michelle M. Estrella","orcid":"https://orcid.org/0000-0002-8902-9576","observed_orcids":["https://orcid.org/0000-0002-8902-9576"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle M. Estrella","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"11S","first_page":"579","last_page":"579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.949999988079071},{"id":"https://openalex.org/keywords/under-detection","display_name":"under-detection","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8740000128746033},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/urine-albumin-creatinine-ratio","display_name":"urine albumin-creatinine ratio","score":0.871999979019165},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.7879999876022339},{"id":"https://openalex.org/keywords/predictive-model","display_name":"prediction model","score":0.6019999980926514},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6050000190734863},{"id":"https://openalex.org/keywords/ckd-progression-prevention","display_name":"CKD progression prevention","score":0.628000020980835},{"id":"https://openalex.org/keywords/racial-and-ethnic-disparities","display_name":"racial and ethnic disparities","score":0.5950000286102295},{"id":"https://openalex.org/keywords/health-insurance-status","display_name":"health insurance status","score":0.33399999141693115},{"id":"https://openalex.org/keywords/socioeconomic-status","display_name":"socioeconomic status","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44505512714385986},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4288371205329895},{"id":"https://openalex.org/C2988170871","wikidata":"https://www.wikidata.org/wiki/Q11000047","display_name":"Healthcare system","level":3,"score":0.4174298644065857},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33354753255844116},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.16568389534950256},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.15160277485847473},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.12774717807769775}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20223311s1579a","doi":"https://doi.org/10.1681/asn.20223311s1579a","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1579a","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385294595","https://openalex.org/W4396992894","https://openalex.org/W7151979341","https://openalex.org/W4416866188","https://openalex.org/W4416995858","https://openalex.org/W7168177152","https://openalex.org/W7108083136","https://openalex.org/W3188495695","https://openalex.org/W4404480100","https://openalex.org/W4408684776"],"abstract_inverted_index":{"Background:":[0],"Albuminuria":[1],"testing":[2,42,151,213],"is":[3,13],"widely":[4],"underused":[5],"in":[6,43],"persons":[7,85],"at":[8],"risk":[9],"for":[10,177,312],"CKD":[11,23,302,314],"but":[12],"crucial":[14],"to":[15,21,31,39,102,140,162,183,295,308],"guide":[16],"implementation":[17],"of":[18,35,41,50,166,175,186,215,223,239,248,264,288,297,301],"evidence-based":[19],"treatments":[20],"prevent":[22],"progression":[24,315],"and":[25,61,68,123,179,316],"reduce":[26],"cardiovascular":[27,318],"morbidity.":[28],"We":[29,57,83],"aimed":[30],"estimate":[32,163],"the":[33,69,157,164,184,224,236,245,261],"extent":[34],"albuminuria":[36,104,150,170,190,212,219,240,251,291],"underdetection":[37],"due":[38,294],"lack":[40,296],"a":[44,98,275,304],"large":[45],"real":[46],"world":[47],"US":[48,80],"cohort":[49],"patients":[51,131,188,198,229,249,289],"with":[52,89,132,189,204,250,279,290],"hypertension":[53,280],"or":[54,92,281],"diabetes.":[55],"Methods:":[56],"used":[58],"National":[59],"Health":[60],"Nutrition":[62],"Examination":[63],"Survey":[64],"(NHANES)":[65],"2007-2018":[66],"data":[67,77],"Optum":[70,126,187,193],"EHR":[71,76,127],"5PCT":[72],"Database,":[73],"which":[74],"includes":[75],"from":[78,136,160],"diverse":[79],"healthcare":[81],"organizations.":[82],"included":[84,130,196],"aged":[86],"\u226518":[87],"years":[88],"hypertension,":[90],"diabetes,":[91,117,282],"both.":[93],"Using":[94],"NHANES,":[95],"we":[96,155,283],"developed":[97],"logistic":[99],"regression":[100],"model":[101,159,172],"predict":[103],"(urine":[105],"albumin/creatinine":[106],"ratio":[107],"\u226530":[108],"mg/g)":[109],"using":[110],"age,":[111],"sex,":[112],"race-ethnicity,":[113],"systolic":[114],"blood":[115],"pressure,":[116],"heart":[118],"failure,":[119],"coronary":[120],"artery":[121],"disease,":[122],"eGFR.":[124],"Our":[125],"study":[128,194,226],"population":[129,195,278],"\u22652":[133],"outpatient":[134],"visits":[135],"January":[137],"1,":[138],"2017":[139],"December":[141],"31,":[142],"2018.":[143],"Among":[144,228],"those":[145],"who":[146,230,252],"did":[147],"not":[148,232],"have":[149],"during":[152],"this":[153],"period,":[154],"applied":[156,182],"prediction":[158,171],"NHANES":[161,178],"prevalence":[165,238],"albuminuria.":[167],"Results:":[168],"The":[169,192],"had":[173,211,218,231,253,269],"c-statistics":[174],"0.73":[176],"0.68":[180],"when":[181],"subset":[185],"testing.":[191,298],"192,108":[197],"(mean":[199],"age":[200],"60\u00b115":[201],"years;":[202],"26%":[203],"diabetes;":[205],"mean":[206],"eGFR":[207],"84\u00b121":[208],"ml/min/1.73m2).":[209],"18%":[210],"(n=33,629),":[214],"whom":[216],"34%":[217],"(n=11,525),":[220],"representing":[221],"6.0%":[222],"total":[225],"population.":[227],"been":[233,254,270],"tested":[234,271],"(n=158,479),":[235],"predicted":[237,265],"was":[241,256],"15%":[242],"(n=23,369).":[243],"Thus,":[244],"projected":[246],"proportion":[247],"detected":[255],"only":[257,267],"11,525/34,894":[258],"(33%).":[259],"In":[260,274],"top":[262],"quintile":[263],"risk,":[266],"37%":[268],"(14,033/38,421).":[272],"Conclusions:":[273],"real-world":[276],"patient":[277],"estimated":[284],"that":[285],"approximately":[286],"2/3":[287],"are":[292],"undetected":[293],"Improving":[299],"detection":[300],"represents":[303],"significant":[305],"missed":[306],"opportunity":[307],"optimize":[309],"care":[310],"delivery":[311],"reducing":[313],"its":[317],"complications.":[319],"Funding:":[320],"Commercial":[321],"Support":[322],"-":[323],"Bayer":[324],"Inc":[325]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-05-18T00:00:00"}