{"id":"https://openalex.org/W4396978436","doi":"https://doi.org/10.1097/shk.0000000000002377","title":"TEMPORAL CHANGES IN INNATE AND ADAPTIVE IMMUNITY DURING SEPSIS AS DETERMINED BY ELISPOT","display_name":"TEMPORAL CHANGES IN INNATE AND ADAPTIVE IMMUNITY DURING SEPSIS AS DETERMINED BY ELISPOT","publication_year":2024,"publication_date":"2024-05-03","ids":{"openalex":"https://openalex.org/W4396978436","doi":"https://doi.org/10.1097/shk.0000000000002377","pmid":"https://pubmed.ncbi.nlm.nih.gov/38168302","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760123"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0000000000002377","doi":"https://doi.org/10.1097/shk.0000000000002377","is_oa":true,"landing_page_url":"https://doi.org/10.1097/shk.0000000000002377","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/shk.0000000000002377","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025683989","display_name":"Jacqueline Unsinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Unsinger","raw_affiliation_strings":["Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112587904","display_name":"Dale Osborne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale Osborne","raw_affiliation_strings":["Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016775989","display_name":"Andrew H. Walton","orcid":"https://orcid.org/0000-0003-2805-6666","observed_orcids":["https://orcid.org/0000-0003-2805-6666"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew H. Walton","raw_affiliation_strings":["Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ethan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Han","raw_affiliation_strings":["Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097502204","display_name":"Lauren Sheets","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Sheets","raw_affiliation_strings":["Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087271085","display_name":"Monty B. Mazer","orcid":"https://orcid.org/0000-0002-4159-8585","observed_orcids":["https://orcid.org/0000-0002-4159-8585"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monty B. Mazer","raw_affiliation_strings":["Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio","Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081462586","display_name":"Kenneth E. Remy","orcid":"https://orcid.org/0000-0001-5222-9884","observed_orcids":["https://orcid.org/0000-0001-5222-9884"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Remy","raw_affiliation_strings":["Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio","Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076681768","display_name":"Thomas S. Griffith","orcid":"https://orcid.org/0000-0002-7205-9859","observed_orcids":["https://orcid.org/0000-0002-7205-9859"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210117246","display_name":"Minneapolis VA Health Care System","ror":"https://ror.org/02ry60714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas S. Griffith","raw_affiliation_strings":["Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 USA","Department of Urology, University of Minnesota Medical 47 School, Minneapolis, Minnesota 55455, USA","Minneapolis VA Healthcare System, Minneapolis, Minnesota 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Urology, University of Minnesota Medical 47 School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Minneapolis VA Healthcare System, Minneapolis, Minnesota 55417, USA","institution_ids":["https://openalex.org/I4210117246","https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027749474","display_name":"Mahil Rao","orcid":"https://orcid.org/0000-0001-6729-9869","observed_orcids":["https://orcid.org/0000-0001-6729-9869"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahil Rao","raw_affiliation_strings":["Department of Pediatrics, University of Iowa Carver College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Iowa Carver College of Medicine","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090796277","display_name":"Vladimir P. Badovinac","orcid":"https://orcid.org/0000-0003-3180-2439","observed_orcids":["https://orcid.org/0000-0003-3180-2439"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir P. Badovinac","raw_affiliation_strings":["Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 USA","Experimental Pathology Ph.D. Program, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Experimental Pathology Ph.D. Program, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090126800","display_name":"Scott C. Brakenridge","orcid":"https://orcid.org/0000-0002-7327-3718","observed_orcids":["https://orcid.org/0000-0002-7327-3718"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Brakenridge","raw_affiliation_strings":["Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington","Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington 98133 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2802336062"]},{"raw_affiliation_string":"Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington 98133 USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2802336062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024134070","display_name":"Isaiah R. Turnbull","orcid":"https://orcid.org/0000-0002-1437-8480","observed_orcids":["https://orcid.org/0000-0002-1437-8480"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaiah Turnbull","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, Missouri","Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031214939","display_name":"Philip Alexander Efron","orcid":"https://orcid.org/0000-0002-3931-650X","observed_orcids":["https://orcid.org/0000-0002-3931-650X"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip A. Efron","raw_affiliation_strings":["Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida","Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610 USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081164839","display_name":"Lyle L. Moldawer","orcid":"https://orcid.org/0000-0002-9041-9838","observed_orcids":["https://orcid.org/0000-0002-9041-9838"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyle L. Moldawer","raw_affiliation_strings":["Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida","Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610 USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037974493","display_name":"Charles C. Caldwell","orcid":"https://orcid.org/0000-0003-1692-4550","observed_orcids":["https://orcid.org/0000-0003-1692-4550"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles C. Caldwell","raw_affiliation_strings":["Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio","Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001543982","display_name":"Richard S. Hotchkiss","orcid":"https://orcid.org/0000-0002-5470-3655","observed_orcids":["https://orcid.org/0000-0002-5470-3655"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard S. Hotchkiss","raw_affiliation_strings":["Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5001543982"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":1.8189,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85065368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"62","issue":"2","first_page":"255","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":1.0},{"id":"https://openalex.org/keywords/elispot-assay","display_name":"ELISPOT assay","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cytokine-secreting-cells","display_name":"cytokine-secreting cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.984000027179718},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9179999828338623},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.9010000228881836},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.7049999833106995},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.5270000100135803},{"id":"https://openalex.org/keywords/elisa-comparison","display_name":"ELISA comparison","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.9675127267837524},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.7394031286239624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6802705526351929},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6233945488929749},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6158936023712158},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5587523579597473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4358977675437927},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4335518777370453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35141539573669434},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.21268731355667114}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1097/shk.0000000000002377","doi":"https://doi.org/10.1097/shk.0000000000002377","is_oa":true,"landing_page_url":"https://doi.org/10.1097/shk.0000000000002377","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"doi:10.1101/2023.12.14.571668","doi":"https://doi.org/10.1101/2023.12.14.571668","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.12.14.571668","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/12/14/2023.12.14.571668.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38168302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38168302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:38754032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38754032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11348958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11348958","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11348958/pdf/nihms-1986176.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Shock","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11121426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11348958","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10760123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/shk.0000000000002377","doi":"https://doi.org/10.1097/shk.0000000000002377","is_oa":true,"landing_page_url":"https://doi.org/10.1097/shk.0000000000002377","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2260850109","display_name":"Hematopoietic Stem and Progenitor Cell Dysfunction is an Underlying Mechanism of Injury-Inuced Immunosuppression","funder_award_id":"R35GM133756","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2710325305","display_name":null,"funder_award_id":"IK6 BX006192","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3971240354","display_name":"Cellular and molecular mechanisms controlling sepsis-induced immunoparalyses state","funder_award_id":"R35GM134880","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4795747401","display_name":null,"funder_award_id":"GM-008721","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G728908076","display_name":null,"funder_award_id":"R01 GM-132364","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G800749521","display_name":"Stratifying Patient Immune Endotypes in Sepsis (SPIES Study)","funder_award_id":"R01GM139046","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000856248","display_name":"Molecular Biology in Burns and Trauma","funder_award_id":"T32GM008721","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000860861","display_name":"Understanding Cell Division","funder_award_id":"R35GM126980","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000880037","display_name":"Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology","funder_award_id":"RM1GM139690","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000880136","display_name":"Enhancing Innate and Adaptive Immunity to Improve Sepsis Survival","funder_award_id":"R35GM126928","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000890856","display_name":"Pathological Myeloid Activation After Sepsis and Trauma","funder_award_id":"R35GM140806","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000912336","display_name":"CD4 T cell dysfunction and reprogramming during sepsis","funder_award_id":"R35GM140881","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W58783245","https://openalex.org/W748993927","https://openalex.org/W1977905350","https://openalex.org/W2012110029","https://openalex.org/W2026170842","https://openalex.org/W2063510122","https://openalex.org/W2127844966","https://openalex.org/W2164990391","https://openalex.org/W2280404143","https://openalex.org/W2735805106","https://openalex.org/W2787981407","https://openalex.org/W2811389806","https://openalex.org/W2969742757","https://openalex.org/W2971784664","https://openalex.org/W2972686526","https://openalex.org/W3003151787","https://openalex.org/W3013240402","https://openalex.org/W3083473848","https://openalex.org/W3090624419","https://openalex.org/W3092400338","https://openalex.org/W3096137571","https://openalex.org/W3097692394","https://openalex.org/W3109896211","https://openalex.org/W3164295946","https://openalex.org/W3164725297","https://openalex.org/W3188038808","https://openalex.org/W4210580828","https://openalex.org/W4221062698","https://openalex.org/W4310772912","https://openalex.org/W4381235956","https://openalex.org/W4385294987","https://openalex.org/W4385751860","https://openalex.org/W4386041720","https://openalex.org/W4386752967","https://openalex.org/W4389781100","https://openalex.org/W6666234981"],"related_works":["https://openalex.org/W3109896211","https://openalex.org/W4409584860","https://openalex.org/W4401528150","https://openalex.org/W4387598881","https://openalex.org/W4389743640","https://openalex.org/W4283819837","https://openalex.org/W6901912277","https://openalex.org/W4404178980","https://openalex.org/W4386752967","https://openalex.org/W4389781100"],"abstract_inverted_index":{"ABSTRACT:":[0],"Background:":[1],"The":[2,25,148,261],"inability":[3],"to":[4,109,152,161,193,203,233,248,272,282],"evaluate":[5],"host":[6,69],"immunity":[7,89,159,182,200,258],"in":[8,13,84,155,162,196,201,212,277,294,299],"a":[9,31,63,177,213,245,291],"rapid":[10],"quantitative":[11],"manner":[12],"patients":[14],"with":[15,166],"sepsis":[16,185],"has":[17],"severely":[18],"hampered":[19],"development":[20],"of":[21,38,45,55,68,105,150,224,253,280],"novel":[22],"immune":[23,106,164,285,297],"therapies.":[24],"enzyme-linked":[26,145,228],"immunospot":[27],"(ELISpot)":[28],"assay":[29,79,230],"is":[30,57],"functional":[32,251],"bioassay":[33],"that":[34,76,266],"measures":[35],"the":[36,42,49,74,77,103,220,250,276],"number":[37],"cytokine-secreting":[39],"cells":[40],"and":[41,87,112,124,127,132,137,144,157,169,180,198,210,227,256,274],"relative":[43],"amount":[44],"cytokine":[46],"produced":[47],"at":[48],"single-cell":[50],"level.":[51],"A":[52],"key":[53],"advantage":[54],"ELISpot":[56,78,100,143,151,175,189,226,243,267],"its":[58],"excellent":[59],"dynamic":[60,82],"range":[61],"enabling":[62],"more":[64],"precise":[65],"quantifiable":[66,215],"assessment":[67],"immunity.":[70,114],"Herein,":[71],"we":[72],"tested":[73,98],"hypothesis":[75],"can":[80,268],"detect":[81,102,153,194,273],"changes":[83,154,195],"both":[85,254],"innate":[86,111,156,179,199,257],"adaptive":[88,113,158,181,197,255],"as":[90,217],"they":[91],"often":[92],"occur":[93],"during":[94,184],"sepsis.":[95,300],"We":[96],"also":[97,172,191,269],"whether":[99],"could":[101],"effect":[104],"drug":[107],"therapies":[108,298],"modulate":[110],"Methods:":[115],"Mice":[116],"were":[117,129,140,240],"made":[118],"septic":[119],"using":[120],"sublethal":[121],"cecal":[122],"ligation":[123],"puncture.":[125],"Blood":[126],"spleens":[128],"harvested":[130],"serially,":[131],"ex":[133],"vivo":[134,163,278],"interferon":[135],"\u03b3":[136],"TNF-\u03b1":[138],"production":[139],"compared":[141],"by":[142,219],"immunosorbent":[146,229],"assay.":[147],"capability":[149,247,288],"due":[160],"therapy":[165],"dexamethasone,":[167,208],"IL-7,":[168,211],"arginine":[170],"was":[171,190],"evaluated.":[173],"Results:":[174],"confirmed":[176],"decreased":[178],"responsiveness":[183],"progression.":[186],"More":[187],"importantly,":[188],"able":[192],"response":[202],"immune-modulatory":[204],"reagents,":[205],"for":[206],"example,":[207],"arginine,":[209],"readily":[214],"manner,":[216],"predicted":[218],"reagents":[221],"known":[222],"mechanisms":[223],"action.":[225],"results":[231,262],"tended":[232],"parallel":[234],"one":[235],"another":[236],"although":[237],"some":[238],"differences":[239],"noted.":[241],"Conclusion:":[242],"offers":[244],"unique":[246],"assess":[249],"status":[252],"over":[259],"time.":[260],"presented":[263],"herein":[264],"demonstrate":[265],"be":[270,290],"used":[271],"follow":[275],"effects":[279],"drugs":[281],"ameliorate":[283],"sepsis-induced":[284],"dysfunction.":[286],"This":[287],"would":[289],"major":[292],"advance":[293],"guiding":[295],"new":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-05-17T00:00:00"}
