{"id":"https://openalex.org/W4396972602","doi":"https://doi.org/10.2147/ccid.s464672","title":"Drug Reaction with Eosinophilia and Systemic Symptoms Induced by Diosmin and Hesperidin: A Case Report","display_name":"Drug Reaction with Eosinophilia and Systemic Symptoms Induced by Diosmin and Hesperidin: A Case Report","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396972602","doi":"https://doi.org/10.2147/ccid.s464672","pmid":"https://pubmed.ncbi.nlm.nih.gov/38770090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11104364"},"language":"en","primary_location":{"id":"doi:10.2147/ccid.s464672","doi":"https://doi.org/10.2147/ccid.s464672","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s464672","pdf_url":"https://www.dovepress.com/getfile.php?fileID=99121","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=99121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028445072","display_name":"Pasita Palakornkitti","orcid":"https://orcid.org/0000-0003-0012-927X","observed_orcids":["https://orcid.org/0000-0003-0012-927X"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Pasita Palakornkitti","raw_affiliation_strings":["Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-0012-927X","affiliations":[{"raw_affiliation_string":"Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016686245","display_name":"Teerapong Rattananukrom","orcid":"https://orcid.org/0000-0002-1654-9706","observed_orcids":["https://orcid.org/0000-0002-1654-9706"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Teerapong Rattananukrom","raw_affiliation_strings":["Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-1654-9706","affiliations":[{"raw_affiliation_string":"Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016686245","https://openalex.org/A5028445072"],"corresponding_institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":1.2093,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7409201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"Volume 17","issue":null,"first_page":"1127","last_page":"1132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-reaction-with-eosinophilia-and-systemic-symptoms","display_name":"DRESS syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/clothing","display_name":"clothing","score":0.8999999761581421},{"id":"https://openalex.org/keywords/diosmin","display_name":"diosmin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hesperidin","display_name":"hesperidin","score":1.0},{"id":"https://openalex.org/keywords/acute-generalized-exanthematous-pustulosis","display_name":"acute generalized exanthematous pustulosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/severe-cutaneous-adverse-reactions","display_name":"severe cutaneous adverse reactions","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chronic-venous-insufficiency","display_name":"chronic venous insufficiency","score":0.9070000052452087},{"id":"https://openalex.org/keywords/daflon","display_name":"Daflon","score":0.9629999995231628},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8849999904632568},{"id":"https://openalex.org/keywords/facial-swelling","display_name":"facial swelling","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2780565469","wikidata":"https://www.wikidata.org/wiki/Q2607865","display_name":"Diosmin","level":4,"score":0.8806171417236328},{"id":"https://openalex.org/C2776128092","wikidata":"https://www.wikidata.org/wiki/Q385937","display_name":"Hesperidin","level":3,"score":0.6892423033714294},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6398211121559143},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5782939791679382},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.5360942482948303},{"id":"https://openalex.org/C2992787096","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic reaction","level":3,"score":0.5094948410987854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4461643099784851},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42384040355682373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1819668412208557},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.11691153049468994},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11211982369422913},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ccid.s464672","doi":"https://doi.org/10.2147/ccid.s464672","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s464672","pdf_url":"https://www.dovepress.com/getfile.php?fileID=99121","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11104364","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11104364","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11104364/pdf/ccid-17-1127.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cosmet Investig Dermatol","raw_type":"Text"},{"id":"pmid:38770090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38770090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, cosmetic and investigational dermatology","raw_type":"Case Reports"},{"id":"pmh:oai:dovepress.com/92693","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/drug-reaction-with-eosinophilia-and-systemic-symptoms-induced-by-diosm-peer-reviewed-fulltext-article-CCID","pdf_url":"https://www.dovepress.com/article/download/92693","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1f6ad8ec11504321aefed8d9ea8c3c2c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f6ad8ec11504321aefed8d9ea8c3c2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology, Vol Volume 17, Pp 1127-1132 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/ccid.s464672","doi":"https://doi.org/10.2147/ccid.s464672","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s464672","pdf_url":"https://www.dovepress.com/getfile.php?fileID=99121","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396972602.pdf","grobid_xml":"https://content.openalex.org/works/W4396972602.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W33921392","https://openalex.org/W164546800","https://openalex.org/W1883148027","https://openalex.org/W2014810381","https://openalex.org/W2035413014","https://openalex.org/W2052964580","https://openalex.org/W2066724445","https://openalex.org/W2067670322","https://openalex.org/W2067978628","https://openalex.org/W2111106542","https://openalex.org/W2195518498","https://openalex.org/W2730950519","https://openalex.org/W2899520069","https://openalex.org/W2984664284","https://openalex.org/W2988153590","https://openalex.org/W3010200145","https://openalex.org/W3025417223","https://openalex.org/W3157583531","https://openalex.org/W3199661532","https://openalex.org/W3205914875","https://openalex.org/W4229038770","https://openalex.org/W4282595930","https://openalex.org/W4319053765","https://openalex.org/W4388971272","https://openalex.org/W4391746206"],"related_works":["https://openalex.org/W4414682013","https://openalex.org/W2241293679","https://openalex.org/W1919335710","https://openalex.org/W7205009587","https://openalex.org/W2912263288","https://openalex.org/W4387939701","https://openalex.org/W2795272022","https://openalex.org/W4386530999","https://openalex.org/W2016351536","https://openalex.org/W4379208920"],"abstract_inverted_index":{"Abstract:":[0],"Drug":[1],"reaction":[2,14],"with":[3,28],"eosinophilia":[4],"and":[5,40,46],"systemic":[6],"symptoms":[7],"(DRESS)":[8],"is":[9],"a":[10,17,24],"severe":[11,59,76],"cutaneous":[12,60,77],"adverse":[13,78],"which":[15],"exhibits":[16],"diverse":[18],"range":[19],"of":[20,38,57],"presentations.":[21],"We":[22],"described":[23],"48-year-old":[25],"man":[26],"diagnosed":[27],"acute":[29],"generalized":[30],"exanthematous":[31],"pustulosis":[32],"(AGEP)-like":[33],"DRESS":[34,48],"following":[35],"the":[36],"administration":[37],"diosmin":[39,45],"hesperidin.":[41],"To":[42],"our":[43],"knowledge,":[44],"hesperidin-induced":[47],"are":[49],"exceptionally":[50],"rare.":[51],"This":[52],"aims":[53],"to":[54],"raise":[55],"awareness":[56],"potential":[58],"side":[61],"effects":[62],"in":[63],"patients":[64],"taking":[65],"these":[66],"agents.":[67],"Keywords:":[68],"chronic":[69],"venous":[70],"insufficiency,":[71],"daflon,":[72],"facial":[73],"edema,":[74],"flavonoid,":[75],"reactions":[79]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-17T00:00:00"}