{"id":"https://openalex.org/W4396953753","doi":"https://doi.org/10.1161/circ.149.suppl_1.p397","title":"Abstract P397: Choline Metabolites Are Associated With Non-Alcoholic Fatty Liver Disease: A Coronary Artery Risk Development in Young Adults (CARDIA) Study","display_name":"Abstract P397: Choline Metabolites Are Associated With Non-Alcoholic Fatty Liver Disease: A Coronary Artery Risk Development in Young Adults (CARDIA) Study","publication_year":2024,"publication_date":"2024-03-19","ids":{"openalex":"https://openalex.org/W4396953753","doi":"https://doi.org/10.1161/circ.149.suppl_1.p397"},"language":"en","primary_location":{"id":"doi:10.1161/circ.149.suppl_1.p397","doi":"https://doi.org/10.1161/circ.149.suppl_1.p397","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.149.suppl_1.p397","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003039293","display_name":"Jessica Sprinkles","orcid":"https://orcid.org/0009-0003-5731-7324","observed_orcids":["https://orcid.org/0009-0003-5731-7324"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica K Sprinkles","raw_affiliation_strings":["Univ of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028457441","display_name":"Susan McRitchie","orcid":"https://orcid.org/0000-0002-7126-5933","observed_orcids":["https://orcid.org/0000-0002-7126-5933"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan U McRitchie","raw_affiliation_strings":["UNC, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132845188","display_name":"Blake Rushing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake U Rushing","raw_affiliation_strings":["Univ of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054001184","display_name":"James Greg Terry","orcid":"https://orcid.org/0000-0001-6659-3441","observed_orcids":["https://orcid.org/0000-0001-6659-3441"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G Terry","raw_affiliation_strings":["Vanderbilt, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046537554","display_name":"Xiuxia Du","orcid":"https://orcid.org/0000-0002-3468-9585","observed_orcids":["https://orcid.org/0000-0002-3468-9585"]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiuxia U Du","raw_affiliation_strings":["Univ of North Carolina, Charlotte, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Charlotte, NC","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067191302","display_name":"Yuankai Huo","orcid":"https://orcid.org/0000-0002-2096-8065","observed_orcids":["https://orcid.org/0000-0002-2096-8065"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuankai Z Huo","raw_affiliation_strings":["Vanderbilt, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043242150","display_name":"Christy L. Avery","orcid":"https://orcid.org/0000-0002-1044-8162","observed_orcids":["https://orcid.org/0000-0002-1044-8162"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christy L Avery","raw_affiliation_strings":["Univ N Carolina, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ N Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062296084","display_name":"Kari E. North","orcid":"https://orcid.org/0000-0002-8903-0366","observed_orcids":["https://orcid.org/0000-0002-8903-0366"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari E North","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028657341","display_name":"Penny Gordon\u2010Larsen","orcid":"https://orcid.org/0000-0001-5322-4188","observed_orcids":["https://orcid.org/0000-0001-5322-4188"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Penny Z Gordon-Larsen","raw_affiliation_strings":["UNC-Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC-Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045544656","display_name":"Lisa B. VanWagner","orcid":"https://orcid.org/0000-0002-6264-2573","observed_orcids":["https://orcid.org/0000-0002-6264-2573"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa B VanWagner","raw_affiliation_strings":["Lisa VanWagner, Richardson, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lisa VanWagner, Richardson, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017418373","display_name":"Donald M. Lloyd\u2010Jones","orcid":"https://orcid.org/0000-0003-0847-6110","observed_orcids":["https://orcid.org/0000-0003-0847-6110"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald M Lloyd-Jones","raw_affiliation_strings":["Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005915006","display_name":"J. Jeffrey Carr","orcid":"https://orcid.org/0000-0002-4398-8237","observed_orcids":["https://orcid.org/0000-0002-4398-8237"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Jeffery Z Carr","raw_affiliation_strings":["Vanderbilt, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077627182","display_name":"SUSAN S. SUMNER","orcid":"https://orcid.org/0000-0003-3381-6084","observed_orcids":["https://orcid.org/0000-0003-3381-6084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan U Sumner","raw_affiliation_strings":["Univ of North Carolina, Kannapolis, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Kannapolis, NC","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033178523","display_name":"Katie A. Meyer","orcid":"https://orcid.org/0000-0001-7490-5273","observed_orcids":["https://orcid.org/0000-0001-7490-5273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katie A Meyer","raw_affiliation_strings":["Univ of North Carolina, Kannapolis, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of North Carolina, Kannapolis, NC","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"149","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/choline-metabolites","display_name":"choline metabolites","score":0.9700000286102295},{"id":"https://openalex.org/keywords/betaine","display_name":"betaine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.8230000138282776},{"id":"https://openalex.org/keywords/plasma-metabolites","display_name":"plasma metabolites","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cardia-cohort","display_name":"CARDIA cohort","score":0.6380000114440918},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.5379999876022339},{"id":"https://openalex.org/keywords/liver-attenuation","display_name":"liver attenuation","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9598733186721802},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7505641579627991},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6117804646492004},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.5887531042098999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5496028661727905},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4863217771053314},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4153568744659424},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4108763337135315},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3721252381801605}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.149.suppl_1.p397","doi":"https://doi.org/10.1161/circ.149.suppl_1.p397","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.149.suppl_1.p397","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039951533","https://openalex.org/W1975783069","https://openalex.org/W2028793155","https://openalex.org/W2228161816","https://openalex.org/W2066517796","https://openalex.org/W2166004088","https://openalex.org/W2083168128","https://openalex.org/W2131876028","https://openalex.org/W1569473466","https://openalex.org/W1969803459"],"abstract_inverted_index":{"Background:":[0],"Non-alcoholic":[1],"fatty":[2],"liver":[3,11,83,112],"disease":[4,84],"(NAFLD),":[5],"a":[6,22,55,109,213,219,257],"common":[7],"cause":[8],"of":[9,27,57,232,245],"chronic":[10],"disease,":[12],"has":[13,19,39,53],"become":[14],"increasingly":[15],"prevalent.":[16],"Choline":[17],"deficiency":[18],"long":[20],"been":[21,40,54],"model":[23],"for":[24,146,154],"the":[25,250],"study":[26],"accelerated":[28],"NAFLD,":[29,180],"in":[30,65,196,212],"preclinical":[31],"and":[32,47,63,67,97,134,166,181,210,218,225,263],"small-scale":[33],"human":[34],"studies.":[35,70],"More":[36],"recently,":[37],"NAFLD":[38,64,105,119,195,211],"associated":[41,178,186,193],"with":[42,179,187,194],"choline":[43,61,164,190,261],"metabolites":[44,62,165],"betaine":[45,175,209,228],"(inversely)":[46],"trimethylamine":[48],"N-oxide":[49],"(TMAO)":[50],"(positively).":[51],"There":[52],"paucity":[56],"research":[58],"on":[59,260],"circulating":[60],"diverse":[66],"population-based":[68,215],"cohort":[69],"Methods:":[71],"We":[72],"used":[73,129],"data":[74],"from":[75,95,103,137,238],"2,413":[76],"CARDIA":[77],"participants":[78],"who":[79],"did":[80],"not":[81,192],"self-report":[82],"or":[85],"heavy":[86],"alcohol":[87],"intake":[88,231],"at":[89],"Y15,":[90,96],"had":[91],"stored":[92,138],"plasma":[93,139,163,174,182,208,223],"available":[94],"chest":[98],"computed":[99],"tomography":[100],"(CT)":[101],"measures":[102],"Y25.":[104],"was":[106,120,128,150,176,184,191],"defined":[107],"as":[108,234,236],"mean":[110],"CT-derived":[111],"attenuation":[113],"score":[114],"<51":[115],"Hounsfield":[116,122],"units;":[117],"severe":[118],"<40":[121],"units.":[123],"Liquid":[124],"chromatography":[125],"mass":[126],"spectrometry":[127],"to":[130,256],"quantify":[131],"choline,":[132,246],"betaine,":[133,233],"TMAO":[135,149,183,224,240],"concentrations":[136,143],"samples.":[140],"Plasma":[141,148,189],"metabolite":[142],"were":[144],"standardized":[145],"analysis.":[147],"natural":[151],"log":[152],"transformed":[153],"normality.":[155],"Multivariable-adjusted":[156],"logistic":[157],"regression":[158],"models":[159],"quantified":[160],"associations":[161],"between":[162,207,222],"NAFLD.":[167,188,226],"Results":[168],"(Table):":[169],"In":[170],"fully":[171,197],"adjusted":[172,198],"models,":[173],"inversely":[177],"positively":[185],"models.":[199],"Conclusions:":[200],"Our":[201],"findings":[202],"support":[203],"an":[204,242],"inverse":[205],"association":[206,221],"diverse,":[214],"US":[216],"cohort,":[217],"positive":[220],"Circulating":[227],"reflects":[229,241],"dietary":[230],"well":[235],"conversion":[237],"choline.":[239],"alternative":[243],"fate":[244],"through":[247],"metabolism":[248,262],"by":[249],"gut":[251],"microbiota.":[252],"These":[253],"results":[254],"contribute":[255],"growing":[258],"literature":[259],"cardiometabolic":[264],"risk.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
