{"id":"https://openalex.org/W4396949111","doi":"https://doi.org/10.1021/acsbiomaterials.3c01579","title":"Electrophoresis-Based Approach for Characterizing Dendrimer\u2013Protein Interactions: A Proof-of-Concept Study","display_name":"Electrophoresis-Based Approach for Characterizing Dendrimer\u2013Protein Interactions: A Proof-of-Concept Study","publication_year":2024,"publication_date":"2024-05-16","ids":{"openalex":"https://openalex.org/W4396949111","doi":"https://doi.org/10.1021/acsbiomaterials.3c01579","pmid":"https://pubmed.ncbi.nlm.nih.gov/38753577"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.3c01579","doi":"https://doi.org/10.1021/acsbiomaterials.3c01579","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.3c01579","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/09/02/2023.08.31.555747.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092733412","display_name":"Simone A. Douglas-Green","orcid":"https://orcid.org/0009-0002-1086-5780","observed_orcids":["https://orcid.org/0009-0002-1086-5780"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simone\nA. Douglas-Green","raw_affiliation_strings":["Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , 500 Main St , , ,","Massachusetts Institute of Technology , , 77 Massachusetts Ave , , ,","Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, United States","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St, Cambridge, Massachusetts 02142, United States"],"raw_orcid":"https://orcid.org/0009-0002-1086-5780","affiliations":[{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , 500 Main St , , ,","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology , , 77 Massachusetts Ave , , ,","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St, Cambridge, Massachusetts 02142, United States","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112992968","display_name":"Juan A. Aleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan A. Aleman","raw_affiliation_strings":["Massachusetts Institute of Technology , , 77 Massachusetts Ave , , ,","Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology , , 77 Massachusetts Ave , , ,","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069094503","display_name":"Paula Therese Hammond","orcid":"https://orcid.org/0000-0002-9835-192X","observed_orcids":["https://orcid.org/0000-0002-9835-192X"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paula T. Hammond","raw_affiliation_strings":["Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , 500 Main St , , ,","Massachusetts Institute of Technology , , 77 Massachusetts Ave , , ,","Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, United States","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St, Cambridge, Massachusetts 02142, United States"],"raw_orcid":"https://orcid.org/0000-0002-9835-192X","affiliations":[{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , 500 Main St , , ,","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology , , 77 Massachusetts Ave , , ,","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St, Cambridge, Massachusetts 02142, United States","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069094503"],"corresponding_institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3174,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.41487893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"10","issue":"6","first_page":"3747","last_page":"3758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-corona","display_name":"protein corona","score":0.9459999799728394},{"id":"https://openalex.org/keywords/complement-proteins","display_name":"complement proteins","score":0.9380000233650208},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8209999799728394},{"id":"https://openalex.org/keywords/c4a","display_name":"C4A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nanoparticle-biocompatibility","display_name":"nanoparticle biocompatibility","score":0.7149999737739563},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C55637122","wikidata":"https://www.wikidata.org/wiki/Q903923","display_name":"Dendrimer","level":2,"score":0.9654133319854736},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.7888914346694946},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.6981126070022583},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5363482236862183},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.43774089217185974},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4307671785354614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4277094900608063},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3502933382987976},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3182337284088135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15309494733810425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14104574918746948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000075082","descriptor_name":"Proof of Concept Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050091","descriptor_name":"Dendrimers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050091","descriptor_name":"Dendrimers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsbiomaterials.3c01579","doi":"https://doi.org/10.1021/acsbiomaterials.3c01579","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.3c01579","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science &amp; Engineering","raw_type":"journal-article"},{"id":"doi:10.1101/2023.08.31.555747","doi":"https://doi.org/10.1101/2023.08.31.555747","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.08.31.555747","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/09/02/2023.08.31.555747.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38753577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38753577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2023.08.31.555747","doi":"https://doi.org/10.1101/2023.08.31.555747","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.08.31.555747","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/09/02/2023.08.31.555747.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1936111655","display_name":"Multivalent Nano-conjugates for Targeted Penetration of and Delivery to Dense Extracellular Matrices","funder_award_id":"R01EB026344","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6331095106","display_name":null,"funder_award_id":"1021694","funder_id":"https://openalex.org/F4320306133","funder_display_name":"Burroughs Wellcome Fund"},{"id":"https://openalex.org/G7434647902","display_name":null,"funder_award_id":"DOD W81XWH2010481","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G879723708","display_name":null,"funder_award_id":"3-R01-EB026344-03S1","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306081","display_name":"Ford Foundation","ror":"https://ror.org/02fvtx219"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320316943","display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","ror":"https://ror.org/01xd6q208"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396949111.pdf","grobid_xml":"https://content.openalex.org/works/W4396949111.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W924174307","https://openalex.org/W1873323767","https://openalex.org/W1985947600","https://openalex.org/W1986824448","https://openalex.org/W1988554418","https://openalex.org/W2009805582","https://openalex.org/W2012368513","https://openalex.org/W2014073819","https://openalex.org/W2016525467","https://openalex.org/W2017255665","https://openalex.org/W2021538200","https://openalex.org/W2052293595","https://openalex.org/W2066404267","https://openalex.org/W2081971345","https://openalex.org/W2093621960","https://openalex.org/W2103716701","https://openalex.org/W2125123295","https://openalex.org/W2129505547","https://openalex.org/W2138883423","https://openalex.org/W2169207702","https://openalex.org/W2239911165","https://openalex.org/W2460068665","https://openalex.org/W2562957244","https://openalex.org/W2606968610","https://openalex.org/W2737286255","https://openalex.org/W2792407616","https://openalex.org/W2805168616","https://openalex.org/W2810759329","https://openalex.org/W2810759423","https://openalex.org/W2897827263","https://openalex.org/W2902300433","https://openalex.org/W2904421759","https://openalex.org/W2923736255","https://openalex.org/W2939008797","https://openalex.org/W2944690546","https://openalex.org/W2955475140","https://openalex.org/W2984821377","https://openalex.org/W2990016411","https://openalex.org/W2996243448","https://openalex.org/W2997461724","https://openalex.org/W3000173939","https://openalex.org/W3014236874","https://openalex.org/W3037252060","https://openalex.org/W3082590214","https://openalex.org/W3092733286","https://openalex.org/W3097143966","https://openalex.org/W3126104798","https://openalex.org/W3138472028","https://openalex.org/W3162889119","https://openalex.org/W4214592158","https://openalex.org/W4283122330","https://openalex.org/W4292179380","https://openalex.org/W4293199528","https://openalex.org/W4360782236","https://openalex.org/W4360849792"],"related_works":["https://openalex.org/W7214780223","https://openalex.org/W3124229851","https://openalex.org/W2885698846","https://openalex.org/W2205447394","https://openalex.org/W2103716701","https://openalex.org/W1967870961","https://openalex.org/W3195970198","https://openalex.org/W3095049108","https://openalex.org/W2087106163","https://openalex.org/W1982009705"],"abstract_inverted_index":{"Improving":[0],"the":[1,20,24],"clinical":[2],"translation":[3],"of":[4,22],"nanomedicine":[5],"requires":[6],"better":[7],"knowledge":[8],"about":[9],"how":[10,29],"nanoparticles":[11,51],"interact":[12,102],"with":[13,73,94,103,112],"biological":[14,33],"environments.":[15],"As":[16],"researchers":[17],"are":[18,39],"recognizing":[19],"importance":[21],"understanding":[23],"protein":[25],"corona":[26],"and":[27,37,84,108,125],"characterizing":[28],"nanocarriers":[30],"respond":[31],"in":[32],"systems,":[34],"new":[35],"tools":[36],"techniques":[38],"needed":[40],"to":[41,63,89,123],"analyze":[42,90],"nanocarrier-protein":[43],"interactions,":[44],"especially":[45],"for":[46],"smaller":[47],"size":[48],"(<10":[49],"nm)":[50],"like":[52],"polyamidoamine":[53],"(PAMAM)":[54],"dendrimers.":[55],"Here,":[56],"we":[57,79],"developed":[58],"a":[59,68],"streamlined,":[60],"semiquantitative":[61],"approach":[62,119],"assess":[64],"dendrimer-protein":[65,127],"interactions":[66],"using":[67],"nondenaturing":[69],"electrophoresis":[70],"technique":[71],"combined":[72],"mass":[74],"spectrometry.":[75],"With":[76],"this":[77],"protocol,":[78],"detect":[80],"fluorescently":[81],"tagged":[82],"dendrimers":[83,92,100],"proteins":[85],"simultaneously,":[86],"enabling":[87],"us":[88],"when":[91],"migrate":[93],"proteins.":[95],"We":[96],"found":[97],"that":[98,117],"PAMAM":[99],"mostly":[101],"complement":[104],"proteins,":[105],"particularly":[106],"C3":[107],"C4a,":[109],"which":[110],"aligns":[111],"previously":[113],"published":[114],"data,":[115],"verifying":[116],"our":[118],"can":[120],"be":[121],"used":[122],"isolate":[124],"identify":[126],"interactions.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-17T00:00:00"}