{"id":"https://openalex.org/W4396946973","doi":"https://doi.org/10.1097/01.aog.0001013208.89701.73","title":"Concurrent Chemoradiotherapy Compared With Neoadjuvant Chemotherapy Followed by Radical Hysterectomy for FIGO Stage IIB Cervical Cancer Patients: A Systematic Review and Meta-analysis [ID 2683429]","display_name":"Concurrent Chemoradiotherapy Compared With Neoadjuvant Chemotherapy Followed by Radical Hysterectomy for FIGO Stage IIB Cervical Cancer Patients: A Systematic Review and Meta-analysis [ID 2683429]","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396946973","doi":"https://doi.org/10.1097/01.aog.0001013208.89701.73"},"language":"en","primary_location":{"id":"doi:10.1097/01.aog.0001013208.89701.73","doi":"https://doi.org/10.1097/01.aog.0001013208.89701.73","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.aog.0001013208.89701.73","pdf_url":null,"source":{"id":"https://openalex.org/S139838620","display_name":"Obstetrics and Gynecology","issn_l":"0029-7844","issn":["0029-7844","1873-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics & Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109544247","display_name":"Ahmed Soliman","orcid":"https://orcid.org/0009-0002-1475-5490","observed_orcids":["https://orcid.org/0009-0002-1475-5490","https://orcid.org/0009-0007-1052-7550"]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Soliman","raw_affiliation_strings":["Mansoura University, Mansoura, Ad Daqahliyah, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mansoura University, Mansoura, Ad Daqahliyah, Egypt","institution_ids":["https://openalex.org/I159247623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113209292","display_name":"Rawda Adel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rawda Adel","raw_affiliation_strings":["Mansoura University, Mansoura, Ad Daqahliyah, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mansoura University, Mansoura, Ad Daqahliyah, Egypt","institution_ids":["https://openalex.org/I159247623"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohamed Elnaggar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Elnaggar","raw_affiliation_strings":["Mansoura University, Mansoura, Ad Daqahliyah, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mansoura University, Mansoura, Ad Daqahliyah, Egypt","institution_ids":["https://openalex.org/I159247623"]}]},{"author_position":"last","author":{"id":null,"display_name":"Amr Soliman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amr Soliman","raw_affiliation_strings":["Mansoura University, Mansoura, Ad Daqahliyah, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mansoura University, Mansoura, Ad Daqahliyah, Egypt","institution_ids":["https://openalex.org/I159247623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I159247623"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13090806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"143","issue":"5S","first_page":"26S","last_page":"27S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8090000152587891},{"id":"https://openalex.org/keywords/figo-stage-iib","display_name":"FIGO stage IIB","score":0.9610000252723694},{"id":"https://openalex.org/keywords/locally-advanced-cervical-cancer","display_name":"locally advanced cervical cancer","score":0.9020000100135803},{"id":"https://openalex.org/keywords/concurrent-chemoradiotherapy","display_name":"concurrent chemoradiotherapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/radical-hysterectomy","display_name":"radical hysterectomy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6890000104904175},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-comparison","display_name":"treatment comparison","score":0.8700000047683716},{"id":"https://openalex.org/keywords/parametrial-invasion","display_name":"parametrial invasion","score":0.7760000228881836},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.3070000112056732},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5910000205039978},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.36500000953674316},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7160000205039978},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.7508096098899841},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7105086445808411},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.7093485593795776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.689113974571228},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6401893496513367},{"id":"https://openalex.org/C2910227796","wikidata":"https://www.wikidata.org/wiki/Q550675","display_name":"Radical Hysterectomy","level":4,"score":0.5837486982345581},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5293676853179932},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.4859079420566559},{"id":"https://openalex.org/C2779494336","wikidata":"https://www.wikidata.org/wiki/Q550675","display_name":"Hysterectomy","level":2,"score":0.41922181844711304},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.41613659262657166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3956209421157837},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.37808340787887573},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29733824729919434},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2168523669242859},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.06631454825401306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.03641238808631897},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.aog.0001013208.89701.73","doi":"https://doi.org/10.1097/01.aog.0001013208.89701.73","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.aog.0001013208.89701.73","pdf_url":null,"source":{"id":"https://openalex.org/S139838620","display_name":"Obstetrics and Gynecology","issn_l":"0029-7844","issn":["0029-7844","1873-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics & Gynecology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4253158507","https://openalex.org/W2792839210","https://openalex.org/W3006572148","https://openalex.org/W2987116990","https://openalex.org/W3033698860","https://openalex.org/W4307149949","https://openalex.org/W3044608122","https://openalex.org/W4250943769","https://openalex.org/W4322012109","https://openalex.org/W4399983561"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Cervical":[1],"cancer":[2,13,43],"is":[3,58],"the":[4,27,76,86,258,266],"fourth":[5],"most":[6],"common":[7],"malignant":[8],"disease":[9],"and":[10,34,79,98,104,115,137,149,189,229,237],"cause":[11],"of":[12,26,96,128,274,289],"death":[14],"in":[15,146,270,287],"women":[16,253],"worldwide.":[17],"FIGO":[18,55,118,154,201,277],"stage":[19,56,119,155,202,278],"IIB":[20,57,203,279],"includes":[21],"cervical":[22,42,280],"carcinomas":[23],"with":[24,39,113,117,153,172,200,254,257,265,276],"invasion":[25],"parametria.":[28],"Despite":[29],"innovative":[30],"treatment":[31,52],"approaches,":[32],"recurrence":[33],"mortality":[35],"rates":[36],"among":[37],"patients":[38,112,199,275],"locally":[40],"advanced":[41],"(LACC)":[44],"have":[45],"not":[46,248],"been":[47],"significantly":[48,206],"reduced.":[49],"The":[50],"current":[51],"recommendation":[53],"for":[54,101,111,160,198,210,226,252,297],"concurrent":[59],"chemoradiotherapy":[60],"(CCRT).":[61],"Neoadjuvant":[62],"chemotherapy":[63],"followed":[64],"by":[65],"radical":[66],"hysterectomy":[67],"(NACT+HE)":[68],"represents":[69],"a":[70,205,271],"valid":[71],"alternative.":[72],"METHODS:":[73],"According":[74],"to":[75,90,143,175,213,262,285],"PRISMA":[77],"guidelines":[78],"Cochrane":[80,99],"handbook":[81],"recommendations,":[82],"we":[83],"systematically":[84],"searched":[85],"following":[87],"databases":[88],"up":[89],"January":[91],"2023:":[92],"PubMed,":[93],"Scopus,":[94],"Web":[95],"Science,":[97],"CENTRAL":[100],"relevant":[102],"studies":[103,132],"reports":[105],"that":[106],"compare":[107],"NACT+HE":[108,173,214,259,286],"versus":[109],"CCRT":[110,176,211,267,282],"LACC":[114,255],"specifically":[116],"IIB.":[120],"RESULTS:":[121],"Our":[122],"search":[123],"results":[124],"revealed":[125],"1,034":[126],"records,":[127],"them":[129],"only":[130],"6":[131],"(n=2,055);":[133],"2":[134],"clinical":[135],"trials":[136],"4":[138],"observational":[139],"cohorts":[140],"were":[141],"eligible":[142],"be":[144],"included":[145],"both":[147],"qualitative":[148],"quantitative":[150],"analyses.":[151],"Patients":[152],"IB2\u2013IVA":[156],"showed":[157,204],"no":[158,221,292],"advantage":[159,251],"5-year":[161,208,227,230],"overall":[162],"survival":[163,166,170],"(OS),":[164],"disease-free":[165],"(DFS),":[167],"or":[168,299],"progression-free":[169],"(PFS)":[171],"compared":[174,212,261],"(hazard":[177],"ratio":[178],"[HR]":[179],"0.66":[180],"[95%":[181,186,192,217,234,240],"CI:":[182,187,193,218,235,241],"0.43\u20131.01];":[183],"HR":[184,190,238],"0.62":[185],"0.23\u20131.65];":[188],"0.88":[191,233],"0.51\u20131.50]).":[194],"A":[195],"subgroup":[196],"analysis":[197,273],"better":[207],"DFS":[209],"(HR":[215,232],"1.86":[216],"1.23\u20132.81]);":[219],"however,":[220],"significant":[222,293],"improvement":[223],"was":[224,283,295],"shown":[225,296],"OS":[228,298],"PFS":[231],"0.52\u20131.49]":[236],"0.85":[239],"0.56\u20131.29]),":[242],"respectively.":[243],"CONCLUSION:":[244],"This":[245],"meta-analysis":[246],"did":[247],"show":[249],"any":[250],"treated":[256,264],"approach":[260],"those":[263],"approach.":[268],"However,":[269],"stage-specific":[272],"cancer,":[281],"superior":[284],"terms":[288],"DFS,":[290],"whereas":[291],"difference":[294],"PFS.":[300]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-05-17T00:00:00"}