{"id":"https://openalex.org/W4396935975","doi":"https://doi.org/10.1101/2024.05.14.594119","title":"ERK inhibits Cic repressor function via multisite phosphorylation","display_name":"ERK inhibits Cic repressor function via multisite phosphorylation","publication_year":2024,"publication_date":"2024-05-14","ids":{"openalex":"https://openalex.org/W4396935975","doi":"https://doi.org/10.1101/2024.05.14.594119"},"language":"en","primary_location":{"id":"doi:10.1101/2024.05.14.594119","doi":"https://doi.org/10.1101/2024.05.14.594119","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.05.14.594119","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/05/14/2024.05.14.594119.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2024/05/14/2024.05.14.594119.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081087380","display_name":"Sayantanee Paul","orcid":"https://orcid.org/0000-0003-4616-1216","observed_orcids":["https://orcid.org/0000-0003-4616-1216"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayantanee Paul","raw_affiliation_strings":["Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","Department of Discovery Oncology, Genentech Inc., South San Francisco, CA 94080, USA","Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA"],"raw_orcid":"https://orcid.org/0000-0003-4616-1216","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Discovery Oncology, Genentech Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039902118","display_name":"Khandan Ilkhani","orcid":"https://orcid.org/0000-0002-4697-608X","observed_orcids":["https://orcid.org/0000-0002-4697-608X"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khandan Ilkhani","raw_affiliation_strings":["Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA"],"raw_orcid":"https://orcid.org/0000-0002-4697-608X","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098447799","display_name":"Nathan Strozewski","orcid":"https://orcid.org/0009-0001-9467-8853","observed_orcids":["https://orcid.org/0009-0001-9467-8853"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Strozewski","raw_affiliation_strings":["Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611156","display_name":"Liu Yang","orcid":"https://orcid.org/0000-0003-1578-4795","observed_orcids":["https://orcid.org/0000-0003-1578-4795"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liu Yang","raw_affiliation_strings":["Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098447800","display_name":"David W. Denberg","orcid":"https://orcid.org/0000-0001-7798-0746","observed_orcids":["https://orcid.org/0000-0001-7798-0746"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Denberg","raw_affiliation_strings":["Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","Program in Quantitative and Computational Biology, Princeton University, Princeton, NJ 08544, USA","Program in Quantitative and Computational Biology, Princeton University, Princeton, NJ 085, USA"],"raw_orcid":"https://orcid.org/0000-0001-7798-0746","affiliations":[{"raw_affiliation_string":"Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Program in Quantitative and Computational Biology, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Program in Quantitative and Computational Biology, Princeton University, Princeton, NJ 085, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098447801","display_name":"Wootchelmine Christalin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wootchelmine Christalin","raw_affiliation_strings":["Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012005058","display_name":"Stanislav Y. Shvartsman","orcid":"https://orcid.org/0000-0002-9152-9334","observed_orcids":["https://orcid.org/0000-0002-9152-9334"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4387153999","display_name":"Flatiron Institute","ror":"https://ror.org/00sekdz59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338","https://openalex.org/I4387153999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav Y. Shvartsman","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","Flatiron Institute, New York, NY 10010","Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","Department of Molecular Biology, Princeton University, Princeton, NJ 0844, USA"],"raw_orcid":"https://orcid.org/0000-0002-9152-9334","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Flatiron Institute, New York, NY 10010","institution_ids":["https://openalex.org/I4387153999"]},{"raw_affiliation_string":"Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 0844, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011147929","display_name":"Alexey N. Veraksa","orcid":"https://orcid.org/0000-0003-2920-080X","observed_orcids":["https://orcid.org/0000-0003-2920-080X"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexey Veraksa","raw_affiliation_strings":["Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA"],"raw_orcid":"https://orcid.org/0000-0003-2920-080X","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Biology, University of Massachusetts Boston, Boston, MA 0225, USA","institution_ids":["https://openalex.org/I33434090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011147929"],"corresponding_institution_ids":["https://openalex.org/I33434090"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.16249999403953552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.11559999734163284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/capicua","display_name":"Capicua","score":0.9160000085830688},{"id":"https://openalex.org/keywords/multisite-phosphorylation","display_name":"multisite phosphorylation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/transcriptional-repressor","display_name":"transcriptional repressor","score":0.8169999718666077},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/phosphodegron","display_name":"phosphodegron","score":0.8529999852180481},{"id":"https://openalex.org/keywords/fbxw7","display_name":"FBXW7","score":0.8330000042915344},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7950000166893005},{"id":"https://openalex.org/keywords/signal-interpretation","display_name":"signal interpretation","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8730900883674622},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.843574583530426},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7598513960838318},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6705001592636108},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.5059599280357361},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49759939312934875},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45297589898109436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4422793686389923},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4298229217529297},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35712799429893494},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.19021275639533997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17940080165863037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09519186615943909}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2024.05.14.594119","doi":"https://doi.org/10.1101/2024.05.14.594119","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.05.14.594119","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/05/14/2024.05.14.594119.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2024.05.14.594119","doi":"https://doi.org/10.1101/2024.05.14.594119","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.05.14.594119","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/05/14/2024.05.14.594119.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320313188","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396935975.pdf","grobid_xml":"https://content.openalex.org/works/W4396935975.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W321588607","https://openalex.org/W1267523842","https://openalex.org/W1964439061","https://openalex.org/W1979400866","https://openalex.org/W1993450321","https://openalex.org/W2026465178","https://openalex.org/W2039110985","https://openalex.org/W2052112605","https://openalex.org/W2068573158","https://openalex.org/W2075460872","https://openalex.org/W2093797314","https://openalex.org/W2096720319","https://openalex.org/W2097978324","https://openalex.org/W2122342534","https://openalex.org/W2127013244","https://openalex.org/W2132062633","https://openalex.org/W2138099866","https://openalex.org/W2142183096","https://openalex.org/W2157261826","https://openalex.org/W2160271282","https://openalex.org/W2161118640","https://openalex.org/W2162184208","https://openalex.org/W2170208618","https://openalex.org/W2518353349","https://openalex.org/W2560844515","https://openalex.org/W2624859757","https://openalex.org/W2746926364","https://openalex.org/W2762860579","https://openalex.org/W2913127881","https://openalex.org/W2999234376","https://openalex.org/W3005315289","https://openalex.org/W3009177557","https://openalex.org/W3089176327","https://openalex.org/W3091293836","https://openalex.org/W4220655077","https://openalex.org/W4312075904"],"related_works":["https://openalex.org/W7133818013","https://openalex.org/W3173447400","https://openalex.org/W2058073159","https://openalex.org/W2999234376","https://openalex.org/W2157540307","https://openalex.org/W2068573158","https://openalex.org/W2315839510","https://openalex.org/W4312075904","https://openalex.org/W3091293836","https://openalex.org/W7099508129"],"abstract_inverted_index":{"Abstract":[0],"The":[1,30],"receptor":[2],"tyrosine":[3],"kinase":[4],"(RTK)/Extracellular":[5],"Signal-Regulated":[6],"Kinase":[7],"(ERK)":[8],"signaling":[9,218],"pathway":[10],"controls":[11],"cell":[12],"proliferation,":[13],"differentiation,":[14],"and":[15,46,48,56,91,112,197],"survival.":[16],"How":[17],"ERK":[18,61,90,170],"activation":[19],"is":[20,26,62,141,159],"relayed":[21],"to":[22,120,144,152,154,161,178,199],"its":[23],"phosphorylation":[24,82,184],"targets":[25,186],"not":[27],"well":[28],"understood.":[29],"transcriptional":[31],"repressor":[32],"Capicua":[33],"(Cic)":[34],"has":[35],"emerged":[36],"as":[37,135,195],"a":[38,113,122,136],"key":[39],"target":[40],"for":[41,64],"ERK-mediated":[42,145],"downregulation":[43],"in":[44,50,54,72,83,96,125,130,138,175],"Drosophila":[45,73],"mammals,":[47],"mutations":[49],"human":[51],"CIC":[52],"result":[53],"cancer":[55],"neurological":[57],"diseases.":[58],"Phosphorylation":[59],"by":[60,89,191],"critical":[63],"Cic":[65,74,84,100,102,126,128,164,176,200],"downregulation,":[66,146],"but":[67],"the":[68,107,110,150,208,216],"identities":[69],"of":[70,81,109,115,207,211,215],"phosphosites":[71,103],"are":[75,86,104,189],"unknown.":[76],"Here,":[77],"we":[78,167],"identify":[79],"sites":[80,118,133,174],"that":[85,140,169,188],"directly":[87],"targeted":[88],"validate":[92],"their":[93],"developmental":[94],"functions":[95],"vivo":[97,139],"using":[98],"mutant":[99],"variants.":[101],"distributed":[105],"throughout":[106],"length":[108],"protein,":[111],"group":[114],"centrally":[116],"located":[117],"appears":[119],"have":[121],"primary":[123],"role":[124],"downregulation.":[127,181],"mutated":[129],"20":[131],"high-confidence":[132],"behaves":[134],"\u201csuper-repressor\u201d":[137],"largely":[142],"insensitive":[143],"despite":[147],"fully":[148],"retaining":[149],"ability":[151],"bind":[153],"ERK.":[155],"No":[156],"single":[157],"site":[158],"sufficient":[160],"turn":[162],"off":[163],"activity;":[165],"instead,":[166],"find":[168],"must":[171],"phosphorylate":[172],"multiple":[173],"simultaneously":[177],"achieve":[179],"full":[180],"This":[182,202],"multisite":[183],"likely":[185],"phosphodegrons":[187],"recognized":[190],"ubiquitin":[192],"ligases":[193],"such":[194],"Ago/FBXW7":[196],"contributes":[198],"degradation.":[201],"study":[203],"advances":[204],"our":[205],"understanding":[206],"molecular":[209],"mechanisms":[210],"signal":[212],"interpretation":[213],"downstream":[214],"RTK/ERK":[217],"network.":[219]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-05-16T00:00:00"}