{"id":"https://openalex.org/W4396907239","doi":"https://doi.org/10.1016/j.bbrc.2024.150126","title":"Unique electrophysiological property of a novel Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker, ANP-230","display_name":"Unique electrophysiological property of a novel Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker, ANP-230","publication_year":2024,"publication_date":"2024-05-14","ids":{"openalex":"https://openalex.org/W4396907239","doi":"https://doi.org/10.1016/j.bbrc.2024.150126","pmid":"https://pubmed.ncbi.nlm.nih.gov/38776832"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2024.150126","doi":"https://doi.org/10.1016/j.bbrc.2024.150126","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150126","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbrc.2024.150126","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075775369","display_name":"Tatsuya Kamei","orcid":"https://orcid.org/0009-0002-3418-5691","observed_orcids":["https://orcid.org/0009-0002-3418-5691"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tatsuya Kamei","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan. Electronic address: tatsuya.kamei@sumitomo-pharma.co.jp","Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan"],"raw_orcid":"https://orcid.org/0009-0002-3418-5691","affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan. Electronic address: tatsuya.kamei@sumitomo-pharma.co.jp","institution_ids":[]},{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]},{"raw_affiliation_string":"Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112590676","display_name":"Takehiro Kudo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takehiro Kudo","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hana Yamane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hana Yamane","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan","Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan","institution_ids":[]},{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]},{"raw_affiliation_string":"Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Kobe, 650-0047, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fumiaki Ishibashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumiaki Ishibashi","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]},{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]},{"raw_affiliation_string":"Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077561065","display_name":"Yoshinori Takada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshinori Takada","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Global Corporate Strategy, Sumitomo Pharma Co., Ltd., Tokyo, 104-8356, Japan","Global Corporate Strategy, Sumitomo Pharma Co., Ltd., Tokyo, 104-8356, Japan","Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Global Corporate Strategy, Sumitomo Pharma Co., Ltd., Tokyo, 104-8356, Japan","institution_ids":[]},{"raw_affiliation_string":"Global Corporate Strategy, Sumitomo Pharma Co., Ltd., Tokyo, 104-8356, Japan","institution_ids":[]},{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109357829","display_name":"Shigeyuki Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276485","display_name":"Sumika Chemical Analysis Service, Ltd. (Japan)","ror":"https://ror.org/05hjtwz09","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405276485"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyuki Honda","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Sumika Chemical Analysis Service, Ltd., Osaka, 554-0022, Japan","Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","Sumika Chemical Analysis Service, Ltd., Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Sumika Chemical Analysis Service, Ltd., Osaka, 554-0022, Japan","institution_ids":["https://openalex.org/I4405276485"]},{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]},{"raw_affiliation_string":"Sumika Chemical Analysis Service, Ltd., Osaka, 554-0022, Japan","institution_ids":["https://openalex.org/I4405276485"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuyo Maezawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuyo Maezawa","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077959498","display_name":"Kazuhito Ikeda","orcid":"https://orcid.org/0000-0001-8057-2532","observed_orcids":["https://orcid.org/0000-0001-8057-2532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhito Ikeda","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8057-2532","affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]},{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]},{"raw_affiliation_string":"Platform Technology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079864851","display_name":"Yoshihiro Oyamada","orcid":"https://orcid.org/0000-0001-9582-558X","observed_orcids":["https://orcid.org/0000-0001-9582-558X"]},"institutions":[{"id":"https://openalex.org/I4210133306","display_name":"Osaka Prefectural Government","ror":"https://ror.org/02wymnj87","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210133306"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Oyamada","raw_affiliation_strings":["Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; AlphaNavi Pharma Inc., Osaka, 564-0053, Japan","AlphaNavi Pharma Inc., Osaka, 564-0053, Japan","Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9582-558X","affiliations":[{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan; AlphaNavi Pharma Inc., Osaka, 564-0053, Japan","institution_ids":[]},{"raw_affiliation_string":"AlphaNavi Pharma Inc., Osaka, 564-0053, Japan","institution_ids":["https://openalex.org/I4210133306"]},{"raw_affiliation_string":"Pharmacology Research Unit, Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075775369"],"corresponding_institution_ids":[],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":{"value":2880,"currency":"USD","value_usd":2880},"fwci":1.9547,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86996081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"721","issue":null,"first_page":"150126","last_page":"150126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-channel-blockers","display_name":"sodium channel blockers","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nav1-7","display_name":"Nav1.7","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nav1-8","display_name":"Nav1.8","score":1.0},{"id":"https://openalex.org/keywords/nav1-9","display_name":"Nav1.9","score":1.0},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tonic-block","display_name":"tonic block","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gating-kinetics","display_name":"gating kinetics","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.9929999709129333},{"id":"https://openalex.org/keywords/peripheral-sensory-neurons","display_name":"peripheral sensory neurons","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pharmacological-pain-management","display_name":"pharmacological pain management","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.7855191230773926},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.7640366554260254},{"id":"https://openalex.org/C2777589315","wikidata":"https://www.wikidata.org/wiki/Q18048105","display_name":"NAV1","level":4,"score":0.755118727684021},{"id":"https://openalex.org/C2776414672","wikidata":"https://www.wikidata.org/wiki/Q7553303","display_name":"Sodium channel blocker","level":4,"score":0.6747157573699951},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6293368935585022},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.583890974521637},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.5607370734214783},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5239125490188599},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48599156737327576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45485901832580566},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4452967941761017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.390863835811615},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38343745470046997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2913430333137512},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.20104730129241943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1937728226184845},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.1486130952835083},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14534595608711243},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026941","descriptor_name":"Sodium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061567","descriptor_name":"Voltage-Gated Sodium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D062556","descriptor_name":"NAV1.7 Voltage-Gated Sodium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062556","descriptor_name":"NAV1.7 Voltage-Gated Sodium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062558","descriptor_name":"NAV1.9 Voltage-Gated Sodium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062558","descriptor_name":"NAV1.9 Voltage-Gated Sodium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062559","descriptor_name":"NAV1.8 Voltage-Gated Sodium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062559","descriptor_name":"NAV1.8 Voltage-Gated Sodium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2024.150126","doi":"https://doi.org/10.1016/j.bbrc.2024.150126","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150126","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:38776832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38776832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrc.2024.150126","doi":"https://doi.org/10.1016/j.bbrc.2024.150126","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150126","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W40340874","https://openalex.org/W1187299151","https://openalex.org/W1531283035","https://openalex.org/W1549160512","https://openalex.org/W1988364958","https://openalex.org/W1997333327","https://openalex.org/W2004938469","https://openalex.org/W2018764168","https://openalex.org/W2031180202","https://openalex.org/W2037309880","https://openalex.org/W2043406394","https://openalex.org/W2045007274","https://openalex.org/W2045172500","https://openalex.org/W2047125409","https://openalex.org/W2049433094","https://openalex.org/W2049710812","https://openalex.org/W2063292019","https://openalex.org/W2064625670","https://openalex.org/W2075831855","https://openalex.org/W2080410552","https://openalex.org/W2088237761","https://openalex.org/W2093629630","https://openalex.org/W2097697084","https://openalex.org/W2099453186","https://openalex.org/W2104818454","https://openalex.org/W2109296561","https://openalex.org/W2120411432","https://openalex.org/W2127494940","https://openalex.org/W2147196890","https://openalex.org/W2147268397","https://openalex.org/W2334896286","https://openalex.org/W2337484140","https://openalex.org/W2386115030","https://openalex.org/W2404030918","https://openalex.org/W2514913749","https://openalex.org/W2518567256","https://openalex.org/W2558471778","https://openalex.org/W2562806882","https://openalex.org/W2577015886","https://openalex.org/W2595144937","https://openalex.org/W2765825893","https://openalex.org/W2770574812","https://openalex.org/W2791901353","https://openalex.org/W2811277737","https://openalex.org/W2885640557","https://openalex.org/W2904388809","https://openalex.org/W2912762225","https://openalex.org/W2923498555","https://openalex.org/W2942406429","https://openalex.org/W2952500500","https://openalex.org/W3000074640","https://openalex.org/W3014244669","https://openalex.org/W3084195837","https://openalex.org/W3092610990","https://openalex.org/W3094303505","https://openalex.org/W3095897671","https://openalex.org/W3101921191","https://openalex.org/W3110031865","https://openalex.org/W3121427018","https://openalex.org/W3139569230","https://openalex.org/W3140644077","https://openalex.org/W4200556008","https://openalex.org/W4231011208","https://openalex.org/W4247806383","https://openalex.org/W4365518055","https://openalex.org/W6627706662","https://openalex.org/W6688767643","https://openalex.org/W6726399831","https://openalex.org/W6732100703","https://openalex.org/W7073657715"],"related_works":["https://openalex.org/W4411334776","https://openalex.org/W1506534827","https://openalex.org/W1481443370","https://openalex.org/W192151047","https://openalex.org/W2038223968","https://openalex.org/W2011139091","https://openalex.org/W2065689638","https://openalex.org/W4288639942","https://openalex.org/W4413111006","https://openalex.org/W2145739946"],"abstract_inverted_index":{"Voltage-gated":[0],"sodium":[1,96],"channel":[2,97,129,209],"subtypes,":[3,110],"Nav1.7,":[4,33,112],"Nav1.8,":[5,34,113],"and":[6,28,73,114,130,156,169],"Nav1.9":[7,36,115],"are":[8,22],"predominantly":[9],"expressed":[10],"in":[11,24,89,173,187,223],"peripheral":[12],"sensory":[13],"neurons.":[14,199],"Recent":[15],"genetic":[16],"studies":[17],"have":[18,53],"revealed":[19,144],"that":[20,29,145,233],"they":[21],"involved":[23],"pathological":[25],"pain":[26,67],"processing":[27],"the":[30,57,71,88,166],"blockade":[31],"of":[32,49,56,79,92,152,165,181,207,217],"or":[35],"will":[37],"become":[38],"a":[39,61,94,148,162,203,224,237],"promising":[40,230],"pharmacotherapy":[41],"especially":[42],"for":[43,240],"neuropathic":[44,241],"pain.":[45,242],"A":[46],"growing":[47],"number":[48],"drug":[50,239],"discovery":[51],"programs":[52],"targeted":[54],"either":[55],"subtypes":[58],"to":[59,106,125],"obtain":[60],"selective":[62],"inhibitor":[63],"which":[64],"can":[65],"provide":[66],"relief":[68],"without":[69,154],"affecting":[70],"cardiovascular":[72],"central":[74,132],"nervous":[75],"systems,":[76],"though":[77],"none":[78],"them":[80],"has":[81],"been":[82],"approved":[83],"yet.":[84],"Here":[85],"we":[86],"describe":[87],"vitro":[90],"characteristics":[91],"ANP-230,":[93],"novel":[95],"blocker":[98],"under":[99],"clinical":[100],"development.":[101],"Surprisingly,":[102],"ANP-230":[103,146,160,214,234],"was":[104,184],"shown":[105],"block":[107],"three":[108],"pain-related":[109],"human":[111,126,174,188],"with":[116],"similar":[117],"potency,":[118],"but":[119],"had":[120,147],"only":[121],"low":[122],"inhibitory":[123],"activity":[124],"cardiac":[127],"Nav1.5":[128],"rat":[131,195,218],"Nav":[133,208],"channels.":[134],"The":[135,178],"voltage":[136],"clamp":[137],"experiments":[138],"using":[139],"different":[140],"step":[141],"pulse":[142],"protocols":[143],"\"tonic":[149],"block\"":[150],"mode":[151],"action":[153],"state-":[155],"use-dependency.":[157],"In":[158],"addition,":[159],"caused":[161],"depolarizing":[163,179],"shift":[164,180],"activation":[167,182],"curve":[168,183],"decelerated":[170],"gating":[171],"kinetics":[172],"Nav1.7-stably":[175],"expressing":[176,190],"cells.":[177],"commonly":[185],"observed":[186],"Nav1.8-stably":[189],"cells":[191],"as":[192,194],"well":[193],"dorsal":[196,219],"root":[197,220],"ganglion":[198,221],"These":[200],"data":[201],"suggested":[202],"quite":[204],"unique":[205],"mechanism":[206],"inhibition":[210],"by":[211],"ANP-230.":[212],"Finally,":[213],"reduced":[215],"excitability":[216],"neurons":[222],"concentration":[225],"dependent":[226],"manner.":[227],"Collectively,":[228],"these":[229],"results":[231],"indicate":[232],"could":[235],"be":[236],"potent":[238]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-05-15T00:00:00"}