{"id":"https://openalex.org/W4396904802","doi":"https://doi.org/10.3390/pharmaceutics16050641","title":"Simultaneous Delivery of Curcumin and Resveratrol via In Situ Gelling, Raft-Forming, Gastroretentive Formulations","display_name":"Simultaneous Delivery of Curcumin and Resveratrol via In Situ Gelling, Raft-Forming, Gastroretentive Formulations","publication_year":2024,"publication_date":"2024-05-10","ids":{"openalex":"https://openalex.org/W4396904802","doi":"https://doi.org/10.3390/pharmaceutics16050641","pmid":"https://pubmed.ncbi.nlm.nih.gov/38794303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11124977"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics16050641","doi":"https://doi.org/10.3390/pharmaceutics16050641","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics16050641","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/pharmaceutics16050641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050435590","display_name":"Worrawee Siripruekpong","orcid":"https://orcid.org/0000-0002-9908-7884","observed_orcids":["https://orcid.org/0000-0002-9908-7884"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Worrawee Siripruekpong","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand","Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand","institution_ids":["https://openalex.org/I131868736"]},{"raw_affiliation_string":"Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004430817","display_name":"Rachanida Praparatana","orcid":"https://orcid.org/0000-0003-1627-0470","observed_orcids":["https://orcid.org/0000-0003-1627-0470"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Rachanida Praparatana","raw_affiliation_strings":["Faculty of Medical Technology, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-1627-0470","affiliations":[{"raw_affiliation_string":"Faculty of Medical Technology, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091874660","display_name":"Ousanee Issarachot","orcid":"https://orcid.org/0000-0003-1961-876X","observed_orcids":["https://orcid.org/0000-0003-1961-876X"]},"institutions":[{"id":"https://openalex.org/I4405277467","display_name":"Sirindhorn College of Public Health, Trang","ror":"https://ror.org/02t3knd06","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405277467"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ousanee Issarachot","raw_affiliation_strings":["Department of Pharmacy Technician, Faculty of Public Health and Allied Health Sciences, Sirindhorn College of Public Health Trang, Praboromarajchanok Institute, Kantang, Trang 92110, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Technician, Faculty of Public Health and Allied Health Sciences, Sirindhorn College of Public Health Trang, Praboromarajchanok Institute, Kantang, Trang 92110, Thailand","institution_ids":["https://openalex.org/I4405277467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056524514","display_name":"Ruedeekorn Wiwattanapatapee","orcid":"https://orcid.org/0000-0002-2181-202X","observed_orcids":["https://orcid.org/0000-0002-2181-202X"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Ruedeekorn Wiwattanapatapee","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand","Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand","institution_ids":["https://openalex.org/I131868736"]},{"raw_affiliation_string":"Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand","institution_ids":["https://openalex.org/I131868736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056524514"],"corresponding_institution_ids":["https://openalex.org/I131868736"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":3.3778,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.93022801,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"16","issue":"5","first_page":"641","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/gastroretentive-drug-delivery","display_name":"gastroretentive drug delivery","score":0.9670000076293945},{"id":"https://openalex.org/keywords/in-situ-gelling","display_name":"in situ gelling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/eudragit-epo","display_name":"Eudragit EPO","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sodium-alginate","display_name":"sodium alginate","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pectin","display_name":"pectin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gellan-gum","display_name":"gellan gum","score":1.0},{"id":"https://openalex.org/keywords/calcium-crosslinking","display_name":"calcium crosslinking","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.6259999871253967},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.6380000114440918},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7759407758712769},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7739169597625732},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7407421469688416},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6455919742584229},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.48834702372550964},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39313608407974243},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3239615261554718},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22062581777572632},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21698150038719177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2000671625137329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics16050641","doi":"https://doi.org/10.3390/pharmaceutics16050641","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics16050641","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11124977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11124977","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11124977/pdf/pharmaceutics-16-00641.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:38794303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38794303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:58eebc5cd1ea4662a55b2061041bb937","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/58eebc5cd1ea4662a55b2061041bb937","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 16, Iss 5, p 641 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics16050641","doi":"https://doi.org/10.3390/pharmaceutics16050641","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics16050641","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322614","display_name":"Thailand Research Fund","ror":"https://ror.org/03gd1bh37"},{"id":"https://openalex.org/F4320327548","display_name":"Royal Golden Jubilee (RGJ) Ph.D. Programme","ror":"https://ror.org/05fp08r12"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396904802.pdf","grobid_xml":"https://content.openalex.org/works/W4396904802.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W755452631","https://openalex.org/W1258584912","https://openalex.org/W1966445861","https://openalex.org/W1967246723","https://openalex.org/W1987364433","https://openalex.org/W1987507194","https://openalex.org/W1988890401","https://openalex.org/W1992323513","https://openalex.org/W1995588938","https://openalex.org/W2015368577","https://openalex.org/W2020001968","https://openalex.org/W2058907296","https://openalex.org/W2073579324","https://openalex.org/W2074684825","https://openalex.org/W2078446369","https://openalex.org/W2104961293","https://openalex.org/W2110167136","https://openalex.org/W2112622836","https://openalex.org/W2135230850","https://openalex.org/W2145545281","https://openalex.org/W2178784012","https://openalex.org/W2299625190","https://openalex.org/W2341402103","https://openalex.org/W2571343759","https://openalex.org/W2593460139","https://openalex.org/W2764339438","https://openalex.org/W2765346800","https://openalex.org/W2795648407","https://openalex.org/W2922660706","https://openalex.org/W2964547886","https://openalex.org/W2996717009","https://openalex.org/W3095312205","https://openalex.org/W3118981383","https://openalex.org/W3177301742","https://openalex.org/W3188142519","https://openalex.org/W3191030159","https://openalex.org/W3199595524","https://openalex.org/W3210141429","https://openalex.org/W4200278535","https://openalex.org/W4210458524","https://openalex.org/W4315567687","https://openalex.org/W4327681919","https://openalex.org/W4377043923","https://openalex.org/W4389568414","https://openalex.org/W6804591881"],"related_works":["https://openalex.org/W2795366440","https://openalex.org/W2964547886","https://openalex.org/W755452631","https://openalex.org/W7143398803","https://openalex.org/W4403088802","https://openalex.org/W2418595502","https://openalex.org/W4313389045","https://openalex.org/W7218049764","https://openalex.org/W4313561481","https://openalex.org/W3191030159"],"abstract_inverted_index":{"Curcumin":[0],"and":[1,18,38,71,87,122,126,132,151,180,195,224,227,256,272],"resveratrol":[2,72,196,225,257],"are":[3],"polyphenolic":[4],"compounds":[5,33],"that":[6,244],"have":[7,34],"been":[8],"shown":[9],"to":[10,54,61,83,101,137,148,152],"exhibit":[11],"synergistic":[12],"therapeutic":[13],"properties":[14],"including":[15],"anti-inflammatory,":[16],"anticancer,":[17],"antiulcer":[19],"activities,":[20],"which":[21],"may":[22],"be":[23],"exploited":[24],"for":[25,164,270],"the":[26,85,90,115,143,156,165,185,193,238,259],"treatment":[27],"of":[28,69,89,94,98,188,192,254,261],"gastric":[29,149,175,215],"diseases.":[30],"However,":[31],"both":[32],"poor":[35],"aqueous":[36],"solubility":[37,86],"rapid":[39],"metabolism,":[40],"resulting":[41,183],"in":[42,108,142,173,184,245,258],"a":[43,56,67,95,161,252],"low":[44],"oral":[45],"bioavailability.":[46,63],"In":[47],"situ":[48,109,246],"gelling,":[49,110,247],"liquid":[50,111,248],"formulations":[51,112,168],"were":[52,77,104,135],"developed":[53],"produce":[55,138],"gastroretentive,":[57],"raft-forming":[58],"delivery":[59,268],"vehicle":[60],"improve":[62,84],"Solid":[64,92],"dispersions":[65,93],"containing":[66],"mixture":[68],"curcumin":[70,194,223,255],"with":[73,221,237,251],"Eudragit\u00ae":[74,102],"EPO":[75,103],"(Cur/Res-SD)":[76],"first":[78],"prepared":[79],"using":[80],"solvent":[81],"evaporation,":[82],"dissolution":[88],"compounds.":[91],"weight":[96],"ratio":[97],"1:10":[99],"curcumin/resveratrol":[100],"subsequently":[105],"incorporated":[106],"into":[107],"based":[113,204],"on":[114,146,205],"gelling":[116],"polymers,":[117],"sodium":[118,133,207],"alginate":[119,208],"(low":[120],"viscosity":[121],"medium":[123],"viscosity),":[124],"pectin,":[125],"gellan":[127],"gum,":[128],"respectively.":[129],"Calcium":[130],"carbonate":[131],"bicarbonate":[134],"included":[136],"carbon":[139],"dioxide":[140],"bubbles":[141],"gel":[144],"matrix,":[145],"exposure":[147],"fluid,":[150],"achieve":[153],"flotation.":[154],"Moreover,":[155],"calcium":[157],"ions":[158],"acted":[159],"as":[160,266],"crosslinking":[162],"agent":[163],"hydrogels.":[166],"Optimized":[167],"floated":[169],"rapidly":[170],"(<60":[171],"s)":[172],"simulated":[174],"fluid":[176],"(pH":[177],"=":[178],"1.2)":[179],"remained":[181],"buoyant,":[182],"gradual":[186],"release":[187],"more":[189],"than":[190],"80%":[191],"content":[197],"within":[198],"8":[199],"h.":[200],"The":[201],"optimized":[202],"formulation":[203],"medium-viscosity":[206],"exhibited":[209],"enhanced":[210],"cytotoxic":[211],"activity":[212,230],"toward":[213],"human":[214],"adenocarcinoma":[216],"cell":[217],"lines":[218],"(AGS),":[219],"compared":[220,236],"unformulated":[222],"compounds,":[226],"increased":[228],"anti-inflammatory":[229],"against":[231],"RAW":[232],"264.7":[233],"macrophage":[234],"cells":[235],"NSAID,":[239],"indomethacin.":[240],"These":[241],"findings":[242],"demonstrate":[243],"formulations,":[249],"loaded":[250],"combination":[253],"form":[260],"solid":[262],"dispersions,":[263],"show":[264],"potential":[265],"gastroretentive":[267],"systems":[269],"local":[271],"systemic":[273],"effects.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-05-15T00:00:00"}