{"id":"https://openalex.org/W4396889860","doi":"https://doi.org/10.1042/bsr20231938","title":"Loci cg06256735 and cg15815843 in the MFAP5 gene regulatory regions are hypomethylated in varicose veins apparently due to active demethylation","display_name":"Loci cg06256735 and cg15815843 in the MFAP5 gene regulatory regions are hypomethylated in varicose veins apparently due to active demethylation","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396889860","doi":"https://doi.org/10.1042/bsr20231938","pmid":"https://pubmed.ncbi.nlm.nih.gov/38743016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11139664"},"language":"en","primary_location":{"id":"doi:10.1042/bsr20231938","doi":"https://doi.org/10.1042/bsr20231938","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bsr20231938","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4396889860"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1042/bsr20231938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028810047","display_name":"Mariya A. Smetanina","orcid":"https://orcid.org/0000-0001-6080-4615","observed_orcids":["https://orcid.org/0000-0001-6080-4615"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Mariya\u00a0A. Smetanina","raw_affiliation_strings":["1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","2Department of Fundamental Medicine, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia"],"raw_orcid":"https://orcid.org/0000-0001-6080-4615","affiliations":[{"raw_affiliation_string":"1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]},{"raw_affiliation_string":"2Department of Fundamental Medicine, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042770778","display_name":"Valeria A. Korolenya","orcid":"https://orcid.org/0000-0002-1016-2156","observed_orcids":["https://orcid.org/0000-0002-1016-2156"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valeria\u00a0A. Korolenya","raw_affiliation_strings":["1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","3Department of Natural Sciences, Novosibirsk State University (NSU), Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]},{"raw_affiliation_string":"3Department of Natural Sciences, Novosibirsk State University (NSU), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097471398","display_name":"Fedor A. Sipin","orcid":"https://orcid.org/0000-0001-6921-4646","observed_orcids":["https://orcid.org/0000-0001-6921-4646"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Fedor\u00a0A. Sipin","raw_affiliation_strings":["1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","3Department of Natural Sciences, Novosibirsk State University (NSU), Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]},{"raw_affiliation_string":"3Department of Natural Sciences, Novosibirsk State University (NSU), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030705321","display_name":"Igor P. Oscorbin","orcid":"https://orcid.org/0000-0003-3754-5824","observed_orcids":["https://orcid.org/0000-0003-3754-5824"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Igor\u00a0P. Oscorbin","raw_affiliation_strings":["1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111195595","display_name":"\u0421\u0435\u0432\u043e\u0441\u0442\u044c\u044f\u043d\u043e\u0432\u0430 \u041a\u0441\u0435\u043d\u0438\u044f \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u043d\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Kseniya\u00a0S. Sevostyanova","raw_affiliation_strings":["4Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","5Department of Surgical Diseases, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]},{"raw_affiliation_string":"5Department of Surgical Diseases, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019321916","display_name":"Konstantin A. Gavrilov","orcid":"https://orcid.org/0000-0002-3839-3263","observed_orcids":["https://orcid.org/0000-0002-3839-3263"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin\u00a0A. Gavrilov","raw_affiliation_strings":["4Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","5Department of Surgical Diseases, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]},{"raw_affiliation_string":"5Department of Surgical Diseases, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019935813","display_name":"Andrey Ivanovich Shevela","orcid":"https://orcid.org/0000-0002-3164-9377","observed_orcids":["https://orcid.org/0000-0002-3164-9377"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey\u00a0I. Shevela","raw_affiliation_strings":["4Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","5Department of Surgical Diseases, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]},{"raw_affiliation_string":"5Department of Surgical Diseases, V. Zelman Institute for Medicine and Psychology, Novosibirsk State University (NSU), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083441649","display_name":"\u041c. \u041b. \u0424\u0438\u043b\u0438\u043f\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-8950-5368","observed_orcids":["https://orcid.org/0000-0002-8950-5368","https://orcid.org/0000-0002-6335-4020"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim\u00a0L. Filipenko","raw_affiliation_strings":["1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM), Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028810047"],"corresponding_institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210091979","https://openalex.org/I4210127387"],"apc_list":{"value":1960,"currency":"USD","value_usd":1960},"apc_paid":{"value":1960,"currency":"USD","value_usd":1960},"fwci":0.2043,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.33303613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"44","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varicose-veins","display_name":"varicose veins","score":0.906000018119812},{"id":"https://openalex.org/keywords/mfap5","display_name":"MFAP5","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/5-hydroxymethylcytosine","display_name":"5-hydroxymethylcytosine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/active-demethylation","display_name":"active demethylation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gene-regulatory-regions","display_name":"gene regulatory regions","score":0.7699999809265137},{"id":"https://openalex.org/keywords/venous-wall","display_name":"venous wall","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tunica-intima","display_name":"tunica intima","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gene-upregulation","display_name":"gene upregulation","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2777475103","wikidata":"https://www.wikidata.org/wiki/Q201180","display_name":"Varicose veins","level":2,"score":0.7849080562591553},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5657415986061096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5632820129394531},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5342292785644531},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4996616840362549},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4977722465991974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4726366400718689},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42558029294013977},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19808387756347656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17478054761886597},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06398272514343262}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003285","descriptor_name":"Contractile Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014648","descriptor_name":"Varicose Veins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014648","descriptor_name":"Varicose Veins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bsr20231938","doi":"https://doi.org/10.1042/bsr20231938","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bsr20231938","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11139664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11139664","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11139664/pdf/bsr-44-bsr20231938.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosci Rep","raw_type":"Text"},{"id":"pmid:38743016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38743016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bsr20231938","doi":"https://doi.org/10.1042/bsr20231938","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bsr20231938","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2978043618","display_name":null,"funder_award_id":"121031300045-2","funder_id":"https://openalex.org/F4320321770","funder_display_name":"Siberian Branch, Russian Academy of Sciences"},{"id":"https://openalex.org/G4088588877","display_name":null,"funder_award_id":"22-25-00832","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321770","display_name":"Siberian Branch, Russian Academy of Sciences","ror":"https://ror.org/02frkq021"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396889860.pdf","grobid_xml":"https://content.openalex.org/works/W4396889860.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W272428685","https://openalex.org/W1761895012","https://openalex.org/W1807798837","https://openalex.org/W1888543545","https://openalex.org/W1970256526","https://openalex.org/W1983845869","https://openalex.org/W1989946661","https://openalex.org/W1992585421","https://openalex.org/W1997453048","https://openalex.org/W2005220614","https://openalex.org/W2006643590","https://openalex.org/W2012315214","https://openalex.org/W2015291456","https://openalex.org/W2022640617","https://openalex.org/W2038722690","https://openalex.org/W2040365591","https://openalex.org/W2062982081","https://openalex.org/W2073587729","https://openalex.org/W2083962722","https://openalex.org/W2087256455","https://openalex.org/W2108000305","https://openalex.org/W2108664872","https://openalex.org/W2123032740","https://openalex.org/W2127919322","https://openalex.org/W2138868703","https://openalex.org/W2141963489","https://openalex.org/W2142745453","https://openalex.org/W2150202659","https://openalex.org/W2301098944","https://openalex.org/W2340146999","https://openalex.org/W2461434713","https://openalex.org/W2603718641","https://openalex.org/W2610903912","https://openalex.org/W2612011931","https://openalex.org/W2733972101","https://openalex.org/W2803325584","https://openalex.org/W2886902730","https://openalex.org/W2889057138","https://openalex.org/W2968658941","https://openalex.org/W3004061141","https://openalex.org/W3007080699","https://openalex.org/W3037268682","https://openalex.org/W3155119750","https://openalex.org/W3186572897","https://openalex.org/W3195911145","https://openalex.org/W3205554711","https://openalex.org/W4293101660","https://openalex.org/W4295715489","https://openalex.org/W4313544615","https://openalex.org/W4327703243","https://openalex.org/W4381164735","https://openalex.org/W7096449427"],"related_works":["https://openalex.org/W2886902730","https://openalex.org/W4310036749","https://openalex.org/W2018643013","https://openalex.org/W3088568493","https://openalex.org/W2033568177","https://openalex.org/W2360293452","https://openalex.org/W2038552616","https://openalex.org/W2100839439","https://openalex.org/W2264956975","https://openalex.org/W3047065290"],"abstract_inverted_index":{"Varicose":[0],"vein":[1,129],"disease":[2],"(VVD)":[3],"is":[4,14,146,161,211],"a":[5],"common":[6],"health":[7],"problem":[8],"worldwide.":[9],"Microfibril-associated":[10],"protein":[11],"5":[12],"(MFAP5)":[13],"one":[15,78],"of":[16,38,54,66,77,79,84,111,141,154,204],"the":[17,29,35,39,64,74,85,121,139,155,162,168,181,205],"potential":[18],"key":[19],"players":[20],"in":[21,34,44,81,126,148,171,188,214],"its":[22,50],"pathogenesis.":[23],"Our":[24,115],"previous":[25],"microarray":[26,61,116],"analysis":[27],"revealed":[28],"cg06256735":[30,122,169,182],"and":[31,72,91,101,123,133,183,208],"cg15815843":[32,124,184],"loci":[33,125,145,185],"regulatory":[36],"regions":[37],"MFAP5":[40,206],"gene":[41],"as":[42,106,108],"hypomethylated":[43],"varicose":[45,128,172],"veins":[46],"which":[47],"correlated":[48],"with":[49,190],"up-regulation.":[51],"The":[52],"aim":[53],"this":[55,215],"work":[56],"was":[57,135,176],"to":[58,165,192,202],"validate":[59],"preliminary":[60],"data,":[62],"estimate":[63],"level":[65,140],"5-hydroxymethylcytosine":[67],"(5hmC)":[68],"at":[69,120,143,167,180],"these":[70,144],"loci,":[71],"determine":[73],"methylation":[75],"status":[76],"them":[80],"different":[82],"layers":[83,153],"venous":[86,156],"wall.":[87],"For":[88],"this,":[89],"methyl-":[90],"hydroxymethyl-sensitive":[92],"restriction":[93],"techniques":[94],"were":[95,131],"used":[96],"followed":[97],"by":[98],"real-time":[99],"PCR":[100],"droplet":[102],"digital":[103],"PCR,":[104],"correspondingly,":[105],"well":[107],"bisulfite":[109],"pyrosequencing":[110],"+/-":[112],"oxidized":[113],"DNA.":[114],"data":[117],"on":[118],"hypomethylation":[119,166,179],"whole":[127],"segments":[130],"confirmed":[132],"it":[134,175,195],"also":[136],"demonstrated":[137],"that":[138,178,194],"5hmC":[142],"increased":[147],"VVD.":[149],"Specifically,":[150],"among":[151],"other":[152],"wall,":[157],"tunica":[158],"(t.)":[159],"intima":[160,210],"main":[163],"contributor":[164],"locus":[170],"veins.":[173],"Thus,":[174],"shown":[177],"takes":[186],"place":[187],"VVD,":[189],"evidence":[191],"suggest":[193],"happens":[196],"through":[197],"their":[198],"active":[199],"demethylation":[200],"leading":[201],"up-regulation":[203],"gene,":[207],"t.":[209],"most":[212],"involved":[213],"biochemical":[216],"process.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2024-05-15T00:00:00"}