{"id":"https://openalex.org/W4396889801","doi":"https://doi.org/10.1016/j.cell.2024.04.018","title":"An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis","display_name":"An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis","publication_year":2024,"publication_date":"2024-05-14","ids":{"openalex":"https://openalex.org/W4396889801","doi":"https://doi.org/10.1016/j.cell.2024.04.018","pmid":"https://pubmed.ncbi.nlm.nih.gov/38749423"},"language":"en","primary_location":{"id":"doi:10.1016/j.cell.2024.04.018","doi":"https://doi.org/10.1016/j.cell.2024.04.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2024.04.018","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cell.2024.04.018","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012079206","display_name":"Donna M. Poscablo","orcid":"https://orcid.org/0000-0002-5781-7121","observed_orcids":["https://orcid.org/0000-0002-5781-7121"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna M. Poscablo","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076251598","display_name":"Atesh K. Worthington","orcid":"https://orcid.org/0000-0003-3676-8735","observed_orcids":["https://orcid.org/0000-0003-3676-8735"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atesh K. Worthington","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053182940","display_name":"Stephanie Smith\u2010Berdan","orcid":"https://orcid.org/0000-0001-5406-2088","observed_orcids":["https://orcid.org/0000-0001-5406-2088"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Smith-Berdan","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076396564","display_name":"Marcel G. E. Rommel","orcid":"https://orcid.org/0000-0003-4861-3175","observed_orcids":["https://orcid.org/0000-0003-4861-3175"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel G.E. Rommel","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062336741","display_name":"Bryce A. Manso","orcid":"https://orcid.org/0000-0002-4860-4888","observed_orcids":["https://orcid.org/0000-0002-4860-4888"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryce A. Manso","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085977410","display_name":"Reheman Adili","orcid":"https://orcid.org/0000-0002-1973-9695","observed_orcids":["https://orcid.org/0000-0002-1973-9695"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reheman Adili","raw_affiliation_strings":["Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040242756","display_name":"Lydia Mok","orcid":"https://orcid.org/0000-0002-4029-5793","observed_orcids":["https://orcid.org/0000-0002-4029-5793"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia Mok","raw_affiliation_strings":["Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028618576","display_name":"Roman E. Reggiardo","orcid":"https://orcid.org/0000-0001-6309-249X","observed_orcids":["https://orcid.org/0000-0001-6309-249X"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman E. Reggiardo","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046409149","display_name":"Taylor Cool","orcid":"https://orcid.org/0000-0002-6595-3924","observed_orcids":["https://orcid.org/0000-0002-6595-3924"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Cool","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098489645","display_name":"Raana Mogharrab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raana Mogharrab","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108929111","display_name":"Jenna Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna Myers","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009953613","display_name":"Steven Dahmen","orcid":"https://orcid.org/0000-0002-3517-1358","observed_orcids":["https://orcid.org/0000-0002-3517-1358"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Dahmen","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062309180","display_name":"Paloma Medina","orcid":"https://orcid.org/0000-0001-6760-3525","observed_orcids":["https://orcid.org/0000-0001-6760-3525"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paloma Medina","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016171794","display_name":"Anna E. Beaudin","orcid":"https://orcid.org/0000-0002-8580-8660","observed_orcids":["https://orcid.org/0000-0002-8580-8660"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna E. Beaudin","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007758963","display_name":"Scott W. Boyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott W. Boyer","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Program in Biomedical Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088764798","display_name":"Michael A. Holinstat","orcid":"https://orcid.org/0000-0001-5100-1933","observed_orcids":["https://orcid.org/0000-0001-5100-1933"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Holinstat","raw_affiliation_strings":["Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039825744","display_name":"Vanessa D. J\u00f6nsson","orcid":"https://orcid.org/0000-0002-6732-9607","observed_orcids":["https://orcid.org/0000-0002-6732-9607"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa D. Jonsson","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Applied Mathematics, Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Applied Mathematics, Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Applied Mathematics, Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Applied Mathematics, Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032996052","display_name":"E. Camilla Forsberg","orcid":"https://orcid.org/0000-0002-8740-4299","observed_orcids":["https://orcid.org/0000-0002-8740-4299","https://orcid.org/0000-0003-0715-9703"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. Camilla Forsberg","raw_affiliation_strings":["Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: cforsber@ucsc.edu","Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: cforsber@ucsc.edu","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032996052"],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":{"value":10400,"currency":"USD","value_usd":10400},"fwci":30.6346,"has_fulltext":true,"cited_by_count":114,"citation_normalized_percentile":{"value":0.99838785,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"187","issue":"12","first_page":"3090","last_page":"3107.e21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9610000252723694},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/megakaryocyte-progenitors","display_name":"megakaryocyte progenitors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/platelet-hyperreactivity","display_name":"platelet hyperreactivity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/platelet-engraftment","display_name":"platelet engraftment","score":0.6729999780654907},{"id":"https://openalex.org/keywords/platelet-recovery","display_name":"platelet recovery","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7944245338439941},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7548019886016846},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.731207013130188},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.658400297164917},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6080466508865356},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6003807783126831},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.5679841041564941},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.553412914276123},{"id":"https://openalex.org/C2776958478","wikidata":"https://www.wikidata.org/wiki/Q14914622","display_name":"Thrombopoiesis","level":5,"score":0.4791676104068756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47641193866729736},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4675862789154053},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43480369448661804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32115137577056885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08896136283874512},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055016","descriptor_name":"Megakaryocyte Progenitor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.cell.2024.04.018","doi":"https://doi.org/10.1016/j.cell.2024.04.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2024.04.018","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"doi:10.1101/2024.02.23.581812","doi":"https://doi.org/10.1101/2024.02.23.581812","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.02.23.581812","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38749423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38749423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12047039","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12047039","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12047039/pdf/nihms-1993365.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.cell.2024.04.018","doi":"https://doi.org/10.1016/j.cell.2024.04.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2024.04.018","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1144470859","display_name":null,"funder_award_id":"K12 GM139185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1416682573","display_name":null,"funder_award_id":"CL1\u201000506","funder_id":"https://openalex.org/F4320306171","funder_display_name":"California Institute for Regenerative Medicine"},{"id":"https://openalex.org/G1538950135","display_name":"Defining regulators of hematopoietic stem cell self-renewal and lineage potential","funder_award_id":"F31HL151199","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2002586497","display_name":null,"funder_award_id":"R01 DK100917","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2098138821","display_name":null,"funder_award_id":"R01AG062879","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2172073287","display_name":null,"funder_award_id":"R25-GM058903","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2560966396","display_name":null,"funder_award_id":"T32 GM008646","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3031642474","display_name":"CIRM Training Program in Systems Biology of Stem Cells","funder_award_id":"EDUC4-12759","funder_id":"https://openalex.org/F4320306171","funder_display_name":"California Institute for Regenerative Medicine"},{"id":"https://openalex.org/G3122893257","display_name":null,"funder_award_id":"F99 DK131504","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3127232634","display_name":null,"funder_award_id":"T32GM133391","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3558977070","display_name":"Defining Cellular and Molecular Mechanisms of the Age-Specific Platelet Pathway","funder_award_id":"19PRE34370030","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6313571835","display_name":"CytoFLEX LX Cell Analyzer","funder_award_id":"1s10od030423-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6628019121","display_name":null,"funder_award_id":"T32GM8646","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8422508322","display_name":"UC Santa Cruz IBSC Facility","funder_award_id":"FA1-00617","funder_id":"https://openalex.org/F4320306171","funder_display_name":"California Institute for Regenerative Medicine"},{"id":"https://openalex.org/G9000047598","display_name":null,"funder_award_id":"R01DK100917","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000157085","display_name":null,"funder_award_id":"K12GM139185","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000279376","display_name":null,"funder_award_id":"R25GM058903","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000904686","display_name":"Hematopoietic circRNA-mediated intercellular communication","funder_award_id":"K00DK131504","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306171","display_name":"California Institute for Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308294","display_name":"Tobacco-Related Disease Research Program","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320309018","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W252852947","https://openalex.org/W1707922975","https://openalex.org/W1787222452","https://openalex.org/W1966952910","https://openalex.org/W1974659776","https://openalex.org/W1979058918","https://openalex.org/W1980867815","https://openalex.org/W1985801522","https://openalex.org/W1994254285","https://openalex.org/W1996058648","https://openalex.org/W2003550375","https://openalex.org/W2008223253","https://openalex.org/W2011059916","https://openalex.org/W2018566131","https://openalex.org/W2041982733","https://openalex.org/W2047342532","https://openalex.org/W2049682140","https://openalex.org/W2052670712","https://openalex.org/W2056868742","https://openalex.org/W2074337170","https://openalex.org/W2079785691","https://openalex.org/W2082462757","https://openalex.org/W2090786449","https://openalex.org/W2096364098","https://openalex.org/W2098528717","https://openalex.org/W2099894481","https://openalex.org/W2102100445","https://openalex.org/W2103911902","https://openalex.org/W2104010513","https://openalex.org/W2104994033","https://openalex.org/W2105311018","https://openalex.org/W2112504623","https://openalex.org/W2114917163","https://openalex.org/W2119739306","https://openalex.org/W2134924448","https://openalex.org/W2135359106","https://openalex.org/W2136952968","https://openalex.org/W2142242761","https://openalex.org/W2147407331","https://openalex.org/W2157285575","https://openalex.org/W2171172082","https://openalex.org/W2171245941","https://openalex.org/W2177432730","https://openalex.org/W2179438025","https://openalex.org/W2184331293","https://openalex.org/W2212630848","https://openalex.org/W2261428502","https://openalex.org/W2296754768","https://openalex.org/W2410975830","https://openalex.org/W2443001171","https://openalex.org/W2474073575","https://openalex.org/W2491676614","https://openalex.org/W2509957998","https://openalex.org/W2511159179","https://openalex.org/W2521223951","https://openalex.org/W2567309032","https://openalex.org/W2673025512","https://openalex.org/W2736836364","https://openalex.org/W2743072594","https://openalex.org/W2753382806","https://openalex.org/W2781886817","https://openalex.org/W2788263670","https://openalex.org/W2800392236","https://openalex.org/W2802571930","https://openalex.org/W2807354979","https://openalex.org/W2904698165","https://openalex.org/W2923030606","https://openalex.org/W2924219434","https://openalex.org/W2938719760","https://openalex.org/W2943400272","https://openalex.org/W2949177718","https://openalex.org/W2950372712","https://openalex.org/W2953020124","https://openalex.org/W2957271680","https://openalex.org/W2957572140","https://openalex.org/W2964263062","https://openalex.org/W2974298506","https://openalex.org/W2974806336","https://openalex.org/W2979787352","https://openalex.org/W2986117925","https://openalex.org/W2990741917","https://openalex.org/W2995703197","https://openalex.org/W2999304916","https://openalex.org/W3003299879","https://openalex.org/W3027944362","https://openalex.org/W3049244854","https://openalex.org/W3083850254","https://openalex.org/W3112884628","https://openalex.org/W3118792832","https://openalex.org/W3152911680","https://openalex.org/W3161048064","https://openalex.org/W3165498186","https://openalex.org/W3202649987","https://openalex.org/W3206723683","https://openalex.org/W3209567259","https://openalex.org/W4207017407","https://openalex.org/W4286254590","https://openalex.org/W4289550421","https://openalex.org/W4309593291","https://openalex.org/W4317039246","https://openalex.org/W4365447548","https://openalex.org/W4390618996","https://openalex.org/W6688366440","https://openalex.org/W6731558535","https://openalex.org/W6761364532","https://openalex.org/W6802771981"],"related_works":["https://openalex.org/W1989137940","https://openalex.org/W2353488883","https://openalex.org/W159266914","https://openalex.org/W4247064414","https://openalex.org/W2122641876","https://openalex.org/W2411378646","https://openalex.org/W6403905","https://openalex.org/W2366058481","https://openalex.org/W2059903063","https://openalex.org/W4232821633"],"abstract_inverted_index":{"Platelet":[0],"dysregulation":[1,148],"is":[2,36,46],"drastically":[3],"increased":[4,120],"with":[5,63,132],"advanced":[6],"age":[7],"and":[8,55,72,92,97,100,118,149],"contributes":[9],"to":[10,88],"making":[11],"cardiovascular":[12],"disorders":[13],"the":[14,42,133],"leading":[15],"cause":[16,115],"of":[17,19,76,112],"death":[18],"elderly":[20],"humans.":[21],"Here,":[22],"we":[23],"reveal":[24,139],"a":[25,84,144],"direct":[26],"differentiation":[27],"pathway":[28],"from":[29,48],"hematopoietic":[30,51],"stem":[31,140],"cells":[32],"into":[33],"platelets":[34,94,114,127],"that":[35],"progressively":[37],"propagated":[38],"upon":[39,98],"aging.":[40],"Remarkably,":[41],"aging-enriched":[43,126],"platelet":[44,65,104,135,147],"path":[45],"decoupled":[47],"all":[49],"other":[50],"lineages,":[52],"including":[53],"erythropoiesis,":[54],"operates":[56],"as":[57,143],"an":[58,102],"additional":[59,103],"layer":[60],"in":[61,69,95,106,122],"parallel":[62],"canonical":[64,134],"production.":[66],"This":[67],"results":[68],"two":[70,110],"molecularly":[71],"functionally":[73,129],"distinct":[74],"populations":[75],"megakaryocyte":[77,81],"progenitors.":[78],"The":[79,109],"age-induced":[80,150],"progenitors":[82],"have":[83],"profoundly":[85],"enhanced":[86],"capacity":[87],"engraft,":[89],"expand,":[90],"restore,":[91],"reconstitute":[93],"situ":[96],"transplantation":[99],"produce":[101],"population":[105],"old":[107],"mice.":[108],"pools":[111],"co-existing":[113],"age-related":[116],"thrombocytosis":[117],"dramatically":[119],"thrombosis":[121],"vivo":[123],".":[124],"Strikingly,":[125],"are":[128],"hyper-reactive":[130],"compared":[131],"populations.":[136],"These":[137],"findings":[138],"cell-based":[141],"aging":[142],"mechanism":[145],"for":[146],"thrombosis.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":63},{"year":2024,"cited_by_count":22}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
