{"id":"https://openalex.org/W4396884241","doi":"https://doi.org/10.1080/15257770.2024.2351135","title":"The emerging roles of glutamine amidotransferases in metabolism and immune defense","display_name":"The emerging roles of glutamine amidotransferases in metabolism and immune defense","publication_year":2024,"publication_date":"2024-05-14","ids":{"openalex":"https://openalex.org/W4396884241","doi":"https://doi.org/10.1080/15257770.2024.2351135","pmid":"https://pubmed.ncbi.nlm.nih.gov/38743960","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11561158"},"language":"en","primary_location":{"id":"doi:10.1080/15257770.2024.2351135","doi":"https://doi.org/10.1080/15257770.2024.2351135","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15257770.2024.2351135","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides & Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11561158/pdf/nihms-1992978.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102664434","display_name":"Taolin Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taolin Xie","raw_affiliation_strings":["Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014900922","display_name":"Chao Qin","orcid":"https://orcid.org/0000-0002-3766-771X","observed_orcids":["https://orcid.org/0000-0002-3766-771X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao Qin","raw_affiliation_strings":["Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053814912","display_name":"Ali Can Savas","orcid":"https://orcid.org/0000-0002-2630-9765","observed_orcids":["https://orcid.org/0000-0002-2630-9765"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Can Savas","raw_affiliation_strings":["Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002016215","display_name":"Wayne Wei Yeh","orcid":"https://orcid.org/0000-0002-4477-1523","observed_orcids":["https://orcid.org/0000-0002-4477-1523"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Wei Yeh","raw_affiliation_strings":["Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025300076","display_name":"Pinghui Feng","orcid":"https://orcid.org/0000-0002-8494-0205","observed_orcids":["https://orcid.org/0000-0002-8494-0205"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pinghui Feng","raw_affiliation_strings":["Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025300076"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"],"apc_list":null,"apc_paid":null,"fwci":0.2963,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.27698346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"8","first_page":"783","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine-amidotransferase","display_name":"glutamine amidotransferase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carbamoyl-phosphate-synthetase","display_name":"carbamoyl phosphate synthetase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/aspartate-transcarbamoylase","display_name":"aspartate transcarbamylase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dihydroorotase","display_name":"dihydroorotase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/deamidation","display_name":"deamidation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.925000011920929},{"id":"https://openalex.org/keywords/irf3","display_name":"IRF3","score":0.7870000004768372},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nucleotide-biosynthesis","display_name":"nucleotide synthesis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.4309999942779541},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6849647164344788},{"id":"https://openalex.org/C75972863","wikidata":"https://www.wikidata.org/wiki/Q5572442","display_name":"Glutamine amidotransferase","level":4,"score":0.6213488578796387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48992079496383667},{"id":"https://openalex.org/C200159599","wikidata":"https://www.wikidata.org/wiki/Q4893563","display_name":"Pyrimidine metabolism","level":4,"score":0.45008084177970886},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.4469418525695801},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3970830738544464},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1634737253189087},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004080","descriptor_name":"Dihydroorotase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004080","descriptor_name":"Dihydroorotase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019884","descriptor_name":"Nitrogenous Group Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019884","descriptor_name":"Nitrogenous Group Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/15257770.2024.2351135","doi":"https://doi.org/10.1080/15257770.2024.2351135","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15257770.2024.2351135","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides & Nucleic Acids","raw_type":"journal-article"},{"id":"pmid:38743960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38743960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, nucleotides & nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11561158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11561158","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11561158/pdf/nihms-1992978.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nucleosides Nucleotides Nucleic Acids","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11561158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11561158","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11561158/pdf/nihms-1992978.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nucleosides Nucleotides Nucleic Acids","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000885156","display_name":"Targeting the UL37 deamidase to impede HSV-1 infection.","funder_award_id":"R21AI180537","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000901654","display_name":"Explore roles of HSV-1 in Alzheimer's disease using mouse models","funder_award_id":"R01AG070904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000906922","display_name":"Targeting IKKepsilon-mediated nucleotide synthesis in KSHV-associated lymphoma","funder_award_id":"R01CA285192","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396884241.pdf","grobid_xml":"https://content.openalex.org/works/W4396884241.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W258596374","https://openalex.org/W1498172398","https://openalex.org/W1515253719","https://openalex.org/W1971277788","https://openalex.org/W1973401683","https://openalex.org/W1982789056","https://openalex.org/W1988512943","https://openalex.org/W2002643808","https://openalex.org/W2009916210","https://openalex.org/W2016379301","https://openalex.org/W2019737732","https://openalex.org/W2022410225","https://openalex.org/W2039376541","https://openalex.org/W2044220221","https://openalex.org/W2044510190","https://openalex.org/W2068528443","https://openalex.org/W2077272581","https://openalex.org/W2078154360","https://openalex.org/W2081117751","https://openalex.org/W2085698632","https://openalex.org/W2100153775","https://openalex.org/W2114605359","https://openalex.org/W2117008370","https://openalex.org/W2129920232","https://openalex.org/W2135005899","https://openalex.org/W2141935262","https://openalex.org/W2148994791","https://openalex.org/W2160409135","https://openalex.org/W2549958644","https://openalex.org/W2564332693","https://openalex.org/W2618191408","https://openalex.org/W2619620886","https://openalex.org/W2692288543","https://openalex.org/W2810891852","https://openalex.org/W2885484032","https://openalex.org/W2896506245","https://openalex.org/W2920596865","https://openalex.org/W2965966058","https://openalex.org/W2999334526","https://openalex.org/W3005790512","https://openalex.org/W3008639120","https://openalex.org/W3012246982","https://openalex.org/W3017736279","https://openalex.org/W3020644521","https://openalex.org/W3041527737","https://openalex.org/W3122243405","https://openalex.org/W3126320933","https://openalex.org/W3129152643","https://openalex.org/W3150873048","https://openalex.org/W3185125009","https://openalex.org/W3187018839","https://openalex.org/W3199337201","https://openalex.org/W3203974713","https://openalex.org/W4205574033","https://openalex.org/W4206508239","https://openalex.org/W4221039709","https://openalex.org/W4282843783","https://openalex.org/W4289202490","https://openalex.org/W4296343389","https://openalex.org/W4319310697","https://openalex.org/W4361029823","https://openalex.org/W4376121363","https://openalex.org/W4378173489","https://openalex.org/W4379878802","https://openalex.org/W4381716813","https://openalex.org/W4386369826","https://openalex.org/W4388007308","https://openalex.org/W4388824967","https://openalex.org/W4409926946"],"related_works":["https://openalex.org/W4282843783","https://openalex.org/W3126273453","https://openalex.org/W4405763702","https://openalex.org/W3104970765","https://openalex.org/W3121469875","https://openalex.org/W2205723570","https://openalex.org/W4387121489","https://openalex.org/W2768606928","https://openalex.org/W4405185425","https://openalex.org/W3169837457"],"abstract_inverted_index":{"Glutamine":[0],"amidotransferases":[1],"(GATs)":[2],"catalyze":[3],"the":[4,36,41,46,85,95,116],"synthesis":[5,78],"of":[6,35,45,87,94,126,137,211],"nucleotides,":[7],"amino":[8],"acids,":[9],"glycoproteins":[10],"and":[11,28,39,76,142,181,193,216],"an":[12,207],"enzyme":[13,34],"cofactor,":[14],"thus":[15,147],"serving":[16],"as":[17],"key":[18,88],"metabolic":[19],"enzymes":[20],"for":[21,105],"cell":[22],"proliferation.":[23],"Carbamoyl-phosphate":[24],"synthetase,":[25],"Aspartate":[26],"transcarbamoylase,":[27],"Dihydroorotase":[29],"(CAD)":[30],"is":[31],"a":[32,220],"multifunctional":[33],"GAT":[37],"family":[38],"catalyzes":[40],"first":[42],"three":[43],"steps":[44],"de":[47],"novo":[48],"pyrimidine":[49],"synthesis.":[50,132],"Following":[51],"our":[52],"findings":[53],"that":[54,67,93,156],"cellular":[55,70,212],"GATs":[56,213],"are":[57],"involved":[58],"in":[59,186,199,214],"immune":[60,197,217],"evasion":[61,125],"during":[62],"herpesvirus":[63,200],"infection,":[64],"we":[65,153],"discovered":[66],"CAD":[68,109,122,138],"reprograms":[69],"metabolism":[71,215],"to":[72,123,129,168],"fuel":[73],"aerobic":[74],"glycolysis":[75],"nucleotide":[77,131,140],"via":[79,107],"deamidating":[80,187],"RelA.":[81],"Deamidated":[82],"RelA":[83,104,113],"activates":[84,121],"expression":[86],"glycolytic":[89],"enzymes,":[90],"rather":[91],"than":[92],"inflammatory":[96,127,145],"NF-\u03baB-responsive":[97],"genes.":[98],"As":[99],"such,":[100],"cancer":[101],"cells":[102],"prime":[103],"deamidation":[106],"up-regulating":[108],"activity":[110,210],"or":[111],"accumulating":[112],"mutations.":[114],"Interestingly,":[115],"recently":[117],"emerged":[118],"SARS-CoV-2":[119,150],"also":[120,154],"couple":[124],"response":[128],"activated":[130],"A":[133],"small":[134],"molecule":[135],"inhibitor":[136],"depletes":[139],"supply":[141],"boosts":[143],"antiviral":[144],"response,":[146],"greatly":[148],"reducing":[149],"replication.":[151],"Additionally,":[152],"found":[155],"CTP":[157],"synthase":[158,179],"1":[159],"(CTPS1)":[160],"deamidates":[161],"interferon":[162],"(IFN)":[163],"regulatory":[164],"factor":[165],"3":[166],"(IRF3)":[167],"mute":[169],"IFN":[170],"induction.":[171],"Our":[172],"previous":[173],"studies":[174,204],"have":[175,205],"implicated":[176],"phosphoribosyl":[177,182],"formylglycinamidine":[178],"(PFAS)":[180],"pyrophosphate":[183],"amidotransferase":[184],"(PPAT)":[185],"retinoic":[188],"acid-inducible":[189],"gene":[190],"I":[191],"(RIG-I)":[192],"evading":[194],"dsRNA-induced":[195],"innate":[196],"defense":[198],"infection.":[201],"Overall,":[202],"these":[203,225],"uncovered":[206],"unconventional":[208],"enzymatic":[209],"defense,":[218],"offering":[219],"molecular":[221],"link":[222],"intimately":[223],"coupling":[224],"fundamental":[226],"biological":[227],"processes.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-15T00:00:00"}