{"id":"https://openalex.org/W4396869929","doi":"https://doi.org/10.18311/ti/2024/v31i2/34752","title":"Safety Assessment of Ciprofloxacin and Roxithromycin through Haematological and Biochemical Profiling in Poultry","display_name":"Safety Assessment of Ciprofloxacin and Roxithromycin through Haematological and Biochemical Profiling in Poultry","publication_year":2024,"publication_date":"2024-05-09","ids":{"openalex":"https://openalex.org/W4396869929","doi":"https://doi.org/10.18311/ti/2024/v31i2/34752"},"language":"en","primary_location":{"id":"doi:10.18311/ti/2024/v31i2/34752","doi":"https://doi.org/10.18311/ti/2024/v31i2/34752","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18311/ti/2024/v31i2/34752","pdf_url":null,"source":{"id":"https://openalex.org/S70869226","display_name":"Toxicology International","issn_l":"0971-6580","issn":["0971-6580","0976-5131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://dx.doi.org/10.18311/ti/2024/v31i2/34752","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024476996","display_name":"Ratn Deep Singh","orcid":"https://orcid.org/0000-0003-1725-6128","observed_orcids":["https://orcid.org/0000-0003-1725-6128"]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ratn Deep Singh","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112328337","display_name":"Hitesh B. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hitesh B. Patel","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002209303","display_name":"Vaidehi N. Sarvaiya","orcid":"https://orcid.org/0000-0003-2362-6113","observed_orcids":["https://orcid.org/0000-0003-2362-6113"]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vaidehi N. Sarvaiya","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113909797","display_name":"Samir H. Raval","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samir H. Raval","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat","institution_ids":["https://openalex.org/I3133099055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037092749","display_name":"Sarita Devi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133099055","display_name":"Kamdhenu University","ror":"https://ror.org/02k3mav14","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133099055"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarita Devi","raw_affiliation_strings":["Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry Kamdhenu University, Sardarkrushinagar \u2013 385506, Gujarat","institution_ids":["https://openalex.org/I3133099055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3133099055"],"apc_list":null,"apc_paid":null,"fwci":0.5046,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54503125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"2024","issue":"2","first_page":"335","last_page":"342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.42820000648498535,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.42820000648498535,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":1.0},{"id":"https://openalex.org/keywords/roxithromycin","display_name":"roxithromycin","score":1.0},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.828000009059906},{"id":"https://openalex.org/keywords/broiler-chickens","display_name":"broiler chickens","score":0.8140000104904175},{"id":"https://openalex.org/keywords/concurrent-drug-administration","display_name":"concurrent drug administration","score":0.5690000057220459},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.800000011920929},{"id":"https://openalex.org/keywords/blood-chemistry","display_name":"serum biochemistry","score":0.7929999828338623},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mixed-bacterial-infection","display_name":"mixed bacterial infection","score":0.6710000038146973},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2778423520","wikidata":"https://www.wikidata.org/wiki/Q424037","display_name":"Roxithromycin","level":4,"score":0.9052366018295288},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.7318427562713623},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.6833866834640503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37751537561416626},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.36788350343704224},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34764179587364197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2769666016101837},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16191840171813965},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.13552796840667725},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.10146400332450867},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18311/ti/2024/v31i2/34752","doi":"https://doi.org/10.18311/ti/2024/v31i2/34752","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18311/ti/2024/v31i2/34752","pdf_url":null,"source":{"id":"https://openalex.org/S70869226","display_name":"Toxicology International","issn_l":"0971-6580","issn":["0971-6580","0976-5131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology International","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18311/ti/2024/v31i2/34752","doi":"https://doi.org/10.18311/ti/2024/v31i2/34752","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18311/ti/2024/v31i2/34752","pdf_url":null,"source":{"id":"https://openalex.org/S70869226","display_name":"Toxicology International","issn_l":"0971-6580","issn":["0971-6580","0976-5131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2001923470","https://openalex.org/W2004537334","https://openalex.org/W2018589208","https://openalex.org/W2058704203","https://openalex.org/W2062340036","https://openalex.org/W2068301725","https://openalex.org/W2127826649","https://openalex.org/W2542852919","https://openalex.org/W2886763278","https://openalex.org/W2892632538","https://openalex.org/W3092233380","https://openalex.org/W3199297976","https://openalex.org/W4229771035"],"related_works":["https://openalex.org/W3199297976","https://openalex.org/W1486843963","https://openalex.org/W894275635","https://openalex.org/W3089109299","https://openalex.org/W2799386423","https://openalex.org/W7162304311","https://openalex.org/W1573265825","https://openalex.org/W3139281679","https://openalex.org/W2229227404","https://openalex.org/W7207921837"],"abstract_inverted_index":{"The":[0,22,171,228],"concurrent":[1,85,236],"therapeutic":[2,99,248],"application":[3],"of":[4,34,51,63,87,215,239],"ciprofloxacin":[5,37,90,242],"and":[6,30,38,89,117,135,140,165,169,184,204,219,241],"roxithromycin":[7,39,70,88,240],"has":[8],"been":[9],"suggested":[10],"as":[11,181],"a":[12,49,143,216],"potential":[13],"approach":[14],"for":[15,75,91,247],"addressing":[16],"mixed":[17],"bacterial":[18],"infections":[19],"in":[20,44,177,250],"poultry.":[21,45,251],"present":[23],"investigation":[24],"aimed":[25],"to":[26,96,155,208,221,244],"determine":[27],"the":[28,41,67,79,159,195,201,225,232,235],"hematological":[29],"biochemical":[31,141,189],"safety":[32],"profile":[33],"concurrently":[35],"administered":[36,73],"through":[40],"oral":[42,237],"route":[43],"This":[46],"study":[47,229],"involved":[48],"total":[50],"sixteen":[52],"birds,":[53],"which":[54],"were":[55,106,205],"divided":[56],"into":[57],"two":[58],"equal":[59],"but":[60],"random":[61],"groups":[62],"broiler":[64],"chickens.":[65],"In":[66,101],"first":[68],"group,":[69],"alone":[71],"was":[72,150],"orally":[74],"five":[76,93],"days.":[77],"Conversely,":[78],"Group":[80],"II":[81],"birds":[82],"received":[83],"repeated":[84],"doses":[86],"consecutive":[92],"days":[94],"adhering":[95],"their":[97],"recommended":[98],"dosages.":[100],"both":[102],"groups,":[103],"blood":[104],"samples":[105],"collected":[107],"at":[108,118],"various":[109,162],"intervals,":[110],"including":[111],"before":[112],"drug":[113],"administration":[114,238],"(0":[115],"days),":[116],"6":[119],"hours,":[120,122],"12":[121],"1st":[123],"day,":[124,126,128,130,132,134],"2nd":[125],"3rd":[127],"4th":[129],"5th":[131],"7th":[133],"10th":[136,226],"day.":[137],"Following":[138],"haematological":[139,178],"analyses,":[142],"two-way":[144],"statistical":[145],"analysis":[146,172],"(p":[147],"\u2264":[148],"0.05)":[149],"conducted":[151],"utilizing":[152],"unpaired":[153],"\u2018t-tests\u2019":[154],"compare":[156],"parameters":[157,179],"within":[158,200],"group":[160],"across":[161],"time":[163],"points":[164],"between":[166],"Groups":[167],"I":[168],"II.":[170],"revealed":[173],"statistically":[174],"significant":[175],"differences":[176],"such":[180],"heterophils,":[182],"lymphocytes":[183],"monocytes,":[185],"along":[186],"with":[187,211],"one":[188],"parameter,":[190],"specifically":[191],"aspartate":[192],"transaminase.":[193],"Notably,":[194],"altered":[196],"values":[197],"primarily":[198],"remained":[199],"normal":[202,222],"range":[203],"often":[206],"attributed":[207],"age-related":[209],"changes,":[210],"certain":[212],"fluctuations":[213],"being":[214],"temporary":[217],"nature":[218],"reverting":[220],"levels":[223],"by":[224],"Day.":[227],"findings":[230],"support":[231],"conclusion":[233],"that":[234],"appears":[243],"be":[245],"safe":[246],"use":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-14T00:00:00"}
