{"id":"https://openalex.org/W4396866094","doi":"https://doi.org/10.2147/orr.s454211","title":"Investigating the Impact of Gut Microbiota on Gout Through Mendelian Randomization","display_name":"Investigating the Impact of Gut Microbiota on Gout Through Mendelian Randomization","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396866094","doi":"https://doi.org/10.2147/orr.s454211","pmid":"https://pubmed.ncbi.nlm.nih.gov/38766545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11100514"},"language":"en","primary_location":{"id":"doi:10.2147/orr.s454211","doi":"https://doi.org/10.2147/orr.s454211","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2147/orr.s454211","pdf_url":"https://www.dovepress.com/article/download/92583","source":{"id":"https://openalex.org/S4210183204","display_name":"Orthopedic Research and Reviews","issn_l":"1179-1462","issn":["1179-1462"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic Research and Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/92583","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082949170","display_name":"Chaoqun Tang","orcid":"https://orcid.org/0009-0000-8098-1491","observed_orcids":["https://orcid.org/0009-0000-8098-1491"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoqun Tang","raw_affiliation_strings":["The First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, People's Republic of China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440229","display_name":"Lei Li","orcid":"https://orcid.org/0000-0001-5478-5681","observed_orcids":["https://orcid.org/0000-0001-5478-5681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Jin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Jin","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jinfeng Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinfeng Wang","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031214130","display_name":"Debao Zou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debao Zou","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105230056","display_name":"Yan Hou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Hou","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Yu","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022791526","display_name":"Zhizhou Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhizhou Wang","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074392871","display_name":"Hongjiang Jiang","orcid":"https://orcid.org/0000-0001-8366-9030","observed_orcids":["https://orcid.org/0000-0001-8366-9030"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongjiang Jiang","raw_affiliation_strings":["Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","The First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shandong Wendeng Osteopathic Hospital, Wendeng, Weihai, Shandong, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"The First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, People's Republic of China","institution_ids":["https://openalex.org/I253932293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074392871"],"corresponding_institution_ids":["https://openalex.org/I253932293"],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":0.2829,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58601967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"Volume 16","issue":null,"first_page":"125","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":1.0},{"id":"https://openalex.org/keywords/causal-relationship","display_name":"causal relationship","score":0.6759999990463257},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.5389999747276306},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.7760000228881836},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.4309999942779541},{"id":"https://openalex.org/keywords/reverse-causality","display_name":"reverse causality","score":0.5540000200271606},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9303486347198486},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.6976233720779419},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5537706613540649},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.5326656103134155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46394726634025574},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4537603259086609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4363192319869995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3822644054889679},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32711872458457947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2151569426059723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18002063035964966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1511789858341217},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12267196178436279},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.08639892935752869}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/orr.s454211","doi":"https://doi.org/10.2147/orr.s454211","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2147/orr.s454211","pdf_url":"https://www.dovepress.com/article/download/92583","source":{"id":"https://openalex.org/S4210183204","display_name":"Orthopedic Research and Reviews","issn_l":"1179-1462","issn":["1179-1462"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic Research and Reviews","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11100514","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11100514","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11100514/pdf/orr-16-125.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthop Res Rev","raw_type":"Text"},{"id":"pmid:38766545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38766545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic research and reviews","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f296eddcc57f49bd80118d7dbc68f3cf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f296eddcc57f49bd80118d7dbc68f3cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Orthopedic Research and Reviews, Vol Volume 16, Pp 125-136 (2024)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/92583","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/investigating-the-impact-of-gut-microbiota-on-gout-through-mendelian-r-peer-reviewed-fulltext-article-ORR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/orr.s454211","doi":"https://doi.org/10.2147/orr.s454211","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2147/orr.s454211","pdf_url":"https://www.dovepress.com/article/download/92583","source":{"id":"https://openalex.org/S4210183204","display_name":"Orthopedic Research and Reviews","issn_l":"1179-1462","issn":["1179-1462"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic Research and Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396866094.pdf","grobid_xml":"https://content.openalex.org/works/W4396866094.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W58609645","https://openalex.org/W1994728710","https://openalex.org/W2027533925","https://openalex.org/W2031580166","https://openalex.org/W2039670227","https://openalex.org/W2102090134","https://openalex.org/W2127768736","https://openalex.org/W2143685991","https://openalex.org/W2165067288","https://openalex.org/W2167255704","https://openalex.org/W2231828571","https://openalex.org/W2259791095","https://openalex.org/W2398894736","https://openalex.org/W2480559039","https://openalex.org/W2512982082","https://openalex.org/W2589364187","https://openalex.org/W2593868476","https://openalex.org/W2597385654","https://openalex.org/W2626193283","https://openalex.org/W2649650290","https://openalex.org/W2756936698","https://openalex.org/W2794410882","https://openalex.org/W2799953574","https://openalex.org/W2890217985","https://openalex.org/W2900697674","https://openalex.org/W2911894135","https://openalex.org/W2912337330","https://openalex.org/W2943098102","https://openalex.org/W2951518977","https://openalex.org/W2957204701","https://openalex.org/W2977901918","https://openalex.org/W2990527038","https://openalex.org/W3009231580","https://openalex.org/W3012253283","https://openalex.org/W3034280373","https://openalex.org/W3082070848","https://openalex.org/W3083241614","https://openalex.org/W3097581821","https://openalex.org/W3121407008","https://openalex.org/W3127857648","https://openalex.org/W3159655893","https://openalex.org/W3174798679","https://openalex.org/W3181007031","https://openalex.org/W3188678456","https://openalex.org/W3204928994","https://openalex.org/W3215014958","https://openalex.org/W4200098527","https://openalex.org/W4200191093","https://openalex.org/W4205330071","https://openalex.org/W4210445316","https://openalex.org/W4214511086","https://openalex.org/W4221009473","https://openalex.org/W4225145169","https://openalex.org/W4225469642","https://openalex.org/W4239736175","https://openalex.org/W4248403572","https://openalex.org/W4280553002","https://openalex.org/W4289443609","https://openalex.org/W4289732321","https://openalex.org/W4292470340","https://openalex.org/W4292488414","https://openalex.org/W4292686437","https://openalex.org/W4293769721","https://openalex.org/W4298140805","https://openalex.org/W4321446752","https://openalex.org/W4361276491","https://openalex.org/W4387369866","https://openalex.org/W4391177849"],"related_works":["https://openalex.org/W4387369866","https://openalex.org/W4379651131","https://openalex.org/W4391177849","https://openalex.org/W7011450098","https://openalex.org/W7216544154","https://openalex.org/W4404048591","https://openalex.org/W7017854481","https://openalex.org/W7116284328","https://openalex.org/W4415339671","https://openalex.org/W4402031850"],"abstract_inverted_index":{"Background:":[0],"The":[1,69],"relationship":[2,42,127,182,209],"between":[3,43,128,141,183,210,243],"gout":[4,29,56,99,144,184,214,237,259],"and":[5,46,57,64,67,119,131,143,185,215,226,247,260,269],"gut":[6,22,44,129,186,217,245],"microbiota":[7,45,130,187],"has":[8],"attracted":[9],"significant":[10,180,191,241],"attention":[11],"in":[12,145,167,236],"current":[13],"research.":[14],"However,":[15],"due":[16],"to":[17,38,49,83,123,155,173,231],"the":[18,24,40,51,77,103,125,168,174,211,220,240,255],"diverse":[19],"range":[20],"of":[21,54,93,170,193,213,257],"microbiota,":[23,246],"specific":[25,216],"causal":[26,41,126,139,181,208,221],"effect":[27,222],"on":[28,90,254,267],"remains":[30],"unclear.":[31],"This":[32],"study":[33,73],"utilizes":[34],"Mendelian":[35,87,134,147,176],"randomization":[36,88,135,148],"(MR)":[37],"investigate":[39],"gout,":[47,248],"aiming":[48],"elucidate":[50,232],"underlying":[52,234],"mechanism":[53,235],"microbiome-mediated":[55],"provide":[58,261],"valuable":[59],"guidance":[60],"for":[61,98,264,272],"clinical":[62],"prevention":[63],"treatment.":[65],"Materials":[66],"Methods:":[68],"largest":[70],"genome-wide":[71],"association":[72,140,242],"meta-analysis":[74],"conducted":[75],"by":[76,106],"MiBioGen":[78],"Consortium":[79],"(n=18,340)":[80],"was":[81,153,188,199,223],"utilized":[82,101],"perform":[84],"a":[85,138,164,206],"two-sample":[86],"investigation":[89],"aggregate":[91],"statistics":[92,97],"intestinal":[94],"microbiota.":[95],"Summary":[96],"were":[100,121],"from":[102],"data":[104],"released":[105],"EBI.":[107],"Various":[108],"methods,":[109],"including":[110],"inverse":[111],"variance":[112],"weighted,":[113],"weighted":[114,116],"median,":[115],"model,":[117],"MR-Egger,":[118],"Simple-mode,":[120],"employed":[122],"assess":[124],"gout.":[132,171],"Reverse":[133],"analysis":[136,204],"revealed":[137,205],"bacteria":[142],"forward":[146],"analysis.":[149],"Cochran's":[150],"Q":[151],"statistic":[152],"used":[154],"quantify":[156],"instrumental":[157,194],"variable":[158],"heterogeneity.":[159],"Results:":[160],"is":[161,229],"associated":[162],"with":[163],"marginal":[165],"increase":[166],"risk":[169],"According":[172],"reverse":[175],"Randomization":[177],"results,":[178],"no":[179],"observed.":[189],"No":[190],"heterogeneity":[192],"variables":[195],"or":[196],"level":[197],"pleiotropy":[198],"detected.":[200],"Conclusion:":[201],"Our":[202],"MR":[203],"potential":[207],"development":[212],"microbiota;":[218],"however,":[219],"not":[224],"robust,":[225],"further":[227],"research":[228,266],"warranted":[230],"its":[233],"development.":[238],"Considering":[239],"diet,":[244],"these":[249],"findings":[250],"undoubtedly":[251],"shed":[252],"light":[253],"mechanisms":[256],"microbiota-mediated":[258],"new":[262],"insights":[263],"translational":[265],"managing":[268],"standardizing":[270],"treatment":[271],"this":[273],"condition.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-14T00:00:00"}
