{"id":"https://openalex.org/W4396865752","doi":"https://doi.org/10.1007/s12672-024-01030-z","title":"Clinical research progress of callisperes\u00ae of drug-loaded microsphere arterial chemoembolisation in the treatment of solid tumors","display_name":"Clinical research progress of callisperes\u00ae of drug-loaded microsphere arterial chemoembolisation in the treatment of solid tumors","publication_year":2024,"publication_date":"2024-05-13","ids":{"openalex":"https://openalex.org/W4396865752","doi":"https://doi.org/10.1007/s12672-024-01030-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/38739205","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11091040"},"language":"en","primary_location":{"id":"doi:10.1007/s12672-024-01030-z","doi":"https://doi.org/10.1007/s12672-024-01030-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-024-01030-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s12672-024-01030-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100422785","display_name":"Qin Wang","orcid":"https://orcid.org/0000-0002-2095-6216","observed_orcids":["https://orcid.org/0000-0002-2095-6216"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Wang","raw_affiliation_strings":["Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023570853","display_name":"Lujian Zhu","orcid":"https://orcid.org/0009-0002-4996-1446","observed_orcids":["https://orcid.org/0009-0002-4996-1446"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lujian Zhu","raw_affiliation_strings":["Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109460962","display_name":"Qiyue Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiyue Sheng","raw_affiliation_strings":["Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China. jhsqy139@163.com","Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China. jhsqy139@163.com","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109460962"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":1590,"currency":"USD","value_usd":1590},"apc_paid":{"value":1590,"currency":"USD","value_usd":1590},"fwci":0.4629,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.48101266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"161","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/deb-tace","display_name":"DEB-TACE","score":0.9679999947547913},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.6050000190734863},{"id":"https://openalex.org/keywords/tumor-ischemia","display_name":"tumor ischemia","score":0.746999979019165},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8009099960327148},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6876009106636047},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.613483726978302},{"id":"https://openalex.org/C2776035437","wikidata":"https://www.wikidata.org/wiki/Q1144114","display_name":"Embolization","level":2,"score":0.5625633001327515},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5230194926261902},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47494983673095703},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.470452219247818},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.46317699551582336},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32205232977867126},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2983614206314087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2769049406051636},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27629563212394714},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12672-024-01030-z","doi":"https://doi.org/10.1007/s12672-024-01030-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-024-01030-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11091040","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11091040","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11091040/pdf/12672_2024_Article_1030.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discov Oncol","raw_type":"Text"},{"id":"pmid:38739205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38739205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:787951cd76cb42fc9a762306620e5a20","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/787951cd76cb42fc9a762306620e5a20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discover Oncology, Vol 15, Iss 1, Pp 1-11 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s12672-024-01030-z","doi":"https://doi.org/10.1007/s12672-024-01030-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-024-01030-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396865752.pdf","grobid_xml":"https://content.openalex.org/works/W4396865752.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W637337048","https://openalex.org/W1508040108","https://openalex.org/W1931139149","https://openalex.org/W1994025913","https://openalex.org/W2165447592","https://openalex.org/W2401992257","https://openalex.org/W2604604189","https://openalex.org/W2783948736","https://openalex.org/W2785436625","https://openalex.org/W2786875112","https://openalex.org/W2810298246","https://openalex.org/W2827438165","https://openalex.org/W2845792910","https://openalex.org/W2898016307","https://openalex.org/W2902438402","https://openalex.org/W2912094798","https://openalex.org/W2914501802","https://openalex.org/W2921460411","https://openalex.org/W2921901351","https://openalex.org/W2921970308","https://openalex.org/W2922394035","https://openalex.org/W2924128337","https://openalex.org/W2928954057","https://openalex.org/W2945092409","https://openalex.org/W2963679373","https://openalex.org/W2968150703","https://openalex.org/W2976516489","https://openalex.org/W2977895172","https://openalex.org/W2981142776","https://openalex.org/W2995576522","https://openalex.org/W2995905606","https://openalex.org/W3000623470","https://openalex.org/W3005329759","https://openalex.org/W3008736434","https://openalex.org/W3012687720","https://openalex.org/W3012793576","https://openalex.org/W3013564512","https://openalex.org/W3016606267","https://openalex.org/W3017381091","https://openalex.org/W3022552033","https://openalex.org/W3023057978","https://openalex.org/W3027152648","https://openalex.org/W3031584350","https://openalex.org/W3033280579","https://openalex.org/W3033849254","https://openalex.org/W3037610728","https://openalex.org/W3038128585","https://openalex.org/W3039916142","https://openalex.org/W3041693347","https://openalex.org/W3080208429","https://openalex.org/W3080956387","https://openalex.org/W3087170669","https://openalex.org/W3090624794","https://openalex.org/W3092560687","https://openalex.org/W3098883308","https://openalex.org/W3125224881","https://openalex.org/W3128646645","https://openalex.org/W3132765650","https://openalex.org/W3133626084","https://openalex.org/W3134553072","https://openalex.org/W3136507564","https://openalex.org/W3137016118","https://openalex.org/W3153308999","https://openalex.org/W3154088627","https://openalex.org/W3162305074","https://openalex.org/W3164925433","https://openalex.org/W3165606985","https://openalex.org/W3175662601","https://openalex.org/W3178440930","https://openalex.org/W3179576070","https://openalex.org/W3188467195","https://openalex.org/W3194445586","https://openalex.org/W3209050153","https://openalex.org/W3212473201","https://openalex.org/W4200085572","https://openalex.org/W4200407060","https://openalex.org/W4206878652","https://openalex.org/W4281787866","https://openalex.org/W4283325669","https://openalex.org/W4287427034","https://openalex.org/W4290704211","https://openalex.org/W4291391949","https://openalex.org/W4296299178","https://openalex.org/W4311287841","https://openalex.org/W4313333079","https://openalex.org/W4323356296","https://openalex.org/W4381715214","https://openalex.org/W4385583053","https://openalex.org/W4385751445","https://openalex.org/W4387764505","https://openalex.org/W4394796413","https://openalex.org/W7036665814"],"related_works":["https://openalex.org/W2988554877","https://openalex.org/W2369594162","https://openalex.org/W3179576070","https://openalex.org/W4389827370","https://openalex.org/W4321003529","https://openalex.org/W3125224881","https://openalex.org/W6960346553","https://openalex.org/W2084561148","https://openalex.org/W2783948736","https://openalex.org/W2922394035"],"abstract_inverted_index":{"Abstract":[0],"The":[1,186],"incidence":[2],"and":[3,16,51,62,97,116,141,183,202,204,215,241,287,292,308],"mortality":[4],"of":[5,49,88,112,156,173,188,233,244,280,285,290,296,321],"cancer":[6,212],"is":[7,26,56],"ever-increasing,":[8],"which":[9],"poses":[10],"a":[11,17,28,153,268],"significant":[12],"challengesto":[13],"human":[14],"health":[15],"substantial":[18],"economic":[19],"burden":[20],"to":[21,85,90,94,101,152,314],"patients.":[22,76],"At":[23],"present,":[24],"chemotherapy":[25,35,207,222],"still":[27],"primary":[29],"treatment":[30,320],"for":[31,60,75,318],"various":[32,305,324],"cancers.":[33],"However,":[34],"kills":[36],"tumors":[37,307],"but":[38,175],"also":[39,176],"induces":[40],"the":[41,72,86,225,230,234,239,257,278,283,293,319],"related":[42],"side":[43,73,242],"effects,":[44],"whichadversely":[45],"impacting":[46],"patient":[47],"quality":[48],"life":[50],"exacerbating":[52],"suffering.":[53],"Therefore,":[54,264],"there":[55],"an":[57,109],"urgent":[58],"need":[59],"new":[61,154,316],"effective":[63,110],"treatments":[64],"that":[65],"can":[66,167,210],"control":[67,115],"tumor":[68,92,104,114,200,258],"growth":[69],"while":[70],"reducing":[71],"effects":[74,243],"Arterial":[77],"chemoembolization":[78,129,193],"has":[79,107,117,177,266],"been":[80,118,136],"attracted":[81],"much":[82],"attentionwhich":[83],"attributed":[84],"advantage":[87],"ability":[89,182],"embolize":[91],"vessels":[93,228],"block":[95],"blood":[96,227,231],"nutrition":[98],"supplies.":[99],"Thus,":[100],"achieve":[102],"local":[103,113,253],"control,":[105],"it":[106],"become":[108,267],"means":[111],"widely":[119],"used":[120],"in":[121,271,304,323],"clinical":[122,272,302],"practice.":[123],"Despite":[124],"its":[125,261,301],"efficacy,":[126],"conventional":[127],"arterial":[128,192],"techniques,":[130],"limited":[131],"by":[132],"embolization":[133,140],"materials,":[134],"have":[135,148],"associated":[137],"with":[138,190],"incomplete":[139],"suboptimal":[142],"drug":[143,180,249,254],"delivery":[144],"outcomes.":[145],"Gradually,":[146],"researchers":[147],"shifted":[149],"their":[150,217],"attention":[151],"type":[155],"embolic":[157,163],"material":[158],"called":[159],"CalliSperes":[160],"\u00ae":[161],"drug-eluting":[162],"bead":[164],"(DEB).":[165],"DEB":[166],"not":[168],"only":[169],"load":[170],"high":[171],"doses":[172],"drugs,":[174],"strong":[178],"sustained":[179,248],"release":[181,250],"good":[184],"biocompatibility.":[185],"integration":[187],"DEBs":[189],"traditional":[191],"(DEB-TACE)":[194],"promises":[195],"targeted":[196],"vascular":[197],"embolization,":[198],"mitigated":[199],"ischemia":[201],"hypoxia,":[203],"direct":[205],"intravascular":[206],"delivery.":[208],"It":[209],"prevent":[211],"cell":[213],"differentiation":[214],"accelerate":[216],"death,":[218],"meanwhile,":[219],"directly":[220],"injecting":[221],"drugs":[223],"into":[224],"target":[226],"reduced":[229,238],"concentration":[232],"whole":[235],"body,":[236],"thus":[237],"toxic":[240],"chemotherapy.":[245],"Furthermore,":[246],"DEB-TACE's":[247],"capability":[251],"elevates":[252],"concentrations":[255],"at":[256],"site,":[259],"amplifying":[260],"antitumor":[262],"efficacy.":[263],"DEB-TACE":[265,322],"hot":[269],"spot":[270],"research":[273,286,303],"worldwide.":[274],"This":[275,311],"review":[276,312],"introduces":[277],"pathogenesis":[279],"solid":[281,306,325],"tumors,":[282],"background":[284],"biological":[288],"characteristics":[289],"DEB,":[291],"action":[294],"mechanism":[295],"DEB-TACE,":[297],"as":[298,300],"well":[299],"future":[309],"prospects.":[310],"aims":[313],"provide":[315],"ideas":[317],"tumors.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-05-14T00:00:00"}