{"id":"https://openalex.org/W4396863564","doi":"https://doi.org/10.1007/s00018-024-05245-9","title":"Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome","display_name":"Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome","publication_year":2024,"publication_date":"2024-05-13","ids":{"openalex":"https://openalex.org/W4396863564","doi":"https://doi.org/10.1007/s00018-024-05245-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/38739166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090972"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-024-05245-9","doi":"https://doi.org/10.1007/s00018-024-05245-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-024-05245-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-024-05245-9.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s00018-024-05245-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102876490","display_name":"Manon Moreau","orcid":"https://orcid.org/0009-0004-4746-5769","observed_orcids":["https://orcid.org/0009-0004-4746-5769"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manon Moreau","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008378681","display_name":"Rodolphe Dard","orcid":"https://orcid.org/0000-0001-5878-5064","observed_orcids":["https://orcid.org/0000-0001-5878-5064"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210109121","display_name":"Centre Hospitalier Intercommunal de Poissy","ror":"https://ror.org/015qy8r18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210109121"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]},{"id":"https://openalex.org/I4210166021","display_name":"Biologie de la Reproduction, Environnement, Epig\u00e9n\u00e9tique et D\u00e9veloppement","ror":"https://ror.org/05mfwtg94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I17606148","https://openalex.org/I195731000","https://openalex.org/I197681013","https://openalex.org/I277688954","https://openalex.org/I2800365227","https://openalex.org/I4210088668","https://openalex.org/I4210166021"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rodolphe Dard","raw_affiliation_strings":["D\u00e9partement de G\u00e9n\u00e9tique, CHI de Poissy St Germain en Laye, Poissy, 78300, France","Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","Universit\u00e9 Paris-Saclay, UVSQ, INRAE, ENVA, BREED, Jouy-en-Josas, 78350, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de G\u00e9n\u00e9tique, CHI de Poissy St Germain en Laye, Poissy, 78300, France","institution_ids":["https://openalex.org/I4210109121"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, INRAE, ENVA, BREED, Jouy-en-Josas, 78350, France","institution_ids":["https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210166021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027374470","display_name":"Am\u00e9lia Madani","orcid":"https://orcid.org/0000-0002-8891-4645","observed_orcids":["https://orcid.org/0000-0002-8891-4645"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387155530","display_name":"NeuroDiderot","ror":"https://ror.org/014ndnr76","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387155530"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Am\u00e9lia Madani","raw_affiliation_strings":["NeuroDiderot, INSERM, Universit\u00e9 Paris Cit\u00e9, Paris, F-75019, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NeuroDiderot, INSERM, Universit\u00e9 Paris Cit\u00e9, Paris, F-75019, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387155530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086166580","display_name":"Janany Kandiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Janany Kandiah","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029758858","display_name":"Nadim Kassis","orcid":"https://orcid.org/0000-0002-5013-0132","observed_orcids":["https://orcid.org/0000-0002-5013-0132"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nadim Kassis","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097983443","display_name":"Jessica Ziga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jessica Ziga","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016090360","display_name":"H\u00e9lo\u00efse Castiglione","orcid":"https://orcid.org/0000-0002-7543-0836","observed_orcids":["https://orcid.org/0000-0002-7543-0836"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9lo\u00efse Castiglione","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113206031","display_name":"Solenn Day","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Solenn Day","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079495682","display_name":"Thomas Bourgeois","orcid":"https://orcid.org/0000-0002-9565-9814","observed_orcids":["https://orcid.org/0000-0002-9565-9814"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387155530","display_name":"NeuroDiderot","ror":"https://ror.org/014ndnr76","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387155530"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Bourgeois","raw_affiliation_strings":["NeuroDiderot, INSERM, Universit\u00e9 Paris Cit\u00e9, Paris, F-75019, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NeuroDiderot, INSERM, Universit\u00e9 Paris Cit\u00e9, Paris, F-75019, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387155530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027084837","display_name":"Boris Matrot","orcid":"https://orcid.org/0000-0002-7845-9618","observed_orcids":["https://orcid.org/0000-0002-7845-9618"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387155530","display_name":"NeuroDiderot","ror":"https://ror.org/014ndnr76","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387155530"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Boris Matrot","raw_affiliation_strings":["NeuroDiderot, INSERM, Universit\u00e9 Paris Cit\u00e9, Paris, F-75019, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NeuroDiderot, INSERM, Universit\u00e9 Paris Cit\u00e9, Paris, F-75019, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387155530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024549593","display_name":"Fran\u00e7ois Vialard","orcid":"https://orcid.org/0000-0002-5774-2756","observed_orcids":["https://orcid.org/0000-0002-5774-2756"]},"institutions":[{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210109121","display_name":"Centre Hospitalier Intercommunal de Poissy","ror":"https://ror.org/015qy8r18","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210109121"]},{"id":"https://openalex.org/I4210166021","display_name":"Biologie de la Reproduction, Environnement, Epig\u00e9n\u00e9tique et D\u00e9veloppement","ror":"https://ror.org/05mfwtg94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I17606148","https://openalex.org/I195731000","https://openalex.org/I197681013","https://openalex.org/I277688954","https://openalex.org/I2800365227","https://openalex.org/I4210088668","https://openalex.org/I4210166021"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Vialard","raw_affiliation_strings":["D\u00e9partement de G\u00e9n\u00e9tique, CHI de Poissy St Germain en Laye, Poissy, 78300, France","Universit\u00e9 Paris-Saclay, UVSQ, INRAE, ENVA, BREED, Jouy-en-Josas, 78350, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de G\u00e9n\u00e9tique, CHI de Poissy St Germain en Laye, Poissy, 78300, France","institution_ids":["https://openalex.org/I4210109121"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, INRAE, ENVA, BREED, Jouy-en-Josas, 78350, France","institution_ids":["https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210166021"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051194462","display_name":"Nathalie Janel","orcid":"https://orcid.org/0000-0002-4746-8941","observed_orcids":["https://orcid.org/0000-0002-4746-8941"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nathalie Janel","raw_affiliation_strings":["Laboratoire BFA, Universit\u00e9 Paris Cit\u00e9, 3 rue Marie-Andr\u00e9e Lagroua Weill Hall\u00e9, Case, Paris cedex 13, 7104, F-75205, France. nathalie.janel@u-paris.fr","Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France. nathalie.janel@u-paris.fr","Laboratoire BFA, Universit\u00e9 Paris Cit\u00e9, 3 rue Marie-Andr\u00e9e Lagroua Weill Hall\u00e9, Case, Paris cedex 13, 7104, F-75205, France"],"raw_orcid":"https://orcid.org/0000-0002-4746-8941","affiliations":[{"raw_affiliation_string":"Laboratoire BFA, Universit\u00e9 Paris Cit\u00e9, 3 rue Marie-Andr\u00e9e Lagroua Weill Hall\u00e9, Case, Paris cedex 13, 7104, F-75205, France. nathalie.janel@u-paris.fr","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210137329"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, BFA, UMR 8251, CNRS, Paris, F-75013, France. nathalie.janel@u-paris.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]},{"raw_affiliation_string":"Laboratoire BFA, Universit\u00e9 Paris Cit\u00e9, 3 rue Marie-Andr\u00e9e Lagroua Weill Hall\u00e9, Case, Paris cedex 13, 7104, F-75205, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5051194462"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":1.3154,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77986218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"81","issue":"1","first_page":"215","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/preimplantation-factor","display_name":"preimplantation factor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/fetal-therapy","display_name":"fetal therapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/perinatal-treatment","display_name":"perinatal treatment","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.6629999876022339},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7950000166893005},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.7910000085830688},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dyrk1a","display_name":"DYRK1A","score":0.9279999732971191},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.75},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8628506660461426},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7451457977294922},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6360974907875061},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.49739888310432434},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.49510136246681213},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.4918339252471924},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.49139466881752014},{"id":"https://openalex.org/C2779042817","wikidata":"https://www.wikidata.org/wiki/Q6815736","display_name":"Memory improvement","level":3,"score":0.42888081073760986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4224138855934143},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36651933193206787},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3615032136440277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35843202471733093},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2943252921104431},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2571570575237274},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1326809525489807},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097603","descriptor_name":"Dyrk Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00018-024-05245-9","doi":"https://doi.org/10.1007/s00018-024-05245-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-024-05245-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-024-05245-9.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11090972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090972","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11090972/pdf/18_2024_Article_5245.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},{"id":"pmid:38739166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38739166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04586794v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04586794","pdf_url":"https://hal.science/hal-04586794v1/file/s00018-024-05245-9.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Life Sciences, 2024, 81 (1), pp.215. &#x27E8;10.1007/s00018-024-05245-9&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00018-024-05245-9","doi":"https://doi.org/10.1007/s00018-024-05245-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-024-05245-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-024-05245-9.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2083914112","display_name":"PIF (preImplantation factor) evaluation as a prenatal treatment in a Down syndrome mouse model","funder_award_id":"ANR-19-CE18-0023","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396863564.pdf","grobid_xml":"https://content.openalex.org/works/W4396863564.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W120484358","https://openalex.org/W1520236834","https://openalex.org/W1562480431","https://openalex.org/W1839738398","https://openalex.org/W1972280500","https://openalex.org/W1977198183","https://openalex.org/W1985724300","https://openalex.org/W2008803278","https://openalex.org/W2015658471","https://openalex.org/W2018320164","https://openalex.org/W2028537932","https://openalex.org/W2040670434","https://openalex.org/W2042076636","https://openalex.org/W2044570219","https://openalex.org/W2047516576","https://openalex.org/W2051685982","https://openalex.org/W2074458732","https://openalex.org/W2078814822","https://openalex.org/W2086398583","https://openalex.org/W2089405384","https://openalex.org/W2097045133","https://openalex.org/W2099268443","https://openalex.org/W2101458866","https://openalex.org/W2101899539","https://openalex.org/W2102979724","https://openalex.org/W2108244474","https://openalex.org/W2138298735","https://openalex.org/W2152891102","https://openalex.org/W2165432413","https://openalex.org/W2306947905","https://openalex.org/W2344404994","https://openalex.org/W2413465592","https://openalex.org/W2417190380","https://openalex.org/W2485687471","https://openalex.org/W2550098251","https://openalex.org/W2559515124","https://openalex.org/W2590262026","https://openalex.org/W2736147832","https://openalex.org/W2783152534","https://openalex.org/W2887515249","https://openalex.org/W2918344406","https://openalex.org/W3033142738","https://openalex.org/W3091844202","https://openalex.org/W3115799002","https://openalex.org/W3202187531","https://openalex.org/W3205119510","https://openalex.org/W4220906722","https://openalex.org/W4220914263","https://openalex.org/W4226027615","https://openalex.org/W4291002583","https://openalex.org/W4294042844","https://openalex.org/W4308954859","https://openalex.org/W4313472237","https://openalex.org/W4324143764","https://openalex.org/W4383482420","https://openalex.org/W4385753490","https://openalex.org/W4388830823","https://openalex.org/W4390477234"],"related_works":["https://openalex.org/W4406880355","https://openalex.org/W2152891102","https://openalex.org/W7034204710","https://openalex.org/W2752797455","https://openalex.org/W2995813292","https://openalex.org/W3197012766","https://openalex.org/W2605185479","https://openalex.org/W2010772274","https://openalex.org/W2075656486","https://openalex.org/W4280634185"],"abstract_inverted_index":{"Down":[0],"syndrome":[1],"(DS)":[2],"is":[3,16,50,208],"a":[4,9,42,59,62,68,159,205],"genetic":[5],"disease":[6],"characterized":[7],"by":[8,80],"supernumerary":[10],"chromosome":[11],"21.":[12],"Intellectual":[13],"deficiency":[14],"(ID)":[15],"one":[17],"of":[18,23,54,64,70,91,105,123,130,168,203],"the":[19,46,89,110,124,128,135,165,201,218],"most":[20],"prominent":[21],"features":[22],"DS.":[24,214,254],"Central":[25],"nervous":[26],"system":[27],"defects":[28],"lead":[29],"to":[30,171],"learning":[31],"disabilities,":[32],"motor":[33],"and":[34,37,77,84,96,118,120,158,164,173,192],"language":[35],"delays,":[36],"memory":[38,139,234],"impairments.":[39],"At":[40],"present,":[41],"prenatal":[43],"treatment":[44,133,197,224,240],"for":[45,247],"ID":[47],"in":[48,67,210,213,232,235,251],"DS":[49],"lacking.":[51],"Subcutaneous":[52],"administration":[53,93],"synthetic":[55],"preimplantation":[56],"factor":[57],"(sPIF,":[58],"peptide":[60],"with":[61,152,178,185,198,217,225,229,241,253],"range":[63],"biological":[65],"functions)":[66],"model":[69,104],"severe":[71],"brain":[72],"damage":[73],"has":[74],"shown":[75],"neuroprotective":[76],"anti-inflammatory":[78],"properties":[79],"directly":[81],"targeting":[82],"neurons":[83],"microglia.":[85],"Here,":[86],"we":[87],"evaluated":[88,141],"effect":[90],"PIF":[92],"during":[94],"gestation":[95],"until":[97],"weaning":[98],"on":[99,142,188,221],"Dp(16)1Yey":[100,146,237],"mice":[101],"(a":[102],"mouse":[103],"DS).":[106],"Possible":[107],"effects":[108,187,220],"at":[109,134],"juvenile":[111],"stage":[112],"were":[113],"assessed":[114],"using":[115],"behavioral":[116,150],"tests":[117],"molecular":[119],"histological":[121],"analyses":[122],"brain.":[125],"To":[126],"test":[127],"influence":[129],"perinatal":[131,223],"sPIF":[132,179,199,226,242],"adult":[136,236],"stage,":[137],"hippocampus-dependent":[138],"was":[140,227],"postnatal":[143,182],"day":[144],"90.":[145],"pups":[147],"showed":[148],"significant":[149],"impairment,":[151],"impaired":[153],"neurogenesis,":[154,184,222],"microglial":[155,161],"cell":[156,162,174,193],"activation":[157],"low":[160],"count,":[163],"deregulated":[166],"expression":[167],"genes":[169],"linked":[170],"neuroinflammation":[172],"cycle":[175,194],"regulation.":[176],"Treatment":[177],"restored":[180,200],"early":[181],"hippocampal":[183],"beneficial":[186,219],"astrocytes,":[189],"microglia,":[190],"inflammation,":[191],"markers.":[195],"Moreover,":[196],"level":[202],"DYRK1A,":[204],"protein":[206],"that":[207],"involved":[209],"cognitive":[211,249],"impairments":[212,250],"In":[215],"line":[216],"associated":[228],"an":[230,245],"improvement":[231],"working":[233],"mice.":[238],"Perinatal":[239],"might":[243],"be":[244],"option":[246],"mitigating":[248],"people":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-14T00:00:00"}
