{"id":"https://openalex.org/W4396857528","doi":"https://doi.org/10.1111/cns.14736","title":"CD22 blockade aggravates EAE and its role in microglia polarization","display_name":"CD22 blockade aggravates EAE and its role in microglia polarization","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396857528","doi":"https://doi.org/10.1111/cns.14736","pmid":"https://pubmed.ncbi.nlm.nih.gov/38739106","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090149"},"language":"en","primary_location":{"id":"doi:10.1111/cns.14736","doi":"https://doi.org/10.1111/cns.14736","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14736","pdf_url":null,"source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/cns.14736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026556999","display_name":"Weiwei Xiang","orcid":"https://orcid.org/0000-0002-9250-2723","observed_orcids":["https://orcid.org/0000-0002-9250-2723"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiwei Xiang","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-9250-2723","affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403709","display_name":"Kan Wang","orcid":"https://orcid.org/0000-0001-9811-4142","observed_orcids":["https://orcid.org/0000-0001-9811-4142","https://orcid.org/0000-0002-2856-6845"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kan Wang","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100663241","display_name":"Lu Han","orcid":"https://orcid.org/0000-0002-6119-4895","observed_orcids":["https://orcid.org/0000-0002-6119-4895"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Han","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443555","display_name":"Ze Wang","orcid":"https://orcid.org/0000-0002-8339-5567","observed_orcids":["https://orcid.org/0000-0002-8339-5567"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze Wang","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109427548","display_name":"Zhiyang Zhou","orcid":"https://orcid.org/0000-0001-9951-7015","observed_orcids":["https://orcid.org/0000-0001-9951-7015"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210146205","display_name":"Obstetrics and Gynecology Hospital of Fudan University","ror":"https://ror.org/04rhdtb47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146205"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyang Zhou","raw_affiliation_strings":["Institute of Reproduction and Development, Obstetrics &amp; Gynecology Hospital Fudan University Shanghai China","Shanghai Key Laboratory of Reproduction and Development, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproduction and Development, Obstetrics &amp; Gynecology Hospital Fudan University Shanghai China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210146205"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Reproduction and Development, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030504993","display_name":"Shuwei Bai","orcid":"https://orcid.org/0000-0001-5618-5591","observed_orcids":["https://orcid.org/0000-0001-5618-5591"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuwei Bai","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684872","display_name":"Jing Peng","orcid":"https://orcid.org/0000-0003-4213-7542","observed_orcids":["https://orcid.org/0000-0003-4213-7542"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Peng","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0003-4213-7542","affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025915072","display_name":"Chong Xie","orcid":"https://orcid.org/0000-0001-9604-5921","observed_orcids":["https://orcid.org/0000-0001-9604-5921"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chong Xie","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028964836","display_name":"Yangtai Guan","orcid":"https://orcid.org/0000-0003-0813-4073","observed_orcids":["https://orcid.org/0000-0003-0813-4073"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210146239","display_name":"Punan Hospital","ror":"https://ror.org/05cxk4q81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146239"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yangtai Guan","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Department of Neurology, Shanghai Punan Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Department of Neurology, Shanghai Punan Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210146239"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025915072","https://openalex.org/A5028964836"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210146239"],"apc_list":{"value":3580,"currency":"USD","value_usd":3580},"apc_paid":{"value":3580,"currency":"USD","value_usd":3580},"fwci":2.2683,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.87801552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"30","issue":"5","first_page":"e14736","last_page":"e14736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd22","display_name":"CD22","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.6320000290870667},{"id":"https://openalex.org/keywords/microglial-polarization","display_name":"microglial polarization","score":0.9309999942779541},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.8460000157356262},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8727079629898071},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.7587652206420898},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6172814965248108},{"id":"https://openalex.org/C111700020","wikidata":"https://www.wikidata.org/wiki/Q5009798","display_name":"CD22","level":4,"score":0.5415558815002441},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.495767205953598},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49430060386657715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49061623215675354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48815590143203735},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.47288790345191956},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.42307111620903015},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.41773465275764465},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4072417616844177},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3884270489215851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3084009289741516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2645581364631653},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13531869649887085},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09867709875106812},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.08727827668190002},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051918","descriptor_name":"Sialic Acid Binding Ig-like Lectin 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063308","descriptor_name":"Myelin-Oligodendrocyte Glycoprotein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D063308","descriptor_name":"Myelin-Oligodendrocyte Glycoprotein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/cns.14736","doi":"https://doi.org/10.1111/cns.14736","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14736","pdf_url":null,"source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11090149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neurosci Ther","raw_type":"Text"},{"id":"pmid:38739106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38739106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS neuroscience & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cns.14736","doi":"https://doi.org/10.1111/cns.14736","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14736","pdf_url":null,"source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5534530679","display_name":null,"funder_award_id":"82071341","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8862007855","display_name":null,"funder_award_id":"81801195","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1909916749","https://openalex.org/W1991805788","https://openalex.org/W1993662841","https://openalex.org/W2001404020","https://openalex.org/W2010229872","https://openalex.org/W2017808415","https://openalex.org/W2018805974","https://openalex.org/W2029602090","https://openalex.org/W2034949980","https://openalex.org/W2096790403","https://openalex.org/W2151157422","https://openalex.org/W2253301869","https://openalex.org/W2538110449","https://openalex.org/W2620266814","https://openalex.org/W2769071992","https://openalex.org/W2772453351","https://openalex.org/W2782743749","https://openalex.org/W2783582599","https://openalex.org/W2795213045","https://openalex.org/W2796437903","https://openalex.org/W2893525181","https://openalex.org/W2934339908","https://openalex.org/W2948421973","https://openalex.org/W2949996247","https://openalex.org/W2999235182","https://openalex.org/W3003215804","https://openalex.org/W3014459671","https://openalex.org/W3045681195","https://openalex.org/W3128547640","https://openalex.org/W3197940317","https://openalex.org/W3217040496","https://openalex.org/W4211048507","https://openalex.org/W4286008767","https://openalex.org/W4306410382","https://openalex.org/W4307695821","https://openalex.org/W4315619345","https://openalex.org/W4385064560"],"related_works":["https://openalex.org/W2610524617","https://openalex.org/W2139157577","https://openalex.org/W1892094570","https://openalex.org/W4315702561","https://openalex.org/W4282838641","https://openalex.org/W2941500440","https://openalex.org/W4404873739","https://openalex.org/W2008823687","https://openalex.org/W3204576894","https://openalex.org/W2077003881"],"abstract_inverted_index":{"AIMS:":[0],"Multiple":[1],"sclerosis":[2],"(MS)":[3],"is":[4],"a":[5,144],"neuroinflammatory":[6],"demyelinating":[7],"disease.":[8],"Microglia":[9],"are":[10],"reportedly":[11],"involved":[12],"in":[13,29,71,74,85,91,102,113,122,147,153],"the":[14,19,24,98,148],"pathogenesis":[15],"of":[16,27,52,65,82,100,150],"MS.":[17],"However,":[18],"key":[20],"molecules":[21],"that":[22,95,105,117,134],"control":[23,47],"inflammatory":[25],"activity":[26],"microglia":[28,103],"MS":[30],"have":[31],"not":[32],"been":[33],"identified.":[34],"METHODS:":[35],"Experimental":[36],"autoimmune":[37],"encephalomyelitis":[38],"(EAE)":[39],"mice":[40,123],"were":[41,55,68],"randomized":[42],"into":[43],"CD22":[44,54,66,84,101,106,118,135],"blockade":[45,67,107,119],"and":[46,61,73,104,124,141],"groups.":[48],"The":[49,63],"expression":[50,81,99],"levels":[51],"microglial":[53,83,109,126],"measured":[56],"by":[57],"flow":[58],"cytometry,":[59],"qRT-PCR,":[60],"immunofluorescence.":[62],"effects":[64],"examined":[69],"via":[70],"vitro":[72,92],"vivo":[75,114],"studies.":[76],"RESULTS:":[77],"We":[78],"detected":[79],"increased":[80],"EAE":[86,121,140,154],"mice.":[87,155],"In":[88],"addition,":[89],"an":[90,112],"study":[93,115,132],"revealed":[94],"lipopolysaccharide":[96],"upregulated":[97],"modulated":[108],"polarization.":[110,128],"Moreover,":[111],"demonstrated":[116],"aggravated":[120],"promoted":[125],"M1":[127],"CONCLUSION:":[129],"Collectively,":[130],"our":[131],"indicates":[133],"may":[136,142],"be":[137],"protective":[138],"against":[139],"play":[143],"critical":[145],"role":[146],"maintenance":[149],"immune":[151],"homeostasis":[152]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-05-14T00:00:00"}
