{"id":"https://openalex.org/W4396851754","doi":"https://doi.org/10.1038/s41598-024-61646-7","title":"In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase","display_name":"In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase","publication_year":2024,"publication_date":"2024-05-13","ids":{"openalex":"https://openalex.org/W4396851754","doi":"https://doi.org/10.1038/s41598-024-61646-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/38740850","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11091111"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-61646-7","doi":"https://doi.org/10.1038/s41598-024-61646-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-61646-7","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-024-61646-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079252576","display_name":"Linyue Shang","orcid":"https://orcid.org/0009-0007-3619-2234","observed_orcids":["https://orcid.org/0009-0007-3619-2234"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linyue Shang","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083982382","display_name":"Huimei Wei","orcid":"https://orcid.org/0009-0000-6493-6412","observed_orcids":["https://orcid.org/0009-0000-6493-6412"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huimei Wei","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101487708","display_name":"Jing Ti Deng","orcid":"https://orcid.org/0000-0002-4660-7516","observed_orcids":["https://orcid.org/0000-0002-4660-7516"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Deng","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060453747","display_name":"Madeline J. Stewart","orcid":"https://orcid.org/0000-0002-6304-6298","observed_orcids":["https://orcid.org/0000-0002-6304-6298"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeline J. Stewart","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093701540","display_name":"Johnathan E LeSaint","orcid":"https://orcid.org/0009-0000-6783-2010","observed_orcids":["https://orcid.org/0009-0000-6783-2010"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johnathan E. LeSaint","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075069884","display_name":"Annet Kyomuhangi","orcid":"https://orcid.org/0009-0001-5527-5015","observed_orcids":["https://orcid.org/0009-0001-5527-5015"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annet Kyomuhangi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073728038","display_name":"Shawn Park","orcid":"https://orcid.org/0000-0001-5858-3956","observed_orcids":["https://orcid.org/0000-0001-5858-3956"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn Park","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113205601","display_name":"Elise C. Maul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise C. Maul","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100676088","display_name":"Chang\u2010Guo Zhan","orcid":"https://orcid.org/0000-0002-4128-7269","observed_orcids":["https://orcid.org/0000-0002-4128-7269"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chang-Guo Zhan","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. zhan@uky.edu","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. zhan@uky.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. zhan@uky.edu","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. zhan@uky.edu","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001124751","display_name":"Fang Zheng","orcid":"https://orcid.org/0000-0001-8571-3744","observed_orcids":["https://orcid.org/0000-0001-8571-3744"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fang Zheng","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. fzhen2@uky.edu","Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. fzhen2@uky.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. fzhen2@uky.edu","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. fzhen2@uky.edu","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001124751","https://openalex.org/A5100676088"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.5175,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5598623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"1","first_page":"10952","last_page":"10952"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-dependence","display_name":"cocaine dependence","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cocaine-hydrolysis","display_name":"cocaine hydrolysis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7910000085830688},{"id":"https://openalex.org/keywords/storage-temperature","display_name":"storage temperature","score":0.6840000152587891},{"id":"https://openalex.org/keywords/enzyme-half-life","display_name":"enzyme half-life","score":0.5109999775886536},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7570000290870667},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.5009999871253967},{"id":"https://openalex.org/keywords/bioreactor-production","display_name":"bioreactor production","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.9192147254943848},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7687550783157349},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5681315064430237},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.5549474954605103},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5113725066184998},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47637292742729187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30094319581985474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23244065046310425},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-024-61646-7","doi":"https://doi.org/10.1038/s41598-024-61646-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-61646-7","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11091111","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11091111","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11091111/pdf/41598_2024_Article_61646.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38740850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38740850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:eeaa4ba4e86944dab6007d0ff59edf53","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eeaa4ba4e86944dab6007d0ff59edf53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-61646-7","doi":"https://doi.org/10.1038/s41598-024-61646-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-61646-7","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1640199488","display_name":"Development of Long-acting Cocaine Hydrolase as a Treatment for Cocaine Abuse","funder_award_id":"UH3DA041115","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2860329135","display_name":"Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning","funder_award_id":"UG3NS134920","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3888965337","display_name":"Ghrelin Deacylase as a Treatment for Opioid Polysubstance Abuse","funder_award_id":"1r01da056646-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5330388222","display_name":null,"funder_award_id":"R01 DA056646","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5774926618","display_name":"Development of a Cocaine-Metabolizing Enzyme for Drug Overdose Treatment","funder_award_id":"R01DA032910","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6500318467","display_name":"Development of a Long-acting Enzyme Therapy for Treatment of Cocaine Abuse","funder_award_id":"U01DA051079","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6928297188","display_name":"Validation of ghrelin hydrolysis as an effective approach to treatment of substance use disorders","funder_award_id":"U18DA052319","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7896298148","display_name":"Long-lasting cocaine-metabolizing enzyme for cocaine addiction treatment","funder_award_id":"R01DA035552","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8362094636","display_name":"Redesign of Butyrylcholinesterase for Cocaine Metabolism","funder_award_id":"R01DA013930","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000059500","display_name":null,"funder_award_id":"UH2/UH3 DA041115","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000223770","display_name":null,"funder_award_id":"DA041115","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000280494","display_name":null,"funder_award_id":"UG3/UH3 NS134920","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000897387","display_name":"Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning","funder_award_id":"4uh3ns134920-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G92836787","display_name":"Development of Long-acting Cocaine Hydrolase as a Treatment for Cocaine Abuse","funder_award_id":"UH2DA041115","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396851754.pdf","grobid_xml":"https://content.openalex.org/works/W4396851754.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1548319816","https://openalex.org/W1905265600","https://openalex.org/W1907375093","https://openalex.org/W1936859001","https://openalex.org/W1964780815","https://openalex.org/W1984120373","https://openalex.org/W1986711964","https://openalex.org/W1992087265","https://openalex.org/W1993795668","https://openalex.org/W1999737174","https://openalex.org/W2005923831","https://openalex.org/W2018267812","https://openalex.org/W2020649868","https://openalex.org/W2029297436","https://openalex.org/W2031822363","https://openalex.org/W2033038595","https://openalex.org/W2038510181","https://openalex.org/W2038966267","https://openalex.org/W2046983748","https://openalex.org/W2050561536","https://openalex.org/W2061773495","https://openalex.org/W2065582840","https://openalex.org/W2066330320","https://openalex.org/W2068033427","https://openalex.org/W2072967966","https://openalex.org/W2096082249","https://openalex.org/W2104571873","https://openalex.org/W2109713239","https://openalex.org/W2115085431","https://openalex.org/W2123951107","https://openalex.org/W2127431228","https://openalex.org/W2155411617","https://openalex.org/W2167166330","https://openalex.org/W2211619483","https://openalex.org/W2260114137","https://openalex.org/W2316654304","https://openalex.org/W2324258732","https://openalex.org/W2328299881","https://openalex.org/W2331411291","https://openalex.org/W2400708833","https://openalex.org/W2401950056","https://openalex.org/W2402208217","https://openalex.org/W2465043395","https://openalex.org/W2618910370","https://openalex.org/W2767725402","https://openalex.org/W2769415471","https://openalex.org/W2790434769","https://openalex.org/W2793086096","https://openalex.org/W2936252092","https://openalex.org/W2971102090","https://openalex.org/W2990902083","https://openalex.org/W3005569861","https://openalex.org/W3012480243","https://openalex.org/W3023534215","https://openalex.org/W3034155845","https://openalex.org/W3189481087","https://openalex.org/W4280648370","https://openalex.org/W4283693941","https://openalex.org/W4289527773","https://openalex.org/W4294300887","https://openalex.org/W4307973159","https://openalex.org/W4315702437","https://openalex.org/W4364323353"],"related_works":["https://openalex.org/W2793086096","https://openalex.org/W2211619483","https://openalex.org/W2890108950","https://openalex.org/W6903531509","https://openalex.org/W6884853544","https://openalex.org/W2170243062","https://openalex.org/W2131985675","https://openalex.org/W2118141474","https://openalex.org/W2497717046","https://openalex.org/W2039285866"],"abstract_inverted_index":{"It":[0],"is":[1,41],"recognized":[2],"as":[3,45,232],"a":[4,31,92,99,171,233],"promising":[5,234],"therapeutic":[6,235],"strategy":[7],"for":[8,101,156,177,237],"cocaine":[9,21,36,49,85,178,240],"use":[10,241],"disorder":[11],"to":[12,22],"develop":[13],"an":[14,196],"efficient":[15,35,48],"enzyme":[16],"which":[17,40],"can":[18],"rapidly":[19],"convert":[20],"physiologically":[23],"inactive":[24],"metabolites.":[25],"We":[26],"have":[27,218],"designed":[28],"and":[29,59,81,88,105,153,207,214,228],"discovered":[30],"series":[32],"of":[33,75,91,129,144,173,193,199,216,239],"highly":[34],"hydrolases,":[37],"including":[38,147],"CocH5-Fc(M6)":[39,93,131,194,217,222],"the":[42,46,53,60,67,72,126,130,138,165,182,188,204,212,224],"currently":[43],"known":[44],"most":[47],"hydrolase":[50],"with":[51,170,195],"both":[52],"highest":[54],"catalytic":[55,82],"activity":[56,83],"against":[57,84],"(-)-cocaine":[58],"longest":[61],"biological":[62],"half-life":[63,172,198],"in":[64,86,89,98,103,106,183,205,208,226,229],"rats.":[65],"In":[66,160],"present":[68],"study,":[69],"we":[70],"characterized":[71],"time":[73],"courses":[74],"protein":[76,132,139,166],"appearance,":[77],"pH,":[78],"structural":[79],"integrity,":[80],"vitro":[87,104,206,227],"vivo":[90,107,184,209,230],"bulk":[94],"drug":[95],"substance":[96],"produced":[97],"bioreactor":[100],"its":[102],"stability":[108,215,231],"after":[109,137],"long-time":[110],"storage":[111],"under":[112],"various":[113],"temperatures":[114,146],"(-":[115],"80,":[116,149],"-":[117,148,150],"20,":[118,151],"4,":[119,152],"25,":[120],"or":[121],"37":[122,163],"\u00b0C).":[123],"Specifically,":[124],"all":[125],"tested":[127],"properties":[128],"did":[133],"not":[134],"significantly":[135],"change":[136],"was":[140,167],"stored":[141],"at":[142,162],"any":[143],"four":[145],"25":[154],"\u00b0C":[155],"~":[157,174,200],"18":[158],"months.":[159],"comparison,":[161],"\u00b0C,":[164],"less":[168],"stable,":[169],"82":[175],"days":[176],"hydrolysis":[179],"activity.":[180],"Additionally,":[181],"studies":[185],"further":[186],"confirmed":[187],"linear":[189],"elimination":[190,197],"PK":[191],"profile":[192],"9":[201],"days.":[202],"All":[203],"data":[210],"on":[211],"efficacy":[213],"consistently":[219],"demonstrated":[220],"that":[221],"has":[223],"desired":[225],"candidate":[236],"treatment":[238],"disorder.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-14T00:00:00"}
