{"id":"https://openalex.org/W4396850265","doi":"https://doi.org/10.1124/jpet.017.128217","title":"Identification of Potential Targets Mediating Polymyxin Toxicity in Human Alveolar Epithelial Cells","display_name":"Identification of Potential Targets Mediating Polymyxin Toxicity in Human Alveolar Epithelial Cells","publication_year":2024,"publication_date":"2024-05-13","ids":{"openalex":"https://openalex.org/W4396850265","doi":"https://doi.org/10.1124/jpet.017.128217"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.017.128217","doi":"https://doi.org/10.1124/jpet.017.128217","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.017.128217","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077644272","display_name":"Mohammad Tuhin Ali","orcid":"https://orcid.org/0000-0002-0889-6548","observed_orcids":["https://orcid.org/0000-0002-0889-6548"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mohammad Tuhin Ali","raw_affiliation_strings":["Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100575540","display_name":"Jing Lu","orcid":"https://orcid.org/0000-0002-0791-2841","observed_orcids":["https://orcid.org/0000-0002-0791-2841"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jing Lu","raw_affiliation_strings":["Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078610833","display_name":"Ghizal Siddiqui","orcid":"https://orcid.org/0000-0002-3153-3198","observed_orcids":["https://orcid.org/0000-0002-3153-3198"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ghizal Siddiqui","raw_affiliation_strings":["Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000189190","display_name":"Jinxin Zhao","orcid":"https://orcid.org/0000-0002-0604-3541","observed_orcids":["https://orcid.org/0000-0002-0604-3541"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jinxin Zhao","raw_affiliation_strings":["Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748618","display_name":"Tony Velkov","orcid":"https://orcid.org/0000-0002-0017-7952","observed_orcids":["https://orcid.org/0000-0002-0017-7952"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tony Velkov","raw_affiliation_strings":["Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022732868","display_name":"Qi Tony Zhou","orcid":"https://orcid.org/0000-0002-1438-6990","observed_orcids":["https://orcid.org/0000-0002-1438-6990","https://orcid.org/0000-0002-7609-1725"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi (Tony) Zhou","raw_affiliation_strings":["Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022803092","display_name":"Nitin A. Patil","orcid":"https://orcid.org/0000-0003-0422-9411","observed_orcids":["https://orcid.org/0000-0003-0422-9411"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nitin Patil","raw_affiliation_strings":["Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402448","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-9434-7803","observed_orcids":["https://orcid.org/0000-0001-9434-7803"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07437794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"389","issue":null,"first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.2587999999523163,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.6909999847412109},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/thermal-proteome-profiling","display_name":"thermal proteome profiling","score":0.921999990940094},{"id":"https://openalex.org/keywords/fth1","display_name":"FTH1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/multidrug-resistant-gram-negative-bacteria","display_name":"multidrug-resistant Gram-negative bacteria","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C2780026444","wikidata":"https://www.wikidata.org/wiki/Q1088175","display_name":"Polymyxin B","level":3,"score":0.8322045803070068},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.7528329491615295},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5739409923553467},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5430097579956055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5039350390434265},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4924236238002777},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4344191253185272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37348076701164246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3644629716873169},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2846674621105194},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.13379517197608948},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1124/jpet.017.128217","doi":"https://doi.org/10.1124/jpet.017.128217","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.017.128217","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2898450793","https://openalex.org/W4213413867","https://openalex.org/W2607217081","https://openalex.org/W4392716175","https://openalex.org/W7166546820","https://openalex.org/W7105794743","https://openalex.org/W2901550406","https://openalex.org/W6945944565","https://openalex.org/W7210290980","https://openalex.org/W7203468677"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2024-05-14T00:00:00"}
