{"id":"https://openalex.org/W4396850004","doi":"https://doi.org/10.1124/jpet.070.977900","title":"Enhancement of ANGPTL4 exacerbates post-ischemic myocardial ferroptosis and cellular injury in diabetic conditions via impairing AKT/AMPK signaling","display_name":"Enhancement of ANGPTL4 exacerbates post-ischemic myocardial ferroptosis and cellular injury in diabetic conditions via impairing AKT/AMPK signaling","publication_year":2024,"publication_date":"2024-05-13","ids":{"openalex":"https://openalex.org/W4396850004","doi":"https://doi.org/10.1124/jpet.070.977900"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.070.977900","doi":"https://doi.org/10.1124/jpet.070.977900","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.070.977900","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076811917","display_name":"Weiyi Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Weiyi Xia","raw_affiliation_strings":["Department of Health Technology and Informatics, The Hong Kong Polytechnic University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365438","display_name":"Lin Xie","orcid":"https://orcid.org/0000-0001-7517-2235","observed_orcids":["https://orcid.org/0000-0001-7517-2235","https://orcid.org/0009-0009-3438-7163"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Xie","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779411","display_name":"Zhiyi Li","orcid":"https://orcid.org/0009-0008-0779-9720","observed_orcids":["https://orcid.org/0009-0008-0779-9720"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyi Li","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013378515","display_name":"Jiaqi Zhou","orcid":"https://orcid.org/0000-0002-8233-2740","observed_orcids":["https://orcid.org/0000-0002-8233-2740"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Zhou","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400995","display_name":"Jiajia Chen","orcid":"https://orcid.org/0009-0006-4343-8290","observed_orcids":["https://orcid.org/0009-0006-4343-8290"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Chen","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046419434","display_name":"Kaijia Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaijia Han","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000632436","display_name":"Dongcheng Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongcheng Zhou","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082692871","display_name":"Yin Cai","orcid":"https://orcid.org/0000-0002-7763-0612","observed_orcids":["https://orcid.org/0000-0002-7763-0612"]},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yin Cai","raw_affiliation_strings":["Department of Health Technology and Informatics, The Hong Kong Polytechnic University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100756444","display_name":"Zhengyuan Xia","orcid":"https://orcid.org/0000-0002-7002-5524","observed_orcids":["https://orcid.org/0000-0002-7002-5524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengyuan Xia","raw_affiliation_strings":["Doctoral Training Platform for Research and Translation, BoShiWan, GuanChong Village, Hubei Province"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral Training Platform for Research and Translation, BoShiWan, GuanChong Village, Hubei Province","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12260933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"389","issue":null,"first_page":"70","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angptl4","display_name":"ANGPTL4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9279999732971191},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.890999972820282},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.878000020980835},{"id":"https://openalex.org/keywords/cardiomyocyte-injury","display_name":"cardiomyocyte injury","score":0.7580000162124634},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.5580000281333923},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.8420000076293945},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hl-1-cells","display_name":"HL-1 cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7708415389060974},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6760827898979187},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5858193635940552},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5728245377540588},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5581355690956116},{"id":"https://openalex.org/C77305985","wikidata":"https://www.wikidata.org/wiki/Q18040028","display_name":"ANGPTL4","level":3,"score":0.5450064539909363},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.4791231155395508},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.46437373757362366},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.46318790316581726},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4346839189529419},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4107345938682556},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33862048387527466},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.13412213325500488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10757708549499512},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1124/jpet.070.977900","doi":"https://doi.org/10.1124/jpet.070.977900","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.070.977900","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2993159883","https://openalex.org/W4402690027","https://openalex.org/W4377020646","https://openalex.org/W4403855675","https://openalex.org/W3023669324","https://openalex.org/W4293229345","https://openalex.org/W4377029029","https://openalex.org/W7154044528","https://openalex.org/W4304471515","https://openalex.org/W2799910868"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-05-14T00:00:00"}
