{"id":"https://openalex.org/W4396833902","doi":"https://doi.org/10.1038/s41467-024-48461-4","title":"Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles","display_name":"Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles","publication_year":2024,"publication_date":"2024-05-11","ids":{"openalex":"https://openalex.org/W4396833902","doi":"https://doi.org/10.1038/s41467-024-48461-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/38734698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11088666"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-48461-4","doi":"https://doi.org/10.1038/s41467-024-48461-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-48461-4","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41467-024-48461-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001915332","display_name":"Xufei Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xufei Bian","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]},{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Yang","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109607316","display_name":"Dingxi Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingxi Jiang","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034239729","display_name":"Adam Grippin","orcid":"https://orcid.org/0000-0002-8076-4240","observed_orcids":["https://orcid.org/0000-0002-8076-4240"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Grippin","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-8076-4240","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041253552","display_name":"Yifan Ma","orcid":"https://orcid.org/0000-0002-9371-4365","observed_orcids":["https://orcid.org/0000-0002-9371-4365","https://orcid.org/0009-0005-8434-8059"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yifan Ma","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Wu","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102663511","display_name":"Linchong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linchong Wu","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060071191","display_name":"Xiaoyou Wang","orcid":"https://orcid.org/0000-0002-4588-2460","observed_orcids":["https://orcid.org/0000-0002-4588-2460"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyou Wang","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]},{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102101497","display_name":"Zhongjie Tang","orcid":"https://orcid.org/0009-0003-0534-5411","observed_orcids":["https://orcid.org/0009-0003-0534-5411"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongjie Tang","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014471791","display_name":"Kaicheng Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaicheng Tang","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103000285","display_name":"Weidong Pan","orcid":"https://orcid.org/0000-0001-5726-6481","observed_orcids":["https://orcid.org/0000-0001-5726-6481","https://orcid.org/0000-0002-0380-4210"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Pan","raw_affiliation_strings":["School of Pharmaceutical Sciences, Guizhou University, Guiyang, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Guizhou University, Guiyang, PR China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045960346","display_name":"Shiyan Dong","orcid":"https://orcid.org/0000-0003-2912-8895","observed_orcids":["https://orcid.org/0000-0003-2912-8895"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiyan Dong","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-2912-8895","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017997501","display_name":"Betty Y.S. Kim","orcid":"https://orcid.org/0000-0001-6890-8355","observed_orcids":["https://orcid.org/0000-0001-6890-8355"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty Y. S. Kim","raw_affiliation_strings":["Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0001-6890-8355","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090210760","display_name":"Wen Jiang","orcid":"https://orcid.org/0000-0001-9154-633X","observed_orcids":["https://orcid.org/0000-0001-9154-633X","https://orcid.org/0000-0003-0612-2917","https://orcid.org/0000-0002-6073-3260","https://orcid.org/0000-0001-6858-2666"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wen Jiang","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. wjiang4@mdanderson.org","Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0001-9154-633X","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. wjiang4@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040179504","display_name":"Zhaogang Yang","orcid":"https://orcid.org/0000-0002-6350-4455","observed_orcids":["https://orcid.org/0000-0002-6350-4455"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaogang Yang","raw_affiliation_strings":["School of Life Sciences, Jilin University, Changchun, PR China. zhaogangyang@jlu.edu.cn","School of Life Sciences, Jilin University, Changchun, PR China"],"raw_orcid":"https://orcid.org/0000-0002-6350-4455","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Jilin University, Changchun, PR China. zhaogangyang@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"School of Life Sciences, Jilin University, Changchun, PR China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100424939","display_name":"Chong Li","orcid":"https://orcid.org/0000-0002-6049-7675","observed_orcids":["https://orcid.org/0000-0002-6049-7675"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chong Li","raw_affiliation_strings":["Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China. chongli@swu.edu.cn","State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China. chongli@swu.edu.cn","State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China"],"raw_orcid":"https://orcid.org/0000-0002-6049-7675","affiliations":[{"raw_affiliation_string":"Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China. chongli@swu.edu.cn","institution_ids":["https://openalex.org/I142108993"]},{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China. chongli@swu.edu.cn","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]},{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5040179504","https://openalex.org/A5090210760","https://openalex.org/A5100424939"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I142108993","https://openalex.org/I194450716","https://openalex.org/I20231570","https://openalex.org/I4391768132"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":4.7819,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.97047595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"3987","last_page":"3987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.06469999998807907,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vinpocetine","display_name":"vinpocetine","score":0.972000002861023},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cerebral-autoregulation","display_name":"cerebral autoregulation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/brain-targeting","display_name":"brain targeting","score":0.5289999842643738},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.8650000095367432},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.8069999814033508},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7879999876022339},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2778788455","wikidata":"https://www.wikidata.org/wiki/Q420288","display_name":"Vinpocetine","level":2,"score":0.955257773399353},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.6275536417961121},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43700093030929565},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4368913769721985},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.43615853786468506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42019641399383545},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3508608937263489},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34084999561309814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3190196454524994},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2937721908092499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2700890004634857},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21018457412719727},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.20798027515411377},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15342402458190918}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014748","descriptor_name":"Vinca Alkaloids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014748","descriptor_name":"Vinca Alkaloids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014748","descriptor_name":"Vinca Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014748","descriptor_name":"Vinca Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-024-48461-4","doi":"https://doi.org/10.1038/s41467-024-48461-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-48461-4","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11088666","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11088666","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11088666/pdf/41467_2024_Article_48461.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38734698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38734698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-4303","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/3390","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48461-4","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-48461-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:399c086c69f24b9f9ef5ff25ceb59f42","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/399c086c69f24b9f9ef5ff25ceb59f42","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-48461-4","doi":"https://doi.org/10.1038/s41467-024-48461-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-48461-4","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4244326473","display_name":null,"funder_award_id":"SWURC2020001","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G6851365249","display_name":null,"funder_award_id":"82073789","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000870312","display_name":"Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology","funder_award_id":"T32CA196561","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321135","display_name":"Chongqing University","ror":"https://ror.org/023rhb549"},{"id":"https://openalex.org/F4320327639","display_name":"Centre Scientifique et Technique du B\u00e2timent","ror":"https://ror.org/02fsd1928"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396833902.pdf","grobid_xml":"https://content.openalex.org/works/W4396833902.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W47211728","https://openalex.org/W1487878063","https://openalex.org/W1525853610","https://openalex.org/W1530531377","https://openalex.org/W1968376422","https://openalex.org/W1968877074","https://openalex.org/W1970873827","https://openalex.org/W1976595844","https://openalex.org/W1999103470","https://openalex.org/W2003110090","https://openalex.org/W2004168180","https://openalex.org/W2005569083","https://openalex.org/W2012737483","https://openalex.org/W2017810246","https://openalex.org/W2027084895","https://openalex.org/W2032432537","https://openalex.org/W2037571189","https://openalex.org/W2050303865","https://openalex.org/W2064013003","https://openalex.org/W2077464099","https://openalex.org/W2084134328","https://openalex.org/W2089150369","https://openalex.org/W2091588620","https://openalex.org/W2092854644","https://openalex.org/W2104486619","https://openalex.org/W2111200377","https://openalex.org/W2114324710","https://openalex.org/W2124343455","https://openalex.org/W2125552828","https://openalex.org/W2153663044","https://openalex.org/W2168597028","https://openalex.org/W2184679832","https://openalex.org/W2578392051","https://openalex.org/W2616216465","https://openalex.org/W2618656701","https://openalex.org/W2761524711","https://openalex.org/W2787845337","https://openalex.org/W2791854174","https://openalex.org/W2795326405","https://openalex.org/W2799529459","https://openalex.org/W2806488757","https://openalex.org/W2807253744","https://openalex.org/W2974995951","https://openalex.org/W2986901143","https://openalex.org/W2992823069","https://openalex.org/W2996996697","https://openalex.org/W3001423058","https://openalex.org/W3007542949","https://openalex.org/W3024189585","https://openalex.org/W3033779704","https://openalex.org/W3090225575","https://openalex.org/W3113178943","https://openalex.org/W3118611693","https://openalex.org/W3119952098","https://openalex.org/W3122863646","https://openalex.org/W3127198243","https://openalex.org/W3129263051","https://openalex.org/W3164758721","https://openalex.org/W3188940990","https://openalex.org/W3194272436","https://openalex.org/W4200183417","https://openalex.org/W4200599268","https://openalex.org/W4211075592","https://openalex.org/W4299333187","https://openalex.org/W4302425994","https://openalex.org/W4317739030","https://openalex.org/W4379468914","https://openalex.org/W6911044421"],"related_works":["https://openalex.org/W4409830593","https://openalex.org/W7120404795","https://openalex.org/W4288294010","https://openalex.org/W2068506297","https://openalex.org/W2585732787","https://openalex.org/W4408283092","https://openalex.org/W3044714364","https://openalex.org/W2093175712","https://openalex.org/W2795747368","https://openalex.org/W2921104160"],"abstract_inverted_index":{"Despite":[0],"advances":[1],"in":[2,148],"active":[3],"drug":[4,22,24,46],"targeting":[5,18],"for":[6,143],"blood-brain":[7,104],"barrier":[8],"penetration,":[9],"two":[10],"key":[11],"challenges":[12],"persist:":[13],"first,":[14],"attachment":[15],"of":[16,62,79],"a":[17,71,86],"ligand":[19],"to":[20,40],"the":[21,55,59,103],"or":[23],"carrier":[25],"does":[26],"not":[27],"enhance":[28],"its":[29],"brain":[30,35,49,144],"biodistribution;":[31],"and":[32,84,115,130,138],"second,":[33],"many":[34],"diseases":[36],"are":[37],"intricately":[38],"linked":[39],"microcirculation":[41],"disorders":[42,145],"that":[43],"significantly":[44],"impede":[45],"accumulation":[47],"within":[48],"lesions":[50],"even":[51,126],"after":[52],"they":[53,107,132],"cross":[54],"barrier.":[56],"Inspired":[57],"by":[58],"neuroprotective":[60],"properties":[61],"vinpocetine,":[63],"which":[64],"regulates":[65],"cerebral":[66],"blood":[67],"flow,":[68],"we":[69],"propose":[70],"molecular":[72],"library":[73],"design":[74],"centered":[75],"on":[76],"this":[77],"class":[78],"cyclic":[80],"tertiary":[81],"amine":[82],"compounds":[83],"develop":[85],"self-enhanced":[87],"brain-targeted":[88],"nucleic":[89],"acid":[90],"delivery":[91],"system.":[92],"Our":[93],"findings":[94],"reveal":[95],"that:":[96],"(i)":[97],"vinpocetine-derived":[98],"ionizable-lipidoid":[99],"nanoparticles":[100],"efficiently":[101],"breach":[102],"barrier;":[105],"(ii)":[106],"have":[108,133],"high":[109],"gene-loading":[110],"capacity,":[111],"facilitating":[112],"endosomal":[113],"escape":[114],"intracellular":[116],"transport;":[117],"(iii)":[118],"their":[119],"administration":[120],"is":[121],"safe":[122],"with":[123,127,141],"minimal":[124],"immunogenicity":[125],"prolonged":[128],"use;":[129],"(iv)":[131],"potent":[134],"pharmacologic":[135],"brain-protective":[136],"activity":[137],"may":[139],"synergize":[140],"treatments":[142],"as":[146],"demonstrated":[147],"male":[149],"APP/PS1":[150],"mice.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-05-12T00:00:00"}