{"id":"https://openalex.org/W4396828037","doi":"https://doi.org/10.7759/cureus.60055","title":"Sex Differences in Appendicitis: A Systematic Review","display_name":"Sex Differences in Appendicitis: A Systematic Review","publication_year":2024,"publication_date":"2024-05-10","ids":{"openalex":"https://openalex.org/W4396828037","doi":"https://doi.org/10.7759/cureus.60055","pmid":"https://pubmed.ncbi.nlm.nih.gov/38854248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11162818"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.60055","doi":"https://doi.org/10.7759/cureus.60055","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.60055","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.7759/cureus.60055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004586876","display_name":"Theofanis F Kollias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":false,"raw_author_name":"Theofanis F Kollias","raw_affiliation_strings":["Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD",". Medicine, St. George's University School of Medicine, St. George's, GRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]},{"raw_affiliation_string":". Medicine, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102663393","display_name":"Connor P Gallagher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":false,"raw_author_name":"Connor P Gallagher","raw_affiliation_strings":["Medicine, St. George's University School of Medicine, St. George's, GRD",". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]},{"raw_affiliation_string":". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097632866","display_name":"Abdulahad Albaashiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":false,"raw_author_name":"Abdulahad Albaashiki","raw_affiliation_strings":["Medicine, St. George's University School of Medicine, St. George's, GRD",". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]},{"raw_affiliation_string":". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073115436","display_name":"Venkata Sathya Burle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":false,"raw_author_name":"Venkata Sathya Burle","raw_affiliation_strings":["Medicine, St. George's University School of Medicine, St. George's, GRD",". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]},{"raw_affiliation_string":". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092565301","display_name":"Ethan Slouha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":true,"raw_author_name":"Ethan Slouha","raw_affiliation_strings":["Medicine, St. George's University School of Medicine, St. George's, GRD",". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]},{"raw_affiliation_string":". Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5092565301"],"corresponding_institution_ids":["https://openalex.org/I133879957"],"apc_list":null,"apc_paid":null,"fwci":2.7199,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.90693739,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"16","issue":"5","first_page":"e60055","last_page":"e60055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11473","display_name":"Appendicitis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11473","display_name":"Appendicitis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/appendicitis","display_name":"appendicitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":1.0},{"id":"https://openalex.org/keywords/appendiceal-perforation","display_name":"appendiceal perforation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/appendectomy","display_name":"appendectomy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/laparoscopic-appendectomy","display_name":"laparoscopic appendectomy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/open-appendectomy","display_name":"open appendectomy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pediatric-appendicitis-score","display_name":"Pediatric Appendicitis Score","score":0.8009999990463257},{"id":"https://openalex.org/keywords/appendicitis-diagnosis","display_name":"appendicitis diagnosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ultrasound","display_name":"ultrasound","score":0.7179999947547913},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.8920000195503235},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.5109999775886536},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/symptoms","display_name":"clinical symptoms","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2780016130","wikidata":"https://www.wikidata.org/wiki/Q121041","display_name":"Appendicitis","level":2,"score":0.6676933765411377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44478002190589905},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.4335247278213501},{"id":"https://openalex.org/C2776364125","wikidata":"https://www.wikidata.org/wiki/Q9656","display_name":"Appendix","level":2,"score":0.4150944948196411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17147225141525269},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.05164036154747009}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.60055","doi":"https://doi.org/10.7759/cureus.60055","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.60055","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11162818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11162818","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11162818/pdf/cureus-0016-00000060055.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:38854248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38854248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.60055","doi":"https://doi.org/10.7759/cureus.60055","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.60055","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.4000000059604645}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396828037.pdf","grobid_xml":"https://content.openalex.org/works/W4396828037.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1803583103","https://openalex.org/W1903744504","https://openalex.org/W1982095438","https://openalex.org/W2002192865","https://openalex.org/W2019802104","https://openalex.org/W2036664658","https://openalex.org/W2091577087","https://openalex.org/W2114530458","https://openalex.org/W2133939563","https://openalex.org/W2147801004","https://openalex.org/W2150293028","https://openalex.org/W2151516309","https://openalex.org/W2158592225","https://openalex.org/W2189451004","https://openalex.org/W2335683284","https://openalex.org/W2913919167","https://openalex.org/W2941541889","https://openalex.org/W2978818616","https://openalex.org/W2999202227","https://openalex.org/W3005050311","https://openalex.org/W3022903699","https://openalex.org/W3035398127","https://openalex.org/W3035754316","https://openalex.org/W3039307043","https://openalex.org/W3175768647","https://openalex.org/W4200372862","https://openalex.org/W4282946063","https://openalex.org/W4309755101","https://openalex.org/W4321792861","https://openalex.org/W4362450515","https://openalex.org/W4362510930","https://openalex.org/W4378977534","https://openalex.org/W4386064229"],"related_works":["https://openalex.org/W1803583103","https://openalex.org/W3145488760","https://openalex.org/W4224280459","https://openalex.org/W4416920163","https://openalex.org/W2093051748","https://openalex.org/W139894837","https://openalex.org/W2049300971","https://openalex.org/W1566160645","https://openalex.org/W1479835066","https://openalex.org/W4410114814"],"abstract_inverted_index":{"Appendicitis":[0],"is":[1,49,67],"one":[2],"of":[3,16,21,37,41,86,97,102,126,194,203,224,233],"the":[4,14,18,42,50,83,95,109,124,131,215,238,252,261,280,338],"most":[5,43],"common":[6],"gastrointestinal":[7],"conditions":[8,103,119],"a":[9,76,190],"person":[10],"can":[11,115,341],"develop.":[12],"Throughout":[13],"years":[15],"assessing":[17],"different":[19],"focuses":[20],"appendicitis,":[22,195,250],"such":[23,236],"as":[24,185,196,198,237,271],"origin,":[25],"symptoms,":[26,140],"labs,":[27],"diagnosis,":[28],"treatment,":[29,143],"and":[30,88,91,113,117,144,157,231,243,260,274,349],"complications,":[31],"there":[32],"have":[33,245],"been":[34,105,246],"mere":[35],"mentions":[36],"sex":[38,45,114,132,164],"differences.":[39],"One":[40],"known":[44],"differences":[46,80,133,165],"in":[47,134,166,264,269,293],"appendicitis":[48,60,90,135,240],"fact":[51],"that":[52,68,340],"males":[53,69,188,218],"are":[54,278],"significantly":[55,81,191,255,265,291],"more":[56,72,220,256,297,311,321,329],"likely":[57,73,221,298,312,330],"to":[58,62,74,123,163,178,212,222,248,288,299,304,313,318,331,351],"develop":[59,75],"compared":[61,317],"females.":[63],"Another":[64],"postulated":[65],"difference":[66,100],"may":[70,92],"be":[71],"perforated":[77,204],"appendix.":[78],"These":[79],"affect":[82],"various":[84],"aspects":[85],"diagnosing":[87],"treating":[89],"even":[93],"influence":[94,116],"outcome":[96,125],"appendicitis.":[98,167,205],"Sex":[99],"analysis":[101],"has":[104],"widely":[106],"researched":[107],"over":[108],"last":[110],"two":[111],"decades,":[112],"impact":[118],"from":[120],"initial":[121],"presentation":[122],"treatment.":[127],"This":[128],"paper":[129],"evaluates":[130],"concerning":[136],"incidence,":[137],"risk":[138,202,208],"factors,":[139],"diagnosis":[141],"technique,":[142],"outcomes":[145,344],"across":[146],"ages.":[147],"Following":[148],"PRISMA":[149],"guidelines,":[150],"this":[151],"systematic":[152],"review":[153],"reviewed":[154],"PubMed,":[155],"ScienceDirect,":[156],"ProQuest":[158],"databases":[159],"for":[160,258,283],"articles":[161],"pertaining":[162],"The":[168],"original":[169],"article":[170],"count":[171],"was":[172,175,182,254,290],"21,121,":[173],"which":[174],"narrowed":[176],"down":[177],"28":[179],"publications.":[180],"It":[181],"found":[183,211],"that,":[184],"previously":[186],"described,":[187],"had":[189],"higher":[192],"rate":[193],"well":[197],"were":[199,210,219,296,310,328],"at":[200],"significant":[201],"No":[206],"official":[207],"factors":[209],"differ":[213],"between":[214,347],"sexes,":[216],"but":[217,251],"complain":[223],"symptoms":[225],"like":[226],"right":[227],"lower":[228],"quadrant":[229],"cramps/tenderness/pain":[230],"loss":[232],"appetite.":[234],"Scores":[235],"pediatric":[239],"score":[241],"(PAS)":[242],"Ohmann":[244,262],"used":[247],"diagnose":[249],"PAS":[253],"accurate":[257],"females,":[259,294,319],"resulted":[263],"fewer":[266],"negative":[267],"appendectomies":[268,316,346],"females":[270,327],"well.":[272],"Ultrasound":[273],"computed":[275],"tomography":[276],"(CT)":[277],"still":[279],"gold":[281],"standards":[282],"diagnosis;":[284],"however,":[285],"while":[286],"time":[287],"CT":[289],"delayed":[292],"they":[295],"undergo":[300,314],"extensive":[301],"imaging,":[302],"possibly":[303],"rule":[305],"out":[306],"other":[307],"conditions.":[308],"Males":[309],"open":[315],"who":[320],"frequently":[322],"underwent":[323],"laparoscopic":[324],"appendectomy,":[325],"yet":[326],"experience":[332],"complications.":[333],"Further":[334],"research":[335],"should":[336],"evaluate":[337],"influences":[339],"predict":[342],"postoperative":[343],"following":[345],"sexes":[348],"how":[350],"prevent/reduce":[352],"their":[353],"occurrence.":[354]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-05-12T00:00:00"}
