{"id":"https://openalex.org/W4396808176","doi":"https://doi.org/10.1111/acel.14190","title":"Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation","display_name":"Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation","publication_year":2024,"publication_date":"2024-05-09","ids":{"openalex":"https://openalex.org/W4396808176","doi":"https://doi.org/10.1111/acel.14190","pmid":"https://pubmed.ncbi.nlm.nih.gov/38725282","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11320341"},"language":"en","primary_location":{"id":"doi:10.1111/acel.14190","doi":"https://doi.org/10.1111/acel.14190","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.14190","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/acel.14190","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086200654","display_name":"Maria Elisa Caetano\u2010Silva","orcid":"https://orcid.org/0000-0001-8650-6616","observed_orcids":["https://orcid.org/0000-0001-8650-6616"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Elisa Caetano-Silva","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, USA;","Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0001-8650-6616","affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003212508","display_name":"Akriti Shrestha","orcid":"https://orcid.org/0000-0002-2380-789X","observed_orcids":["https://orcid.org/0000-0002-2380-789X"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akriti Shrestha","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, USA;","Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038627796","display_name":"Audrey F. Duff","orcid":"https://orcid.org/0000-0002-4825-2915","observed_orcids":["https://orcid.org/0000-0002-4825-2915"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey F. Duff","raw_affiliation_strings":["Nationwide Children Hospital, Columbus, OH, USA;","Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0002-4825-2915","affiliations":[{"raw_affiliation_string":"Nationwide Children Hospital, Columbus, OH, USA;","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077740927","display_name":"Danica Kontic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danica Kontic","raw_affiliation_strings":["Nationwide Children Hospital, Columbus, OH, USA;","Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nationwide Children Hospital, Columbus, OH, USA;","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072843598","display_name":"Patricia C. Brewster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia C. Brewster","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, USA;","Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063463537","display_name":"Mikaela C. Kasperek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikaela C. Kasperek","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, USA;","Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091326177","display_name":"Chia\u2010Hao Lin","orcid":"https://orcid.org/0000-0001-6510-8483","observed_orcids":["https://orcid.org/0000-0001-6510-8483"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Hao Lin","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, USA;","Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082027834","display_name":"Derek A. Wainwright","orcid":"https://orcid.org/0000-0001-7232-4264","observed_orcids":["https://orcid.org/0000-0001-7232-4264"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek A. Wainwright","raw_affiliation_strings":["Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA;","Departments of Cancer Biology and Neurological Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0001-7232-4264","affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA;","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"Departments of Cancer Biology and Neurological Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013757111","display_name":"Diego Hern\u00e1ndez\u2010Saavedra","orcid":"https://orcid.org/0000-0002-7110-1525","observed_orcids":["https://orcid.org/0000-0002-7110-1525"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego Hernandez-Saavedra","raw_affiliation_strings":["Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044078132","display_name":"Jeffrey A. Woods","orcid":"https://orcid.org/0000-0002-1770-806X","observed_orcids":["https://orcid.org/0000-0002-1770-806X"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Woods","raw_affiliation_strings":["University of Illinois at Urbana-Champaign, Urbana, IL, USA;","Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana-Champaign, Urbana, IL, USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024340544","display_name":"Michael T. Bailey","orcid":"https://orcid.org/0000-0002-2222-3980","observed_orcids":["https://orcid.org/0000-0002-2222-3980"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Bailey","raw_affiliation_strings":["Nationwide Children Hospital, Columbus, OH, USA;","Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nationwide Children Hospital, Columbus, OH, USA;","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025494373","display_name":"Thomas W. Buford","orcid":"https://orcid.org/0000-0002-9541-4358","observed_orcids":["https://orcid.org/0000-0002-9541-4358"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas W. Buford","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL, USA","Birmingham/Atlanta VA GRECC, Birmingham VA Medical Center, Birmingham, Alabama, USA","Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Birmingham/Atlanta VA GRECC, Birmingham VA Medical Center, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I4210115616"]},{"raw_affiliation_string":"Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020530458","display_name":"Jacob M. Allen","orcid":"https://orcid.org/0000-0001-9476-7605","observed_orcids":["https://orcid.org/0000-0001-9476-7605"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jacob M. Allen","raw_affiliation_strings":["University of Illinois at Urbana Champaign, Urbana, IL, USA;","Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Urbana Champaign, Urbana, IL, USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5020530458"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":{"value":3350,"currency":"USD","value_usd":3350},"fwci":6.6757,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.98471149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"23","issue":"8","first_page":"e14190","last_page":"e14190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tlr5","display_name":"TLR5","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lipopolysaccharide-binding-protein","display_name":"lipopolysaccharide-binding protein","score":0.9179999828338623},{"id":"https://openalex.org/keywords/calprotectin","display_name":"calprotectin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.859000027179718},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.4970000088214874},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.7049999833106995},{"id":"https://openalex.org/keywords/escherichia","display_name":"Escherichia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/proteobacteria","display_name":"Proteobacteria","score":0.6899999976158142},{"id":"https://openalex.org/keywords/colonic-inflammation","display_name":"colonic inflammation","score":0.48899999260902405},{"id":"https://openalex.org/keywords/microbiota-resilience","display_name":"microbiota resilience","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7931417226791382},{"id":"https://openalex.org/C2777338127","wikidata":"https://www.wikidata.org/wiki/Q14914085","display_name":"TLR5","level":5,"score":0.7731118202209473},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7031883001327515},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7028956413269043},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6962946057319641},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6757449507713318},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.65558260679245},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5710079669952393},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5624821186065674},{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.5324628949165344},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5099817514419556},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.49347126483917236},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.4412805438041687},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.42728424072265625},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.4136325716972351},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.24221649765968323},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1553027629852295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12699881196022034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10541772842407227},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/acel.14190","doi":"https://doi.org/10.1111/acel.14190","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.14190","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"doi:10.1101/2024.03.22.586320","doi":"https://doi.org/10.1101/2024.03.22.586320","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.03.22.586320","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/03/27/2024.03.22.586320.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11320341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11320341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"Text"},{"id":"pmid:38725282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38725282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/acel.14190","doi":"https://doi.org/10.1111/acel.14190","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.14190","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1444536522","display_name":"The interaction of IDO and Tregs Leads to Immunosuppression in Glioma","funder_award_id":"K99NS082381","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2883844079","display_name":"The interaction of IDO and Tregs Leads to Immunosuppression in Glioma","funder_award_id":"R00NS082381","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4782455726","display_name":"Age-Related Dysbiosis and Physical Resilience","funder_award_id":"R56AG068747","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7051756560","display_name":"Aging, immunosenescence and glioblastoma","funder_award_id":"K02AG068617","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7738985534","display_name":"The role of IDO and Th17 in an experimental mouse model of glioma","funder_award_id":"F32NS073366","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000879603","display_name":"IDO1 and Immunotolerance in Glioblastoma","funder_award_id":"R01NS097851","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000890928","display_name":"Role of epithelial ROS signaling in mediating psychological stress-induced mucosal dysfunction and colitis predisposition","funder_award_id":"R01DK131133","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000911543","display_name":"Extratumoral biological determinants that decrease survival in older adults with glioblastoma","funder_award_id":"R01NS129835","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396808176.pdf","grobid_xml":"https://content.openalex.org/works/W4396808176.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1616226146","https://openalex.org/W2028595371","https://openalex.org/W2034400607","https://openalex.org/W2082704291","https://openalex.org/W2094788347","https://openalex.org/W2152200355","https://openalex.org/W2169415889","https://openalex.org/W2230907825","https://openalex.org/W2248565900","https://openalex.org/W2337933193","https://openalex.org/W2341425007","https://openalex.org/W2510766756","https://openalex.org/W2607434574","https://openalex.org/W2743073899","https://openalex.org/W2765279273","https://openalex.org/W2799327942","https://openalex.org/W2891903826","https://openalex.org/W2899993341","https://openalex.org/W2922178174","https://openalex.org/W2925339008","https://openalex.org/W2938470411","https://openalex.org/W2971999614","https://openalex.org/W2995430119","https://openalex.org/W3048898688","https://openalex.org/W3084005946","https://openalex.org/W3087892058","https://openalex.org/W3091770772","https://openalex.org/W3132024224","https://openalex.org/W3138747604","https://openalex.org/W3139169691","https://openalex.org/W3173482446","https://openalex.org/W4220902755","https://openalex.org/W4224868124","https://openalex.org/W4226136852","https://openalex.org/W4226350861","https://openalex.org/W4308154019","https://openalex.org/W4309466247","https://openalex.org/W4376132442","https://openalex.org/W4378071881","https://openalex.org/W4378903447","https://openalex.org/W4386134176","https://openalex.org/W4389180298","https://openalex.org/W4389683887","https://openalex.org/W4389767162","https://openalex.org/W4390508981"],"related_works":["https://openalex.org/W7134242623","https://openalex.org/W3082970110","https://openalex.org/W2248565900","https://openalex.org/W2607434574","https://openalex.org/W2765279273","https://openalex.org/W2545416929","https://openalex.org/W3147123805","https://openalex.org/W4391902797","https://openalex.org/W2087043445","https://openalex.org/W2285022550"],"abstract_inverted_index":{"Aging":[0],"is":[1],"associated":[2,53],"with":[3,24,28,54,130,137,173],"low-grade":[4,43],"inflammation":[5,44],"that":[6,81,157,191,199,213],"increases":[7],"the":[8,15,34,158,207],"risk":[9],"of":[10,42,56,67,87,107,128,161,206],"infection":[11],"and":[12,60,73,85,115,117,151,179,224],"disease,":[13],"yet":[14],"underlying":[16],"mechanisms":[17],"remain":[18],"unclear.":[19],"Gut":[20,231],"microbiota":[21,36,149,160,198,216,232],"composition":[22],"shifts":[23,147],"age,":[25],"harboring":[26],"microbes":[27],"varied":[29],"immunogenic":[30,217,233],"capacities.":[31],"We":[32,104,211],"hypothesized":[33],"gut":[35,159,197],"acts":[37,201],"as":[38,239],"an":[39],"active":[40],"driver":[41],"during":[45],"aging.":[46],"Microbiome":[47],"patterns":[48,106],"in":[49,121,148,176,195,242],"aged":[50,88,134,162],"mice":[51,89,124,135,163],"strongly":[52,225],"signs":[55],"bacterial-induced":[57],"barrier":[58],"disruption":[59],"immune":[61,209],"infiltration,":[62],"including":[63],"marked":[64],"increased":[65,91],"levels":[66],"circulating":[68],"lipopolysaccharide":[69],"(LPS)-binding":[70],"protein":[71],"(LBP)":[72],"colonic":[74,83],"calprotectin.":[75],"Ex":[76],"vivo":[77],"immunogenicity":[78,150,182],"assays":[79],"revealed":[80],"both":[82],"contents":[84,132],"mucosa":[86],"harbored":[90],"capacity":[92],"to":[93,167,222,227],"activate":[94],"toll-like":[95],"receptor":[96],"4":[97,126],"(TLR4)":[98],"whereas":[99],"TLR5":[100,181],"signaling":[101,111,204],"was":[102],"unchanged.":[103],"found":[105,212],"elevated":[108],"innate":[109,208],"inflammatory":[110,229,245],"(colonic":[112],"Il6,":[113],"Tnf,":[114],"Tlr4)":[116],"endotoxemia":[118],"(circulating":[119],"LBP)":[120],"young":[122,138],"germ-free":[123],"after":[125],"weeks":[127],"colonization":[129],"intestinal":[131],"from":[133],"compared":[136],"counterparts,":[139],"thus":[140,237],"providing":[141],"a":[142,168,196],"direct":[143],"link":[144],"between":[145],"aging-induced":[146],"host":[152,228],"inflammation.":[153],"Additionally,":[154],"we":[155],"discovered":[156],"exhibited":[164],"unique":[165],"responses":[166],"broad-spectrum":[169],"antibiotic":[170],"challenge":[171,223],"(Abx),":[172],"sustained":[174],"elevation":[175],"Escherichia":[177],"(Proteobacteria)":[178],"altered":[180],"7":[183],"days":[184],"post-Abx":[185],"cessation.":[186],"Together,":[187],"these":[188,214],"data":[189],"indicate":[190],"old":[192],"age":[193],"results":[194],"differentially":[200],"on":[202],"TLR":[203],"pathways":[205],"system.":[210],"age-associated":[215],"signatures":[218,234],"are":[219],"less":[220],"resilient":[221],"linked":[226],"status.":[230],"should":[235],"be":[236],"considered":[238],"critical":[240],"factors":[241],"mediating":[243],"chronic":[244],"diseases":[246],"disproportionally":[247],"impacting":[248],"older":[249],"populations.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":33},{"year":2025,"cited_by_count":25}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-05-11T00:00:00"}
