{"id":"https://openalex.org/W4396807293","doi":"https://doi.org/10.1002/jor.25870","title":"Synovial fluid NMR\u2010based metabolomics in septic and aseptic revision total knee arthroplasty: Implications on diagnosis and treatment","display_name":"Synovial fluid NMR\u2010based metabolomics in septic and aseptic revision total knee arthroplasty: Implications on diagnosis and treatment","publication_year":2024,"publication_date":"2024-05-10","ids":{"openalex":"https://openalex.org/W4396807293","doi":"https://doi.org/10.1002/jor.25870","pmid":"https://pubmed.ncbi.nlm.nih.gov/38725379"},"language":"en","primary_location":{"id":"doi:10.1002/jor.25870","doi":"https://doi.org/10.1002/jor.25870","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.25870","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.25870","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.25870","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044205524","display_name":"Alan de Paula Mozella","orcid":"https://orcid.org/0000-0001-5855-5808","observed_orcids":["https://orcid.org/0000-0001-5855-5808"]},"institutions":[{"id":"https://openalex.org/I4210164859","display_name":"Instituto Nacional de Traumatologia e Ortopedia","ror":"https://ror.org/05nyf1y15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210121739","https://openalex.org/I4210164859"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Alan de Paula Mozella","raw_affiliation_strings":["Department of Knee Surgery, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Knee Surgery, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4210164859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033483664","display_name":"Hugo Alexandre de Ara\u00fajo Barros Cobra","orcid":"https://orcid.org/0000-0002-7315-0961","observed_orcids":["https://orcid.org/0000-0002-7315-0961"]},"institutions":[{"id":"https://openalex.org/I4210164859","display_name":"Instituto Nacional de Traumatologia e Ortopedia","ror":"https://ror.org/05nyf1y15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210121739","https://openalex.org/I4210164859"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hugo Alexandre de Araujo Barros Cobra","raw_affiliation_strings":["Department of Knee Surgery, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Knee Surgery, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4210164859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075783863","display_name":"Idemar Monteiro da Palma","orcid":"https://orcid.org/0000-0003-4193-2376","observed_orcids":["https://orcid.org/0000-0003-4193-2376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Idemar Monteiro da Palma","raw_affiliation_strings":["Department of Knee Surgery, Montese Medical Center, Rio de Janeiro, Brazil","Department of Knee Surgery, Rios D'or Hospital, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Knee Surgery, Montese Medical Center, Rio de Janeiro, Brazil","institution_ids":[]},{"raw_affiliation_string":"Department of Knee Surgery, Rios D'or Hospital, Rio de Janeiro, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015699894","display_name":"Rodrigo Salim","orcid":"https://orcid.org/0000-0003-3978-4888","observed_orcids":["https://orcid.org/0000-0003-3978-4888"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo Salim","raw_affiliation_strings":["Department of Orthopaedics and Anaesthesiology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Anaesthesiology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055565693","display_name":"Jo\u00e4o Ant\u00f4nio Matheus Guimar\u00e4es","orcid":"https://orcid.org/0000-0002-5647-2248","observed_orcids":["https://orcid.org/0000-0002-5647-2248","https://orcid.org/0000-0002-4088-044X"]},"institutions":[{"id":"https://openalex.org/I4210164859","display_name":"Instituto Nacional de Traumatologia e Ortopedia","ror":"https://ror.org/05nyf1y15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210121739","https://openalex.org/I4210164859"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Antonio Matheus Guimar\u00e3es","raw_affiliation_strings":["Teaching and Research Division, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teaching and Research Division, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4210164859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038352101","display_name":"Gilson Alexandre Ostwald Pedro da Costa","orcid":"https://orcid.org/0000-0001-7341-9118","observed_orcids":["https://orcid.org/0000-0001-7341-9118"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Gilson Costa","raw_affiliation_strings":["Department of Genetics, IBRAG, State University of Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, IBRAG, State University of Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008806694","display_name":"Ana Carolina Leal","orcid":"https://orcid.org/0000-0002-2556-3446","observed_orcids":["https://orcid.org/0000-0002-2556-3446"]},"institutions":[{"id":"https://openalex.org/I4210164859","display_name":"Instituto Nacional de Traumatologia e Ortopedia","ror":"https://ror.org/05nyf1y15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210121739","https://openalex.org/I4210164859"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Carolina Leal","raw_affiliation_strings":["Teaching and Research Division, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-2556-3446","affiliations":[{"raw_affiliation_string":"Teaching and Research Division, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4210164859"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038352101","https://openalex.org/A5044205524"],"corresponding_institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210164859"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":1.6477,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.83331531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"42","issue":"10","first_page":"2336","last_page":"2344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.9950000047683716},{"id":"https://openalex.org/keywords/revision-total-knee-arthroplasty","display_name":"revision total knee arthroplasty","score":0.9300000071525574},{"id":"https://openalex.org/keywords/aseptic-failure","display_name":"aseptic failure","score":0.7699999809265137},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6079999804496765},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.8429999947547913},{"id":"https://openalex.org/keywords/beta-hydroxybutyrate","display_name":"beta-hydroxybutyrate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.9649999737739563},{"id":"https://openalex.org/keywords/creatine","display_name":"creatine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.7239999771118164},{"id":"https://openalex.org/keywords/infection-diagnosis","display_name":"infection diagnosis","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.8755415678024292},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.8413357734680176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7183542251586914},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.5967342853546143},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.5892323851585388},{"id":"https://openalex.org/C181268634","wikidata":"https://www.wikidata.org/wiki/Q4071230","display_name":"Aseptic processing","level":2,"score":0.5586903095245361},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5256292223930359},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.46201860904693604},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.4116598069667816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39352932572364807},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3298007547855377},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30947697162628174},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3016245365142822},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.26119548082351685},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22633028030395508},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.22169095277786255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13828951120376587},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016459","descriptor_name":"Prosthesis-Related Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016459","descriptor_name":"Prosthesis-Related Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016459","descriptor_name":"Prosthesis-Related Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jor.25870","doi":"https://doi.org/10.1002/jor.25870","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.25870","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.25870","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:38725379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38725379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jor.25870","doi":"https://doi.org/10.1002/jor.25870","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.25870","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.25870","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396807293.pdf","grobid_xml":"https://content.openalex.org/works/W4396807293.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1980929079","https://openalex.org/W1984991163","https://openalex.org/W2014869787","https://openalex.org/W2028378804","https://openalex.org/W2093310356","https://openalex.org/W2100274576","https://openalex.org/W2109872165","https://openalex.org/W2113638991","https://openalex.org/W2120257409","https://openalex.org/W2147263332","https://openalex.org/W2152169346","https://openalex.org/W2159182105","https://openalex.org/W2438192960","https://openalex.org/W2460791328","https://openalex.org/W2498609637","https://openalex.org/W2605505919","https://openalex.org/W2606104114","https://openalex.org/W2620832850","https://openalex.org/W2737557435","https://openalex.org/W2747004888","https://openalex.org/W2749623640","https://openalex.org/W2954214838","https://openalex.org/W2966426098","https://openalex.org/W2973029090","https://openalex.org/W2999962735","https://openalex.org/W3006476224","https://openalex.org/W3012379787","https://openalex.org/W3012999060","https://openalex.org/W3016592592","https://openalex.org/W3017020958","https://openalex.org/W3041604486","https://openalex.org/W3072630072","https://openalex.org/W3095424424","https://openalex.org/W3119674742","https://openalex.org/W3125157080","https://openalex.org/W3137111959","https://openalex.org/W3138065161","https://openalex.org/W3138924483","https://openalex.org/W3156020921","https://openalex.org/W3159995035","https://openalex.org/W4229743141"],"related_works":["https://openalex.org/W7120342728","https://openalex.org/W2896256869","https://openalex.org/W4361247652","https://openalex.org/W7169781899","https://openalex.org/W4399833502","https://openalex.org/W4415871643","https://openalex.org/W6964235301","https://openalex.org/W4416809094","https://openalex.org/W7220981563","https://openalex.org/W4381683535"],"abstract_inverted_index":{"Abstract":[0],"Periprosthetic":[1],"joint":[2],"infection":[3],"(PJI)":[4],"is":[5,20],"one":[6],"of":[7,23,48,54,63,74,94,127,134,220],"the":[8,26,44,52,60,64,92,167,191,207,218],"most":[9],"challenging":[10],"complications":[11],"following":[12],"total":[13,75,87,126],"knee":[14,76,88],"arthroplasty.":[15],"Despite":[16],"its":[17,29],"importance,":[18],"there":[19],"a":[21,156,180,203,221],"paucity":[22],"reports":[24],"in":[25,43,155,166,190,217],"literature":[27],"regarding":[28],"pathogenesis.":[30],"Recently,":[31],"cellular":[32],"metabolic":[33,182,186,208],"reprogramming":[34],"has":[35],"been":[36],"shown":[37],"to":[38,58,115,137,153,201],"play":[39],"an":[40],"important":[41],"role":[42],"progression":[45],"and":[46,96,109,132,143,149,159,161,197,214],"outcome":[47],"infectious":[49],"diseases.":[50],"Therefore,":[51],"aim":[53],"this":[55],"study":[56],"was":[57],"evaluate":[59],"metabolites":[61,117,129],"composition":[62],"synovial":[65,79,145,168],"fluid":[66,169,174],"from":[67,81,170,175],"patients":[68,83,176],"with":[69,91,98,177],"PJI":[70,95,171,178],"or":[71],"aseptic":[72,99],"failure":[73],"arthroplasties.":[77],"The":[78],"fluids":[80],"21":[82],"scheduled":[84],"for":[85],"revision":[86],"arthroplasty":[89],"(11":[90],"diagnosis":[93],"10":[97],"failures)":[100],"were":[101,113,119,130,151,163],"analyzed":[102],"using":[103],"1D":[104],"1H":[105],"NMR":[106],"spectroscopy.":[107],"Univariate":[108],"multivariate":[110],"statistical":[111],"analyzes":[112],"used":[114],"identify":[116],"that":[118,188],"differentially":[120,139],"abundant":[121,140],"between":[122,141],"those":[123],"groups.":[124],"A":[125],"28":[128],"identified":[131],"five":[133],"them":[135],"found":[136,152,164],"be":[138,154],"infected":[142,192],"non\u2010infected":[144],"fluids.":[146],"Lactate,":[147],"acetate":[148],"3\u2010hydroxybutyrate":[150],"higher":[157],"concentration,":[158],"glucose":[160],"creatine":[162],"reduced":[165],"patients.":[172],"Synovial":[173],"exhibit":[179],"distinct":[181],"profile,":[183],"possibly":[184],"reflecting":[185],"adaptation":[187],"occurs":[189],"periprosthetic":[193],"microenvironment.":[194],"Further":[195],"research":[196],"studies":[198],"are":[199],"warranted":[200],"gain":[202],"broader":[204],"insight":[205],"into":[206],"pathways":[209],"engaged":[210],"by":[211],"both":[212],"pathogen":[213],"immune":[215],"cells":[216],"context":[219],"PJI.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-05-11T00:00:00"}