{"id":"https://openalex.org/W4396799806","doi":"https://doi.org/10.1107/s2053273323082025","title":"Humidity-induced structural transition in orthorhombic lysozyme","display_name":"Humidity-induced structural transition in orthorhombic lysozyme","publication_year":2023,"publication_date":"2023-08-22","ids":{"openalex":"https://openalex.org/W4396799806","doi":"https://doi.org/10.1107/s2053273323082025"},"language":"en","primary_location":{"id":"doi:10.1107/s2053273323082025","doi":"https://doi.org/10.1107/s2053273323082025","is_oa":true,"landing_page_url":"http://doi.org/10.1107/s2053273323082025","pdf_url":"http://dx.doi.org/10.1107/s2053273323082025","source":{"id":"https://openalex.org/S4393918093","display_name":"Acta Crystallographica Section A Foundations and Advances","issn_l":"2053-2733","issn":["2053-2733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-200","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section A Foundations and Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://dx.doi.org/10.1107/s2053273323082025","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108026725","display_name":"K. Ozawa","orcid":"https://orcid.org/0000-0002-6753-9284","observed_orcids":["https://orcid.org/0000-0002-6753-9284"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Ozawa","raw_affiliation_strings":["Graduate School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Shimizu","raw_affiliation_strings":["School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":null,"display_name":"S. Yamamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"S. Yamamura","raw_affiliation_strings":["Graduate School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan","School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I64189623"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"a2","first_page":"C1419","last_page":"C1419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9430000185966492},{"id":"https://openalex.org/keywords/humidity-dependence","display_name":"humidity dependence","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dehydration","display_name":"dehydration","score":0.734000027179718},{"id":"https://openalex.org/keywords/hydration","display_name":"hydration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/structural-phase-transition","display_name":"structural phase transition","score":0.8519999980926514},{"id":"https://openalex.org/keywords/polymorphism","display_name":"polymorphism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/protein-crystals","display_name":"protein crystals","score":0.4790000021457672},{"id":"https://openalex.org/keywords/relative-humidity","display_name":"relative humidity","score":0.6930000185966492},{"id":"https://openalex.org/keywords/hysteresis","display_name":"hysteresis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-rotation","display_name":"protein rotation","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.7048216462135315},{"id":"https://openalex.org/C151420433","wikidata":"https://www.wikidata.org/wiki/Q180600","display_name":"Humidity","level":2,"score":0.6768750548362732},{"id":"https://openalex.org/C37243968","wikidata":"https://www.wikidata.org/wiki/Q648961","display_name":"Orthorhombic crystal system","level":3,"score":0.6365898847579956},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.458048015832901},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44642966985702515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3755883574485779},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34563398361206055},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3189457058906555},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17404448986053467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1276586949825287},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.12077885866165161},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10154637694358826},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.07335153222084045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1107/s2053273323082025","doi":"https://doi.org/10.1107/s2053273323082025","is_oa":true,"landing_page_url":"http://doi.org/10.1107/s2053273323082025","pdf_url":"http://dx.doi.org/10.1107/s2053273323082025","source":{"id":"https://openalex.org/S4393918093","display_name":"Acta Crystallographica Section A Foundations and Advances","issn_l":"2053-2733","issn":["2053-2733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-200","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section A Foundations and Advances","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1107/s2053273323082025","doi":"https://doi.org/10.1107/s2053273323082025","is_oa":true,"landing_page_url":"http://doi.org/10.1107/s2053273323082025","pdf_url":"http://dx.doi.org/10.1107/s2053273323082025","source":{"id":"https://openalex.org/S4393918093","display_name":"Acta Crystallographica Section A Foundations and Advances","issn_l":"2053-2733","issn":["2053-2733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-200","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section A Foundations and Advances","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396799806.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170297840","https://openalex.org/W2007676961","https://openalex.org/W2027072431","https://openalex.org/W2143150898","https://openalex.org/W2020931246","https://openalex.org/W7136440372","https://openalex.org/W1983568003","https://openalex.org/W2900466647","https://openalex.org/W2962676893","https://openalex.org/W1976232903"],"abstract_inverted_index":{"Biomolecules":[0],"such":[1,32],"as":[2,5],"proteins":[3],"crystallize":[4],"hydrates.Most":[6],"of":[7,16,67,94,130,165,185],"those":[8],"hydrates":[9,18],"lose":[10],"their":[11,21],"crystallinity":[12,22],"by":[13],"dehydration.However":[14],"some":[15],"these":[17],"often":[19],"maintain":[20],"and":[23,41,78,87,170],"cause":[24],"structural":[25,33,136,172],"transition":[26,137,166],"during":[27],"dehydration.We":[28],"have":[29,63,105,133],"been":[30,98,102,121],"studying":[31],"change":[34],"in":[35,58,108,145,177,182],"biomolecular":[36],"crystals":[37],"due":[38],"to":[39,45,104,152],"humidity":[40,48,92,118,128,148],"developing":[42],"a":[43,53],"technique":[44],"control":[46],"the":[47,50,90,109,127,131,146],"around":[49],"crystals.Lysozyme":[51],"is":[52],"well-known":[54],"protein":[55,186],"that":[56,161],"exists":[57],"several":[59],"crystal":[60,95],"forms.Orthorhombic":[61],"forms":[62],"mainly":[64],"two":[65],"types":[66],"unit":[68],"cells":[69],"dependent":[70],"on":[71],"crystallization":[72,114],"conditions.One":[73],"crystallizes":[74,82],"under":[75,83],"room":[76],"temperature":[77,86],"alkaline":[79],"conditions.The":[80],"other":[81],"relatively":[84],"high":[85,147],"acidic":[88],"conditions.For":[89],"former,":[91],"dependence":[93,119,129],"structure":[96,158],"has":[97,101,120],"reported.The":[99],"latter":[100],"reported":[103],"three":[106,142],"polymorphs":[107],"same":[110],"drop":[111],"from":[112],"another":[113],"condition,":[115],"although":[116],"no":[117],"reported.In":[122],"this":[123],"paper":[124],"we":[125],"report":[126],"latter.We":[132],"found":[134],"humidity-induced":[135],"involving":[138],"five":[139],"structures":[140,144],"including":[141],"new":[143],"region":[149],"between":[150,168],"99":[151],"85%":[153],"relative":[154],"humidity.The":[155],"most":[156],"dried":[157],"shows":[159],"hysteresis,":[160],"is,":[162],"large":[163,183],"difference":[164],"point":[167],"dehydration":[169],"hydration.Noble":[171],"transformations":[173],"occur":[174],"not":[175],"only":[176],"simple":[178],"translations,":[179],"but":[180],"also":[181],"rotations":[184],"molecules.":[187]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-05-11T00:00:00"}