{"id":"https://openalex.org/W4396790899","doi":"https://doi.org/10.1016/j.jdent.2024.105055","title":"Alterations in salivary biomarkers in relation to periodontal health and obesity among Hong Kong adolescents","display_name":"Alterations in salivary biomarkers in relation to periodontal health and obesity among Hong Kong adolescents","publication_year":2024,"publication_date":"2024-05-10","ids":{"openalex":"https://openalex.org/W4396790899","doi":"https://doi.org/10.1016/j.jdent.2024.105055","pmid":"https://pubmed.ncbi.nlm.nih.gov/38735470"},"language":"en","primary_location":{"id":"doi:10.1016/j.jdent.2024.105055","doi":"https://doi.org/10.1016/j.jdent.2024.105055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jdent.2024.105055","pdf_url":null,"source":{"id":"https://openalex.org/S191726168","display_name":"Journal of Dentistry","issn_l":"0300-5712","issn":["0300-5712","1879-176X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dentistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jdent.2024.105055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072511443","display_name":"Qianyi Deng","orcid":"https://orcid.org/0000-0002-3912-7688","observed_orcids":["https://orcid.org/0000-0002-3912-7688"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Qianyi Deng","raw_affiliation_strings":["Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, PR China","Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China","Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China","Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":"https://orcid.org/0000-0002-3912-7688","affiliations":[{"raw_affiliation_string":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China; Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, PR China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]},{"raw_affiliation_string":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058621529","display_name":"Hai Ming Wong","orcid":"https://orcid.org/0000-0003-3411-6442","observed_orcids":["https://orcid.org/0000-0003-3411-6442"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hai Ming Wong","raw_affiliation_strings":["Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China","Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":"https://orcid.org/0000-0003-3411-6442","affiliations":[{"raw_affiliation_string":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033398718","display_name":"Simin Peng","orcid":"https://orcid.org/0000-0001-6117-3173","observed_orcids":["https://orcid.org/0000-0001-6117-3173"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Simin Peng","raw_affiliation_strings":["Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China. Electronic address: pengsm@hku.hk","Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":"https://orcid.org/0000-0001-6117-3173","affiliations":[{"raw_affiliation_string":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China. Electronic address: pengsm@hku.hk","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033398718"],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":{"value":4040,"currency":"USD","value_usd":4040},"fwci":1.2817,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75828076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"146","issue":null,"first_page":"105055","last_page":"105055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salivary-biomarkers","display_name":"salivary biomarkers","score":0.996999979019165},{"id":"https://openalex.org/keywords/periodontal-inflammation","display_name":"periodontal inflammation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.7200000286102295},{"id":"https://openalex.org/keywords/waist-to-height-ratio","display_name":"waist-to-height ratio","score":0.9120000004768372},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"abdominal obesity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.890999972820282},{"id":"https://openalex.org/keywords/secretory-phospholipase-a2-group-iia","display_name":"sPLA2-IIA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gingival-health","display_name":"gingival health","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6296892166137695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5929511189460754},{"id":"https://openalex.org/C2992672162","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Oral health","level":2,"score":0.5191430449485779},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.45702335238456726},{"id":"https://openalex.org/C2991849382","wikidata":"https://www.wikidata.org/wiki/Q4117950","display_name":"Dental health","level":2,"score":0.4264734387397766},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.41275161504745483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15709301829338074}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006723","descriptor_name":"Hong Kong","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009909","descriptor_name":"Oral Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010512","descriptor_name":"Periodontal Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058491","descriptor_name":"Bacterial Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065927","descriptor_name":"Waist-Height Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jdent.2024.105055","doi":"https://doi.org/10.1016/j.jdent.2024.105055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jdent.2024.105055","pdf_url":null,"source":{"id":"https://openalex.org/S191726168","display_name":"Journal of Dentistry","issn_l":"0300-5712","issn":["0300-5712","1879-176X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dentistry","raw_type":"journal-article"},{"id":"pmid:38735470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38735470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of dentistry","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/350625","doi":null,"is_oa":true,"landing_page_url":"https://hub.hku.hk/handle/10722/350625","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.jdent.2024.105055","doi":"https://doi.org/10.1016/j.jdent.2024.105055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jdent.2024.105055","pdf_url":null,"source":{"id":"https://openalex.org/S191726168","display_name":"Journal of Dentistry","issn_l":"0300-5712","issn":["0300-5712","1879-176X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dentistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W24997922","https://openalex.org/W1499775116","https://openalex.org/W1963308541","https://openalex.org/W1971706127","https://openalex.org/W1979288174","https://openalex.org/W1995011477","https://openalex.org/W2010058965","https://openalex.org/W2044379852","https://openalex.org/W2063312922","https://openalex.org/W2064426892","https://openalex.org/W2082083952","https://openalex.org/W2082595066","https://openalex.org/W2085546458","https://openalex.org/W2088940658","https://openalex.org/W2095197048","https://openalex.org/W2114014916","https://openalex.org/W2127466890","https://openalex.org/W2133662619","https://openalex.org/W2159981485","https://openalex.org/W2221078985","https://openalex.org/W2279029296","https://openalex.org/W2299929805","https://openalex.org/W2400716300","https://openalex.org/W2409084974","https://openalex.org/W2526405168","https://openalex.org/W2732587388","https://openalex.org/W2783788566","https://openalex.org/W2793840284","https://openalex.org/W2802716640","https://openalex.org/W2901018144","https://openalex.org/W2905742189","https://openalex.org/W2971980901","https://openalex.org/W2983576537","https://openalex.org/W2994393807","https://openalex.org/W3009635936","https://openalex.org/W3017485312","https://openalex.org/W3022245009","https://openalex.org/W3159665062","https://openalex.org/W3178442792","https://openalex.org/W3203241264","https://openalex.org/W3204901048","https://openalex.org/W4307264575","https://openalex.org/W4389922331","https://openalex.org/W6601043459","https://openalex.org/W6797833099"],"related_works":["https://openalex.org/W2139875734","https://openalex.org/W4389922331","https://openalex.org/W4412427173","https://openalex.org/W2163272984","https://openalex.org/W1766341019","https://openalex.org/W7111877660","https://openalex.org/W4401747092","https://openalex.org/W2326044646","https://openalex.org/W2981674552","https://openalex.org/W2350070481"],"abstract_inverted_index":{":":[0,15,122,213,249],"To":[1],"explore":[2],"the":[3,152,165,178,220],"association":[4],"among":[5],"salivary":[6,91,148,161,189,205,251],"biomarkers,":[7],"periodontal":[8,55,64,73,83,223,247,254],"inflammation,":[9],"and":[10,35,52,61,70,76,80,97,109,118,126,128,139,158,185,264],"adiposity":[11,240],"status":[12,241],"in":[13,192,208,225,232,259],"adolescents.":[14],"This":[16],"study":[17],"included":[18],"180":[19],"Hong":[20],"Kong":[21],"adolescents":[22],"aged":[23],"12\u201315":[24],"years.":[25],"Anthropometric":[26],"measurements":[27],"including":[28,102],"central":[29],"obesity":[30],"surrogate,":[31],"waist-to-height":[32],"ratio":[33],"(WHtR),":[34],"dental":[36],"examinations":[37],"were":[38,42,87,113,174,200,217],"conducted.":[39],"The":[40,142],"participants":[41,193,209,226],"classified":[43],"into":[44],"four":[45],"groups":[46,134],"as":[47,278,280],"follows:":[48],"with":[49,58,67,77,177,182,188,194,203,210,219,227,234,238,272],"normal":[50,68,195,228],"WHtR":[51,60,69,79,229],"less":[53,62],"extensive":[54,63,72,82],"inflammation":[56,65,74,84,224],"(NW+LP);":[57],"high":[59,78,211,235],"(HW+LP);":[66],"more":[71,81],"(NW+P);":[75],"(HW+P).":[85],"Saliva":[86],"collected":[88],"to":[89],"measure":[90],"physicochemical":[92],"parameters,":[93],"total":[94,204],"bacterial":[95,206],"load,":[96],"levels":[98,125,173,191,199,216,274],"of":[99,180,222,246,253,275],"protein":[100],"biomarkers":[101,252],"secretory":[103],"phospholipase":[104],"A2":[105],"group":[106,144,154,167],"IIA":[107],"(sPLA2-IIA)":[108],"interleukin-6":[110],"(IL-6).":[111],"Data":[112],"analysed":[114],"by":[115],"Kruskal-Wallis":[116],"test":[117],"Spearman":[119],"correlation":[120],"coefficient.":[121],"Salivary":[123,171,197,214],"IL-6":[124,129,149,172,215],"sPLA2-IIA":[127,162,190,198],"output":[130,150,163],"differed":[131],"significantly":[132,146,159],"between":[133],"(P":[135,155,168],"=":[136,156,169],"0.041,":[137],"0.027,":[138],"0.043,":[140],"respectively).":[141],"NW+P":[143],"had":[145],"higher":[147],"than":[151,164],"NW+LP":[153],"0.034)":[157],"lower":[160],"HW+LP":[166],"0.038).":[170],"negatively":[175,201],"correlated":[176,187,202],"number":[179],"sextants":[181],"healthy":[183],"gingivae":[184],"positively":[186],"WHtR.":[196,212,236],"load":[207],"associated":[218],"extent":[221],"but":[230],"not":[231],"those":[233],"Adolescents":[237],"different":[239,244],"may":[242],"have":[243],"mechanisms":[245],"inflammation.":[248],"Investigating":[250],"health":[255,267],"holds":[256],"potential":[257],"benefits":[258],"identifying":[260],"individuals":[261,271],"at":[262],"risk":[263],"customizing":[265],"oral":[266],"promotion":[268],"strategies":[269],"for":[270],"varying":[273],"adiposity,":[276],"even":[277],"early":[279],"adolescence.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-11T00:00:00"}