{"id":"https://openalex.org/W4396730488","doi":"https://doi.org/10.3390/medicina60050781","title":"Clinical and Ultrasound Efficacy of Topical Hypertonic Cream (Jovita Osmocell\u00ae) in the Treatment of Cellulite: A Prospective, Monocentric, Double-Blind, Placebo-Controlled Study","display_name":"Clinical and Ultrasound Efficacy of Topical Hypertonic Cream (Jovita Osmocell\u00ae) in the Treatment of Cellulite: A Prospective, Monocentric, Double-Blind, Placebo-Controlled Study","publication_year":2024,"publication_date":"2024-05-08","ids":{"openalex":"https://openalex.org/W4396730488","doi":"https://doi.org/10.3390/medicina60050781","pmid":"https://pubmed.ncbi.nlm.nih.gov/38792964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11122878"},"language":"en","primary_location":{"id":"doi:10.3390/medicina60050781","doi":"https://doi.org/10.3390/medicina60050781","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina60050781","pdf_url":null,"source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/medicina60050781","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039891350","display_name":"Antonio Di Guardo","orcid":"https://orcid.org/0000-0002-0117-346X","observed_orcids":["https://orcid.org/0000-0002-0117-346X"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Di Guardo","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0117-346X","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053153816","display_name":"Carmen Solito","orcid":"https://orcid.org/0009-0008-9643-7202","observed_orcids":["https://orcid.org/0009-0008-9643-7202"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmen Solito","raw_affiliation_strings":["Department of Radiology, Oncology, Anatomo-Pathology, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Oncology, Anatomo-Pathology, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026634873","display_name":"Vito Cantisani","orcid":"https://orcid.org/0000-0003-1525-214X","observed_orcids":["https://orcid.org/0000-0003-1525-214X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vito Cantisani","raw_affiliation_strings":["Department of Radiology, Oncology, Anatomo-Pathology, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Oncology, Anatomo-Pathology, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013329589","display_name":"Federica Rega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Rega","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108545284","display_name":"Luca Gargano","orcid":"https://orcid.org/0009-0006-0727-8314","observed_orcids":["https://orcid.org/0009-0006-0727-8314"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Gargano","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Giovanni Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Rossi","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092985346","display_name":"Noah Musolff","orcid":"https://orcid.org/0009-0003-6952-0661","observed_orcids":["https://orcid.org/0009-0003-6952-0661"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Noah Musolff","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093786764","display_name":"Giulia Azzella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Azzella","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008379466","display_name":"Giovanni Paolino","orcid":"https://orcid.org/0000-0002-3032-2217","observed_orcids":["https://orcid.org/0000-0002-3032-2217","https://orcid.org/0000-0002-4146-8975"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Paolino","raw_affiliation_strings":["Unit of Dermatology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Dermatology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054727273","display_name":"Luigi Losco","orcid":"https://orcid.org/0000-0001-9105-1839","observed_orcids":["https://orcid.org/0000-0001-9105-1839"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Losco","raw_affiliation_strings":["Plastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9105-1839","affiliations":[{"raw_affiliation_string":"Plastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023018813","display_name":"Antonia Rivieccio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonia Rivieccio","raw_affiliation_strings":["Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086793471","display_name":"Elena Campione","orcid":"https://orcid.org/0000-0001-7447-6798","observed_orcids":["https://orcid.org/0000-0001-7447-6798"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Campione","raw_affiliation_strings":["Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004401304","display_name":"Luca Bianchi","orcid":"https://orcid.org/0000-0001-8697-6896","observed_orcids":["https://orcid.org/0000-0001-8697-6896","https://orcid.org/0000-0001-5159-4863"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Bianchi","raw_affiliation_strings":["Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8697-6896","affiliations":[{"raw_affiliation_string":"Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077950251","display_name":"Steven Paul Nistic\u00f2","orcid":"https://orcid.org/0000-0002-3828-0883","observed_orcids":["https://orcid.org/0000-0002-3828-0883"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Steven Paul Nistic\u00f2","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000163818","display_name":"Giovanni Pellacani","orcid":"https://orcid.org/0000-0002-7222-2951","observed_orcids":["https://orcid.org/0000-0002-7222-2951"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Pellacani","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004866698","display_name":"Carmen Cantisani","orcid":"https://orcid.org/0000-0003-2181-951X","observed_orcids":["https://orcid.org/0000-0003-2181-951X"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Carmen Cantisani","raw_affiliation_strings":["Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2181-951X","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004866698"],"corresponding_institution_ids":["https://openalex.org/I2800330116","https://openalex.org/I861853513"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2046},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2046},"fwci":3.3509,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.92491932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"60","issue":"5","first_page":"781","last_page":"781"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12173","display_name":"Body Contouring and Surgery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12173","display_name":"Body Contouring and Surgery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellulite","display_name":"cellulite","score":0.996999979019165},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.824999988079071},{"id":"https://openalex.org/keywords/topical-therapy","display_name":"topical treatment","score":0.6430000066757202},{"id":"https://openalex.org/keywords/thigh-circumference","display_name":"thigh circumference","score":0.6790000200271606},{"id":"https://openalex.org/keywords/water-retention","display_name":"water retention","score":0.6959999799728394},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8109999895095825},{"id":"https://openalex.org/keywords/osmosis","display_name":"osmosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ultrasound-evaluation","display_name":"ultrasound evaluation","score":0.47600001096725464},{"id":"https://openalex.org/keywords/subcutaneous-tissue-thickness","display_name":"subcutaneous tissue thickness","score":0.8379999995231628},{"id":"https://openalex.org/keywords/female-patients","display_name":"female patients","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8349792957305908},{"id":"https://openalex.org/C2780078609","wikidata":"https://www.wikidata.org/wiki/Q242510","display_name":"Cellulite","level":3,"score":0.807072639465332},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6276223063468933},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6021333336830139},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5692379474639893},{"id":"https://openalex.org/C117277713","wikidata":"https://www.wikidata.org/wiki/Q925744","display_name":"Tonicity","level":2,"score":0.4389322102069855},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4064194858074188},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32449206709861755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2767041027545929},{"id":"https://openalex.org/C2777238321","wikidata":"https://www.wikidata.org/wiki/Q876887","display_name":"Cellulitis","level":2,"score":0.25156041979789734},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16160285472869873},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071697","descriptor_name":"Cellulite","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013848","descriptor_name":"Thigh","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063465","descriptor_name":"Skin Cream","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/medicina60050781","doi":"https://doi.org/10.3390/medicina60050781","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina60050781","pdf_url":null,"source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11122878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11122878","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11122878/pdf/medicina-60-00781.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmid:38792964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38792964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1717134","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11573/1717134","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1717134/1/medicina-60-00781.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:art.torvergata.it:2108/394442","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2108/394442","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:17b91ce5deb7407a8d96cebcda31bd50","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/17b91ce5deb7407a8d96cebcda31bd50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 60, Iss 5, p 781 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medicina60050781","doi":"https://doi.org/10.3390/medicina60050781","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina60050781","pdf_url":null,"source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W577260235","https://openalex.org/W1493038003","https://openalex.org/W1962891361","https://openalex.org/W1967292766","https://openalex.org/W1986221925","https://openalex.org/W2007847213","https://openalex.org/W2035727822","https://openalex.org/W2040088687","https://openalex.org/W2053582356","https://openalex.org/W2058999401","https://openalex.org/W2076023741","https://openalex.org/W2083596113","https://openalex.org/W2097431175","https://openalex.org/W2105976853","https://openalex.org/W2140386267","https://openalex.org/W2143062164","https://openalex.org/W2148913634","https://openalex.org/W2154663262","https://openalex.org/W2161154980","https://openalex.org/W2495193810","https://openalex.org/W2570668154","https://openalex.org/W2884297351","https://openalex.org/W2924005317","https://openalex.org/W3010902328","https://openalex.org/W3089068626","https://openalex.org/W3158419773","https://openalex.org/W3174772255","https://openalex.org/W3183517548","https://openalex.org/W4205283933","https://openalex.org/W4210331796","https://openalex.org/W4323843499","https://openalex.org/W4381660710"],"related_works":["https://openalex.org/W2774274749","https://openalex.org/W2957566294","https://openalex.org/W2109096722","https://openalex.org/W2138050621","https://openalex.org/W4412526458","https://openalex.org/W2096479299","https://openalex.org/W3192510838","https://openalex.org/W2398600282","https://openalex.org/W3026801222","https://openalex.org/W7027819115"],"abstract_inverted_index":{"Background":[0],"and":[1,12,20,43,57,90,98,162,184,203,211,221,224],"Objectives:":[2],"Cellulite,":[3],"or":[4,73,83],"edemato-fibro-sclerotic":[5],"panniculopathy":[6],"(EFP),":[7],"is":[8],"characterized":[9],"by":[10],"dermal":[11],"hypodermal":[13],"changes":[14,133,149],"leading":[15],"to":[16,50,79,121],"adipose":[17,47,188],"tissue":[18],"accumulation":[19],"compromised":[21],"venous":[22],"circulation.":[23],"This":[24,206],"study":[25,65,207],"investigates":[26],"the":[27,52,109,122,135,140,143,153,158,209],"efficacy":[28,176,210],"of":[29,142,213],"a":[30,84,114],"hypertonic":[31,81,110,173,214],"cream":[32,82,111,174],"containing":[33],"concentrated":[34],"sodium":[35,215],"chloride":[36,216],"(Jovita":[37],"Osmocell\u00ae)":[38],"in":[39,46,117,134,152,177,187,218],"addressing":[40,181],"water":[41,182],"retention":[42,183],"structural":[44,185],"alterations":[45,186],"tissue,":[48],"aiming":[49],"interrupt":[51],"cellulite":[53,219],"formation":[54],"process.":[55],"Materials":[56],"Methods:":[58],"A":[59],"12-week,":[60],"prospective,":[61],"monocentric,":[62],"double-blind,":[63],"placebo-controlled":[64],"enrolled":[66],"30":[67],"female":[68],"subjects":[69],"with":[70,166],"grade":[71],"II":[72],"III":[74],"cellulite.":[75],"Patients":[76],"were":[77,93,103,150],"randomized":[78],"receive":[80],"placebo.":[85],"Thigh":[86],"circumference,":[87,180],"ultrasound":[88,129],"evaluations,":[89],"standardized":[91],"photographs":[92],"collected":[94],"at":[95],"baseline,":[96],"intermediate,":[97],"endpoint":[99],"visits.":[100],"Adverse":[101],"events":[102],"monitored.":[104],"Results:":[105],"After":[106],"84":[107],"days,":[108],"group":[112,124],"exhibited":[113],"significant":[115,132,148],"reduction":[116],"thigh":[118,179],"circumference":[119],"compared":[120],"placebo":[123,154],"(p":[125],"=":[126],"0.0037).":[127],"B-mode":[128],"examinations":[130],"revealed":[131],"parameters":[136],"studied,":[137],"such":[138],"as":[139],"thickness":[141],"subcutaneous":[144],"tissue.":[145,189],"No":[146],"statistically":[147],"noticed":[151],"group.":[155],"Volunteers":[156],"reported":[157,168],"investigational":[159],"product\u2019s":[160],"pleasantness":[161],"good":[163],"anti-cellulite":[164],"activity,":[165],"no":[167],"adverse":[169],"events.":[170],"Conclusions:":[171],"The":[172,190],"demonstrated":[175],"reducing":[178,204],"proposed":[191],"mechanism":[192],"involves":[193],"osmosis,":[194],"releasing":[195],"accumulated":[196],"fluids":[197],"between":[198],"fat":[199],"cells,":[200],"supporting":[201],"drainage,":[202],"inflammation.":[205],"supports":[208],"safety":[212,223],"emulsions":[217],"treatment":[220],"confirms":[222],"user":[225],"satisfaction.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-09T00:00:00"}