{"id":"https://openalex.org/W4396644253","doi":"https://doi.org/10.1016/j.aace.2024.04.009","title":"Parathyroid Hormone\u2013Related Peptide Secretion From a Pancreatic Neuroendocrine Tumor: A Rare Case Report of Severe Hypercalcemia","display_name":"Parathyroid Hormone\u2013Related Peptide Secretion From a Pancreatic Neuroendocrine Tumor: A Rare Case Report of Severe Hypercalcemia","publication_year":2024,"publication_date":"2024-05-04","ids":{"openalex":"https://openalex.org/W4396644253","doi":"https://doi.org/10.1016/j.aace.2024.04.009","pmid":"https://pubmed.ncbi.nlm.nih.gov/39100635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11294741"},"language":"en","primary_location":{"id":"doi:10.1016/j.aace.2024.04.009","doi":"https://doi.org/10.1016/j.aace.2024.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aace.2024.04.009","pdf_url":"http://www.aaceclinicalcasereports.com/article/S2376060524000452/pdf","source":{"id":"https://openalex.org/S2764745361","display_name":"AACE Clinical Case Reports","issn_l":"2376-0605","issn":["2376-0605"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AACE Clinical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.aaceclinicalcasereports.com/article/S2376060524000452/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Erin Foley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099880","display_name":"Rotorua Hospital","ror":"https://ror.org/012eghd53","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4210099880"]},{"id":"https://openalex.org/I4405259026","display_name":"Health New Zealand","ror":"https://ror.org/01jvwvd85","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4405259026"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Erin Foley","raw_affiliation_strings":["Rotorua Hospital, Te Whatu Ora Lakes, Rotorua, New Zealand","Te Whatu Ora Lakes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotorua Hospital, Te Whatu Ora Lakes, Rotorua, New Zealand","institution_ids":["https://openalex.org/I4210099880","https://openalex.org/I4405259026"]},{"raw_affiliation_string":"Te Whatu Ora Lakes","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038301634","display_name":"Prashanth Hari Dass","orcid":"https://orcid.org/0000-0003-4832-0639","observed_orcids":["https://orcid.org/0000-0003-4832-0639"]},"institutions":[{"id":"https://openalex.org/I4210099880","display_name":"Rotorua Hospital","ror":"https://ror.org/012eghd53","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4210099880"]},{"id":"https://openalex.org/I4405259026","display_name":"Health New Zealand","ror":"https://ror.org/01jvwvd85","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4405259026"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Prashanth Hari Dass","raw_affiliation_strings":["Rotorua Hospital, Te Whatu Ora Lakes, Rotorua, New Zealand","Te Whatu Ora Lakes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotorua Hospital, Te Whatu Ora Lakes, Rotorua, New Zealand","institution_ids":["https://openalex.org/I4210099880","https://openalex.org/I4405259026"]},{"raw_affiliation_string":"Te Whatu Ora Lakes","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010721263","display_name":"Esther O'Sullivan","orcid":"https://orcid.org/0000-0002-4750-6880","observed_orcids":["https://orcid.org/0000-0002-4750-6880"]},"institutions":[{"id":"https://openalex.org/I4210099880","display_name":"Rotorua Hospital","ror":"https://ror.org/012eghd53","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4210099880"]},{"id":"https://openalex.org/I4405259026","display_name":"Health New Zealand","ror":"https://ror.org/01jvwvd85","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4405259026"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Esther O\u2019Sullivan","raw_affiliation_strings":["Rotorua Hospital, Te Whatu Ora Lakes, Rotorua, New Zealand","Te Whatu Ora Lakes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotorua Hospital, Te Whatu Ora Lakes, Rotorua, New Zealand","institution_ids":["https://openalex.org/I4210099880","https://openalex.org/I4405259026"]},{"raw_affiliation_string":"Te Whatu Ora Lakes","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010721263"],"corresponding_institution_ids":["https://openalex.org/I4210099880","https://openalex.org/I4405259026"],"apc_list":{"value":900,"currency":"USD","value_usd":900},"apc_paid":{"value":900,"currency":"USD","value_usd":900},"fwci":0.5315,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64857244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"10","issue":"4","first_page":"160","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.3009999990463257,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parathyroid-hormone-related-protein","display_name":"parathyroid hormone-related protein","score":0.921999990940094},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hypercalcemia-of-malignancy","display_name":"hypercalcemia of malignancy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/refractory-hypercalcemia","display_name":"refractory hypercalcemia","score":0.8100000023841858},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9800000190734863},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.968999981880188},{"id":"https://openalex.org/keywords/cancer-associated-hypercalcemia","display_name":"cancer-associated hypercalcemia","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9256750345230103},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6860675811767578},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.5707960724830627},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.5303559899330139},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.488278865814209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47929471731185913},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4283345341682434},{"id":"https://openalex.org/C2778828131","wikidata":"https://www.wikidata.org/wiki/Q2007821","display_name":"Parathyroid hormone-related protein","level":4,"score":0.42695170640945435},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.42678558826446533},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.37539201974868774},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.32315248250961304},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3226233124732971},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.22186017036437988},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.08539536595344543},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.aace.2024.04.009","doi":"https://doi.org/10.1016/j.aace.2024.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aace.2024.04.009","pdf_url":"http://www.aaceclinicalcasereports.com/article/S2376060524000452/pdf","source":{"id":"https://openalex.org/S2764745361","display_name":"AACE Clinical Case Reports","issn_l":"2376-0605","issn":["2376-0605"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AACE Clinical Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11294741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11294741","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11294741/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AACE Clin Case Rep","raw_type":"Text"},{"id":"pmid:39100635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39100635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AACE clinical case reports","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:5b0c0dbf5c0d4c54a5c3561231c3193f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5b0c0dbf5c0d4c54a5c3561231c3193f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AACE Clinical Case Reports, Vol 10, Iss 4, Pp 160-163 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.aace.2024.04.009","doi":"https://doi.org/10.1016/j.aace.2024.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aace.2024.04.009","pdf_url":"http://www.aaceclinicalcasereports.com/article/S2376060524000452/pdf","source":{"id":"https://openalex.org/S2764745361","display_name":"AACE Clinical Case Reports","issn_l":"2376-0605","issn":["2376-0605"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AACE Clinical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396644253.pdf","grobid_xml":"https://content.openalex.org/works/W4396644253.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W163165071","https://openalex.org/W1621696727","https://openalex.org/W1964389660","https://openalex.org/W2035974322","https://openalex.org/W2059814333","https://openalex.org/W2070636400","https://openalex.org/W2079701729","https://openalex.org/W2082303686","https://openalex.org/W2089678680","https://openalex.org/W2095539703","https://openalex.org/W2134608001","https://openalex.org/W2173934737","https://openalex.org/W2416614764","https://openalex.org/W2608160487","https://openalex.org/W2808537568","https://openalex.org/W2985807125","https://openalex.org/W3015314028","https://openalex.org/W4233995690","https://openalex.org/W4312095328","https://openalex.org/W6756684289"],"related_works":["https://openalex.org/W2059814333","https://openalex.org/W4380264615","https://openalex.org/W2035974322","https://openalex.org/W3160895911","https://openalex.org/W2088185761","https://openalex.org/W4407405339","https://openalex.org/W4386448974","https://openalex.org/W2597717093","https://openalex.org/W4280515890","https://openalex.org/W4414351286"],"abstract_inverted_index":{"Background/Objective:":[0],"Hypercalcemia":[1,181],"is":[2,119,127],"a":[3,11,58,63,102,110,150],"common":[4],"occurrence":[5],"associated":[6,121],"with":[7,43,80,101,122,179],"malignancy,":[8],"due":[9,53],"to":[10,54,132],"number":[12],"of":[13,21,45,68,112,137,139,145,153,177,186],"causes:":[14],"(1)":[15],"lytic":[16],"bone":[17],"metastases,":[18],"(2)":[19],"production":[20],"1,25-dihydroxyvitamin":[22],"D":[23],"from":[24,34,57,125],"lymphoma,":[25],"and":[26,85,129],"(3)":[27],"parathyroid":[28],"hormone-related":[29],"peptide":[30],"(PTHrP)":[31],"secretion":[32,56,124],"usually":[33],"solid":[35],"tumors.":[36],"Case":[37],"Report:":[38],"A":[39],"56-year-old":[40],"woman":[41],"presented":[42],"symptoms":[44],"severe":[46,92],"hypercalcemia.":[47,114,180],"Investigations":[48],"determined":[49],"that":[50,118],"this":[51],"was":[52,78,182],"PTHrP":[55,123],"pancreatic":[59],"neuroendocrine":[60],"tumor":[61],"(pNET),":[62],"noted":[64],"complication":[65],"in":[66,163,188],"1.1%":[67],"pNET":[69,178],"cases.":[70,165],"Although":[71],"unfit":[72],"for":[73],"curative":[74],"therapy,":[75],"the":[76,106,133,146,171,183],"patient":[77,107],"treated":[79],"fluid":[81],"replacement,":[82],"bisphosphonates,":[83],"calcitonin,":[84],"denosumab.":[86],"After":[87],"treatment,":[88],"she":[89],"had":[90],"recurrent":[91],"symptomatic":[93],"hypercalcemia":[94,117,138],"on":[95],"several":[96],"occasions":[97],"despite":[98],"adjunctive":[99],"therapy":[100],"somatostatin":[103],"analog.":[104],"Ultimately,":[105],"died":[108],"as":[109],"result":[111],"refractory":[113,131],"Discussion:":[115],"The":[116],"rarely":[120],"pNETs":[126],"aggressive":[128],"often":[130],"usual":[134],"medical":[135],"treatment":[136,142],"malignancy.":[140,193],"Effective":[141],"requires":[143],"cytoreduction":[144],"causative":[147],"tumor.":[148],"Denosumab,":[149],"receptor":[151],"activator":[152],"nuclear":[154],"factor":[155],"kappa":[156],"beta":[157],"ligand":[158],"inhibitor,":[159],"has":[160],"proven":[161],"useful":[162],"some":[164],"Conclusion:":[166],"This":[167],"challenging":[168],"case":[169],"highlighted":[170],"rare":[172],"but":[173],"potentially":[174],"fatal":[175],"association":[176],"main":[184],"cause":[185],"mortality":[187],"an":[189],"otherwise":[190],"relatively":[191],"indolent":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-05-05T00:00:00"}