{"id":"https://openalex.org/W4396616031","doi":"https://doi.org/10.1007/s00381-024-06399-4","title":"Prospects of CSF shunt independence among chronically shunted patients","display_name":"Prospects of CSF shunt independence among chronically shunted patients","publication_year":2024,"publication_date":"2024-05-03","ids":{"openalex":"https://openalex.org/W4396616031","doi":"https://doi.org/10.1007/s00381-024-06399-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/38700705"},"language":"en","primary_location":{"id":"doi:10.1007/s00381-024-06399-4","doi":"https://doi.org/10.1007/s00381-024-06399-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00381-024-06399-4","pdf_url":null,"source":{"id":"https://openalex.org/S65770309","display_name":"Child s Nervous System","issn_l":"0256-7040","issn":["0256-7040","1433-0350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child's Nervous System","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dx.doi.org/10.21203/rs.3.rs-4125850/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048821219","display_name":"Joyce Koueik","orcid":"https://orcid.org/0000-0003-3809-3225","observed_orcids":["https://orcid.org/0000-0003-3809-3225"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Koueik","raw_affiliation_strings":["Departments of Neurological Surgery, University of Wisconsin, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0003-3809-3225","affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery, University of Wisconsin, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033329636","display_name":"Aimee Teo Broman","orcid":"https://orcid.org/0000-0003-3783-2807","observed_orcids":["https://orcid.org/0000-0003-3783-2807"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aimee Teo Broman","raw_affiliation_strings":["Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069551412","display_name":"Bermans J. Iskandar","orcid":"https://orcid.org/0000-0002-3856-1597","observed_orcids":["https://orcid.org/0000-0002-3856-1597"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bermans J. Iskandar","raw_affiliation_strings":["Departments of Neurological Surgery, University of Wisconsin, Madison, WI, USA. iskandar@neurosurgery.wisc.edu","University of Wisconsin School of Medicine and Public Health, K4/832 Clinical Science Center, Mail Code, 600 Highland Avenue, Madison, WI, 8660, 53792-8660, USA. iskandar@neurosurgery.wisc.edu","University of Wisconsin School of Medicine and Public Health, K4/832 Clinical Science Center, Mail Code, 600 Highland Avenue, Madison, WI, 8660, 53792-8660, USA"],"raw_orcid":"https://orcid.org/0000-0002-3856-1597","affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery, University of Wisconsin, Madison, WI, USA. iskandar@neurosurgery.wisc.edu","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, K4/832 Clinical Science Center, Mail Code, 600 Highland Avenue, Madison, WI, 8660, 53792-8660, USA. iskandar@neurosurgery.wisc.edu","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin School of Medicine and Public Health, K4/832 Clinical Science Center, Mail Code, 600 Highland Avenue, Madison, WI, 8660, 53792-8660, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069551412"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.1743,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.40232492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"40","issue":"8","first_page":"2401","last_page":"2409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12622","display_name":"Neurosurgical Procedures and Complications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shunt-independence","display_name":"shunt independence","score":0.9589999914169312},{"id":"https://openalex.org/keywords/endoscopic-third-ventriculostomy","display_name":"endoscopic third ventriculostomy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chronic-hydrocephalus","display_name":"chronic hydrocephalus","score":0.7429999709129333},{"id":"https://openalex.org/keywords/ventriculoperitoneal-shunt","display_name":"ventriculoperitoneal shunt","score":0.7599999904632568},{"id":"https://openalex.org/keywords/shunt-removal","display_name":"shunt removal","score":0.7580000162124634},{"id":"https://openalex.org/keywords/shunt-revision","display_name":"shunt revision","score":0.7710000276565552},{"id":"https://openalex.org/keywords/congenital-hydrocephalus","display_name":"congenital hydrocephalus","score":0.7900000214576721},{"id":"https://openalex.org/keywords/posthemorrhagic-hydrocephalus","display_name":"posthemorrhagic hydrocephalus","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aqueductal-stenosis","display_name":"aqueductal stenosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/myelomeningocele","display_name":"myelomeningocele","score":0.8330000042915344},{"id":"https://openalex.org/keywords/shunt-complications","display_name":"shunt complications","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C35651441","wikidata":"https://www.wikidata.org/wiki/Q625303","display_name":"Independence (probability theory)","level":2,"score":0.6119527816772461},{"id":"https://openalex.org/C2780968331","wikidata":"https://www.wikidata.org/wiki/Q1890115","display_name":"Shunt (medical)","level":2,"score":0.5317932963371277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4382967948913574},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3824608027935028},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3315715193748474},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16238859295845032},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08562341332435608}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002557","descriptor_name":"Cerebrospinal Fluid Shunts","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006849","descriptor_name":"Hydrocephalus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014696","descriptor_name":"Ventriculostomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020542","descriptor_name":"Third Ventricle","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D044583","descriptor_name":"Neuroendoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00381-024-06399-4","doi":"https://doi.org/10.1007/s00381-024-06399-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00381-024-06399-4","pdf_url":null,"source":{"id":"https://openalex.org/S65770309","display_name":"Child s Nervous System","issn_l":"0256-7040","issn":["0256-7040","1433-0350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child's Nervous System","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4125850/v1","doi":"https://doi.org/10.21203/rs.3.rs-4125850/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4125850/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:38700705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38700705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-4125850/v1","doi":"https://doi.org/10.21203/rs.3.rs-4125850/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4125850/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1514024495","https://openalex.org/W1980427053","https://openalex.org/W1982448710","https://openalex.org/W1995828963","https://openalex.org/W1996927985","https://openalex.org/W2000331194","https://openalex.org/W2020511273","https://openalex.org/W2031330193","https://openalex.org/W2033155321","https://openalex.org/W2036322075","https://openalex.org/W2050876212","https://openalex.org/W2064347825","https://openalex.org/W2072941185","https://openalex.org/W2076036712","https://openalex.org/W2076826413","https://openalex.org/W2097144474","https://openalex.org/W2109348483","https://openalex.org/W2122864182","https://openalex.org/W2140784786","https://openalex.org/W2141129836","https://openalex.org/W2399917756","https://openalex.org/W2606568970","https://openalex.org/W2885434748","https://openalex.org/W2990394826","https://openalex.org/W4245307032","https://openalex.org/W4283212093","https://openalex.org/W4288736339","https://openalex.org/W4387220275","https://openalex.org/W6835133954"],"related_works":["https://openalex.org/W6908604749","https://openalex.org/W4288736339","https://openalex.org/W2038656214","https://openalex.org/W2955213522","https://openalex.org/W1502690518","https://openalex.org/W2990394826","https://openalex.org/W1991474504","https://openalex.org/W2912873883","https://openalex.org/W2035855265","https://openalex.org/W2166020409"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,9,99,163,195,205,231,293],"objectives":[3],"CSF":[4,108],"shunt":[5,44,60,85,92,112,184,215,221,246,256,279,290],"placement":[6,216],"for":[7,35,47,126,245,261],"hydrocephalus":[8,130,134,160,165],"other":[10],"etiologies":[11,227],"has":[12,42],"arguably":[13],"been":[14],"the":[15,23,57,192,198,236,250,295,298],"most":[16],"life-saving":[17],"intervention":[18],"in":[19,22,69,191,197,281,294],"pediatric":[20],"neurosurgery":[21],"past":[24],"6":[25,166],"decades.":[26],"Yet,":[27],"chronic":[28],"shunting":[29,127],"remains":[30],"a":[31,77,121,172],"source":[32],"of":[33,37,59,118,136,253,264,288],"morbidity":[34],"patients":[36,83,106,182],"all":[38],"ages.":[39],"Neuroendoscopic":[40],"surgery":[41],"made":[43,176],"independence":[45,61,257,280],"possible":[46],"newly":[48],"diagnosed":[49],"hydrocephalic":[50],"patients.":[51,72],"In":[52],"this":[53,267],"study,":[54],"we":[55],"examine":[56],"prospects":[58],"with":[62,94,107],"or":[63,88,95,115],"without":[64,96],"endoscopic":[65],"third":[66],"ventriculostomy":[67],"(ETV)":[68],"chronically":[70,282],"shunted":[71,283],"Methods":[73],"After":[74],"IRB":[75],"approval,":[76],"retrospective":[78],"analysis":[79,204],"was":[80,86,175,189],"completed":[81],"on":[82,178],"whose":[84],"ligated":[87,114],"removed":[89],"to":[90,170],"achieve":[91],"independence,":[93],"ETV.":[97,123],"Clinical":[98],"imaging":[100],"data":[101,274],"were":[102,242],"collected.":[103],"Results":[104],"Eighty-eight":[105],"shunts":[109],"had":[110,120],"their":[111],"either":[113],"removed,":[116],"57":[117],"whom":[119],"concomitant":[122],"Original":[124],"reasons":[125],"included:":[128],"congenital":[129],"20":[131],"(23%),":[132],"post-hemorrhagic":[133],"(PHH)":[135],"prematurity":[137],"14":[138],"(16%),":[139],"aqueductal":[140],"stenosis":[141],"10":[142],"(11%),":[143],"intracranial":[144],"cyst":[145],"8":[146,149,154],"(9%),":[147,150,155],"tumor":[148],"infantile":[151],"subdural":[152],"hematomas":[153],"myelomeningocele":[156],"7":[157,161],"(8%),":[158],"post-traumatic":[159],"(8%)":[162],"post-infectious":[164],"(7%).":[167],"The":[168,186],"decision":[169],"perform":[171],"simultaneous":[173],"ETV":[174,193,200,237,296],"based":[177],"etiology.":[179],"Forty-nine":[180],"(56%)":[181],"became":[183],"independent.":[185],"success":[187],"rate":[188],"46%":[190],"group":[194],"73%":[196],"no":[199,220],"group.":[201],"Using":[202],"multivariate":[203],"Cox":[206],"Proportional":[207],"Hazards":[208],"models,":[209],"age":[210],">":[211,233],"4":[212],"months":[213],"at":[214],"(p":[217,223,228,239],"=":[218,224,229,240],"0.032),":[219],"revisions":[222],"0.01),":[225],"select":[226],"0.043),":[230],"ETVSS":[232],"70":[234],"(in":[235],"group)":[238],"0.017),":[241],"protective":[243],"factors":[244,276],"independence.":[247],"Conclusion":[248],"Considering":[249],"long-term":[251],"complications":[252],"shunting,":[254],"achieving":[255],"may":[258],"provide":[259],"hope":[260],"improved":[262],"quality":[263],"life.":[265],"While":[266],"study":[268],"is":[269],"underpowered,":[270],"it":[271],"provides":[272],"pilot":[273],"identifying":[275],"that":[277],"predict":[278],"patients,":[284],"namely":[285],"age,":[286],"absence":[287],"prior":[289],"revision,":[291],"etiology,":[292],"group,":[297],"ETVSS.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-04T00:00:00"}
